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DBU-catalyzed substitution-controlled synthesis of oxa[3.3.1] bridged ring and naphthylamine derivatives

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00012A, Research Article
Shiyu Xu, Zhihui Sun, Pengyutian Liu, Yuanlin Wei, Fan Sun, Man Zhao, Ying Wang, Ming Zhang, Guofeng Li, Hong Liang
A switchable cascade cyclization reaction of ortho-alkynyl arylketones with amines has been developed, where the different reaction pathways are controlled by the substituent on the α-carbon of in-situ-generated ortho-alkynyl arylaldimines.
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Modular synthesis of C2-symmetric nitrogen-containing polyaromatics via visible light-enabled reductive aza-6π electrocyclization

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00140K, Research Article
Qun-Liang Zhang, Qing-Tian Fan, Yirong Zhou, Jingli Zhang, Fang-Lin Zhang
Here, an unprecedented one-step modular construction of C2-symmetric N-PACs through  reduction/aza-6π electrocyclization was reported and the resultant C2-symmetric N-PAC could be  converted into  a powerful organic photocatalyst.
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Neighboring group-directed asymmetric [2 + 2 + 2] cycloaddition to access C–N axially chiral indoles

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00042K, Research Article
Xuan Zhang, Qi Teng, Yanru Ren, Baitong Wei, Chen-Ho Tung, Zhenghu Xu
A Rh-catalyzed neighboring group-directed asymmetric [2 + 2 + 2] cycloaddition of 1,6-diynes and ynamides to generate C–N axially chiral indole derivatives has been developed.
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Sustainable synthesis of long-acting local anesthetics ropivacaine and levobupivacaine under batch and continuous flow via asymmetric hydrogenation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00072B, Research Article
Zhi Yang, Hanlin Chen, Linxi Wan, Xinyi Feng, Lingshuang Ma, Pei Tang, Fen-Er Chen
A sustainable synthesis method was developed for long-acting local anesthetics, ropivacaine and levobupivacaine, using both batch and continuous flow processes via asymmetric hydrogenation.
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Vaska's complex–PMHS combination enabled mild and chemoselective reduction of sulfoxides to sulfides with low catalyst loading

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00312H, Research Article
Fang-Fang Xu, Zhong-Lei Ruan, Pei-Qiang Huang
We report a highly efficient, versatile, and chemoselective method for the catalytic reduction of sulfoxides to sulfides under mild conditions.
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Decarbonylative C(sp2)–C(sp2) reductive cross-coupling of aroyl fluorides with aryl bromides by palladium/cobalt co-catalysis

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00305E, Research Article
Chen He, Zhiyong Song, Wei Yao, Rui Lin, Yuanhong Ma
Herein, we report a decarbonylative C(sp2)–C(sp2) reductive cross-coupling of aroyl fluorides with aryl bromides by palladium and cobalt co-catalysis.
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Electrochemically dehydrogenative C(sp2)–H/S–H cross-coupling: efficient synthesis of ortho-aminophenyl thioglycoside derivatives

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00171K, Research Article
Li-Yan Hu, Li Zhu, Shen-Yuan Zhang, Yu-Xin Guo, Yuan Li, Jie Zhu, Lei Wu
A method has been reported for synthesizing aryl thioglycosides through direct electrocatalytic dehydrogenative C(sp2)–H/S–H cross-coupling.
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Triazatriangulenium salts – hosts and guests in supramolecular assemblies in solution

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00500G, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sayan Sarkar, Michael Böck, Agnes Uhl, Aleksandr Agafontsev, Jürgen Schatz, Evgeny A. Kataev
Self-assembly of triangulenium dyes bearing C3-C8 substituents and their interaction with aromatic compounds and cyclophanes were studied in solution.
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Nickel metallaphotoredox-catalyzed C–O bond activation/Csp2–Csp3 coupling enabled by phosphine

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00310A, Research Article
Jiaxi Fang, Ziheng Jian, Huan Liu, Yuting Wang, Xianbo Yu, Zehuai Mou, Huifei Wang
A novel and general nickel/photoredox dual catalysis platform for benzyl alcohol C–O bond activation/Csp2–Csp3 cross coupling of benzothiazolyl bromide and free alcohol, enabled by the catalytic generation of an alkyl radical, is reported.
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Electrochemical switching in mechanically interlocked molecules (MIMs)

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00061G, Review Article
Ayush Bhadani, Murugavel Kathiresan
Mechanically interlocked molecules (MIMs) which include rotaxanes and catenanes are formed by the mechanical linking of two or more components and has the ability to switch between different states in the presence of an external stimuli.
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Visible-light-mediated catalyst-free synthesis of trifluoromethyl(spiro)-epoxides bearing contiguous quaternary centers

