ng Perpendicular magnetic recording disk with multiple magnetic layers and intermediate dual nucleation films for control of grain size By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A perpendicular magnetic recording disk has a graded-anisotropy recording layer (RL) formed of at least two ferromagnetically exchange coupled CoPtCr-oxide magnetic layers (MAG1 and MAG2) with two nucleation films (NF1 and NF2) between the magnetic layers. NF1 is a metal film, preferably Ru or a Ru-based alloy like RuCr, sputter deposited on MAG1 at low pressure to a thickness between about 0.1-1.5 nm. NF2 is a metal oxide film, preferably an oxide of Ta, sputter deposited on NF1 at high pressure to a thickness between about 0.2-1.0 nm. MAG2 is sputter deposited over NF2. NF1 and NF2 provide a significant reduction in average grain size in the RL from a graded-anisotropy RL without nucleation films between MAG1 and MAG2, while also assuring that MAG1 and MAG2 are strongly exchange coupled. Full Article
ng Organic compound, light-emitting element, light-emitting device, electronic device, and lighting device By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A novel substance with which an increase in life and emission efficiency of a light-emitting element can be achieved is provided. A carbazole compound having a structure represented by General Formula (G1) is provided. Note that a substituent which makes the HOMO level and the LUMO level of a compound in which a bond of the substituent is substituted with hydrogen deep and shallow, respectively is used as each of substituents in General Formula (G1) (R1, R2, Ar3, and α3). Further, a substituent which makes the band gap (Bg) and the T1 level of a compound in which a bond of the substituent is substituted with hydrogen wide and high is used as each of the substituents in General Formula (G1) (R1, R2, Ar3, and α3). Full Article
ng Optical film, method of producing optical film, antireflective film, polarizing plate and image display device By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT An optical film has a cellulose acylate film base material containing cellulose acylate and a plurality of sugar ester compounds having different ester substitution degrees in which an average ester substitution degree of the plurality of sugar ester compounds is from 60 to 94%, and an antistatic hardcoat layer formed from a coating composition containing at least an organic antistatic agent and a curable compound having a (meth)acryloyl group in a molecule of the curable compound. Full Article
ng Liquid crystalline polyester composition and metal composite molded product using the same By www.freepatentsonline.com Published On :: Tue, 02 Jun 2015 08:00:00 EDT A liquid crystalline polyester composition containing at least 100 parts by weight of liquid crystalline polyester (A) and 10 to 100 parts by weight of talc (B). The talc (B) has a ratio (a1/a2) of oil absorption (a1) ml/100 g to specific surface area (a2) m2/g in a range of 14.0 to 26.0 (ml·g)/(100 g·m2) and has a number-average particle diameter of 10 to 30 μm. Full Article
ng Heterocyclic compound and organic light-emitting device including the same By www.freepatentsonline.com Published On :: Tue, 09 Jun 2015 08:00:00 EDT Embodiments of the present invention are directed to heterocyclic compounds and organic light-emitting devices including the heterocyclic compounds. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltages, high luminance and long lifespans. Full Article
ng Low profile, wrappable elongate members spacer and method of maintaining elongate members in fixed, spaced relative relation By www.freepatentsonline.com Published On :: Tue, 23 Jun 2015 08:00:00 EDT A low profile, wrappable spacer and method for maintaining a pair of elongate members in fixed, spaced relation to one another is provided. The wrappable spacer includes a flexible elongate body having oppositely facing inner and outer faces extending along laterally spaced, lengthwise extending edges between opposite ends. The inner face has an adhesive surface. At least one member extends between the edges transversely to the lengthwise extending edges. The member extends outwardly from the adhesive surface, wherein the adhesive surface is configured for adhesion to at least one of the member, the elongate members or the outer face. Full Article
ng Organic light-emitting device By www.freepatentsonline.com Published On :: Tue, 30 Jun 2015 08:00:00 EDT A heterocyclic compound represented by Formula 1 or Formula 2 below and an organic light-emitting device including the heterocyclic compound: wherein X1, X2, and R1 through R16 are defined as in the specification. Full Article
ng Zinc-plated steel sheet for hot pressing having outstanding surface characteristics, hot-pressed moulded parts obtained using the same, and a production method for the same By www.freepatentsonline.com Published On :: Tue, 30 Jun 2015 08:00:00 EDT Provided is a zinc-plated steel sheet for hot pressing having outstanding surface characteristics, comprising: a steel foundation plate comprising a metal surface diffusion layer of which the Gibbs free energy reduction per mole of oxygen during oxidation is less than that of Cr; an aluminum-rich layer containing at least 30 wt. % of aluminum formed on the surface diffusion layer, and a zinc plating layer formed on the aluminum-rich layer. In this way, a metal having a low affinity for oxygen is coated to an effective thickness prior to annealing and thus the creation of annealing oxides at the surface of the steel sheet is suppressed and a uniform zinc plating layer is formed, and alloying of the zinc plating layer is promoted during press-processing heat treatment. Cracking in the steel foundation plate during hot press molding is prevented. Full Article
