Scott Carey is in the hosting chair this week as we have a rotating cast of staffers from across Macworld, Tech Advisor, Techworld and Computerworld to discuss our two favourite techie things of the year, from the best games and films, to our favourite devices and even, microchips.

Thank you for listening this year and for your continued support for the UK Tech Weekly Podcast and we will see you in the new year.

See acast.com/privacy for privacy and opt-out information.

Find here most important blogs for CRM Software. Here CRM Software related Information, guidelines, and helpful Blog.

Henry "Hank" Aaron was born in Alabama three years after Willie Mays, 85 years ago Tuesday. Now, all this time later, Aaron is as much the conscience and the soul of baseball as any man alive. But we don't just celebrate a great baseball life today. We celebrate a great American life.

Bastiaan Bloem, consultant neurologist at Radboud University Nijmegen Medical Centre, Netherlands, discussing his revolutionary approach to patient centred care. Read more from the summit: http://www.bmj.com/content/350/bmj.h1172

Abdominal aortic aneurysms (AAA) are usually asymptomatic until they rupture, which is fatal in more than 80% of cases. Screening aims to detect the aneurysm before it ruptures, enabling preventive surgery and hence reducing morbidity and mortality. However, preventive surgery has a mortality of 3.9-4.5%. As the prevalence of risk factors, ie...

Posttreatment high-grade gliomas are usually monitored with contrast-enhanced MRI, but its diagnostic accuracy is limited as it cannot adequately distinguish between true tumor progression and treatment-related changes. According to recent Response Assessment in Neuro-Oncology recommendations, PET overcomes this limitation. However, it is currently unknown which tracer yields the best results. Therefore, a systematic review and metaanalysis were performed to compare the diagnostic accuracy of the different PET tracers in differentiating tumor progression from treatment-related changes in high-grade glioma patients. Methods: PubMed, Web of Science, and Embase were searched systematically. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Metaanalysis was performed using a bivariate random-effects model when at least 5 studies were included. Results: The systematic review included 39 studies (11 tracers). ¹⁸F-FDG (12 studies, 171 lesions) showed a pooled sensitivity and specificity of 84% (95% confidence interval, 72%–92%) and 84% (95% confidence interval, 69%–93%), respectively. O-(2-¹⁸F-fluoroethyl)-l-tyrosine (¹⁸F-FET) (7 studies, 172 lesions) demonstrated a sensitivity of 90% (95% confidence interval, 81%–95%) and specificity of 85% (95% confidence interval, 71%–93%). For S-¹¹C-methyl)-l-methionine (¹¹C-MET) (8 studies, 151 lesions), sensitivity was 93% (95% confidence interval, 80%–98%) and specificity was 82% (95% confidence interval, 68%–91%). The numbers of included studies for the other tracers were too low to combine, but sensitivity and specificity ranged between 93%–100% and 0%–100%, respectively, for ¹⁸F-FLT; 85%–100% and 72%–100%, respectively, for 3,4-dihydroxy-6-¹⁸F-fluoro-l-phenylalanine (¹⁸F-FDOPA); and 100% and 70%–88%, respectively, for ¹¹C-choline. Conclusion: ¹⁸F-FET and ¹¹C-MET, both amino-acid tracers, showed a comparably higher sensitivity than ¹⁸F-FDG in the differentiation between tumor progression and treatment-related changes in high-grade glioma patients. The evidence for other tracers is limited; thus, ¹⁸F-FET and ¹¹C-MET are preferred when available. Our results support the incorporation of amino-acid PET tracers for the treatment evaluation of high-grade gliomas.

Following a ruling in federal court two days prior, the Department of Health and Human Services announced Jan. 25 that the Health Insurance Portability and Accountability Act Privacy Rule fee limitations do not apply to requests to transmit copies of records to third-parties.

