Zoya Akhtar, Anurag Kashyap, Dibakar Banerjee and Karan Johar talk to Namrata Joshi on what scares them in film and in real life, 'sanskari ghosts' and questioning authority

Mercedes-Benz SUV makes driving an exhilarating experience as it can be driven in five different modes

BMW X1 is bigger, stronger and has more features than its earlier version

There is nothing to be worried about as bilateral ties are robust with solid foundations.

Chinese Ambassador to Pakistan Jiang Zaidong urged that the government should launch a crackdown against all anti-China terrorist groups after two deadly attacks took place in Pakistan within only six months, The Express Tribune reported.

On this World Environment Day, a look at the boom in biodegradable cutlery and crockery made from agricultural residue

FC Goa registered a 2-1 victory over Punjab FC on Wednesday in the Indian Super League marking their second consecutive win to climb to top-three in standings.

The Vertex Venture-backed company wants to clock revenue of $75-100 million and achieve profitability by 2021.

The post SG’s Nium eyes profitability by Q3 next year, NYSE listing by 2022 appeared first on DealStreetAsia.

The firm's CEO Sameer Nigam speaks about turning profitable, synergies with Flipkart and operations during pandemic.

The post India: PhonePe aims to be profitable by 2022, go public in 2023 appeared first on DealStreetAsia.

CP Group said it would fund the deal with cash flow from group companies and loans.

The post Tesco Lotus set to return to Thai conglomerate CP Group’s stable in $10.6b deal appeared first on DealStreetAsia.

Company: FIS Global Business Solutions India Private Limited
Experience: 0 to 50
location: India, Pune
Ref: 24828714
Summary: Job Description : Position Type : Full time Type Of Hire : Experienced (relevant combo of work and education) Education Desired : Bachelor of Computer Engineering Travel Percentage : 0%GENERAL....

Company: P & I Management Consultants
Experience: 5 to 7
location: India
Ref: 24341067
Summary: Job Description: Qualification: B Tech/DME with 5-7 yr experience in Pharmaceutical unit Maintenance. Work Profile: • HVAC system planned/unplanned maintenance, breakdown & troubleshooting. • Having experience of process....

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

Tabu and Aishwarya Rai Bachchan's movie, Kandukondain Kandukondain completed 20 years today and this movie besides being based on Jane Austen's Sense and Sensibility was also a fashion treat. Tabu and Aishwarya Rai looked gorgeous on-screen and gave us

Rotch Library - ML189.M87 2019

supportet by Karen

Scientists know that two-star systems can support planets, but the question has remained whether an Earth-size terrestrial planet were orbiting two suns could it support life. A study in the journal Nature Communications has now found that an Earth-like planet orbiting two stars could be habitable if it were within a certain range from its two stars.

Research Event

Event participants

Dr Doyin Okupe, Senior Special Assistant on Public Affairs to the President of Nigeria 

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.

Extracellular matrix-evoked angiostasis and autophagy within the tumor microenvironment represent two critical, but unconnected, functions of the small leucine-rich proteoglycan, decorin. Acting as a partial agonist of vascular endothelial growth factor 2 (VEGFR2), soluble decorin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic degradation of intracellular vascular endothelial growth factor A (VEGFA). Here, we discovered that soluble decorin evokes intracellular catabolism of endothelial VEGFA that is mechanistically independent of mTOR, but requires an autophagic regulator, paternally expressed gene 3 (PEG3). We found that administration of autophagic inhibitors such as chloroquine or bafilomycin A1, or depletion of autophagy-related 5 (ATG5), results in accumulation of intracellular VEGFA, indicating that VEGFA is a basal autophagic substrate. Mechanistically, decorin increased the VEGFA clearance rate by augmenting autophagic flux, a process that required RAB24 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic compartments. We validated these findings by demonstrating the physiological relevance of this process in vivo. Mice starved for 48 h exhibited a sharp decrease in overall cardiac and aortic VEGFA that could be blocked by systemic chloroquine treatment. Thus, our findings reveal a unified mechanism for the metabolic control of endothelial VEGFA for autophagic clearance in response to decorin and canonical pro-autophagic stimuli. We posit that the VEGFR2/AMPK/PEG3 axis integrates the anti-angiogenic and pro-autophagic bioactivities of decorin as the molecular basis for tumorigenic suppression. These results support future therapeutic use of decorin as a next-generation protein therapy to combat cancer.

Rock 'n' roll icon Little Richard, singer-songwriter John Prine, New Orleans jazz legend Ellis Marsalis, soul singer Bill Withers, jazz icon Manu Dibango, country music icon Kenny Rogers, NASA mathematician Katherine Johnson, Oscar-winning actor Kirk Douglas, NBA legend Kobe Bryant, and WWE wrestler Rocky Johnson are among the famous people who have died in 2020.

Easter provides an opportunity to share with a neighbour.

If you only owned the ground you stood on, how would you make the most out of it? A creative idea becomes a sustainable reality.

As workers wonder how to reach people with the good news, they find God has already prepared the way.

In Tongwa village husbands and wives don't know how to love each other. A young couple is working to change that.

OM Zambia develops women through skills training in sewing, cooking, embroidery and more to bring change to communities.

The A.J. and Sigismunda Palumbo Charitable Trust has committed an additional $50,000 to a scholarship fund that will help students earn an education at Penn State DuBois. The Palumbo Scholarship at Penn State DuBois was established in 2008 with a $25,000 gift from the Palumbo Charitable Trust. To date, the trust has gifted more than $525,000 to campus scholarship funds.

Does the Skoda Kodiaq Scout bring something new to the table? Is it just a visual makeover of is there more than meets the eye? We answer these and all the other question related to this new variant of Skoda flagship SUV in India in this review.

The new Jaguar XE has looks to kill for and at the same time has enough poke to tackle city as well as highway duties.

Last month, the fund house had closed six of its debt funds, citing redemption pressures and lack of liquidity in the bond markets. 

The ratings agency explained that private sector is dominated by small doctor-run facilities in terms of number of facilities and number of beds.

The president has claimed that he was being sarcastic when he talked about injecting disinfectant and exposure to high-dose UV rays as ways to fight Covid-19.

With wage-flow stoppered, and unable to get ration in the cities, most migrant workers have had to rely on food distribution by government and NGOs.

In an interactive online session organised by All India Management Association (AIMA) on post-COVID-19 scenario for Indian economy, he listed healthcare, education, mobility, genomics, AI, 5G network, fintech and manufacturing as high priority areas for rapid and radical structural reforms.

Food Secretary Sudhanshu Pandey said already intra-state ration card portability is being used, but the transactions are not significant.

The district magistrates will explore the possibility of sending those Tablighi members, who belong to other states, in buses to their designated places in accordance with social distancing norms and other protocols, DDMA Special CEO K S Meena said in a letter to deputy commissioners (administration).

Kant has said as many as 69 million people in the country have opted for a self-assessment test in the app which takes the adoption rate of the app to 71 per cent.

Hi,

I am designing a resistive feedback TIA which needs a capacitor in its feedback loop for stability.

I would like to know the effect of a feedback capacitor on the phase margin to determine the optimal capacitance value.

My plan is to add it to the results after the stb analysis by using the direct plot>main form > phase margin (add to outputs).However it not getting added to my results list.

What could be a problem? Is there a way to add phase margin to the results using the calculator? 

I also find that the gain from the stability analysis(the closed loop gain) is different from that of the gain obtained for the closed loop simulation in AC analysis. Why is the difference, how is it computed in stability analysis?

Thanks,

-Rakesh.