To date, 4 small to moderate sized studies have revealed conflicting results on the clinically important question whether thrombocytopenia contributes to persistent patent ductus arteriosus (PDA) in very immature, preterm infants.

Thrombocytopenia in the first 24 hours after birth was not associated with the incidence of PDA at postnatal day of life 4 to 5 in a large cohort of preterm infants with <1500 g birth weight. Platelet dysfunction, rather than platelet number, might play a role in ductus arteriosus patency. (Read the full article)

Physical inactivity is one of the major modifiable factors contributing to the growing national epidemic of childhood obesity. There is lack of literature on pedometer-determined physical activity (PA) during the school day in US minority kindergarten and first-grade students.

This is the first study to assess school-day PA in US urban minority kindergarten and first-grade students. Higher grade level, participation in physical education class, and outdoor recess were found to be independent predictors of PA. (Read the full article)

The triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) estimates atherogenic small, dense low-density lipoprotein cholesterol and predicts arterial stiffness and hard cardiovascular events in adults. Whether TG/HDL-C predicts intermediate noninvasive end points (arterial stiffness) in youth is not known.

This study is the first to document stiffer vessels in youth with higher cardiovascular risk factor–adjusted TG/HDL-C, with the effect especially strong in obese subjects. Evaluating TG/HDL-C may be helpful in identifying young subjects at risk for obesity-related atherosclerosis. (Read the full article)

At least half of the achievement gap for low-income, minority children is present at kindergarten entry; however, there are no population-level early childhood interventions that effectively engage and support families and teachers to ameliorate the impact of adversity on achievement.

This study evaluated ParentCorps, a family-centered, school-based intervention to promote self-regulation and learning for all children entering school in disadvantaged, urban neighborhoods. ParentCorps results in higher kindergarten achievement among low-income, minority children. (Read the full article)

Blood lead levels well below 10 µg/dL are now recognized as causing adverse cognitive effects, including lower scores on standardized reading and math tests.

This is the first study to show that reading readiness early in kindergarten is independently associated with blood lead levels well below 10 µg/dL. Results suggest that lead exposure may have a larger impact on urban education than national estimates suggest. (Read the full article)

Elevated blood pressure (BP) has long-term influence on the atherosclerotic process. The relative predictive ability of the standard BP definition endorsed by the National High Blood Pressure Education Program and the recently proposed 2 simplified definitions has not been studied.

Simplified pediatric BP tables predict risk of high adult arterial stiffness as well as the complex table does. These simple screening tools could be used for identifying pediatric subjects at risk and for intervening to improve adult cardiovascular outcomes. (Read the full article)

Minority children are less likely than white children to be diagnosed and treated with attention-deficit/hyperactivity disorder. However, diagnosis patterns over time in early and middle childhood and whether confounding factors explain these disparities are not currently well understood.

Racial/ethnic disparities in attention-deficit/hyperactivity disorder diagnosis occur by kindergarten and continue until eighth grade. Racial/ethnic disparities among diagnosed children in medication use occur in both fifth and eighth grades. These disparities are not attributable to confounding factors. (Read the full article)

Previous research has established steep socioeconomic status gradients in children’s cognitive ability at kindergarten entry. Few studies have had comprehensive data to examine the contribution of a wide range of risk and protective factors across early childhood to these gradients.

Family background, health, home learning, parenting, and early care and education factors explain over half the gaps in reading and math ability between US children in the lowest versus highest socioeconomic status quintiles, suggesting a need for comprehensive early interventions. (Read the full article)

Neonatal arterial ischemic stroke is associated with later cerebral palsy and cognitive impairment. Many studies on neonatal ischemic stroke are limited by modest sample sizes, and prospective studies that include outcomes assessments are scarce.

Results from this prospective, nationwide, population-based study provide information on the epidemiology, associated clinical variables, clinical manifestation, vascular distribution, and treatment of neonatal arterial ischemic stroke. The study also provides outcomes regarding motor function and cognition. (Read the full article)

Late preterm infants, compared with full-term infants, have less proficiency in reading and math at school age, with increased need for individualized educational plans and special education services. They also have lower cognitive performance on standardized IQ exams.