The American Dental Association and American Academy of Pediatric Dentistry filed comments Feb. 28 on the Centers for Medicare and Medicaid Services’ proposed 2021 notice of benefit and payment parameters for the Affordable Care Act.

Anaheim, Calif. — The American Association of Dental Editors & Journalists is hosting Dental Editors University West May 14-15 at the Anaheim Hilton in Anaheim, California.

Ogden, Utah — The Office for Civil Rights announced March 3 that it had reached a settlement with Dr. Steven A. Porter’s medical practice to settle a potential violation of the Health Insurance Portability and Accountability Act security rule.

The International Association for Dental Research and American Association for Dental Research have canceled their general session scheduled for March 18-21 in Washington, D.C., in light of the coronavirus disease outbreak.

As part of its ongoing efforts to support dentists during the COVID-19 pandemic, the ADA is offering members two free e-books the week of April 8-14: “Managing Finances: Best Practices” and “The ADA Practical Guide to HIPAA Training.”

Textron was awarded a $20.7 million contract modification Friday for work on the Navy's Unmanned Influence Sweep System and Unmanned Surface Vehicle program.

Our Indian chef whips these delicious naan breads up for us every day to go with her chicken tikka and vegetarian curries Brushed with garlic butter as they come out of the stone oven, they are quite a treat (thats why she has to make so many everyday.....)Thanks Nancylt;i>f

Curtis Jones, a U.S. Army veteran who has led Georgia's Bibb County school system since 2015, has been named the 2019 AASA National Superintendent of the Year.

Hubbard was the AP Big 12 Offensive Player of the Year and finished eighth in the Heisman Trophy voting, the third-best finish for a Canadian player. It was the second-best single-season total in school history, trailing only Barry Sanders' 1988 Heisman season. Hubbard was the runner-up for the Cornish Trophy in 2019 after his redshirt freshman season.

"If a school doesn’t reopen, then they’re not going to be playing sports. It’s really that simple," Emmert said.

Autism spectrum disorders in children.

Vaccination -- History.

Self-actualization (Psychology) in old age.

London : D. Bogue, 1881.

Leipzig : G. Thieme, 1890-1891.

Christiania : Malling, 1883.

[Wien] : [publisher not identified], 1860.

Leipzig : Duncker & Humblot, 1898.

Hannover : Schmorl & von Seefeld, 1866.

Stuttgart : Enke, 1905.

Amsterdam : J. Muller, 1896.

David Schuler, the superintendent of Township High School District 214 in Arlington Heights, Ill., has been named 2018 National Superintendent of the Year.

Ducks defensemen Christian Djoos and Jani Hakanpaa will stay with the team through the 2020-21 season after each signed a one-year, one-way contract extension.

Halle (Saale) : Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften ; Stuttgart : Wissenschaftliche Verlagsgesellschaft, 2019.

Rockville, Maryland : The National Institute on Drug Abuse, 1976.

Over four years in Eugene, Ruthy Hebard has made a name for herself with reliability and dynamic play. She's had many memorable moments in a Duck uniform. But her career day against Washington State (34 points), her moment reaching 2,000 career points and her NCAA record for consecutive made FGs (2018) tops the list. Against the Trojans, she set the record (30) and later extended it to 33.

Arizona's Aari McDonald and Pac-12 Networks' Ashley Adamson discuss the guard's decision to return for her senior season in Tucson and how she now has the opportunity to be the face of the league. McDonald, the Pac-12 Defensive Player of the Year, was one of the nation's top scorers in 2019-20, averaging 20.6 points per game.

The women's basketball committee will start using the NCAA Evaluation Tool instead of RPI to help evaluate teams for the tournament starting with the upcoming season. “It’s an exciting time for the game as we look to the future,” said Nina King, senior deputy athletics director and chief of staff at Duke, who chair the Division I Women’s Basketball Committee next season. “We felt after much analysis that the women’s basketball NET, which will be determined by who you played, where you played, how efficiently you played and the result of the game, is a more accurate tool and should be used by the committee going forward.”

