On 20th March, we held the 'Coronavirus Insights and practical solutions for landlords' webinar. 

On 20th March, we held the 'Coronavirus Insights and practical solutions for landlords' webinar.  In this webinar, our speakers discussed how the outbreak of Covid-19 and the subsequent political and economic impact is having a signific...

After a 15-year study, an international team of astronomers has unveiled a map with the highest resolution to date of the spiral structure of the Milky Way, offering clear proof that it is a barred spiral

Alternative forms of dispute resolution are becoming ever more common. Encouraged by the courts and increasingly favoured by parties, options such as mediation, arbitration and adjudication are becoming more widely used. But what are the differences...

Jonathan Davidson, Executive Director of Supervision, Retail and Authorisations at the FCA, has written to CEOs of insurers concerning non-financial misconduct in wholesale general insurance firms. Davidson reminds firms of the FCA’s clear exp...

Eversheds Sutherland advised Optimas OE Solutions on the sale of part of its French business relating to certain industrial customers to Accursia Capital GmbH. This transaction took place in the context of the sale of other distinct parts of the Opt...

Overview On 30 January 2020, the World Health Organization (WHO) declared a Public Health Emergency of International Concern (PHEIC) in response to the spread of the Wuhan coronavirus, the sixth time that the WHO has made this declaration since adop...

FAISALABAD: Punjab Higher Education Department Secretary Zulfiqar Ahmad Ghumman has said that agriculture scientists should come up with the viable solutions to fight locust attack that is playing havoc with the food security of the country.He said this while visiting Faisalabad on the directions...

Franciscka Lucien is Executive Director of the Institute for Justice & Democracy in Haiti. Joel Curtain is the Director of Advocacy at Partners in Health.

The post Time for the World Bank and IMF to Be the Solution, Not the Problem appeared first on Inter Press Service.

The United States prevented a vote Friday in the UN Security Council on a resolution on the coronavirus pandemic, apparently because it made implicit mention of the World Health Organization, diplomats said.

ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation. A detailed...

ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation.A detailed...

ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation.A detailed...

Despite decreases in hunger due to economic growth, millions in Asia remain malnourished and without direct action the situation could get worse.

Crafting small business support efforts to specific country circumstances could help save millions of livelihoods in poor communities and fortify economies against future shocks.

Reduce Memory Costs and Retain Data at Power Loss with Microchip’s EERAM Memory Solutions

Enabling Cloud Connectivity to All MCUs and MPUs, Microchip Launches a Range of Embedded IoT Solutions for Rapid Prototyping

ADB's support to Asia and the Pacific’s transport sector has helped improve domestic connectivity and economic efficiency in the region, says a report released by ADB’s Independent Evaluation Department.

ADB has a vacancy for the position of Intern - Solutions Delivery Division, OIST - 2012 in the Office of Information Systems and Technology. The deadline for submitting applications is on 15 September 2019.

Dentons has advised KPS Capital Partners, a global private equity firm focused on investing in manufacturing and industrial companies across a diverse array of industries, on its acquisition of the Lufkin rod lift solutions business from Baker Hughes. 

ADB pilot project with the Philippines’ Cantilan Bank tests cloud-based banking.

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The Caspian region still has some alternatives that can develop it into a cohesive area.

AN3467 - Crystals and Oscillators for Next Generation Timing Solutions

CES 2019, LAS VEGAS – JANUARY 7, 2019 – HARMAN Professional Solutions, the global leader in audio, video, lighting and control systems, today announced new AKG DMS100 and DMS300 professional digital wireless systems.

HARMAN charmed scores of musicians and audiophiles at the start of the new decade with yet another successful appearance at events like NAMM and CES 2020. From all-star meet and greets to the debut of HARMAN’s Professional Solutions latest and greatest...

At HARMAN, it’s our mission to develop state-of-the-art audio solutions that provide enhanced listening experiences for music lovers at home, on the road, and on-stage. In recognition of Make Music Day 2018, we spoke with William “Bootsy” Collins,...

At CES 2019, HARMAN is the only vendor powering our entire exhibit. Pro’s Director of Global Marketing & Event Installations discusses how the team does it....

CES 2020 - LAS VEGAS, NV - JANUARY 6, 2020 – HARMAN, a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today launched the HARMAN ExP Integrated Solution Suite,...

