A study involving more than 1,500 found that an earlier return to school benefited children ages 8 to 18, who had less severe symptoms two weeks after their concussion compared with kids who stayed home longer.

Western University researchers are taking a unique global approach to finding an effective treatment for people living with long COVID. Led by Schulich School of Medicine & Dentistry professor Dr. Douglas Fraser, the projects represent the first multi-continental research conducted on long COVID, with study sites in Africa and North and South Americas. The long-term effects of long COVID – including symptoms such as brain fog, fatigue and difficulty breathing – can be debilitating and greatly impact quality of life. At least 65 million people around the world are affected by the condition. 

New research from the Salk Institute is providing hope for people who suffer from PTSD, panic attacks, migraines, and more. "Our body has an alarm system that detects danger from the environment or inside our body," explains Dr. Sung Han, an Associate Professor at the Salk Institute and lead researcher for this project. "Sometimes our bodies generate false alarms... We need to understand (what) molecules send the false signal to the brain so that we can block (it)."

Posttraumatic stress disorder (PTSD) among active-duty service members and veterans impacts not only individuals experiencing PTSD, but also their spouses and families. Left untreated, PTSD is typically chronic and very impairing. However, for individuals experiencing PTSD, one weekend retreat with their partner can support recovery while simultaneously improving their romantic relationships, according to a pilot study led by Steffany Fredman, associate professor of human development and family studies and associate professor of psychology at Penn State.

Two weeks of an intensive diabetes treatment can improve periodontal disease inflammation among patients with type 2 diabetes.

Spatial proteomics identifies JAKi as treatment for a lethal skin disease  Nature.com

NRC and CCAB invest over $1M to advance innovative therapies first discovered at UofTToronto, ON – An innovative collaboration between government, industry, and academia aims to accelerate the development of cancer treatments in Canada. The National Research Council of Canada (NRC) and the Toronto-based Centre for the Commercialization of Antibodies and Biologics (CCAB) have put […]

Toronto, ON –  University of Toronto professor Michael Sefton (ChemE, IBBME) has been presented with a major research award from international diabetes foundation JDRF to advance treatment research for type 1 diabetes (T1D). The funding, valued at approximately $1.1 million ($845,135 USD), supports a three-year study at the University of Toronto’s Institute of Biomaterials & […]

Likely due to high temperatures and uncoordinated treatmentToronto, ON – High ocean temperatures and poor timing of parasite management likely led to an epidemic of sea lice in 2015 throughout salmon farms in British Columbia’s Queen Charlotte Strait, a University of Toronto-led study has found. The sea lice spread to migrating juvenile wild salmon, resulting in […]

Other findings: Non-perpetrators in the home act as a buffer and “youngest old” experience most severe forms of abuseToronto, ON – A new study examining elder abuse–released today by researchers at the University of Toronto, Cornell University, and Weill-Cornell Medical College–has found that older adult victims living alone with their abuser were up to four times more likely to endure more […]

One-year study conducted on Atlanta commercial high rise’s HVAC systems proves UVC lamps reap energy efficiency payback benefits.

The city of Phoenix sought an energy-efficient HVAC solution that would restore Phoenix Art Museum’s lost efficiency and improve the indoor climate for the museum’s specialized environment while also contributing to the city’s energy conservation goals.

Lab testing and evaluation of wastewater among services now offered by online shop.

New lawsuits claim that the U.S. Defense Department and the Department of Veteran Affairs are making it difficult and sometimes impossible for veterans to get infertility treatments. Multiple lawsuits were filed Wednesday in federal courts in New York and Boston seeking to hold the United States accountable for creating obstacles to health care access for a population that advocates say has a higher rate of infertility than the population at large. The lawsuits seek to obtain in vitro fertilization coverage for military service members and veterans who don't fit the Veterans Affairs definition of infertility as pertaining solely to married, heterosexual couples.

The post Veterans sue US Defense and Veterans Affairs departments to get access to infertility treatments first appeared on Federal News Network.

Computer games help children overcome pain from cancer treatment

Researchers found that topical treatment products containing benzoyl peroxide can degrade into the carcinogen benzene if improperly transported or stored.