ng Printed flexible film for food packaging By www.freepatentsonline.com Published On :: Tue, 11 Aug 2015 08:00:00 EDT The printed image on a major face of a flexible food packaging film is covered by a shellac barrier coating. Full Article
ng Coated cutting tool By www.freepatentsonline.com Published On :: Tue, 13 Oct 2015 08:00:00 EDT The present invention relates to a coated cutting tool comprising a PVD coating and a cemented carbide substrate comprising Co in an amount of 12.5-17 wt %, Cr in an amount such that the Cr/Co weight ratio is 0.05-0.15, a Ti of between 50 to 300 ppm by weight and a CW_Cr value between 0.8-0.97. Full Article
ng Organic light-emitting device By www.freepatentsonline.com Published On :: Tue, 13 Oct 2015 08:00:00 EDT An organic light-emitting device, including a first electrode, the first electrode having a smaller absolute value of a work function energy level than an absolute value of a work function energy level of ITO, a second electrode facing the first electrode, and an organic layer between the first electrode and the second electrode. Full Article
ng Method for controlling pump transitions in a multi-mode hybrid transmission By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A method of controlling a pump for a hybrid transmission includes commanding a first line pressure of the transmission and deriving a first torque value—an open-loop torque value—from the first line pressure command, and commanding the pump to operate at the first torque value. The method monitors actual speed of the pump and derives a second torque value—a closed-loop torque value—therefrom. A third torque value is derived from the first and second torque values, and the pump commanded to operate at the third torque value. A first speed value may be derived from the first line pressure command, and the second torque value derived from the difference between the monitored and the first speed values. Deriving the third torque value may include a substantially-linear combination of the first and second torque values. Full Article
ng Belt drive arrangement for an auxiliary unit of a motor vehicle, motor vehicle, and method for operating an auxiliary unit of a motor vehicle By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A belt drive arrangement for an auxiliary unit of a motor vehicle includes, but is not limited to a belt pulley for receiving a drive belt, a shaft of the auxiliary unit that can be driven with the torque of the belt pulley, and a clutch device for the releasable torque transmission between the belt pulley and the shaft of the auxiliary unit. The clutch device includes, but is not limited to an electromagnet and a spring element. The spring element is preloaded in such a manner that the clutch in a currentless state of the electromagnet is closed. Full Article
ng Engine ignition-transmission shift interlock By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A method for controlling a vehicle equipped with a manual transmission and engine includes automatically engaging a brake, locking the transmission in neutral and starting the engine, in response to a signal whose origin is remote from the vehicle representing a desired engine start; and automatically engaging a brake and locking the transmission in neutral in response to a second signal indicating that the driver has exited the vehicle while the engine is running. Full Article
ng Pilot downshifting system and method By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT Methods and systems are provided for performing a multiple gear downshift of a transmission gear by transiently operating in an intermediate gear. In response to air mass flow not reaching a threshold for CAC self-cleansing for a set duration, the transmission gear may be downshifted from a higher gear to an intermediate gear, and then to a requested lower gear. Downshifting through an intermediate gear may also be controlled based on the gear shift request and maximum air mass flow levels for engine misfire. Full Article
ng Method for controlling the engine of a motor vehicle having a manual transmission By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT In a motor vehicle having a manual transmission, for, in particular, limiting the engine speed during the start-up operation when fulfilling at least one permission criterion for the engine torque, the criterion depending on the driving state of the motor vehicle, a default engine torque is preset, which is specified according to at least one engine characteristic value and which can be reduced with regard to the set engine torque called for by the position of the accelerator pedal of the motor vehicle. Full Article
ng Systems and methods for aircraft braking and taxiing By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT Systems and methods are disclosed for aircraft braking and taxiing systems for use in, for example, an aircraft. In this regard, system comprising an electric motor coupled to a first transmission, a first clutch for selectively engaging the first transmission to a propulsion transmission and a brake clamping system, wherein, in response to engagement with the propulsion transmission, the electric motor drives an aircraft wheel, wherein, in response to engagement with the actuator ram, the electric motor drives the brake clamping system to apply force to an aircraft brake disk stack. Full Article