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00184B, Research Article
Jingchuan Lin, Yu Zhang, Jinxin Wang, Xinyu Han, Shenglan Zhu, Tong Li, Yanping Zhu, Wei-Dong Zhang
Herein, we describe a non-covalent complex-mediated epoxidation strategy that can yield highly selective central spiro-epoxides by irradiation with visible light without the need for catalyst addition.
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Unprecedented single-electron-transfer reduction-based N → C acyl migration reactions of imides enabled by redox-neutral photocatalysis

Org. Chem. Front., 2024, 11,2344-2350
DOI: 10.1039/D3QO01955A, Research Article
Linge Huai, Li Zhang, Zhentao Wang, Yewen Fang
N → C acyl migration: in the absence of a base, redox-neutral photocatalyzed acyl migration reactions have been realized via the reaction of N-vinylimides with alkyl radicals derived from alkyl silicates.
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Synthesis of benzothiophenes via sulfonium-[3,3]-rearrangement of aryl sulfoxides with allenenitriles

Org. Chem. Front., 2024, 11,2208-2214
DOI: 10.1039/D4QO00121D, Research Article
Lei Zhang, Kun Wan, Huanhuan Wang, Mengyao Wang, Ao Cui, Xin Huang, Bo Peng
A facile synthesis of benzothiophenes from readily available aryl sulfoxides and allenenitriles has been established through sulfonium-rearrangement triggered cyclization.
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Deoxygenation of N-heterocyclic N-oxides using isopropanol as a recyclable reductant

Org. Chem. Front., 2024, 11,2249-2268
DOI: 10.1039/D4QO00208C, Research Article
Ho Kyeong Ryu, Yun Do Song, Jun Hee Lee
An organic photoredox-based recyclable strategy that facilitates the chemoselective deoxygenation of various functionalised N-heterocyclic N-oxides is presented.
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Synthesis of enantiopure 1,2,3-triazolylidene-type mesoionic carbene (MIC) conjugate acids featuring a rigid bicyclic scaffold

Org. Chem. Front., 2024, 11,2178-2181
DOI: 10.1039/D4QO00269E, Research Article
Vojtěch Dočekal, Mohand Melaimi, Simona Petrželová, Jan Veselý, Xiaoyu Yan, Guy Bertrand
Chiral NHCs have found numerous applications as ligands for transition metals and in their own right for asymmetric catalysis. We report a synthetic route from L-malic acid to enantiopure 1,2,3-triazoliums with the chiral center in a fused ring.
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Visible light/copper catalysis enabled Heck-like coupling between alkenes and cyclic sulfonium salts via selective C–S bond cleavage

Org. Chem. Front., 2024, 11,2195-2200
DOI: 10.1039/D3QO02009F, Research Article
Xianqin Liu, Xufeng Li, Linyuan Wang, Yongjia Shi, Jian Lv, Daoshan Yang
A Heck-like coupling of cyclic sulfonium salts with alkenes via selective C–S bond cleavage using a copper complex as a photosensitizer through a visible-light-driven redox-neutral process has been developed.
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Electrode-switchable: exploring this new strategy to achieve regiodivergent azidoiodination of alkenes

Org. Chem. Front., 2024, 11,2189-2194
DOI: 10.1039/D3QO01935G, Research Article
Xin-Lei Sun, Chen-Xi Xia, Yue Ren, Yu-Jin Li, Zhi-Qian Cao, Ling-Guo Meng
An “electrode-switchable” organic electrochemistry method for the azidoiodination of alkenes, where the choice of anode dictates the regiodivergent alkene azidoiodination, reveals a novel pathway for controlled regioisomers.
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Selective photochemical synthesis of primary arylamines and symmetric diarylamines via amination of aryl bromides using Ni(NH3)6Cl2 as a nitrogen source and catalyst

Org. Chem. Front., 2024, 11,2313-2318
DOI: 10.1039/D4QO00116H, Research Article
Zhehui Xu, Jianyang Dong, Geyang Song, Fuqiang Kong, Gang Li, Dong Xue
The selective synthesis of primary arylamines and diarylamines via coupling reactions with ammonia as a nitrogen source is still challenging.
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Contributors to the Organic Chemistry Frontiers Emerging Investigator Series 2022–2023