A growing body of evidence points to MDMA’s therapeutic potential for managing an array of hard-to-treat conditions like PTSD and depression.

When it comes to mental illness, we’ve come a long way since the days of superstition and sorcery. But we still have work to do.

Location: Engineering Library- TD442.5.H36 2016

Location: Engineering Library- TD442.5.M4586 2016

Location: Engineering Library- TD442.5.M4674 2016

Treatment of Christians around the world

For parents considering autism interventions for their children, evaluating treatments can be daunting. Experts talked to The Times about what to watch for.

Few drugs are available to treat heavy metals that enter the body, either from lead poisoning or nuclear fallout. A UC Berkeley startup hopes to change that.

Zymo Research, Unravel Biosciences, and Channel Islands Marine & Wildlife Institute team up to combat increasing cases of domoic acid poisoning in sea lions.

In the early morning of June 10, 2015, Dennis Platz woke up to go open the gate to his Colbert property and let in his neighbor, Dan Carver, who planned to borrow a field sprayer…

A Good Hope consultant has won international recognition for leading a new treatment study

Most Canadians are secure knowing that they benefit from universal health care. All you have to do is walk into a clinic or hospital and you will be treated. For an estimated 500,000 people who live and work among us, it’s a different reality.

Bermuda Hospitals Board [BHB] is “partnering with Lahey Hospital & Medical Center, Optimum Wellness and the Bermuda College Division of Nursing & Allied Health to offer a free, public panel discussion about the latest treatment options for male and female incontinence.” A spokesperson said, “The free event will take place from 3pm to 5pm on Saturday […]

The hepatitis E virus protein ORF1 contains a region that scientists have struggled to characterize, making the structure and function of this region the subject of much debate. Now, Princeton scientists show that this region of the protein does not behave as a protease, as has been previously suggested, but instead serves as a molecular scaffold to stabilize the rest of the ORF1 protein.

(Nov. 9, to kick off Veterans Day weekend)  MOBILE, Alabama — On this Veterans Day, Alabama is roiled by a doozy of a veterans-related controversy. Republican Gov. Kay Ivey last month invoked […]

The post Gov. Ivey’s treatment of Bama veterans is a scandal appeared first on Quin Hillyer.

The Ipswich legend and former Scotland manager says he is feeling optimistic after his initial treatment.

Conroy Overdose's 'Life of a Star' birthday bash sizzled recently at Cool Breeze Entertainment Complex in Church Pen, St Catherine. Glamorous ladies and dapper gents gathered for a night of high fashion and revelry. The Sharper Lane venue pulsed...

The increasing consumption of high-fat foods combined with a lack of exercise is a major contributor to the burden of obesity in humans. Aerobic exercise such as running is known to provide metabolic benefits, but how the over-consumption of a high fat diet (HFD) and exercise interact is not well characterized at the molecular level. Here, we examined the plasma proteome in mice for the effects of aerobic exercise as both a treatment and as a preventative regime for animals on either HFD or a healthy control diet. This analysis detected large changes in the plasma proteome induced by the HFD, such as increased abundance of SERPINA7, ALDOB, and down-regulation of SERPINA1E, CFD (adipsin). Some of these changes were significantly reverted using exercise as a preventative measure, but not as a treatment regime. To determine if either the intensity, or duration, of exercise influenced the outcome, we compared high-intensity interval training (HIIT) and endurance running. Endurance running slightly out-performed HIIT exercise, but overall, both provided similar reversion in abundance of plasma proteins modulated by the high-fat diet including SERPINA7, APOE, SERPINA1E, and CFD. Finally, we compared the changes induced by over-consumption of HFD to previous data from mice fed an isocaloric high saturated fat (SFA) or polyunsaturated fat (PUFA) diet. This identified several common changes including increased APOC2 and APOE, but also highlighted changes specific for either over-consumption of HFD (ALDOB, SERPINA7, CFD), SFA-based diets (SERPINA1E), or PUFA-based diets (Haptoglobin - Hp). Together, these data highlight the importance of early intervention with exercise to revert HFD-induced phenotypes and suggest some of the molecular mechanisms leading to the changes in the plasma proteome generated by high fat diet consumption. Web-based interactive visualizations are provided for this dataset (larancelab.com/hfd-exercise), which give insight into diet and exercise phenotypic interactions on the plasma proteome.

