Hi

I have tried using "add net constraints" command to place one-cold constraints on a tristate enable bus. In the command line we need to specify the "net pathname" on which the constraints are to be enforced.

The bus here is 20-bit. How should the net pathname be specified to make this 20-bit bus signals one_hot or one_cold.

The bus was declared as follows:
ten_bus [19:0]

The command I used was

add net constraints one_hot /ren_bus[19]

What would the above command mean?
Should we not specify all the nets' pathnames on the bus?
Is it sufficient to specify the pathname of one net on the bus?
I could not get much info regarding the functionality of this command. I would be obliged if anyone can throw some light.

Thanks
Prasad.

Optimizing PCB thermal performance is essential in today’s high-density designs, as it ensures stability, prolongs component life, and prevents potential thermal issues. One of the first steps to achieving this is with strategic component placement. Positioning high-power components—such as regulators, power transistors, or processors—away from heat-sensitive parts can prevent thermal interference, and placing them near the edges of the PCB often helps dissipate heat more effectively. It’s also beneficial to group components by their heat generation, creating dedicated thermal zones that can manage localized heating and reduce impact on other areas of the board.

Using thermal vias is another effective technique. By placing thermal vias under components like BGAs or power ICs, heat can be transferred from the surface to internal layers or ground planes. Increasing the size and number of these vias, or using thicker plating, enhances heat conductivity and helps manage heat more evenly across layers in multilayer boards. Increasing copper thickness on the PCB also has a major impact. Opting for thicker copper layers (e.g., 2 oz or even 3 oz copper) significantly boosts the heat dissipation capabilities of power planes and traces, especially in high-current areas. Large copper planes, such as dedicated ground or power planes, are equally effective in spreading heat efficiently. Adding thermal pads directly beneath heat-generating components improves this heat distribution.

Thermal relief pads help regulate heat flow for through-hole components by controlling heat transfer, which reduces thermal stress during soldering and prevents excessive heat spread to nearby sensitive areas. Performing thermal analysis with software tools like Celsius can be invaluable, as it allows you to simulate and model heat distribution, spot potential thermal issues, and refine your design before finalizing it.

Using heat sinks and thermal pads provides a direct way to draw heat from high-power components. Heat sinks can be attached with thermal adhesives, screws, or clamps, while thermal interface materials (TIMs), such as thermal pads or conductive adhesives, further reduce thermal resistance, enhancing heat-transfer efficiency. Optimizing the PCB layer stackup is also a key factor. Dedicated ground and power layers improve heat conduction across the PCB, enabling heat transfer between layers, particularly in high-density and multilayer PCBs.

In designs with high power requirements, active cooling options like fans, blowers, or heat pipes can be essential, helping to direct airflow across the PCB and further improving heat dissipation. Adding ventilation slots around hot zones and considering passive cooling paths enhance natural airflow, making the design more thermally efficient. By combining several of these techniques, you can create a PCB that handles heat effectively, resulting in a robust, long-lasting, and reliable product.

Let us know if you’ve had any challenges with thermal management in your designs—I’d be glad to discuss further!

Conformal ECO Designer enables you to implement RTL engineering change orders (ECOs) for pre- and post-mask layout and offers early ECO prototyping capabilities for driving critical project decisions.

Conformal ECO compares two designs and generates a functional patch that implements the changes between the two designs.

One major criterion for determining patch quality is whether the patch can meet timing closure. To determine this, you typically need to run the time-consuming process of incremental synthesis and place-and-route. Instead, Conformal can analyze path logic depth changes before and after ECO patch generation. This provides a faster way to evaluate timing impact in patch generation stages.

After the patch is created and applied, it is passed to Genus to optimize the patch.

During patch optimization, you can choose to do many things like:

• Keeping constants in the patch
• Allowing tie cell inversion
• Specifying tie cell types
• Preserve DFF cells and cell types in the patch
• Preserve all cells and nets in the patch
• Preserve clock buffer cell in the patch
• Turn on/off sequential constant and sequential merge in patch optimization
• Allowing phase mapping for DFFs
• Map to spare cells
• Force fix DRC before timing

What's Next?

