The present disclosure provides an auxiliary communication method and system, a device having base station function and a terminal. The auxiliary communication method includes: determining whether it is needed to provide auxiliary communication for any terminal according to channel quality of communication channels with the any terminal and data transmission requirement of the any terminal; selecting a specified terminal which is connected to the device having the base station function as an auxiliary terminal for assisting communication of the any terminal, when it is determined that it is needed to provide auxiliary communication for the any terminal; communicating with the any terminal through the auxiliary terminal. The present disclosure enables accurately to determine the terminal assisted in communication. Wasting communication sources and blind assistance are avoided. And higher channel quality of the terminal between the terminal and the base station and higher data transmission rate can be ensured.

Provided are a device-to-device (D2D) operation method carried out by a terminal in an RRC connection state in a wireless communication system, and a terminal using the method. The method is characterized by: determining whether a radio resource control (RRC) connection establishment process is problematic; and transmitting a D2D signal using an exception resource, when the RRC connection establishment process is determined to be problematic.

Provided are a device-to-device (D2D) operation method carried out by a terminal in an RRC connection state in a wireless communication system, and a terminal using the method. The method is characterized by: determining whether a communication link with a base station is problematic; and transmitting a D2D signal using an exception resource, when the communication link with the base station is determined to be problematic.

At the time of setting authority, a management apparatus stores a database in which authority information corresponding to authority to physically drive a drive apparatus, which is a tangible object, using a terminal apparatus, and registration identification information corresponding to a subject that is given the authority are associated, and outputs information representing any of the registration identification information; and a permission apparatus receives and stores the information. At the time of exercising the authority, the terminal apparatus outputs information representing identification information, and the permission apparatus receives the information and, when the identification information corresponds to registration identification information comprised in setting information, outputs information representing authority exercise information required to exercise the authority. The terminal apparatus receives the information representing the authority exercise information and outputs a drive signal corresponding to the authority exercise information. By this drive signal, a drive apparatus, which is a tangible object, is physically driven.

A gear cam mounting device in a dual-hinge device for a portable terminal is provided, in which first and second hinge shafts provide first and second parallel hinge axes, respectively, first and second gear cams are fixed around the first and second hinge shafts, in engagement with each other, and first and second locking units penetrate respectively through the first and second gear cams in a direction that is perpendicular to the first and second hinge axes, for locking the first and second gear cams to surround the first and second hinge shafts.

A crimp terminal has a crimp barrel which is crimped onto a core wire of a cable. The crimp barrel has an inner surface in which a plurality of cavities which are independent from one another is formed. Each of the cavities has a predetermined shape in a plane orthogonal to a depth direction thereof before the crimp barrel is crimped onto a core wire. The predetermined shape has at least two straight portions and a concave curved portion connecting the straight portions. The concave curved portion is indented inward of the predetermined shape. A plurality of the concave curved portions which are close to each other and included respectively in the predetermined shapes distinct from each other is arranged on an identical imaginary circle or rounded rectangular.

A terminal attaching/detaching device includes a housing, an engaging member, and a movable member. The engaging member is configured to move in a first direction toward a terminal inserted in the housing to engage with the terminal, and is configured to move from the terminal inserted in the housing in a second direction to disengage from the terminal. The movable member is configured to move in concert with the engaging member in the moving process thereof in the first direction, and is configured to move the engaging member from the terminal inserted in the housing in the second direction, so that the engaging member is disengaged from the terminal.

An electrical connector includes a housing having pockets formed in a receiving end of the housing. A terminal module is inserted into the pockets wherein the terminal modules are constructed from a stitch plate including a plurality of terminals retained therein, A cover having a plurality of spaced apart walls form thereon is arranged on the stitch plate and is moved into engagement with the stitch plate with the walls disposed in the intervening space between adjacent terminals. The connector assembly is pressed onto a circuit board in which a force is applied to the connector housing and is directly transferred to the terminal tails of the terminal modules causing electrical contact between conductive holes of the circuit board and the terminals.

Switchable grounded terminal loads are built into, or otherwise coupled to, connectors on motherboards and control devices. The terminal loads are coupled to the bus termination at the connector when the connector is “stuffed” (connected to a mating connector). The switchable grounded terminal loads replace dummy connectors in preventing empty “unstuffed” connectors from increasing error risks on active channels.