ng Method for operating a brake system of a work machine and brake system for a work machine By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A method for operating a brake system for a work machine that includes at least one operating brake acting directly or indirectly on at least one ground engagement element of the work machine and at least one operating brake actuator which is movable between a fully engaged position and a fully released position and an accelerator actuator for activating propulsion of the work machine. In an activated state of the brake system the operating brake actuator is moved automatically to its fully engaged position when the accelerator actuator is released. Full Article
ng Engine restart strategy By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A method of controlling a vehicle, where the vehicle includes an internal combustion engine and a transmission having a neutral state and an engaged state, includes setting the state of the transmission. The state of the transmission is set as the neutral state or the engaged state based on a restart condition, where the restart condition is one of: (i) a no wheel torque restart condition, and (ii) a wheel torque restart condition. The method additionally includes starting the engine. Full Article
ng Engaging force control of lockup clutch By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A torque converter (1) connecting an engine (14) and a transmission (15) of a vehicle is provided with a lockup clutch (2), and a controller (5) is programmed to increase an engagement force of a lockup clutch (2) under open loop control before shifting to feedback control of the engaging force using a target slip rotation speed. When an engine output torque rapidly decreases during open loop control (S59, S60), the controller (5) decreases the engaging force according to a variation amount of the engine output torque (S61, S65), thereby preventing an unintentional sudden engagement of the lockup clutch (2) due to decrease in the engine output torque. Full Article
ng Method and device for operating a drive device By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT The invention relates to a method for operating a drive device (1) of a motor vehicle, said drive device (1) comprising at least one combustion engine (3) and at least one electric machine (9), as well as a dual clutch transmission (4) which can be functionally connected to the combustion engine (3) and which comprises a first sub-transmission (5), a first clutch (6) being associated therewith, and a second sub-transmission (7), a second clutch (8) and the electric machine (9) being associated therewith. In a purely electrical driving operation, the electric machine (9) is operated in a motorized manner, a driving gear is engaged in the second sub-transmission (7), and both clutches (6, 8) are disengaged. According to the invention, in order to start the combustion engine (3) during the electric driving operation, the second clutch (8) is engaged so as to drive the combustion engine (3) by means of the electric machine (9), a gear is engaged in the first sub-transmission (5), said gear having a lower gear ratio than the engaged driving gear of the second sub-transmission (7), the first clutch (6) is brought into a slip position and the second sub-transmission (7) is subsequently brought into a neutral position, the rotational speed of the electric machine (9) is increased at least to a starting rotational speed for the combustion engine (3) with the slip of the first clutch (6) being adjusted to maintain a forward torque of the motor vehicle, and the combustion engine (3) is started once its starting rotational speed has been reached. In addition, the invention relates to a device for operating a drive device of a motor vehicle. Full Article
ng System for determining that driving of a hybrid vehicle is disabled By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A system for determining disablement of driving of a hybrid vehicle is disclosed. The system for determining disablement of driving of a hybrid vehicle may include: power electronic components having a battery at which DC electricity is stored, an inverter converting the DC electricity of the battery into AC electricity, and a motor receiving the AC electricity from the inverter and generating driving torque; an engine burning a fuel so as to generate driving torque and being selectively connected to the motor; an engine clutch selectively connecting the engine to the motor; a transmission connected to the motor to receive the driving torque of the motor or the driving torque of the engine; and a control portion controlling operations of the power electronic components, the engine, and the engine clutch, wherein the control portion turns off a system ready indication in a case that driving of the vehicle is disabled. Full Article
ng Method and system for determining clutch assembly vent time for transmission shift control By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A method and transmission control unit configured to improve shift event performance in a vehicle with an automatic transmission by determining a vent time for release of a clutch assembly in a transmission of a vehicle. The vehicle must be stopped and a gear selector in the vehicle must be set to a drive condition. If these conditions are met, the clutch assembly is vented. The vent time from when venting begins to when a turbine (or input shift) speed of the transmission rises is tracked. Once the turbine speed of the transmission rises, the clutch assembly is reapplied. The clutch assembly vent time is set based on the tracked vent time. Full Article