The process is based on the U.S. three-phase federal guidelines for easing social distancing and re-opening non-essential businesses.

London : Cleanair (33 Stillness Rd, London, SE23 1NG), [198-?]

Brian Zingg
Apr 15, 2020; 40:3250-3267
Systems/Circuits

Revealing the organization and function of neural circuits is greatly facilitated by viral tools that spread transsynaptically. Adeno-associated virus (AAV) exhibits anterograde transneuronal transport, however, the synaptic specificity of this spread and its broad application within a diverse set of circuits remains to be explored. Here, using anatomic, functional, and molecular approaches, we provide evidence for the preferential transport of AAV1 to postsynaptically connected neurons and reveal its spread is strongly dependent on synaptic transmitter release. In addition to glutamatergic pathways, AAV1 also spreads through GABAergic synapses to both excitatory and inhibitory cell types. We observed little or no transport, however, through neuromodulatory projections (e.g., serotonergic, cholinergic, and noradrenergic). In addition, we found that AAV1 can be transported through long-distance descending projections from various brain regions to effectively transduce spinal cord neurons. Combined with newly designed intersectional and sparse labeling strategies, AAV1 can be applied within a wide variety of pathways to categorize neurons according to their input sources, morphology, and molecular identities. These properties make AAV1 a promising anterograde transsynaptic tool for establishing a comprehensive cell-atlas of the brain, although its capacity for retrograde transport currently limits its use to unidirectional circuits.

SIGNIFICANCE STATEMENT The discovery of anterograde transneuronal spread of AAV1 generates great promise for its application as a unique tool for manipulating input-defined cell populations and mapping their outputs. However, several outstanding questions remain for anterograde transsynaptic approaches in the field: (1) whether AAV1 spreads exclusively or specifically to synaptically connected neurons, and (2) how broad its application could be in various types of neural circuits in the brain. This study provides several lines of evidence in terms of anatomy, functional innervation, and underlying mechanisms, to strongly support that AAV1 anterograde transneuronal spread is highly synapse specific. In addition, several potentially important applications of transsynaptic AAV1 in probing neural circuits are described.

Browse the collections for artworks with a CC0 license as part of the Smithsonian's Open Access Initiative,

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">RT @imconair Song Contest: Raab und Engelke sollen Eurovision-Finale moderieren http://bit.ly/fsr6gD #IMCRadio.net: Song Contest: Raa...</span></span>

This rapid and efficient method to prepare highly purified recombinant adeno-associated viruses (rAAVs) is based on binding of negatively charged rAAV capsids to an anion-exchange resin that is pH dependent.

This is a simple method for rapid preparation of recombinant adeno-associated virus (rAAV) stocks, which can be used for in vivo gene delivery. The purity of these vectors is considerably lower than that obtained by either CsCl gradient centrifugation or by combination of iodixanol gradient ultracentrifugation followed by column chromatography.

The most commonly used method for production of recombinant adeno-associated virus (rAAVs) in research laboratories is by transient triple transfection of 293 cells with AAV cis and trans plasmids and an adenovirus helper plasmid. This protocol describes the processes required to prepare the transfected cell suspension for virus purification.

"I have tied up with several NGO’s like Parivartan the change who donate food to over 500 people every day as well with welfare organisations like 4dogsakeindia where we feed over 200 street dogs."

Netizens celebrate as Kamal Haasan crosses 6 million mark on Twitter  DNA India

5 Dance Moves Made Popular By Salman Khan Which Prove Sometimes Even ‘Pappu Can Dance Saala’  MensXP.com

Every day there is something or the other happening in the entertainment industry the proceeds of which are being given away for fighting the corona crisis.

Darin Isaac has been elected chief of the Selkirk First Nation while Jeremy Harper, Morris Morrison, Carmen Lee Baker and Ashley Edzerza were voted in as councillors. Cody Sims has been elected youth councillor.