Org. Chem. Front., 2024, 11,2149-2154
DOI: 10.1039/D4QO90025A, Profile

This profile article showcases researchers who have contributed an article to the Organic Chemistry Frontiers Emerging Investigator Series.
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Assembly of ionic supramolecular polymers using a decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00447G, Research Article
Qian Li, Danying Ma, Yue-Yang Liu, Hui Wang, Wei Zhou, Dan-Wei Zhang, Zhan-Ting Li
A multicationic pillar[5]arene noncovalently crosslinks hyaluronic acid to afford ionic supramolecular polymers for intramolecular delivery of short DNA.
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Cr-mediated Photocatalytic Decarboxylative Coupling of alpha-Oxo Acids with Benzylic Pyridinium Salts

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00475B, Research Article
Jia Cao, Yan Liu, Zhixiang Wang, Le Liu
Herein, we report the chromium/photoredox dual catalytic synthesis of ketones using α-oxo acids with benzylic pyridinium salts. This reaction proceeded by photocatalytic generation of acyl radical from α-oxo acids and...
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Visible-light Induced [1, 3]-Brook Rearrangements of α-Ketoacylsilanes and Its Subsequent Trapping in a Tandem Annulation with 1, 3, 5-Triazinanes and Azomethine Imines

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00463A, Research Article
Zhong Zhang, Sirui Wu, Yuqiao Zhou, Bao-Lin Li, Siyue Xiao, Xiaohu Zhao, Zhipeng Yu
An unusual visible light-induced [1, 3]-Brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazinanes and C,N-cyclic azomethine imines has been developed under catalyst-free and mild reaction conditions. The strategy offers...
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Cobalt-catalysed Csp3–Csp3 cross-coupling of benzyl Katritzky pyridinium salts with Callyl–O electrophiles

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00402G, Research Article
Mengyu Gao, Corinne Gosmini
Different allylbenzyl derivatives are synthesized by Co-catalyzed reductive cross-coupling from functionalized benzyl Katritzky pyridinium salts and various allylic acetates, ethers or carbonates in moderate to good yields under mild conditions.
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Synthesis of oxindole fused 1,3-oxazepanes via hydride transfer initiated ring expansion of pyrrolidine

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00474D, Research Article
Peng He, Zongkang Wang, Qiongwen Kang, Nana Fei, Chengyu Wang, Yanzhong Li
An efficient B(C6F5)3 catalyzed protocol for the synthesis of oxindole fused 1,3-oxazepanes from pyrrolidine substituted aryl alkynones has been developed.
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Halogen-Bond-Promoted Direct Cross-Coupling of Ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with Coumarins/Quinolinones

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00484A, Research Article
Guoliang Pu, Shi-Yuan Song, Jian Yang, Peng Guo, Jia Jia, Peijun Liu, Xuefei Li, Ping Liu, Chun-Yang He
Herein, we developed a practical method for the direct cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with coumarins/quinolinones, leveraging a halogen bond as the pivotal non-covalent interaction. Employing this protocol, a library of...
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Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00481G, Research Article
Jia-Chen Xiang, Yu-Die Wang, Peng Yuan, Hui-Min Zhu, Tong Lei, An-Xin Wu, Zhixin Liao
Three typical substrates for the Mannich reaction, p-anisidine, aldehyde, and a nucleophile, did not afford the predictable linear Mannich base under an aerobic copper oxidation condition, but rendering a 2,2-disubstituted indolin-3-one product.
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Integrating continuous flow reaction and work-up: chiral amine resolution, separation and purification using a novel coalescing filter system

React. Chem. Eng., 2024, Accepted Manuscript
DOI: 10.1039/D4RE00442F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Bethan May Rowley, Lisa Alice Thompson, Luke Power, James Daglish, Emma Parks, James Birbeck, Stephen P Marsden, Nikil Kapur, John Blacker
To maximize the benefits of a continuous flow reaction, a continuous work-up is also needed. Herein, we present a process design and novel equipment for a continuous amine resolution reaction,...
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Upcycling polymethyl methacrylate to methacrylic acid

React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00341A, Paper
Yanfa Zhuang, Nooshin Saadatkhah, Tien-Dat Nguyen, Jacopo De Tommaso, Clive Yi Jie Ng, Chunyu Wang, Abdellah Ajji, Gregory S. Patience
Upcycling PMMA to methacrylic acid rather than methyl methacrylate is a viable economic alternative to treat end-of-life plastic.
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A Hierarchical Surrogate Approach to Biomass Ethanolysis Reaction Kinetic Modelling

React. Chem. Eng., 2024, Accepted Manuscript
DOI: 10.1039/D4RE00378K, Paper
Ailís O'Shea, Conall McNamara, Prajwal Rao, Mícheál Séamus Howard, Mohammad Reza Ghaani, Stephen Dooley
The reaction mechanism and kinetics of the sulfuric acid catalysed ethanolysis of glucose, cellulose, xylan, and corncob was investigated using a combination of experiments and empirical reaction mechanism modelling. The...
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Scalable electrified cementitious materials production and recycling