Join the Conformal ECO course to:

• Explore the many options and capabilities of Conformal ECO
• Use Conformal Engineering Change Order (ECO) for flat and hierarchical designs
• Generate a functional ECO patch, apply it to a design, optimize it, and map it to a specified technology
• Run a hierarchical design through ECO and run a comparison to prove the ECO is equivalent
• Run a postmask ECO using Conformal ECO GXL

Make sure you have experience with Conformal Equivalence Checker or completed the Conformal Equivalence Checking course before taking this course.

The online class is free for all Cadence customers with a Cadence Learning and Support Portal account. If you don’t have a Cadence Support account, go to Registration Help or Register Now and complete the requested information. For instructor-led training sessions "Live" or "Blended" please contact Cadence Training.

Please don't forget to obtain your Digital Badge after completing the training. Add your free digital badge to your email signature or any social media and networking platform to show your qualities and build trust, making you and your projects even more successful.

Research by fDi Intelligence reveals which countries receive more than their ‘expected share’ of FDI. 

This GFN Thursday, the GeForce NOW Priority membership is getting enhancements and a fresh name to go along with it. The new Performance membership offers more GeForce-powered premium gaming — at no change in the monthly membership cost. Gamers having a hard time deciding between the Performance and Ultimate memberships can take them both for Read Article

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

wellington, new zealand — New Zealand's Prime Minister Christopher Luxon made a “formal and unreserved” apology in Parliament on Tuesday for the widespread abuse, torture and neglect of hundreds of thousands of children and vulnerable adults in care. “It was horrific. It was heartbreaking. It was wrong. And it should never have happened,” Luxon said, as he spoke to lawmakers and a public gallery packed with survivors of the abuse. An estimated 200,000 people in state, foster and faith-based care suffered “unimaginable” abuse over a period of seven decades, a blistering report released in July said at the end of the largest inquiry ever undertaken in New Zealand. They were disproportionately Māori, New Zealand’s Indigenous people. “For many of you it changed the course of your life, and for that, the government must take responsibility,” Luxon said. He said he was apologizing for previous governments too. In foster and church care — as well as in state-run institutions, including hospitals and residential schools — vulnerable people “should have been safe and treated with respect, dignity and compassion," he added. “But instead, you were subjected to horrific abuse and neglect and, in some cases, torture.” The findings of the six-year investigation believed to be the widest-ranging of comparable probes worldwide were a “national disgrace,” the inquiry's report said. New Zealand's investigation followed two decades of such inquiries around the globe as nations struggle to reckon with authorities’ transgressions against children removed from their families and placed in care. Of 650,000 children and vulnerable adults in New Zealand's state, foster, and church care between 1950 and 2019 — in a country that today has a population of 5 million — nearly a third endured physical, sexual, verbal or psychological abuse. Many more were exploited or neglected. “We will never know that true number,” Chris Hipkins, the leader of the opposition, told Parliament. “Many people entering into state and faith-based institutions were undocumented. Records were incomplete, they've gone missing, and in some cases, yes, they were deliberately destroyed.” In response to the findings, New Zealand’s government agreed for the first time that historical treatment of some children in a notorious state-run hospital amounted to torture — a claim successive administrations had rejected. “I am deeply sorry that New Zealand did not do better by you. I am sorry you were not believed when you came forward to report your abuse,” Luxon said. “I am sorry that many abusers were not made to face justice which meant that other people experienced abuse that could have been prevented.” His government was working on 28 of the inquiry's 138 recommendations, Luxon said, although he did not yet have concrete details on financial redress, which the inquiry had exhorted since 2021 and said could run to billions of dollars. Luxon was decried by some survivors and advocates earlier Tuesday for not divulging compensation plans alongside the apology. He told Parliament a single redress system would be established in 2025. He did not, however, suggest a figure for the amount the government expected to pay. “There will be a big bill, but it's nothing compared to the debt we owe those survivors and it must not be the reason for any further delay,” said Hipkins, the opposition leader. Survivors began to arrive at Parliament hours before the apology, having won spots in the public gallery — which only seats about 200 people — by ballot. Some were reluctant to accept the state's words, because they said the scale of the horror was not yet fully understood by lawmakers and public servants. Jeering was so loud during an apology from the country's solicitor-general that her speech was inaudible. Others called out or left the room in tears while senior public servants from relevant health and welfare agencies spoke before Luxon's remarks. Survivors invited to give speeches were required to do so before Luxon's apology — rather than in response to it, said Tu Chapman, one of those asked to speak. “Right now I feel alone and in utter despair at the way in which this government has undertaken the task of acknowledging all survivors,” she told a crowd at Parliament. The abuse "ripped families and communities apart, trapping many into a life of prison, incarceration, leaving many uneducated,” said Keith Wiffin — a survivor of abuse in a notorious state-run boys' home. “It has tarred our international reputation as an upholder of human rights, something this nation likes to dine out on.” The inquiry's recommendations included seeking apologies from state and church leaders, among them Pope Francis. It also endorsed creating offices to prosecute abusers and enact redress, renaming streets and monuments dedicated to abusers, reforming civil and criminal law, rewriting the child welfare system and searching for unmarked graves at psychiatric facilities. Its writers were scathing about how widely the abuse — and the identities of many abusers — were known about for years, with nothing done to stop it. “This has meant you have had to re-live your trauma over and over again,” said Luxon. “Agencies should have done better and must commit to doing so in the future.” He did not concede that public servants or ministers in his government who had denied state abuse was widespread when they served in previous administrations should lose their jobs. Luxon has also rejected suggestions by survivors that policies he has enacted which disproportionately target Māori — such as crackdowns on gangs and the establishment of military-style boot camps for young offenders — undermine his government's regret about the abuse. Māori are over-represented in prisons and gangs. In 2023, 68% of children in state care were Māori, although they are less than 20% of New Zealand's population. “It's not enough to say sorry,” said Fa’afete Taito, a survivor of violent abuse at another state-run home, and a former gang member. “It's what you do to heal the wounds of your actions and make sure it never happens again that really counts.”