A terminal block for an electronic device, which block can be attached to an electronics housing of the electronic device, includes at least one base strip comprising a plurality of connector sockets; and a plurality of connector modules that can be attached to the connector sockets of the at least one base strip in at least one insertion direction, are held on the connector sockets in an inserted position, and can be released from the connector sockets to be removed from the at least one base strip; and a locking device. The locking device includes: an actuating part that can be moved relative to the at least one base strip in an actuation direction; and a plurality of locking elements that are engaged in a locking manner in mating elements of the connector modules in a locked position.

The present invention board relates to a game system using a portable terminals and a game board therefor. According to the present invention, there is provided a board game system, including: one or more pieces configured to correspond to respective game players; a game board configured to display a path through which the pieces move, and to detect a changed location of each of the pieces on the path; and one or more personal portable terminals each configured to check the changed location of the piece detected by the game board while communicating with the game board, and to output information about operations, which will be performed by each of the game players, or options, which can be selected by each of the game players based on a location of one of the pieces corresponding to each of the game players.

Disclosed is a mobile terminal which comprises a GPS antenna, a back cover and a main board. The GPS antenna comprises a metallic radiation layer and a metallic grounding layer configured on a surface of the back cover, the metallic radiation layer and the metallic grounding layer are separated by insulating materials, the main board is provided with a feed wire and a ground wire; the metallic radiation layer is provided with a feed portion, the feed portion is connected to the feed wire which is on the main board, the feed portion serves as a radiation body of the GPS antenna, the metallic grounding layer is provided with a grounding portion, the grounding portion is connected to the ground wire which is on the main board, the grounding portion is used for grounding the GPS antenna, and the grounding portion is connected to the ground wire of the main board via a plurality of points of contact.

Provided is a torque sensor terminal block structure including an electric motor (1) which outputs driving force for driving a load (8), a strain body (3) interposed on a way of a power transmission system from the electric motor (1) to the load (8), a power detector (4) which outputs a detection signal according to a strain of the strain body (3) as a signal indicating a driving force transmitted from the electric motor (1) to the load (8), and a terminal block (6) which acquires the detection signal of the power detector (4) and transmits the output result to a signal processing circuit section. The terminal block (6) is set parallel to a magnetic flux output from the electric motor (1).

Provided is a torque sensor terminal block structure including an electric motor (1) which outputs driving force for driving a load (8), a strain body (3) interposed on a way of a power transmission system from the electric motor (1) to the load (8), a plurality of power detectors (4) which output a detection signal according to strain of the strain body (3) as a signal indicating the driving force, and a terminal block (6) which acquires the detection signal of the power detectors (4) and transmits the output result to a signal processing circuit section (10). The wirings to the signal processing circuit section (10) are twisted spirally as a single stranded wire, and an opening degree between single wirings when the stranded wire extending from the power detectors (4) to the terminal block (6) is unwound, is set to be same for each of the power detectors (4).

HAMPSHIRE is set to receive a massive £360m boost in a deal that aims to create thousands of jobs and new homes and revitalise the economy.

PLANS for a new £15m ferry terminal in Southampton's flagship Royal Pier development are set to go on display.

THIS is the vision for what a new ferry terminal in Southampton could look like.

RESIDENTS have had their first chance to have their say on major plans for a new ferry terminal on Southampton’s waterfront.

PLANS for a multi-million pound new ferry terminal in Southampton could be given the green light this week.

PLANS for the £450m redevelopment of Southampton's Royal Pier have taken a step forward after plans for a new ferry terminal were approved.

I have a health condition with a high mortality rate, where about one quarter of us die within the first year, and two-thirds of us don't last five years. I'm on Year 4 now and I'm doing okay, and I'm thankful to be receiving excellent care, and I'm generally optimistic that I'll get to stick around for a while.

Ramping up to my diagnosis, I thought my life was over. And that was both utterly untrue and completely true at the same time. You can't really know what it's like until you have the actual diagnosis, and even then it's been a world of surprises. You may or may not be able to do some of the things you would like to do.

For me to deal with it in a healthy way, I kind of had to create a hard line in the sand. I had to take time to grieve the person I'd been before falling ill, take stock of my accomplishments, and most importantly, I had to REALIZE MY ACCOMPLISHMENTS WERE ENOUGH for my lifetime. If I'd been hit by a bus, my life would have been over in a snap, and whatever I'd accomplished by that point would have had to be enough. Taking that pressure off myself was the kindest thing I could do for myself.

