Don Tapscott, CEO of New Paradigm and coauthor of "Wikinomics: How Mass Collaboration Changes Everything."

Katherine Phillips, a professor at Columbia Business School, discusses research showing that African-Americans are often reluctant to tell their white colleagues about their personal lives — and that it hurts their careers. She says people should expect and welcome differences at work, and she gives practical advice for strengthening connections among colleagues of different racial backgrounds. Phillips is a coauthor of the article “Diversity and Authenticity,” in the March–April 2018 issue of Harvard Business Review.

The selection recognizes Nancy A. Marino's commitment to excellence in the Retail industry and Consulting/Advisory sector.

Many physicians are aware that the medical services they provide are typically exempt from sales tax. However, the physician may still be required to pay sales or use tax in his or her medical practice. The liability depends on the… Read More

The post Are Physicians Exempt from Sales and Use Tax in Missouri and Illinois? appeared first on Anders CPAs.

Applying this to financial markets helps investors to determine their chances of success in a fixed number of attempts (or trials). Another application of binomial distribution is to find out the probability of a company reporting positive growth in the EPS.

Trump’s move, a clear attempt to bolster his base ahead of the US election, shakes the very foundation of the image of America in the minds of many. This is a country where the immigrant story has had its fullest most Technicolor rendition, where politicians routinely boast about their immigrant roots.

Everyone loves holidays, especially the annual colorful and vibrant Holi festival. Various companies hold special promotions to extend this magical time of ...

The payments bank sees average monthly remittances of close to Rs 5,000 crore from daily wage earners working in various factories, construction sites, small businesses, plumbers, carpenters, cab drivers, among others.

The iconic Chicago Theater, Chicago. Image courtesy - iStock Romance the Great Lake Region in the state of Illinois. While most of us recognise the state th...

When the Kentucky Horse Racing Committee holds its next scheduled meeting on June 16, it will have a new chairman and four new members. On April 28, an executive order from Democratic Gov. Andy Beshear appointed Alan J. Leavitt, Dr. Naveed Chowhan, Jonathan Rabinowitz and James Edwin “Ed” Worley to the commission. Charles Francis O'Connor […]

The post Beshear Appoints Four New Kentucky Racing Commissioners, Rabinowitz New Chairman appeared first on Horse Racing News | Paulick Report.

VINO ROSSO (USA) [126] posted an impressive victory in the LONGINES Breeders' Cup Classic (G1) to join the top five of the ninth edition of the LONGINES World's Best Racehorse Rankings for 2019. Vino Rosso improved his rating from 121 to 126 when he defeated MCKINZIE (USA) [123] by 4 1/4 lengths at Santa Anita. Earlier […]

The post World’s Best Racehorse Rankings: Vino Rosso’s Breeders’ Cup Classic Win Vaults Him Into Top Five appeared first on Horse Racing News | Paulick Report.

Milwaukee Journal Sentinel: ‘We have to test more people’: Wisconsin expands coronavirus testing for African American, Latino and tribal communities. “All African Americans, Latinos and tribal community members in Wisconsin will have access to free COVID-19 testing under a plan announced Thursday by Gov. Tony Evers. Evers’ plan is an effort to combat the staggering … Continue reading ‘We have to test more people’: Wisconsin expands coronavirus testing for African American, Latino and tribal communities (Milwaukee Journal Sentinel)

The Hall of Fame defensive end also had his name on a chain of restaurants.

Marino, Jenna Lyn Oct 24, 1980 - Apr 27, 2020 Jenna Lyn Marino, 39, of Sarasota, Florida, died on Apr 27, 2020. Funeral arrangements .....

https://www.nps.gov/grca/learn/news/2012-10-10_mva.htm

At approximately 1:00 p.m. on Monday, July 15 a lightning strike near Mather Point resulted in several visitors reporting injuries to the Grand Canyon Visitors Center. https://www.nps.gov/grca/learn/news/lightning-causes-minor-injuries-at-grand-canyon-national-park.htm

Fire crews report that the Pinon Park fire is now 100% contained. On Wednesday, June 3 at approximately 3 pm the Grand Canyon Regional Communications Center received a call reporting a wildfire at Pinon Park located within the South Rim Village. https://www.nps.gov/grca/learn/news/pinon-contained.htm

