Washington — A coalition of 10 aviation industry groups led by Airlines for America, a trade association of U.S. passenger and cargo carriers, is requesting that the Department of Justice “commit to the full and public prosecution of onboard acts of violence” by passengers against airline employees.

Washington — The Department of Labor has increased civil penalty amounts for violations to adjust for inflation, effective Jan. 15.

Washington — The Department of Transportation has updated civil penalty amounts for violations to adjust for inflation, effective Dec. 28.

San Diego — A U.S. Department of Agriculture proposal to remove maximum line speeds in pork-processing plants “will translate into even more illness and injury” among workers, according to the National Council for Occupational Safety and Health.

New York – The risk of developing lung cancer increases when workers smoke, are exposed to asbestos and have asbestosis, according to a new study from the American Thoracic Society.

Washington – Three advocacy groups on June 25 filed a petition with the Inter-American Commission on Human Rights alleging that unsafe conditions in poultry plants threaten workers’ basic human rights.

Rockville, MD – Several construction industry trade associations have formed a coalition in response to OSHA’s proposed rule on crystalline silica.

Despite the downward trend in workplace fatalities, safety advocates are calling for stepped-up efforts to protect workers.

Washington – President Barack Obama should veto proposed funding legislation that would cut OSHA’s budget, 76 advocacy groups urged in an Aug. 5 letter.

Washington – Several public health advocacy groups have filed a motion to intervene in a lawsuit that aims to undo OSHA’s requirement for employers to electronically submit worker injury and illness data for public view.

Washington — Advocacy groups Farmworker Justice and Earthjustice filed a joint Freedom of Information Act lawsuit April 17 seeking Environmental Protection Agency meeting notes related to a pair of regulatory changes regarding worker protection.

Grain Valley, MO — The Owner-Operator Independent Drivers Association, Advocates for Highway and Auto Safety and 12 other organizations have sent a letter to lawmakers urging them to oppose two House bills that would allow drivers younger than 21 to operate interstate commercial motor vehicles.

Washington — More than 130 organizations and 90 individuals are petitioning OSHA to issue regulations aimed at protecting workers against heat stress.

Washington — The National Employment Law Project and the Economic Analysis and Research Network recently released a policy brief intended to advise incoming governors and state legislators on best practices “to protect workers in their states so that all communities can thrive and grow.”

Washington — The National Employment Law Project and two other labor advocacy groups have filed a complaint against the Department of Labor, claiming DOL violated the Information Quality Act in its move to roll back child labor laws to allow unsupervised teens to operate powered patient lifts in health care settings.

Washington — A coalition of roadway safety advocacy groups, in conjunction with the International Brotherhood of Teamsters, has filed a lawsuit against the Federal Motor Carrier Safety Administration and the Department of Transportation challenging a controversial final rule FMCSA claims will add flexibility to hours-of-service regulations for commercial truck drivers.

Washington — A pair of advocacy groups are calling on the National Highway Traffic Safety Administration to reconsider a final rule aimed at strengthening protections for drivers and passengers in light vehicles involved in “underride” crashes, which occur when vehicles strike the rear of large trucks and slide underneath.

Washington — The U.S. District Court of Appeals for the District of Columbia Circuit on April 4 heard oral arguments on why it should order OSHA to issue a permanent standard on COVID-19 for the health care industry.

Washington — The U.S. District Court of Appeals for the District of Columbia Circuit has ruled it doesn’t have the authority to order OSHA to issue a permanent standard on COVID-19 for the health care industry, denying an emergency petition filed by National Nurses United and other labor groups.

Washington — Hearing conservation and women in construction are among the topics scheduled for discussion during an upcoming Advisory Committee on Construction Safety and Health meeting.

As with the syrups in its restaurants, IHOP retail syrups also do not contain high fructose corn syrup and feature the same iconic flavors that have made IHOP the leader in breakfast.

Gardein, a brand of Conagra Brands, Inc. debuted five new Gardein Soups, the first-ever line-up of soups featuring plant-based meat alternatives.

Featuring high-quality ingredients and Indian family recipes, Maya Kaimal Foods is committed to taking the time to carefully prepare its namesake products, so consumers don't have to. The new Inspired Soup options are ready to eat, and simply need to be heated on the stovetop or in a microwave-safe container.

Kettle cooked in small batches to feature rich, simmered-all-day taste, each are free of artificial ingredients and preservatives, and crafted with one of Zoup!'s homestyle broths as a base.