I found I had to let a lot of things go and not compare Previous Me to Sick Me. Previous Me was active, enjoyed travel, able to hold down complex and interesting work. Sick Me can't do much of that, but Sick Me does pretty okay for a sick person, and Sick Me does so much more than Dead Me could possibly do! Seriously, compared to Dead Me, Sick Me is a total winner. Sick Me can do a little modest gardening, enough to keep the weeds away. Sick Me can care for my dog and handle the occasional load of laundry. Sick Me finds a lot of joy in my friends and family and internet communities, and has transferred my social life to text, email, and the occasional dining out when the stars align and energy allows. (Metafilter is a lifesaver because I can pick it up whenever my energy level allows and people are so welcoming and understanding.)

As you're waiting for news, it's easy to fall to worry. Please be kind to yourself and don't suffer those fears and losses before you need to. Right now, you are there for your children. Don't put yourself through the punishment of losing them multiple times unnecessarily. And don't say you won't ever get to do a painting class -- I took my first painting class last fall and it was a boon to my soul and it renewed my capacity for beauty.

In the meantime, take as much control of the situation as you need to. Write down a list of questions to review with your doctors. (I've actually typed them out and distributed copies for them to follow along.) You can google, and it's hard not to, but please never tell a doctor that your questions or concerns are coming from google. Also, do not call yourself a hypochondriac -- what you are feeling is what you are feeling, and your concerns are valid and deserving of respect.

Waiting is hard. Please be extra kind to yourself.

The company sent an email inquiry to the Federal Aviation Administration on Thursday about shutting the terminal down, given the minimal passenger traffic amid the ongoing coronavirus pandemic.

This week, a bill proposes to widen eligibility for medical assistance in dying (MAID), including removing the requirement that someone's natural death be "reasonably foreseeable."

Australia's first liquid natural gas import terminal will be built at Port Kembla, south of Sydney, with hopes it will secure thousands of jobs and meet the bulk of the state's gas needs.

UN Secretary General, Antonio Guterres, has issued a dire warning about the state of international cooperation. The long-standing international order, he says, is dividing and that threatens future global stability. So, are his concerns valid? How is the international order likely to change over coming decades? And what practical steps can be taken to reinforce the global rule of law?

Jesper V. Olsen
Jun 1, 2004; 3:608-614
Technology

In Staphylococcus aureus–caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating human prothrombin (ProT) and evading immune clearance. A previous structural comparison of the SC(1–325) fragment bound to thrombin and its inactive precursor prethrombin 2 has indicated that SC activates ProT by inserting its N-terminal dipeptide Ile1-Val2 into the ProT Ile16 pocket, forming a salt bridge with ProT's Asp194, thereby stabilizing the active conformation. We hypothesized that these N-terminal SC residues modulate ProT binding and activation. Here, we generated labeled SC(1–246) as a probe for competitively defining the affinities of N-terminal SC(1–246) variants preselected by modeling. Using ProT(R155Q,R271Q,R284Q) (ProTQQQ), a variant refractory to prothrombinase- or thrombin-mediated cleavage, we observed variant affinities between ∼1 and 650 nm and activation potencies ranging from 1.8-fold that of WT SC(1–246) to complete loss of function. Substrate binding to ProTQQQ caused allosteric tightening of the affinity of most SC(1–246) variants, consistent with zymogen activation through occupation of the specificity pocket. Conservative changes at positions 1 and 2 were well-tolerated, with Val1-Val2, Ile1-Ala2, and Leu1-Val2 variants exhibiting ProTQQQ affinity and activation potency comparable with WT SC(1–246). Weaker binding variants typically had reduced activation rates, although at near-saturating ProTQQQ levels, several variants exhibited limiting rates similar to or higher than that of WT SC(1–246). The Ile16 pocket in ProTQQQ appears to favor nonpolar, nonaromatic residues at SC positions 1 and 2. Our results suggest that SC variants other than WT Ile1-Val2-Thr3 might emerge with similar ProT-activating efficiency.

VOLUME 295 (2020) PAGES 1898–1914Yichen Zhong's name was misspelled. The correct spelling is shown above.