Women in Buddhism Application Information

This infographic examines how extreme heat disproportionately impacts women in Asia and the Pacific, presenting data on health and economic vulnerabilities shaped by intersecting factors like age, hormonal influences, caregiving roles, and limited cooling access.

This paper examines enterprise performance in the North-East region of the People's Republic of China.

This paper is part of a cross-country study on corporate governance in Asia. A consensus has yet to be reached about exactly what factors were behind the crisis of 1998 and how these factors interacted in bringing about the crisis.

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Migration may reinforce less productive forms of informal employment in rural Nepal.

This brief shows how India sparked a digital payments boom and boosted financial inclusion through the introduction of its Unified Payments Interface (UPI) and outlines ways countries in the region can ramp up their own digital transformation.

Advances in generative AI mean fake images, videos, audio and bots are now everywhere. But studies have revealed the best ways to tell if something is real

Information contained within quantum objects gets scrambled when they interact. Physicists have now derived a speed limit for this process, challenging the idea that black holes are the fastest data scramblers

A debating technique known as the "truth sandwich" is helping archaeologists combat a false narrative about an advanced ancient civilisation forgotten in human history

Title: Good Nutrition Can Boost School Performance, Expert Says
Category: Health News
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Objective:

In this study, we sought to comprehensively evaluate GPT-4 (Generative Pre-trained Transformer)’s performance on the 2022 American Board of Family Medicine’s (ABFM) In-Training Examination (ITE), compared with its predecessor, GPT-3.5, and the national family residents’ performance on the same examination.