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE03529A, Paper
Open Access
Xiao Kun Lu, Wenxin Zhang, Brianna N. Ruggiero, Linsey C. Seitz, Jiaqi Li
Our electrochemical production uses carbon-free rocks, water electrolysis, and CO2 capture/circulation for carbon-neutral/negative cement and green H2, turning cement from the second-largest industrial CO2 emitter to a gigaton-scale CCUS enabler.
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Efficient Fully Textured Perovskite Silicon Tandems with Thermally Evaporated Hole Transporting Materials

Energy Environ. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4EE03899A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Bhushan Kore, Oussama Er-raji, Oliver Fischer, Adrian Callies, Oliver Schultz-Wittmann, Patricia Samia Cerian Schulze, Martin Bivour, Stefaan De Wolf, Stefan W Glunz, Juliane Borchert
Fully textured perovskite silicon tandem solar cells effectively minimize the reflection losses and are compatible with industrial silicon production lines. To facilitate scalability and industrial deployment of perovskite silicon tandems...
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Contribution of an instructional module incorporating PhET simulations to Rwandan students' knowledge of chemical reactions, acids, and bases through social interactions

Chem. Educ. Res. Pract., 2024, Advance Article
DOI: 10.1039/D4RP00105B, Paper
Jean-Baptiste Ndagijimana, Jeannette Musengimana, Henriette Mushimiyimana, Evode Mukama, Olivier Habimana, Paulin Manirakiza, Jean Claude Dushimimana, Jean Pierre Alpha Munyaruhengeri, Samia Khan, Elizabeth Lakin
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New treatment option for young women with hormone-sensitive breast cancer

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.




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Inference with Gemma using Dataflow and vLLM

vLLM's continuous batching and Dataflow's model manager optimizes LLM serving and simplifies the deployment process, delivering a powerful combination for developers to build high-performance LLM inference pipelines more efficiently.




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IIT Kharagpur-led study says tropical rainforests could survive global warming

The study, published online in the Elsevier journal, was conducted on records of rainforests in sediments from Gujarat’s Vastan coal mines deposited in coastal lagoons around 56 million years ago




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Let's ensure resounding victory together: Rahul Gandhi to Wayanad voters

‘She [Priyanka Gandhi Vadra] will be more than just a representative – she will be your sister, your daughter, and your advocate’, says Rahul Gandhi in a post on X on bypoll day




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E.P. Jayarajan’s ‘autobiography’ row: publishing house remains tight lipped, refuses to clear the air

Jayarajan claims that circulating excerpts from his ‘autobiography’ are baseless nonsense and asserts that he had not granted publishing rights for his autobiography to any establishment




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‘Sea ranching’ launched off Thiruvananthapuram as follow-up to artificial reef project

Minister of State for Fisheries George Kurian launches project; 10 lakh pompano, cobia fingerlings to be deposited in 10 selected locations




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Waqf Board can initiate criminal proceedings in post-2013 Waqf land encroachment cases

A Single Judge of the Kerala High Court quashed the proceedings against two people in an alleged pre-2013 land encroachment case on Tuesday by noting that such acts were made punishable only through an amendment to the Waqf Act in 2013, the accused were in possession of the property even before the introduction of the amendment, and no penal acts could be given retrospective operation




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KHTC looking to resume boating in Anayirankal dam

Agency, in an affidavit submitted in the Kerala High Court, outlines plans to make boating facility more eco-friendly




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Women’s Commission sitting held in Kollam




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One-fourth of people living with diabetes in India, Lancet study estimates

Of the 82.8 crore, India's share formed over a quarter (21.2 crore). Another 14.8 crore were in China, while 4.2 crore, 3.6 crore and 2.2 crore lived in the US, Pakistan and Brazil, respectively, the researchers found




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Tata Power Renewable Energy unveils 126 MW Omkareshwar floating solar project, setting new global standards

With this project, TPREL’s total renewable capacity reaches 10.9 GW, reinforcing its position in India’s journey towards a greener energy future.




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Bangladesh includes 1,000 threatened species in 'Red List of Plants'




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Africa's policymakers, educators seek ways to end learning poverty on continent




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Decline in Austria's fruit farming linked to climate change




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India, Russia discuss economic cooperation, facilitating mobility of talent and skills




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South Africa expects G20 summit to strengthen multilateralism




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South Korea to double marine protection zone, address climate change




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Carpet fibres used by Australian researchers to make stronger concrete