James A. Wilkins
Apr 13, 2020; 0:RA120.001944v1-mcp.RA120.001944
Research

Post-translational modifications play a critical and diverse role in regulating cellular activities. Despite their fundamentally important role in cellular function, there has been no report to date of an effective generalized approach to the targeting, extraction and characterization of the critical c-terminal regions of natively prenylated proteins. Various chemical modification and metabolic labelling strategies in cell culture have been reported. However, their applicability is limited to cell culture systems and does not allow for analysis of tissue samples. The chemical characteristics (hydrophobicity, low abundance, highly basic charge) of many of the c-terminal regions of prenylated proteins have impaired the use of standard proteomic workflows. In this context, we sought a direct approach to the problem in order to examine these proteins in tissue without the use of labelling.  Here we demonstrate that prenylated proteins can be captured on chromatographic resins functionalized with mixed disulfide functions. Protease treatment of resin-bound proteins using chymotryptic digestion revealed peptides from many known prenylated proteins. Exposure of the protease-treated resin to reducing agents and hydro organic mixtures released c-terminal peptides with intact prenyl groups along with other enzymatic modifications expected in this protein family. Database and search parameters were selected to allow for c-terminal modifications unique to these molecules such as CAAX box processing and c-terminal methylation. In summary, we present a direct approach to enrich and obtain information at a molecular level of detail about prenylation of proteins from tissue and cell extracts using high performance LCMS without the need for metabolic labeling and derivatization.

VOLUME 295 (2020) PAGES 1898–1914Yichen Zhong's name was misspelled. The correct spelling is shown above.

In Staphylococcus aureus–caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating human prothrombin (ProT) and evading immune clearance. A previous structural comparison of the SC(1–325) fragment bound to thrombin and its inactive precursor prethrombin 2 has indicated that SC activates ProT by inserting its N-terminal dipeptide Ile1-Val2 into the ProT Ile16 pocket, forming a salt bridge with ProT's Asp194, thereby stabilizing the active conformation. We hypothesized that these N-terminal SC residues modulate ProT binding and activation. Here, we generated labeled SC(1–246) as a probe for competitively defining the affinities of N-terminal SC(1–246) variants preselected by modeling. Using ProT(R155Q,R271Q,R284Q) (ProTQQQ), a variant refractory to prothrombinase- or thrombin-mediated cleavage, we observed variant affinities between ∼1 and 650 nm and activation potencies ranging from 1.8-fold that of WT SC(1–246) to complete loss of function. Substrate binding to ProTQQQ caused allosteric tightening of the affinity of most SC(1–246) variants, consistent with zymogen activation through occupation of the specificity pocket. Conservative changes at positions 1 and 2 were well-tolerated, with Val1-Val2, Ile1-Ala2, and Leu1-Val2 variants exhibiting ProTQQQ affinity and activation potency comparable with WT SC(1–246). Weaker binding variants typically had reduced activation rates, although at near-saturating ProTQQQ levels, several variants exhibited limiting rates similar to or higher than that of WT SC(1–246). The Ile16 pocket in ProTQQQ appears to favor nonpolar, nonaromatic residues at SC positions 1 and 2. Our results suggest that SC variants other than WT Ile1-Val2-Thr3 might emerge with similar ProT-activating efficiency.

The action potential (AP) waveform controls the opening of voltage-gated calcium channels and contributes to the driving force for calcium ion flux that triggers neurotransmission at presynaptic nerve terminals. Although the frog neuromuscular junction (NMJ) has long been a model synapse for the study of neurotransmission, its presynaptic AP waveform has never been directly studied, and thus the AP waveform shape and propagation through this long presynaptic nerve terminal are unknown. Using a fast voltage-sensitive dye, we have imaged the AP waveform from the presynaptic terminal of male and female frog NMJs and shown that the AP is very brief in duration and actively propagated along the entire length of the terminal. Furthermore, based on measured AP waveforms at different regions along the length of the nerve terminal, we show that the terminal is divided into three distinct electrical regions: A beginning region immediately after the last node of Ranvier where the AP is broadest, a middle region with a relatively consistent AP duration, and an end region near the tip of nerve terminal branches where the AP is briefer. We hypothesize that these measured changes in the AP waveform along the length of the motor nerve terminal may explain the proximal-distal gradient in transmitter release previously reported at the frog NMJ.

SIGNIFICANCE STATEMENT The AP waveform plays an essential role in determining the behavior of neurotransmission at the presynaptic terminal. Although the frog NMJ is a model synapse for the study of synaptic transmission, there are many unknowns centered around the shape and propagation of its presynaptic AP waveform. Here, we demonstrate that the presynaptic terminal of the frog NMJ has a very brief AP waveform and that the motor nerve terminal contains three distinct electrical regions. We propose that the changes in the AP waveform as it propagates along the terminal can explain the proximal-distal gradient in transmitter release seen in electrophysiological studies.