Campbell's® unveiled two gluten free cooking soups. The new condensed options, available in Cream of Mushroom and Cream of Chicken, two of the brand's most popular flavors, will help serve the nearly one out of five Americans currently avoiding gluten.

Old El Paso is stepping into the soup aisle and launching a lineup of canned soups. With five new flavors, each style of Old El Paso Tex-Mex-inspired soup will bring life and zest to the dinner table without any artificial flavors or colors.

Upshoot's Phytopúr products are made of wholesome fruits and vegetables from trusted farms, and are supported by sound science, patented technology, and rigorous quality standards.

Driven by a passion to deliver product innovations that contain flavorful organic, unprocessed, clean, and recognizable ingredients, Mother Raw debuted shelf-stable condiments. The new condiment offerings include Organic Ketchups and Plant-Based Mayos.

The two new syrups add to Cheeky's current lineup of syrups and juices, which are all shelf-stable versions of professional bar ingredients usually made from scratch, including 100% Lemon and Lime Juices and syrups like Espresso, Honey Ginger, Agave and more. 

The new soup collection includes several gluten-free and dairy-free options.

Located in Adelboden, Switzerland, The Brecon offers a luxurious escape in the Swiss Alps for ultimate relaxation and the alpine experience.

The post Improving Representation in Clinical Trials and Research: Building Research Equity for Women and Underrepresented Groups was curated by information for practice.

The post NIHR launches pipeline of Mental Health Research Groups across England [ £27 million to support mental health research teams in nine regions ] was curated by information for practice.

The post Conceptualizing bias in EHR data: A case study in performance disparities by demographic subgroups for a pediatric obesity incidence classifier was curated by information for practice.

Current Directions in Psychological Science, Ahead of Print. Conspiracy theories have been treated mostly as a homogeneous phenomenon in empirical research. However, to fully understand their causes and consequences, a multifaceted approach to conspiracy theories would be useful. Here, we propose an organizational framework with three facets (groups, ideology, and status) to conceptualize conspiracy theories. […]

The post Conspiracy Theories: Groups, Ideology, and Status as Three Distinct Bases for Expressions in Society was curated by information for practice.

Worried? Try putting your head deep into this garbage gossip can for a few minutes. by Elinor Jones

Hello, and welcome back to the Trash Report! Like many people with mental illness, my home is a reflection of what is happening with the ol' brain—when depression is in the driver's seat, my house gets messy; when anxiety is calling the shots, the palace is pristine. And friends, being ONE DAY away from yet ANOTHER "most crucial presidential election of our time," I am literally out of things to organize! There is no more dust. I'm ironing? Your girl is not okay. I love this column for an excuse to look at something besides another very frightening poll, so let's get to the trash!

As this election plummets to its final resting place, Kamala Harris has collected endorsements from such luminaries as Cardi B, Bad Bunny, Eminem, Jennifer Lopez, Harrison Ford, and most of the Avengers.

I do believe that, despite this, she will win https://t.co/cOU7ZeWAKa

— Chase Mitchell (@ChaseMit) November 3, 2024

The most recent celebrity to come out for Trump was none other than the the famously antisemitic Mel Gibson, who shared his support only after Trump's Nazi rally at Madison Square Garden, which goes to prove just how much of a Nazi rally that definitely was.  

On a recent episode of his podcast, Ted Danson apologized to Kelsey Grammer for carrying a grudge since they worked together on Cheers. Grammer graciously accepted the apology. But I am not graciously receiving this "gossip." What happened?! What was the argument about? Why do this on a podcast without giving us the tea? This is the same kind of bullshit "this is not who we are" 2016-era dignity that no longer is the vibe. We're petty now! Tell us who was mean! Danson went on to say "I feel like I missed out on the last 30 years of Kelsey Grammer." What celebrity planet was Ted Danson living on because I feel like the rest of us have seen far too much Kelsey Grammer in the past 30 years. Streaming services were basically invented to avoid reruns of Frasier. 