Our objective is to explore quantitative imaging markers for early prediction of treatment response in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) undergoing [¹⁷⁷Lu]Lu-DOTATATE therapy. By doing so, we aim to enable timely switching to more effective therapies in order to prevent time-resource waste and minimize toxicities. Methods: Patients diagnosed with unresectable or metastatic, progressive, well-differentiated, receptor-positive GEP-NETs who received 4 sessions of [¹⁷⁷Lu]Lu-DOTATATE were retrospectively selected. Using SPECT/CT images taken at the end of treatment sessions, we counted all visible tumors and measured their largest diameters to calculate the tumor burden score (TBS). Up to 4 target lesions were selected and semiautomatically segmented. Target lesion peak counts and spleen peak counts were measured, and normalized peak counts were calculated. Changes in TBS (TBS) and changes in normalized peak count (nPC) throughout treatment sessions in relation to the first treatment session were calculated. Treatment responses were evaluated using third-month CT and were binarized as progressive disease (PD) or non-PD. Results: Twenty-seven patients were included (7 PD, 20 non-PD). Significant differences were observed in TBS_second-first, TBS_third-first, and TBS_fourth-first (where second-first, third-first, and fourth-first denote scan number between the second and first, third and first, and fourth and first [¹⁷⁷Lu]Lu-DOTATATE treatment cycles), respectively) between the PD and non-PD groups (median, 0.043 vs. –0.049, 0.08 vs. –0.116, and 0.109 vs. –0.123 [P = 0.023, P = 0.002, and P < 0.001], respectively). nPC_second-first showed significant group differences (mean, –0.107 vs. –0.282; P = 0.033); nPC_third-first and nPC_fourth-first did not reach statistical significance (mean, –0.122 vs. –0.312 and –0.183 vs. –0.405 [P = 0.117 and 0.067], respectively). At the optimal threshold, TBS_fourth-first exhibited an area under the curve (AUC) of 0.957, achieving 100% sensitivity and 80% specificity. TBS_second-first and TBS_third-first reached AUCs of 0.793 and 0.893, sensitivities of 71.4%, and specificities of 85% and 95%, respectively. nPC_second-first, nPC_third-first, and nPC_fourth-first showed AUCs of 0.764, 0.693, and 0.679; sensitivities of 71.4%, 71.4%, and 100%; and specificities of 75%, 70%, and 35%, respectively. Conclusion: TBS and nPC can predict [¹⁷⁷Lu]Lu-DOTATATE response by the second treatment session.

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota–gut–brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.

Scientists converted the patient’s own cells into blood sugar-regulating cell clusters before injecting them back into her abdomen—and one year later, she still doesn't need insulin injections

Across Canada, there’s a growing number of political leaders proposing to force people into treatment for drug addiction, despite inconclusive evidence about its effectiveness.

Active-duty service members and veterans experiencing PTSD have additional opportunities for treatment to support them, along with their partners, after the Department of Defense awarded a $3 million grant to Steffany Fredman, associate professor of human development and family studies, and colleagues in the STRONG STAR Consortium.

Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.

Discovery Health Medical Scheme's (DHMS) 2023 cancer claims payouts were almost 19% higher than the previous year though the scheme says screening rates in South Africa have mostly returned to pre-pandemic levels.

DOVER – Revenue from a new opioid impact fee created by the Delaware General Assembly in 2019 will be used to prevent overdose deaths and provide new services to those seeking treatment for their substance use disorder, the Delaware Department of Health and Social Services (DHSS) and Sen. Stephanie Hansen announced Wednesday. DHSS Secretary Molly […]

DOVER, Del. (March 17, 2023) -  The Delaware Division of Public Health (DPH) saw a decrease in case rates and hospitalizations from COVID-19 over the past month and urges residents to remain vigilant and use the tools proven successful in the fight against the virus to continue these trends. While rates are down from the […]

Man accused of stealing car and taking money from a shrine placed under two-year treatment order by a court