Coconino County Public Health Services District and Grand Canyon National Park will begin monthly monitoring for plague. https://www.nps.gov/grca/learn/news/grand-canyon-and-coconino-county-to-monitor-for-plague.htm

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Center for Biological Diversity Press Release WASHINGTON – Four commonly used neonicotinoid pesticides can harm bees and other pollinators, according to a new analysis by California’s Department of Pesticide Regulation. The study found that current approved uses of the “neonics” … Continue reading →

Fuji released their new flagship camera this month, the X-Pro2. It is the first X-series camera to feature a 24MP sensor (compared to 16MP before) and it has a very interesting hybrid optical & electronic view finder. When I first […]

St-Donat, Bas-St-Laurent, Québec

St-Donat, Bas-St-Laurent, Québec

Large-scale pretrained language models are the major driving force behind recent improvements in performance on the Winograd Schema Challenge, a widely employed test of common sense reasoning ability. We show, however, with a new diagnostic dataset, that these models are sensitive to linguistic perturbations of the Winograd examples that minimally affect human understanding. Our results highlight interesting differences between humans and language models: language models are more sensitive to number or gender alternations and synonym replacements than humans, and humans are more stable and consistent in their predictions, maintain a much higher absolute performance, and perform better on non-associative instances than associative ones. Overall, humans are correct more often than out-of-the-box models, and the models are sometimes right for the wrong reasons. Finally, we show that fine-tuning on a large, task-specific dataset can offer a solution to these issues.

We study the problem of pricing under a Multinomial Logit model where we incorporate network effects over the consumer's decisions. We analyse both cases, when sellers compete or collaborate. In particular, we pay special attention to the overall expected revenue and how the behaviour of the no purchase option is affected under variations of a network effect parameter. Where for example we prove that the market share for the no purchase option, is decreasing in terms of the value of the network effect, meaning that stronger communication among costumers increases the expected amount of sales. We also analyse how the customer's utility is altered when network effects are incorporated into the market, comparing the cases where both competitive and monopolistic prices are displayed. We use tools from stochastic approximation algorithms to prove that the probability of purchasing the available products converges to a unique stationary distribution. We model that the sellers can use this stationary distribution to establish their strategies. Finding that under those settings, a pure Nash Equilibrium represents the pricing strategies in the case of competition, and an optimal (that maximises the total revenue) fixed price characterise the case of collaboration.

ON INLANDER.COM WORLD: Roughly two weeks after Canada's deadliest mass shooting, Prime Minister Justin Trudeau introduced an immediate ban on what he called “military-style assault weapons.”…

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Biocidal compositions and their use in aqueous media, such as metalworking fluids, the compositions comprising a biocidal agent; and a non-biocidal primary amino alcohol compound of the formula (I); wherein R1, R2, R3, R4, and R5 are as defined herein.

Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

A reagent composition for forming fatty acyl amido surfactants is provided which includes an alkali metal or alkaline earth metal salt of an amino compound; a polyol of molecular weight ranging from 76 to 300; and no more than 10% water.

The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R1 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.

The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group,W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl; and n is 1, 2, 3 or 4. Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.

The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I) in the formula, R1 and R2 each independently stands for hydrogen, halogen, alkyl, alkoxy, acyl, amino and the like,R3 stands for alkyl, aryl, saturated carbocyclic group, saturated heterocyclic group, acyl and the like,R4 stands for hydrogen, hydroxy, alkyl or amino,R5 and R8 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkoxy, cyano or nitro,R6 and R7 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, cyano, amino, carbocyclic group, heterocyclic group, COR9 or SO2R9,R9 stands for hydrogen, hydroxy, alkyl, amino, pyrrolidin-1-yl, piperidin-1-yl, pyperazin-1-yl or the like,X stands for S or O, andA1, A2 and A3 each independently stands for N or C.

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain pyridyl-amino-pyrazine carbonitrile compounds that, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or thymidylate synthase (TS) inhibitor; (d) a microtubule targeted agent; and (e) ionizing radiation.