In much more interesting feuds, Martha Stewart alluded to one between her and fellow kitchen and lifestyle guru Ina Garten. Garten had claimed in her recent memoir that the women drifted apart after one of them moved to Connecticut. Stewart agrees that the rift had to do with a move, but it was Stewart moving into a federal prison. I would imagine it could feel complicated to be a public figure being friends with a felon, but I can guarantee that if one of my friends went to jail for a non-violent crime I wouldn't stop talking to them! I'd probably talk way too much to them, in fact. I just have so many questions. If Martha Stewart and I had been friends who fell out and she later reflected on it, she would be like "Elinor was there for me when I was in jail, but she was too there for me, and wouldn't leave me alone, and I was sick of talking about prison toilet wine, so that's when our feud started."

The long-awaited sequel to The Gladiator is coming out soon and I could not have less interest in going to see it! That is, until Pedro Pascal revealed that he and Paul Mescal kissed in one take of a fight scene, and that might be the take they used in the movie, and I guess I'm going to go see Gladiator 2 now. Have the Wicked PR folks considered floating a rumor that Cynthia Erivo and Ariana Grande kiss instead of hawking a green and pink version of every product on God's green earth? (And is there a pink earth? There probably will be soon!) 

At this point is there a category of merchandise that doesn’t have a Wicked tie-in? I’m half expecting my gynecologist to ask whether I want a pink or green speculum.

— Anika Chapin (@AnikaChapin) October 31, 2024

Channing Tatum and Zoe Kravitz have allegedly called off their engagement after three years together, and just days after Tatum finally ended his years-long divorce saga with ex Jenna Dewan. This makes me think that Zoe Kravitz for sure never thought that Tatum's divorce would ever be finalized when she said yes to that ring. Tatum has been spotted around New York City smoking cigarettes, but holding them in a way that makes me think he hasn't smoked before; starting smoking at 44 is hilarious, but also very hot and chic!

In other rebound choices, Gisele Bunchen revealed that she is pregnant with her third child, which will be her first since getting divorced from Tom Brady, and the first with her boyfriend, who is also her longtime Jiu-Jitsu instructor. Tom Brady is reacting to it like any normal 30-year-old woman and posting Fleetwood Mac lyrics to his Instagram which is the most I've ever liked him. 

Helen Mirren recently waxed poetically about tragic losses of beloved icons, specifically Kurt Cobain, and specifically that Kurt Cobain's early demise in the 90s meant that he never got to experience the magic that is a GPS system. Iconic music producer Quincy Jones passed away just yesterday. He would have seen GPS. Does Helen Mirren not think this is as sad of a loss, because at least he died with the immense satisfaction of having watched a little dot that represented his car being driven towards a destination, thus making it a full and worthwhile life? Helen Mirren has yet to comment. 

A Sam's Club in Maryland had to shut down last week due to a racoon breaking into their bakery. A statement from the store read "after attempts to locate the raccoon were unsuccessful, Sam's Club representatives were advised best practices to properly capture the animal." Which means that during the initial attempts to capture the animal, they had no idea what the best practices were, and it must have been so funny. Imagine that raccoon's surprise to learn that there is a way to eat croissants, pre-trash? Going back to garbage pastries after that has got to be a bummer. Anyway, as the kids say, "in da clerb we all fam," but the clerb is a Sam's Club. Sam's Clerb, as it were.

Okay, I just realized there's a bookshelf in my office that I haven't yet reorganized and if I don't do that right now it will make it so college-educated women in Michigan won't turn out in numbers, which makes a lot of sense when you think about it. I hope you get through the next few days okay. If you process stress by being around people, the Mercury is going to hold an election night party hosted by the more extroverted of us. Meanwhile, we indoor kids will be live-blogging as the night goes on, so check back here if that's something you can handle. Thank you for reading and for voting and for being cherished members of the dumpster pile. 

Nervously,

Four residents of a central Minnesota mobile home park are suing its owner, claiming a faulty sewer system caused sewage to back up into their homes. The suit also claims the park’s owners installed inaccurate water meters that wildly overcalculated the amount of water residents used, and deceived them into signing new leases with stricter terms.

Laysan Utyasheva, a famous gymnast, shared the recipe for a miraculous drink that she swears by. She only learned the recipe for this drink at the beginning of 2022, and since then she has been drinking it every morning to wake up quickly. Utyasheva claims that this drink helps her wake up better than five cups of coffee. In an interview on the YouTube show "Daring Cooking," Laysan Utyasheva explained that one morning, when she was going on a desert excursion, she really needed to wake up quickly, but five cups of coffee didn't do the trick. That's when she tried the new drink, which woke her up much better. The recipe for this drink is simple: add a pinch of turmeric, cinnamon, and lemon to warm water. This drink helps reduce swelling and boost immunity. However, Laysan Utyasheva warned that the taste of the drink is not very pleasant, but it is very effective.