The SARS-CoV-2 frameshifting element (FSE) has been intensely studied and explored as a therapeutic target for coronavirus diseases, including COVID-19. Besides the intriguing virology, this small RNA is known to adopt many length-dependent conformations, as verified by multiple experimental and computational approaches. However, the role these alternative conformations play in the frameshifting mechanism and how to quantify this structural abundance has been an ongoing challenge. Here, we show by DMS and dual-luciferase functional assays that previously predicted FSE mutants (using the RAG graph theory approach) suppress structural transitions and abolish frameshifting. Furthermore, correlated mutation analysis of DMS data by three programs (DREEM, DRACO, and DANCE-MaP) reveals important differences in their estimation of specific RNA conformations, suggesting caution in the interpretation of such complex conformational landscapes. Overall, the abolished frameshifting in three different mutants confirms that all alternative conformations play a role in the pathways of ribosomal transition.

Many RNA-binding proteins (RBPs) contain low-complexity domains (LCDs) with prion-like compositions. These long intrinsically disordered regions regulate their solubility, contributing to their physiological roles in RNA processing and organization. However, this also makes these RBPs prone to pathological misfolding and aggregation that are characteristic of neurodegenerative diseases. For example, TAR DNA-binding protein 43 (TDP-43) forms pathological aggregates associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). While molecular chaperones are well-known suppressors of these aberrant events, we recently reported that highly disordered, hydrophilic, and charged heat-resistant obscure (Hero) proteins may have similar effects. Specifically, Hero proteins can maintain the activity of other proteins from denaturing conditions in vitro, while their overexpression can suppress cellular aggregation and toxicity associated with aggregation-prone proteins. However, it is unclear how these protective effects are achieved. Here, we used single-molecule FRET to monitor the conformations of the aggregation-prone prion-like LCD of TDP-43. While we observed high conformational heterogeneity in wild-type LCD, the ALS-associated mutation A315T promoted collapsed conformations. In contrast, an Hsp40 chaperone, DNAJA2, and a Hero protein, Hero11, stabilized extended states of the LCD, consistent with their ability to suppress the aggregation of TDP-43. Our results link single-molecule effects on conformation to macro effects on bulk aggregation, where a Hero protein, like a chaperone, can maintain the conformational integrity of a client protein to prevent its aggregation.

ABSTRACTToxicological emergencies present a significant health challenge in Nepal. Despite the high burden, the country has inadequate formal toxicology training, medical toxicology expertise, and adequate poison control infrastructure. In recognition of this need, the Nepal Poison Information Center (PIC) was established as a collaborative effort involving local and international partners. Through a comprehensive partnership framework, the Nepal PIC provides 24 hours a day, 7 days a week expert guidance to health care workers, conducts educational webinars, and engages in research. Initial data from the pilot phase indicate successful consultation delivery. Challenges include bureaucratic hurdles and the need for sustainable funding. Despite these challenges, the Nepal PIC demonstrates early feasibility and potential for expansion into a comprehensive toxicology center, contributing to the advancement of clinical toxicology in Nepal. Long-term sustainability relies on governmental support and continued advocacy efforts.

ABSTRACTIntroduction:Since the health information system (HIS) in public health care services in Serbia was introduced in 2009, it has gradually expanded. However, it is unclear how well the HIS components have developed and the whole system’s stage of maturity.Method:In June–September 2021, a maturity assessment of the Serbian HIS was conducted for the first time using the HIS Stages of Continuous Improvement (SOCI) toolkit. The toolkit measures HIS status across 5 HIS domains: leadership and governance, management and workforce, information and communication technology (ICT), standards and interoperability, and data quality and use. The domains were further divided into 13 components and 39 subcomponents whose maturity stage was assessed on a 5-point Likert scale, indicating the level of development: (1) emerging/ad hoc; (2) repeatable; (3) defined; (4) managed; and (5) optimized. The toolkit was applied in a working group of 32 professionals and experts who were engaged in developing the new national eHealth strategy and action plan.Results:The overall maturity score of the Serbian HIS was 1.6, which indicates a low level. The highest baseline score (2) was given to the standards and interoperability domain, and the lowest (1.1) was given to ICT infrastructure. The remaining 3 domains (leadership and governance, Management and Workforce, and Data Quality and Use) were similarly rated (1.7, 1.7, and 1.6, respectively).Conclusion:A baseline assessment of the maturity level of Serbian HIS indicates that the majority of components are between the emerging/ad hoc stage and repeatable, which represent isolated, ad hoc efforts, with some basic processes in place and existing and accessible policies. This exercise provided an opportunity to address identified weaknesses in the upcoming national eHealth strategy.