Formaldehyde-free binder compositions are described that include an aldehyde or ketone, a nitrogen-containing salt of an inorganic acid, and an acidic compound. The acidic compound may be an organic acid, such as maleic acid or citric acid among others. The acidic compound is supplied in quantities that lower the pH of the binder composition to about 5 or less. The binder compositions may be used in methods of binding fiberglass and the resulting fiberglass products have an improved tensile strength due to the addition of the acidic compound.

A photovoltaic cell, for example a thin-film photovoltaic cell, having a substrate glass made of aluminosilicate glass, has a glass composition which has SiO2 and Al2O3 as well as the alkali metal oxide Na2O and the alkaline earth oxides CaO, MgO, and BaO, and optionally further components. The glass composition includes 10 to 16 wt.-% Na2O, >0 to 1 to 10 wt.-% BaO, and the ratio of CaO:MgO is in the range of 0.5 to 1.7. The aluminosilicate glass used is crystallization stable because of the selected quotient of CaO/MgO and has a transformation temperature >580° C. and a processing temperature

An alumino-borosilicate glass for the confinement, isolation of a radioactive liquid effluent of medium activity, and a method for treating a radioactive liquid effluent of medium activity, wherein calcination of said effluent is carried out in order to obtain a calcinate, and a vitrification adjuvant is added to said calcinate.

Disclosed are soft, high refractive index, acrylic device materials. The materials contain a copolymeric additive for glistening resistance.

Disclosed are methods for producing rubber-containing bituminous mixtures by pressurizing mixtures of bituminous materials, crumb rubber, and one or more suspension agents with a gas, and then reducing the pressure, creating bubbles of the gas in the mixture. Also disclosed are methods of introducing gas into such mixture by rapid mixing. Mixtures produced by the disclosed methods, such as rubber-containing asphalt mixtures and paving compositions thereof, and their use are also disclosed.

A coating/sealant system that includes a coating and a sealant deposited over at least a portion of the coating, in which the coating includes a reaction product formed from reactants comprising a phosphated epoxy resin and a curing agent, and the sealant includes a sulfur-containing polymer.

Methods of capturing and immobilizing radioactive nuclei with metal fluorite-based inorganic materials are described. For example, a method of capturing and immobilizing radioactive nuclei includes flowing a gas stream through an exhaust apparatus. The exhaust apparatus includes a metal fluorite-based inorganic material. The gas stream includes a radioactive species. The radioactive species is removed from the gas stream by adsorbing the radioactive species to the metal fluorite-based inorganic material of the exhaust apparatus.

Resist stripping agents useful for fabricating circuits and/or forming electrodes on semiconductor devices for semiconductor integrated circuits and/or liquid crystals with reduced metal and metal alloy etch rates (particularly copper etch rates and TiW etch rates), are provided with methods for their use. The preferred stripping agents contain low concentrations of resorcinol or a resorcinol derivative, with or without an added copper salt, and with or without an added amine to improve solubility of the copper salt. Further provided are integrated circuit devices and electronic interconnect structures prepared according to these methods.

Methods employing detergent compositions effective for reducing soil redeposition and accumulation on hard surfaces are disclosed. The detergent compositions employ phosphinosuccinic acid adducts in combination with an alkalinity source and gluconic acid or salts thereof, copolymers of acrylic acid and maleic acids or salts thereof, sodium hypochlorite, sodium dichloroisocyanurate or combinations thereof.

The present invention generally relates to processes for the enzymatic production of a phosphinothricin product or precursor thereof from a nitrile-containing substrate.

Provided is an efficient technology for synthesizing diamino acids (diamino acid derivatives). Disclosed is a manufacturing method for diamino acid derivatives wherein the fluorenyl groups of the diamino acid derivative starting materials represented by General Formula [II] or [IV] are removed.

The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.

Substituted phenylcarbamoyl alkylamino arenes; substituted phenylthiocarbamyl alkylamino arenes; substituted phenylcarbamoyl alkylamino heteroarenes; substituted phenylthiocarbamyl alkylamino heteroarenes; N-substituted aryl, N'-substituted aryl urea compounds; N-substituted aryl, N'-substituted heteroaryl urea compounds; N-substituted aryl, N'-substituted aryl thiourea compounds and N-substituted aryl, N'-substituted heteroaryl thiourea compounds are provided and may find use as androgen receptor modulators. The compounds may find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.