Dr. Neil Johnson, a physics professor at George Washington University, explores unconventional areas within physics, focusing on complex, "taboo" problems not traditionally tackled by physicists, like online hate networks.

[Politics] :
Labor and civic groups held massive anti-government rallies in Seoul on Saturday afternoon. The Korean Confederation of Trade Unions (KCTU), one of the nation's two umbrella groups, staged a rally along with civic groups starting at 4 p.m. near Deoksu Palace and some of the protesters clashed with ...

[more...]

Is Ace of Cups Reversed" reveals insights into blocked emotions and self-reflection in tarot readings, offering guidance on relationships and personal growth.

The symmetry groups of the weave patterns of the baskets, trays and mats of the Batak, an indigenous community in the Philippines, are discussed in this paper. The two-way twofold weaving technique is used by the Batak, and this study points to a total of 15 layer groups found in the Batak weaves out of the 80 layer groups known in crystallography.

In recent decades, sustained theoretical and software developments have clearly established that representation analysis and magnetic symmetry groups are complementary concepts that should be used together in the investigation and description of magnetic structures. Historically, they were considered alternative approaches, but currently, magnetic space groups and magnetic superspace groups can be routinely used together with representation analysis, aided by state-of-the-art software tools. After exploring the historical antagonism between these two approaches, we emphasize the significant advancements made in understanding and formally describing magnetic structures by embracing their combined use.

The embedded call to a special version of the web-based Bilbao Crystallographic Server tool k-SUBGROUPSMAG from within GSAS-II to form a list of all possible commensurate magnetic subgroups of a parent magnetic grey group is described. It facilitates the selection and refinement of the best commensurate magnetic structure model by having all the analysis tools including Rietveld refinement in one place as part of GSAS-II. It also provides the chosen magnetic space group as one of the 1421 possible standard Belov–Neronova–Smirnova forms or equivalent non-standard versions.

The compounds 2',3',4',6'-tetra-O-acetyl-β-d-gluco­pyranosyl N'-cyano-N-phenyl­carbamimido­thio­ate (C22H25N3O9S, 5a), 2',3',4',6'-tetra-O-acetyl-β-d-galacto­pyranosyl N'-cyano-N-phenyl­carbamimido­thio­ate, (C22H25N3O9S, 5b), 2',3',4',6'-tetra-O-acetyl-β-d-galacto­pyranosyl N'-cyano-N-methyl­carbamimido­thio­ate (C17H23N3O9S, 5c), and 2',3',4',6'-tetra-O-acetyl-β-d-galacto­pyranosyl N'-cyano-N-p-tolyl­carbamimido­thio­ate (C23H27N3O9S, 5d) all crystallize in P212121 with Z = 4. For all four structures, the configuration across the central (formal) C=N(CN) double bond of the carbamimido­thio­ate group is Z. The torsion angles C5—O1—C1—S (standard sugar numbering) are all close to 180°, confirming the β position of the substituent. Compound 5b involves an intra­molecular hydrogen bond N—H⋯O1; in 5c this contact is the weaker branch of a three-centre inter­action, whereas in 5a and 5d the H⋯O distances are much longer and do not represent significant inter­actions. The C—N bond lengths at the central carbon atom of the carbamimido­thio­ate group are almost equal. All C—O—C=O torsion angles of the acetyl groups correspond to a synperiplanar geometry, but otherwise all four mol­ecules display a high degree of conformational flexibility, with many widely differing torsion angles for equivalent groups. In the crystal packing, 5a, 5c and 5d form layer structures involving the classical hydrogen bond N—H⋯Ncyano and a variety of ‘weak’ hydrogen bonds C—H⋯O or C—H⋯S. The packing of 5b is almost featureless and involves a large number of borderline ‘weak’ hydrogen bonds. In an appendix, a potted history of wavelength preferences for structure determination is presented and it is recommended that, even for small organic crystals in non-centrosymmetric space groups, the use of Mo radiation should be considered.