ng Battery charging method and system for hybrid vehicle and the hybrid vehicle using the same By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A battery charging method for a hybrid vehicle and the hybrid vehicle using the same are disclosed. The hybrid vehicle includes an engine and a motor as power source and includes the battery in which electrical energy for driving the motor is stored. The method and system may include: determining whether the battery needs to be charged while the vehicle is stopped; transitioning a transmission to a neutral position (N position) when the battery needs to be charged; starting the engine and engaging an engine clutch to connect the engine with the motor so that the motor generates electrical energy via power from the engine. The electrical energy generated by the motor is then stored in the battery accordingly. Full Article
ng Control method for idling anti-rollback of pure electric vehicle By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A control method for idling anti-rollback of a pure electric vehicle is provided, where the pure electric vehicle has a vehicle controller, a motor controller, a motor, a brake pedal, a handbrake device, an accelerator pedal, and a power battery. The method makes use of the differences between a pure electric vehicle from conventional cars, and collects the states of individual parts of the vehicle through the vehicle controller, and controls the output of the torque of the motor based on the state information of various control components, to prevent the vehicle located on a slope from rolling back, and makes the vehicle move forward at idle. Full Article
ng Method and apparatus for executing a shift path to a target powertrain state By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A method for controlling a transmission of a powertrain system includes executing a single source shortest path search to identify a preferred shift path originating with an initial powertrain state and terminating at a target powertrain state, wherein the single source shortest path search employs transition-specific costs and situational costs to identify the preferred shift path. The preferred shift path is executed to achieve the target powertrain state. Full Article
ng Automatic transmission and starting time control method By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A transmission controller increases an indicated hydraulic pressure to a starting frictional engagement element to a normal hydraulic pressure, causes a hydraulic piston to stroke and executes a learning control of the indicated hydraulic pressure so that a time until the starting frictional engagement element starts generating a transmission capacity after the range is switched from the neutral range to the drive range becomes a target time when a range is switched from a neutral range to a drive range. The transmission controller further detects a driver's starting intention and increases the indicated hydraulic pressure to the starting frictional engagement element to a starting time hydraulic pressure higher than the normal hydraulic pressure and prohibits the learning control if the starting intention is detected before the starting frictional engagement element starts generating the transmission capacity. Full Article
ng Multi-speed transmission with an engine start/stop enabler By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A transmission includes an input member, an output member, four planetary gear sets, and a plurality of torque transmitting mechanisms that are selectively engageable to establish at least ten forward speed ratios and at least one reverse speed ratio between the input member and the output member. The transmission further includes one or more locking mechanisms that engage one or more of the plurality of torque transmitting mechanisms during a start/stop event. Full Article
ng Method of shifting a transmission By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A method of controlling a multiple step downshift is disclosed. Two offgoing shift elements are released and two oncoming shift elements are engaged to complete the downshift. During a first phase of the downshift, one of the offgoing shift elements controls the rate of increase of input shaft speed. During a second phase of the downshift, one of the oncoming shift elements controls the rate of increase of the input shaft speed. The method computes target torque capacities such that output torque and input shaft acceleration are continuous during the transition between phases. Furthermore, the method computes target torque capacities such that both oncoming clutches reach zero relative speed simultaneously as the input shaft reaches the final speed ratio. Full Article
ng Vehicle and method for controlling vehicle By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A hybrid vehicle in which at least two shift ranges can be selected for a single running direction includes an engine, a motor generator, an EHC raising the temperature of a catalyst for cleaning up an exhaust gas from the engine, and an ECU. While the vehicle is running, if the engine is stopped and, of the two shift ranges, a shift range where larger decelerating force is produced by regenerative braking of the motor generator has been selected, the ECU causes the EHC to raise the temperature of the catalyst using electric power generated by the motor generator. Full Article
ng Device for controlling automatic transmission By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A device for controlling an automatic transmission including a lock-up clutch control portion and a zero slip control portion for bringing a lock-up clutch into a zero slip state immediately before slippage occurs in accordance with a zero slip request outputted during a non-gear shift, wherein in a case where a target slip amount is equal to or smaller than a slip amount threshold value upon transition to the zero slip state, the zero slip control portion fixes the target slip amount to the slip amount threshold value and retains the fixed target slip amount for a predetermined period of time, and after the predetermined period of time has elapsed, gradually decreases the target slip amount from the slip amount threshold value to a zero slip amount with a predetermined gradient with time. Full Article