Late preterm infants have worse outcomes at school entry, and development is variable during the preschool years, so socioeconomic status, language spoken in the home, maternal education, maternal race, and being a late preterm infant have a large impact. (Read the full article)

The Dallas String Quartet will deliver its passionate fusion of classical and contemporary music to the Community Arts Center at 7:30 p.m. Thursday, March 19.

Groundbreaking, Grammy-winning quartet Béla Fleck & The Flecktones is celebrating its 30th anniversary with an extended tour that will stop by the Community Arts Center on Tuesday, March 24, at 7:30 p.m.

Since 2012, single low dose of primaquine (SLDPQ, 0.25mg/kg) has been recommended with artemisinin-based combination therapies, as first-line treatment of acute uncomplicated Plasmodium falciparum malaria, to interrupt its transmission, especially in low transmission settings of multidrug, including artemisinin, resistance. Policy makers in Cambodia have been reluctant to implement this recommendation due to primaquine safety concerns and lack of data on its efficacy.

In this randomized controlled trial, 109 Cambodians with acute uncomplicated P. falciparum malaria received dihydroartemisinin-piperaquine (DP) alone or combined with SLDPQ on the first treatment day. Transmission-blocking efficacy of SLDPQ was evaluated on Days 0, 1, 2, 3, 7, 14, 21, 28 and recrudescence by reverse transcriptase polymerase chain reaction (RT-PCR) (gametocyte prevalence) and membrane-feeding assays with Anopheles minimus mosquitoes (gametocyte infectivity). Without the influence of recrudescent infections, DP+SLDPQ reduced gametocyte carriage 3 fold compared to DP. Of 48 patients tested on Day 0, only three patients were infectious to mosquitoes (~6%). Post-treatment, three patients were infectious: on D14 (3.5%, 1/29), and on the first and seventh day of recrudescence (8.3%, 1/12 for each); this overall low infectivity precluded our ability to assess its transmission blocking efficacy.

Our study confirms effective gametocyte clearance of SLDPQ when combined with DP in multidrug resistant P. falciparum and the negative impact of recrudescent infections due to poor DP efficacy. Artesunate-mefloquine (ASMQ) has replaced DP and ASMQ-SLDPQ has been deployed to treat all P. falciparum symptomatic patients to further support the elimination of multidrug resistant P. falciparum in Cambodia.

As resistance to artemisinins (current frontline drugs in malaria treatment) emerges in south East Asia, there is an urgent need to identify the genetic determinants and understand the molecular mechanisms underpinning such resistance. Such insights could lead to prospective interventions to contain resistance and prevent the eventual spread to other malaria endemic regions. Artemisinin reduced susceptibility in South East Asia (SEA) has been primarily linked to mutations in P. falciparum Kelch-13, which is currently widely recognised as a molecular marker of artemisinin resistance. However, 2 mutations in a ubiquitin hydrolase, UBP-1, have been previously associated with artemisinin reduced susceptibility in a rodent model of malaria and some cases of UBP-1 mutation variants associating with artemisinin treatment failure have been reported in Africa and SEA. In this study, we have employed CRISPR-Cas9 genome editing and pre-emptive drug pressures to test these artemisinin susceptibility associated mutations in UBP-1 in P. berghei sensitive lines in vivo. Using these approaches, we have shown that the V2721F UBP-1 mutation results in reduced artemisinin susceptibility, while the V2752F mutation results in resistance to chloroquine and moderately impacts tolerance to artemisinins. Genetic reversal of the V2752F mutation restored chloroquine sensitivity in these mutant lines while simultaneous introduction of both mutations could not be achieved and appears to be lethal. Interestingly, these mutations carry a detrimental growth defect, which would possibly explain their lack of expansion in natural infection settings. Our work has provided independent experimental evidence on the role of UBP-1 in modulating parasite responses to artemisinin and chloroquine under in vivo conditions.

There's more than one way to invest in the yellow metal: either by buying it in its physical form, or investing in shares linked to gold. Fin24 asked the experts how to get started.

Lieke Martens has won the UEFA Women's Player of the Year award after her player-of-the-tournament performance at UEFA Women's EURO 2017.