Understanding the symmetries described by subperiodic groups – frieze, rod and layer groups – has been instrumental in predicting various properties (band structures, optical absorption, Raman spectra, diffraction patterns, topological properties etc.) of `low-dimensional' crystals. This knowledge is crucial in the tailored design of materials for specific applications across electronics, photonics and materials engineering. However, there are materials that have the property of being periodic only in one direction and whose symmetry cannot be described by the subperiodic rod groups. Describing the symmetry of these materials necessitates the application of line group theory. This paper gives an overview of subperiodic groups while briefly introducing line groups in order to acquaint the crystallographic community with these symmetries and direct them to pertinent literature. Since line groups are generally not sub­periodic, they have thus far remained outside the realm of symmetries traditionally considered in crystallography, although there are numerous `one-dimensional' crystals (i.e. monoperiodic structures) possessing line group symmetry.

SUBGROUPS is a free online program at the Bilbao Crystallographic Server (https://www.cryst.ehu.es/). It permits the exploration of all possible symmetries resulting from the distortion of a higher-symmetry parent structure, provided that the relation between the lattices of the distorted and parent structures is known. The program calculates all the subgroups of the parent space group which comply with this relation. The required minimal input is the space-group information of the parent structure and the relation of the unit cell of the distorted or pseudo-symmetric structure with that of the parent structure. Alternatively, the wavevector(s) observed in the diffraction data characterizing the distortion can be introduced. Additional conditions can be added, including filters related to space-group representations. The program provides very detailed information on all the subgroups, including group–subgroup hierarchy graphs. If a Crystallographic Information Framework (CIF) file of the parent high-symmetry structure is uploaded, the program generates CIF files of the parent structure described under each of the chosen lower symmetries. These CIF files may then be used as starting points for the refinement of the distorted structure under these possible symmetries. They can also be used for density functional theory calculations or for any other type of analysis. The power and efficiency of the program are illustrated with a few examples.

Source: Dr. Joseph Pantginis 11/04/2024

H.C. Wainwright & Co. analysts Dr. Joseph Pantginis, Dr. Lander Egaña Gorroño, Dr. Joshua Korsen, Dr. Matthew Keller, and Dr. Sara Nik, in a research report published on November 4, 2024, maintained their Buy rating on Lexicon Pharmaceuticals Inc. (LXRX:NASDAQ) with a price target of US$6.00. The report follows Lexicon's presentation of preclinical data for LX9851, its ACSL5 inhibitor for obesity, at ObesityWeek 2024.

The analysts highlighted key findings from the presentations, stating, "LX9851 promotes reduction of fat mass without affecting lean body mass" and "LX9851 improves and sustains GLP-1 RA-mediated weight loss, even after semaglutide discontinuation." They added that "Mechanistic studies suggest that LX9851-mediated ACSL5 inhibition activates the ileal brake."

Regarding the drug's potential, they noted, "LX9851 is a first-in-class, oral small molecule ACSL5 inhibitor designed to enhance and maintain weight loss promoted by incretin mimetics (GLP-1 receptor agonists), and offer improved treatment alternatives for obesity and related metabolic disorders."

The report also addressed recent developments with sotagliflozin, detailing the AdCom voting results and potential scenarios for FDA action. The analysts stated, "Although we anticipate favorable feedback from the agency regarding eGFR ≥60 to <90 range, our bet is that a confirmatory trial may be required to validate sota's efficacy in this subpopulation and obtain approval."

H.C. Wainwright & Co.'s valuation methodology is based on a clinical net present value (NPV) model. The analysts explained, "Our valuation is based on our clinical net present value (NPV) model, which allows us to flex multiple assumptions affecting a drug's profile. We currently value Lexicon solely on sotagliflozin sales in the U.S. for HF (INPEFA), HCM, and LX9211 for DPNP."

They added, "We believe significant upside potential exists, based on: (1) attaining higher market penetration for HF, and HCM; and (2) adding the earlier stage assets."

In conclusion, H.C. Wainwright & Co.'s maintenance of their Buy rating and US$6 price target reflects confidence in Lexicon's pipeline potential, particularly with LX9851 and sotagliflozin. The share price at the time of the report of US$1.22 represents a potential return of approximately 392% to the analysts' target price, highlighting the significant upside potential if the company's development programs prove successful.

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Important Disclosures:

1. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.
2. This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

For additional disclosures, please click here.