ng Method for operating a drive train of a vehicle By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A method of operating a drive-train of a vehicle that comprises a combustion engine whose torque for driving the vehicle can be transmitted to a drive output via a transmission, with a hydraulically actuated clutch when the clutch is engaged. An electric machine provides torque which can act upon the drive-train. The clutch is closed by filling the clutch with hydraulic fluid through a circuit by way of a pump which can be driven by the engine and the electric machine. The method is to engage the clutch when the combustion engine is initially off and/or when the electric machine is initially switched off, determining a driving dynamic based on the behavior of the driver and adjusting the speed of the electric machine based on the determined driving dynamic such that the greater the determined driving dynamic is, the more rapidly the clutch is filled by the pump. Full Article
ng System and method of controlling fail safe for hybrid vehicle By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A system and method of controlling a fail-safe for a vehicle is provided. The method includes determining, by a controller, that remaining hydraulic pressure exists in the clutch when the clutch is not opened and a target value of oil pressure for opening the clutch is maintained for a predetermined time period. In addition, whether a vehicle is stopped is confirmed in response to determining that remaining hydraulic pressure exists in the engine clutch. The controller is further configured to transmit a signal to shift to the vehicle to a neutral (N) stage to a transmission controller and shift to the vehicle to the N-stage in response to determining that the vehicle is stopped. Then, the engine is driven by the controller in response to determining that the vehicle is shifted to the N-stage. Full Article
ng Methods and systems for extending regenerative braking By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Systems and methods for improving operation of a hybrid vehicle are presented. In one example, an electrical load may be automatically activated to consume electrical energy produced during driveline braking so that driveline braking may be extended. The electrical load may be a windscreen heater or other device. Full Article
ng Method for controlling an automated transmission By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A method of controlling an automated transmission for motor vehicles with one or several pressure activated positioning cylinders (6, 8, 20), via the assigned shift valves (10, 12), at least one main cut-off valve (4) which is positioned prior to the shift valves, and a control device for controlling the shift and main cut-off valves. The pressure requests, for the shifting, are determined and the respective main cut-off valves are triggered depending on the determined pressure requests. To enable a variable match of the supply pressure during transmission shifts, respective optimized pressures or pressure patterns are determined for certain shift scenarios which, for instance, consider a mass to be synchronized, the existence of a tooth-on-tooth position, or the like. Through this method, for instance, the load on shift elements, the shift timing, and the shift noise can be positively influenced. Full Article
ng Methods and systems for adjusting driveline disconnect clutch operation By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Systems and methods for improving operation of a hybrid vehicle are presented. In one example, torque transferred via a driveline disconnect clutch is estimated based on characteristics of a torque converter to improve driveline operation. Full Article
ng Method and system for engine control By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Methods and systems are provided for controlling an engine system with a variable cam timing device. In one example, the variable cam timing device is operated to adjust engine valve timing differently at engine stop based on whether the engine stop is in response to an operator request or in response to an automatic controller initiated engine stop without an operator request. Full Article
ng Motor controlling apparatus By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A motor controlling apparatus includes a first target torque value calculator, a frequency detector, a second target torque value calculator, a torque command value calculator, a torque limiter, and a controller. The first target torque value calculator calculates a first target torque value, which is a target value of an output torque of a motor. The frequency detector detects a motor rotational frequency. The second target torque value calculator calculates a second target torque value based on the rotational frequency. The torque command value calculator mathematically combines (e.g., adds) the first and target torque values to calculate a torque command value. The torque limiter sets the signs of the first target torque value and the torque command value to be equal to limit the torque command value according to the first target torque value. The controller controls the motor based on the limited torque command value. Full Article