Anorectal malformations (ARMs) constitute a group of congenital defects of the gastrointestinal and urogenital systems. They affect males and females, with an estimated worldwide prevalence of 1 in 5000 live births. These malformations are clinically heterogeneous and can be part of a syndromic presentation (syndromic ARM) or as a nonsyndromic entity (nonsyndromic ARM). Despite the well-recognized heritability of nonsyndromic ARM, the genetic etiology in most patients is unknown. In this study, we describe three siblings with diverse congenital anomalies of the genitourinary system, anemia, delayed milestones, and skeletal anomalies. Genome sequencing identified a novel, paternally inherited heterozygous Caudal type Homeobox 2 (CDX2) variant (c.722A > G (p.Glu241Gly)), that was present in all three affected siblings. The variant identified in this family is absent from population databases and predicted to be damaging by most in silico pathogenicity tools. So far, only two other reports implicate variants in CDX2 with ARMs. Remarkably, the individuals described in these studies had similar clinical phenotypes and genetic alterations in CDX2. CDX2 encodes a transcription factor and is considered the master regulator of gastrointestinal development. This variant maps to the homeobox domain of the encoded protein, which is critical for interaction with DNA targets. Our finding provides a potential molecular diagnosis for this family's condition and supports the role of CDX2 in anorectal anomalies. It also highlights the clinical heterogeneity and variable penetrance of ARM predisposition variants, another well-documented phenomenon. Finally, it underscores the diagnostic utility of genomic profiling of ARMs to identify the genetic etiology of these defects.

BackgroundMost people with type 2 diabetes receive treatment in primary care by GPs who are not specialised in diabetes. Thus, it is important to uncover the most essential information needs regarding type 2 diabetes in general practice.AimTo identify information needs related to type 2 diabetes for GPs.Design and settingSystematic review focused on literature relating to Western countries.MethodMEDLINE, Embase, PsycInfo and CINAHL were searched from inception to January 2024. Two researchers conducted the selection process, and citation searches were performed to identify any relevant articles missed by the database search. Quality appraisal was conducted with the Mixed Methods Appraisal Tool. Meaning units were coded individually, grouped into categories, and then studies were summarised within the context of these categories using narrative synthesis. An evidence map was created to highlight research gaps.ResultsThirty-nine included studies revealed eight main categories and 36 subcategories of information needs. Categories were organised into a comprehensive hierarchical model of information needs, suggesting ‘Knowledge of guidelines’ and ‘Reasons for referral’ as general information needs alongside more specific needs on ‘Medication’, ‘Management’, ‘Complications’, ‘Diagnosis’, ‘Risk factors’, and ‘Screening for diabetes’. The evidence map provides readers with the opportunity to explore the characteristics of the included studies in detail.ConclusionThis systematic review provides GPs, policymakers, and researchers with a hierarchical model of information and educational needs for GPs, and an evidence map showing gaps in the current literature. Information needs about clinical guidelines and reasons for referral to specialised care overlapped with needs for more specific information.

A baroque fiddle believed to have been played by Robert Burns will be performed live on stage in the United States for the first time.

Take-Two CEO Strauss Zelnick in the company's latest earnings report said he isn't worried about Rockstar getting Grand Theft Auto VI to run on the Xbox Series S.

"Look, we support the platforms where the consumers are for as long as they’re there, and we find a way to support platforms despite different levels of tech," said Zelnick (via VideoGamesChronicle) when asked about the Xbox Series S.