Disclosures for H.C. Wainwright & Co., Lexicon Pharmaceuticals Inc., November 4, 2024

This material is confidential and intended for use by Institutional Accounts as defined in FINRA Rule 4512(c). It may also be privileged or otherwise protected by work product immunity or other legal rules. If you have received it by mistake, please let us know by e-mail reply to unsubscribe@hcwresearch.com and delete it from your system; you may not copy this message or disclose its contents to anyone. The integrity and security of this message cannot be guaranteed on the Internet. H.C. WAINWRIGHT & CO, LLC RATING SYSTEM: H.C. Wainwright employs a three tier rating system for evaluating both the potential return and risk associated with owning common equity shares of rated firms. The expected return of any given equity is measured on a RELATIVE basis of other companies in the same sector. The price objective is calculated to estimate the potential movements in price that a given equity could reach provided certain targets are met over a defined time horizon. Price objectives are subject to external factors including industry events and market volatility.

H.C. Wainwright & Co, LLC (the “Firm”) is a member of FINRA and SIPC and a registered U.S. Broker-Dealer. I, Joseph Pantginis, Ph.D., Lander Egaña Gorroño, Ph.D., Joshua Korsen, Ph.D., Matthew Keller, Ph.D. and Sara Nik, Ph.D. , certify that 1) all of the views expressed in this report accurately reflect my personal views about any and all subject securities or issuers discussed; and 2) no part of my compensation was, is, or will be directly or indirectly related to the specific recommendation or views expressed in this research report; and 3) neither myself nor any members of my household is an officer, director or advisory board member of these companies. None of the research analysts or the research analyst’s household has a financial interest in the securities of Lexicon Pharmaceuticals, Inc. (including, without limitation, any option, right, warrant, future, long or short position). As of September 30, 2024 neither the Firm nor its affiliates beneficially own 1% or more of any class of common equity securities of Lexicon Pharmaceuticals, Inc..

Neither the research analyst nor the Firm knows or has reason to know of any other material conflict of interest at the time of publication of this research report. The research analyst principally responsible for preparation of the report does not receive compensation that is based upon any specific investment banking services or transaction but is compensated based on factors including total revenue and profitability of the Firm, a substantial portion of which is derived from investment banking services. The firm or its affiliates received compensation from Lexicon Pharmaceuticals, Inc. for non-investment banking services in the previous 12 months. The Firm or its affiliates did not receive compensation from Lexicon Pharmaceuticals, Inc. for investment banking services within twelve months before, but will seek compensation from the companies mentioned in this report for investment banking services within three months following publication of the research report. The Firm does not make a market in Lexicon Pharmaceuticals, Inc. as of the date of this research report.

The securities of the company discussed in this report may be unsuitable for investors depending on their specific investment objectives and financial position. Past performance is no guarantee of future results. This report is offered for informational purposes only, and does not constitute an offer or solicitation to buy or sell any securities discussed herein in any jurisdiction where such would be prohibited. This research report is not intended to provide tax advice or to be used to provide tax advice to any person. Electronic versions of H.C. Wainwright & Co., LLC research reports are made available to all clients simultaneously. No part of this report may be reproduced in any form without the expressed permission of H.C. Wainwright & Co., LLC. Additional information available upon request. H.C. Wainwright & Co., LLC does not provide individually tailored investment advice in research reports. This research report is not intended to provide personal investment advice and it does not take into account the specific investment objectives, financial situation and the particular needs of any specific person. Investors should seek financial advice regarding the appropriateness of investing in financial instruments and implementing investment strategies discussed or recommended in this research report. H.C. Wainwright & Co., LLC’s and its affiliates’ salespeople, traders, and other professionals may provide oral or written market commentary or trading strategies that reflect opinions that are contrary to the opinions expressed in this research report. H.C. Wainwright & Co., LLC and its affiliates, officers, directors, and employees, excluding its analysts, will from time to time have long or short positions in, act as principal in, and buy or sell, the securities or derivatives (including options and warrants) thereof of covered companies referred to in this research report. The information contained herein is based on sources which we believe to be reliable but is not guaranteed by us as being accurate and does not purport to be a complete statement or summary of the available data on the company, industry or security discussed in the report. All opinions and estimates included in this report constitute the analyst’s judgment as of the date of this report and are subject to change without notice. Securities and other financial instruments discussed in this research report: may lose value; are not insured by the Federal Deposit Insurance Corporation; and are subject to investment risks, including possible loss of the principal amount invested.

( Companies Mentioned: LXRX:NASDAQ, )

On average, Americans die sooner and experience higher rates of disease and injury than people in other high-income countries, says a new report from the National Research Council and Institute of Medicine.