ng Transmission shift assembly for a vehicle and a method of monitoring the same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention provides for a transmission shift assembly for a vehicle and methods of monitoring and controlling the same. The transmission shift assembly includes a transmission having a shift position member movable between a plurality of gear positions, an actuator configured to move the shift position between the gear positions, and a linkage coupled to the actuator and movable between a plurality of positions in response to movement of the actuator. The assembly further includes a controller to control the actuator, an ignition to receive a key, and at least one key sensor positioned within the ignition and configured to transmit a signal to the controller upon sensing removal of the key, the controller controlling the actuator to move the shift position member to a predetermined gear position upon receiving the signal from the key sensor that the key has been removed from the ignition. Full Article
ng Battery charge/discharge control device, battery charge/discharge control method, and hybrid working machine with battery charge/discharge control device By www.freepatentsonline.com Published On :: Tue, 02 Jun 2015 08:00:00 EDT A battery charge/discharge control device which performs battery charge/discharge control in a working machine with a battery capable of storing electric energy generated by a generator motor coupled to an engine and driving the generator motor or at least one of other electric actuators by the stored electric energy and a controller which controls a distribution of the electric energy among the battery, the generator motor, and the electric actuator, wherein the controller performs the charge/discharge control in which the electric energy of the battery is discharged when the engine is driven and recharging to the battery is permitted on a condition that a state in which an engine speed is equal to or lower than a predetermined engine speed is maintained for a predetermined time after the battery is completely discharged. Full Article
ng Method for the treatment of automimmune diseases comprising administering rapamycin and IL-10 By www.freepatentsonline.com Published On :: Tue, 11 Dec 2012 08:00:00 EST The invention discloses a combined preparation containing IL-10 and rapamycin, able to induce immunosuppression and antigen-specific immune tolerance, and the use thereof in the treatment of diseases involving an excessive, dysfunctional or uncontrolled immune responses mediated by T cells. Full Article
ng Derivatives of the NF-κB inducing enzyme, their preparation and use By www.freepatentsonline.com Published On :: Tue, 11 Dec 2012 08:00:00 EST The invention relates to the use of NF-κB inducing kinase (NIK) and related molecules for the modulation of signal activities controlled by cytokines, and some new such molecules. Full Article
ng Indolesulfonyl protecting groups for protection of guanidino and amino groups By www.freepatentsonline.com Published On :: Tue, 30 Apr 2013 08:00:00 EDT The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof. Full Article
ng Methods for inhibiting lymphotoxin-β receptor signaling in TH1 cell-associated disorders By www.freepatentsonline.com Published On :: Tue, 04 Jun 2013 08:00:00 EDT This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This invention relates to soluble forms of the lymphotoxin-β receptor extracellular domain that act as lymphotoxin-β receptor blocking agents. This invention also relates to the use of antibodies directed against either the lymphotoxin-β receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-β receptor blocking agents. A novel screening method for selecting soluble receptors, antibodies and other agents that block LT-β receptor signalling is provided. Full Article
ng Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders By www.freepatentsonline.com Published On :: Tue, 11 Jun 2013 08:00:00 EDT Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity. Full Article
ng Immobilizing an entity in a desired orientation on a support material By www.freepatentsonline.com Published On :: Tue, 09 Jul 2013 08:00:00 EDT The present invention relates to the identification and selection of attachment molecules that attach/immobilize an entity having a detectable activity or property on a support in an orientation that provides a detectable activity or property, and to surfaces made of the attachment molecules. Full Article
ng Immobilized tumor necrosis factor-α muteins for enhancing immune response in mammals By www.freepatentsonline.com Published On :: Tue, 06 Aug 2013 08:00:00 EDT The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors such as soluble TNF receptor from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partner(s) such as TNFα muteins capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as a TNFα mutein, capable of specifically binding to a targeted immune system inhibitor such as soluble TNF receptor. Full Article
ng Method for preventing formation of trisulfide derivatives of polypeptides By www.freepatentsonline.com Published On :: Tue, 10 Sep 2013 08:00:00 EDT A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid medium with a gas, suitably a chemically unreactive gas such as nitrogen or argon. Full Article
ng Methods for treating diabetic foot ulcers By www.freepatentsonline.com Published On :: Tue, 17 Sep 2013 08:00:00 EDT The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers. Full Article
ng Compositions and methods for inhibiting tumor cell growth By www.freepatentsonline.com Published On :: Tue, 24 Sep 2013 08:00:00 EDT The present invention relates to compositions and methods for inhibiting the activity of an enzyme, for example, Protein Kinase B, p70S6K and/or Abl using the catalytic subunit of Protein Kinase A (PKAc), or at least one PKAc fragment or variant PKAc fragment thereof. In this regard, methods for preventing or treating cancer or a neurodegenerative disease or disorder are also provided. Full Article