Zelnick added, "Our labels are really good at that. I’m not really worried. I’ve never worried about where hardware was going. And I’ve said this many times over the years because, first of all, I don’t worry about things over which I have zero control.

"Secondly, I believe in the audience. The audience is going to show up if you have great properties, and so we just have to make sure to be on an array of platforms."

Zelnick added PC is an important platform to release games on, despite the fact Grand Theft Auto VI has not been announced for PC.

"If one platform diminishes in value, there’s always another one," he said. "So we’re seeing great growth in PC right now, for example. And I have been able to view that open formats would continue to grow. PC is an open format.

"I do think PC will continue to be a more and more important part of the console business going forward, and that isn’t complicated for us to support at all. So the bottom line is we are selective about which platforms we support. We make the tech work when we can make it work as long as the audience is big enough to make that worthwhile."

Grand Theft Auto VI will launch for the PlayStation 5 and Xbox Series X|S in Fall 2025.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463023/take-two-ceo-is-not-worried-about-grand-theft-auto-vi-performance-on-xbox-series-s/

A cyberterrorism charge in Pakistan connected to riots in the UK illustrates how authorities are reaching across borders to tackle disinformation, but bringing overseas suspects to justice won't always be possible

Advances in generative AI mean fake images, videos, audio and bots are now everywhere. But studies have revealed the best ways to tell if something is real

As misinformation about the upcoming US elections rockets across social media, creating chaos, companies need to be honest about where this content is coming from, says Annalee Newitz

AI chatbots from Google and Microsoft sometimes parrot disinformation when answering questions about Russia’s invasion of Ukraine – but their performance depends on language and changes over time

Ryzen and Epyc chips have two main issues; L3 cache latency, and 'preferred core' tech.

It turns out microplastics have an effect on the weather and climate.

As we head into 2025, CEOs are focused on a clear set of priorities—AI-enabled growth, dynamic capacity, risk management, and human-machine integration.

The post Driving AI Transformation appeared first on Gigaom.

AI isn’t just another tool in the technology toolkit; it’s a revolution waiting to be led. As tech leaders, this is your

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Muhammad Musthafa’s sophomore directorial ‘Mura’ is a gangster drama that revolves around revenge and friendship starring a bunch of new as well as seasoned performers

An inquiry found abuse, torture and neglect of some 200,000 people in state care over 70 years. People with disabilities or from Maori and Pacific Islander communities were especially vulnerable.

Fujifilm is developing a medium-format, 102-megapixel cinema camera, the company said in a surprise announcement. Due next year, the GFX Eterna will carry a boxy, modular design reminiscent of Sony's FX6 or the new Blackmagic Pyxis and will likely be launched with a top handle, electronic viewfinder and other optional accessories.

The new camera will have a medium format GFX 102-megapixel (MP) CMOS II HS sensor, the same one used on the GFX100 II. That sensor is 43.8mm x 32.9 mm in size, or 1.7 times larger than the full-frame sensor found on the aforementioned FX or Pyxis. That will be one of the largest cinema camera sensors available, even bigger than RED's V-Raptor XL sensor.

The benefits will be extra dynamic range, potentially high resolution and a very shallow depth of field that should allow for cinematic shots when paired with the right lens. That does bring up the fact that Fujifilm currently has no GFX glass designed specifically for film production. However, the company said it's developing a 32-90mm power zoom lens (24-70mm full-frame equivalent) and will have a mount adapter for GFX to PL lenses, which are widely used in cinema. 

One other concern might be rolling shutter distortion. RED's V-Raptor XL uses a global shutter that has zero distortion, but the sensor Fujifilm will employ has a fair bit of it . In addition, the GFX100 II captures 8K with a 1.53x crop, negating many of the benefits of a medium format sensor — so, hopefully Fujifilm will resolve those issues with its cinema camera. 

Fujifilm will show off the GFX Eterna starting tomorrow at the InterBEE 2024 media exhibition in Chiba City, Japan. It's set to be released sometime in 2025, with an exact date and pricing yet to be announced.