All around the world, parents, students and professionals alike are adjusting to a new reality that involves strict quarantine, social distancing and work from home measures. Without a doubt, the COVID-19 pandemic has changed the way people lead their...

CES 2015, LAS VEGAS – HARMAN, the premium global audio, visual, infotainment and enterprise automation group (NYSE:HAR), announced today that its Clari-Fi™ music restoration technology has been ported to the Cirrus Logic Smart Codec platform.

GENEVA MOTOR SHOW 2015 – HARMAN, the premium global audio, visual, infotainment and enterprise automation group (NYSE:HAR), will demo its expanded scalable embedded infotainment platform at the Geneva International Motor Show. The offering addresses the full spectrum of vehicle segments, including entry- to mid-level cars, with a feature-rich, automotive-grade platform that leverages the latest smartphone integration technologies such as Apple CarPlay, Android Auto™ and MirrorLink for best-in-class connectivity for the world’s automakers.

Shanghai Auto Show 2019 – SHANGHAI – April 16, 2019 – HARMAN , a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today announced a continued partnership with the...

ABSTRACT

Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibiotic to which GBS is intrinsically resistant. Reductions in the MIC of TMP reached as high as 512-fold across a diverse panel of isolates. To better understand HMOs’ mechanism of action, we characterized the metabolic response of GBS to HMO treatment using ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UPLC-HRMS/MS) analysis. These data showed that when challenged by HMOs, GBS undergoes significant perturbations in metabolic pathways related to the biosynthesis and incorporation of macromolecules involved in membrane construction. This study represents reports the metabolic characterization of a cell that is perturbed by HMOs.

IMPORTANCE Group B Streptococcus is an important human pathogen that causes serious infections during pregnancy which can lead to chorioamnionitis, funisitis, premature rupture of gestational membranes, preterm birth, neonatal sepsis, and death. GBS is evolving antimicrobial resistance mechanisms, and the work presented in this paper provides evidence that prebiotics such as human milk oligosaccharides can act as adjuvants to restore the utility of antibiotics.

ABSTRACT

A bioinformatics approach was employed to identify transcriptome alterations in the peripheral blood mononuclear cells of well-characterized human subjects who were diagnosed with early disseminated Lyme disease (LD) based on stringent microbiological and clinical criteria. Transcriptomes were assessed at the time of presentation and also at approximately 1 month (early convalescence) and 6 months (late convalescence) after initiation of an appropriate antibiotic regimen. Comparative transcriptomics identified 335 transcripts, representing 233 unique genes, with significant alterations of at least 2-fold expression in acute- or convalescent-phase blood samples from LD subjects relative to healthy donors. Acute-phase blood samples from LD subjects had the largest number of differentially expressed transcripts (187 induced, 54 repressed). This transcriptional profile, which was dominated by interferon-regulated genes, was sustained during early convalescence. 6 months after antibiotic treatment the transcriptome of LD subjects was indistinguishable from that of healthy controls based on two separate methods of analysis. Return of the LD expression profile to levels found in control subjects was concordant with disease outcome; 82% of subjects with LD experienced at least one symptom at the baseline visit compared to 43% at the early convalescence time point and only a single patient (9%) at the 6-month convalescence time point. Using the random forest machine learning algorithm, we developed an efficient computational framework to identify sets of 20 classifier genes that discriminated LD from other bacterial and viral infections. These novel LD biomarkers not only differentiated subjects with acute disseminated LD from healthy controls with 96% accuracy but also distinguished between subjects with acute and resolved (late convalescent) disease with 97% accuracy.

IMPORTANCE Lyme disease (LD), caused by Borrelia burgdorferi, is the most common tick-borne infectious disease in the United States. We examined gene expression patterns in the blood of individuals with early disseminated LD at the time of diagnosis (acute) and also at approximately 1 month and 6 months following antibiotic treatment. A distinct acute LD profile was observed that was sustained during early convalescence (1 month) but returned to control levels 6 months after treatment. Using a computer learning algorithm, we identified sets of 20 classifier genes that discriminate LD from other bacterial and viral infections. In addition, these novel LD biomarkers are highly accurate in distinguishing patients with acute LD from healthy subjects and in discriminating between individuals with active and resolved infection. This computational approach offers the potential for more accurate diagnosis of early disseminated Lyme disease. It may also allow improved monitoring of treatment efficacy and disease resolution.