The International Crisis Group congratulates the members of the Tunisian National Dialogue Quartet as this year’s recipient of the Nobel Peace Prize. It is an apt recognition of its achievement in allowing the spirit of inclusion and compromise to triumph over the polarisation and violence that has been all too prevalent in the region, and of the central role civil society can play at moments of crisis.

Arsenal, Glasgow and Paris have joined Atlético, Barcelona, Bayern, holders Lyon and Wolfsburg in the last eight.

Holders Lyon face Bayern, Atlético take on Barcelona, Arsenal meet Paris and Glasgow play Wolfsburg.

Real Madrid, Chelsea, Liverpool, Atlético Madrid, Tottenham and Porto won their round of 16 ties on Wednesday to join Barcelona and Manchester City in the quarter-finals.

Holders Barcelona, fellow two-time winners Chelsea, Porto and debutants Hoffenheim won their quarter-finals to reach Nyon.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

There will be two all-European quarter-finals at the FIFA Futsal World Cup with Spain meeting Russia, and Portugal up against Italy following the conclusion of the round of 16 in Thailand.

Guilty plea to murder in Dover killing; Change in state’s securities act leads to guilty plea to theft and identity theft Beatriz Fana-Ruiz, the woman who set fire to the home where she lived leading to the deaths of 3 Wilmington firefighters has been sentenced to 30 years in prison. Deputy Attorneys General Barzilai Axelrod […]

Unearthing cartels by invoking applicant confidence: Lesser penalty regulations, 2009

SBI Cards and Payment Services on Friday posted a 66 per cent fall in net profit at Rs 84 crore for the quarter ended March 31

Gross non-performing assets came in at 5.53% in the quarter ended March 31, as against 5.95% in the previous quarter.

535 kindergarten students at McIlvaine Early Childhood Center in Magnolia learned fire safety from Smokey Bear as part of the Delaware Forest Service's annual education program. Located in the Caesar Rodney School District, McIlvaine is the largest kindergarten program in the First State.

Agency: DSU Closing Date: 5/19/2020

Welcome to the first post for the Getting Started with Python Integration to SAS Viya series! With the popularity of the Python programming language for data analysis and SAS Viya's ability to integrate with Python, I thought, why not create tutorials for users integrating the two? To begin the series [...]

Getting Started with Python Integration to SAS® Viya® - Part 1 - Making a Connection was published on SAS Users.

Welcome to the first post for the Getting Started with Python Integration to SAS Viya series! With the popularity of the Python programming language for data analysis and SAS Viya's ability to integrate with Python, I thought, why not create tutorials for users integrating the two? To begin the series [...]

Getting Started with Python Integration to SAS® Viya® - Part 1 - Making a Connection was published on SAS Users.

"ArcelorMittal recorded a net loss for quarter 1, 2020 of USD 1.1 billion... as compared to a net loss for quarter 4, 2019 of USD 1.9 billion and a net income for quarter 1, 2019 of USD 0.4 billion," the company said. 

Charges against US President Donald Trump’s first national security adviser, General Michael Flynn, have been dropped due to new evidence showing they were baseless. Flynn was the first to be targeted in the ‘Russiagate’ probe.
Read Full Article at RT.com

   OpenCL™ Basic Tutorial for Android* OS provides guidelines on using OpenCL in Android applications. The tutorial is an interactive image processing Android application. The main focus for...

  We are gearing up for two of the biggest shows of the year: Game Developers Conference (GDC) in San Francisco and Mobile World Conference (MWC) in Barcelona, Spain - both the week of March 2. Come loo...

  Last month, Pokémon GO officially launched in… Oh, wait! Not again! Not another article about augmented reality starting with Pokémon GO! It almost seems as if Pokémon GO a...

Through key exhibitions and texts, Celant was an influential proponent of the work of young Italian artists in Turin, Milan, Genoa and Rome, working with natural materials and elements such as dirt, sticks or rags who were seeking to challenge the commercial art scene at the time

'Organised crime has many faces. The trafficking of cultural goods is one of them. It is not a glamorous business run by flamboyant gentlemen forgers, but by international criminal networks'

Guidance for year has been cautious; FY20/21e EPS up 1/0.4%; valuations are fair; ‘Neutral’ maintained

Revenues from anti-retroviral (ARV) formulations stood at Rs313.4 crore as against Rs281.3 crore, an increase by 11.4% y-o-y.