When Berlin Brandenburg Airport is put into operation at the end of October 2020, Schönefeld Airport will become Terminal 5 (T5) of BER. In order to avoid duplicate names of terminal sections, gates and car parks at BER, the building and car park infras...

The Dahme-Spreewald administrative district’s local building inspection authority confirmed the completion of the passenger terminal (Terminal 1) at BER following completion of the construction work.

Now we're typing with scan lines!

As of today, the terminal sections of Schönefeld Airport have new designations: K, L, M Departures, M Arrivals and Q.

The Dahme-Spreewald administrative district’s local building inspection authority confirmed the completion of Terminal T1 at BER on 28 April following the completion of the construction work.

ZOC Terminal version 7.25.5 denial of service proof of concept exploit.

ZOC Terminal version 7.25.5 Script denial of service proof of concept exploit.

MCP2221 I2C/SMBus Terminal (v2.0.1)

ABSTRACT

Reversible repression of HIV-1 5' long terminal repeat (5'-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency. Identification of host factors that modulate LTR activity and viral latency may help develop new antiretroviral therapies. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are known to regulate gene expression and possess multiple physiological functions. hnRNP family members have recently been identified as the sensors for viral nucleic acids to induce antiviral responses, highlighting the crucial roles of hnRNPs in regulating viral infection. A member of the hnRNP family, X-linked RNA-binding motif protein (RBMX), has been identified in this study as a novel HIV-1 restriction factor that modulates HIV-1 5'-LTR-driven transcription of viral genome in CD4⁺ T cells. Mechanistically, RBMX binds to HIV-1 proviral DNA at the LTR downstream region and maintains the repressive trimethylation of histone H3 lysine 9 (H3K9me3), leading to a blockage of the recruitment of the positive transcription factor phosphorylated RNA polymerase II (RNA pol II) and consequential impediment of transcription elongation. This RBMX-mediated modulation of HIV-1 transcription maintains viral latency by inhibiting viral reactivation from an integrated proviral DNA. Our findings provide a new understanding of how host factors modulate HIV-1 infection and latency and suggest a potential new target for the development of HIV-1 therapies.

IMPORTANCE HIV-1 latency featuring silence of transcription from HIV-1 proviral DNA represents a major obstacle for HIV-1 eradication. Reversible repression of HIV-1 5'-LTR-mediated transcription represents the main mechanism for HIV-1 to maintain latency. The 5'-LTR-driven HIV gene transcription can be modulated by multiple host factors and mechanisms. The hnRNPs are known to regulate gene expression. A member of the hnRNP family, RBMX, has been identified in this study as a novel HIV-1 restriction factor that modulates HIV-1 5'-LTR-driven transcription of viral genome in CD4⁺ T cells and maintains viral latency. These findings provide a new understanding of how host factors modulate HIV-1 infection and latency and suggest a potential new target for the development of HIV-1 therapies.

Jasmonate-induced protein 60 (JIP60) is a ribosome-inactivating protein (RIP) from barley (Hordeum vulgare) and is involved in the plant immune response dependent on jasmonate hormones. Here, we demonstrate in Nicotiana benthamiana that transient expression of the N-terminal domain of JIP60, from which the inhibitor domain (amino acids 163–185) is removed, initiates cell death, leading to extensive necrosis of leaf tissues. We used structure prediction of JIP60 to identify potential catalytic amino acids in the active site and tested these by mutagenesis and in planta assays of necrosis induction by expression in N. benthamiana, as well as through an in vitro translation-inactivation assay. We found that Tyr 96, Glu 201, Arg 204, and Trp 234 in the presumptive active site of JIP60 are conserved in 815 plant RIPs in the Pfam database that were identified by HUMMR as containing a RIP domain. When these amino acid residues are individually mutated, the necrosis-inducing activity is completely abolished. We therefore propose that the role of these amino acids in JIP60 activity is to depurinate adenosine in ribosomes. This study provides insight into the catalytic mechanism of JIP60.

N-terminal (Nt) acetylation (NTA) is an ample and irreversible cotranslational protein modification catalyzed by ribosome-associated Nt-acetyltransferases. NTA on specific proteins can act as a degradation signal (called an Ac/N-degron) for proteolysis in yeast and mammals. However, in plants, the biological relevance of NTA remains largely unexplored. In this study, we reveal that Arabidopsis (Arabidopsis thaliana) SIGMA FACTOR-BINDING PROTEIN1 (SIB1), a transcription coregulator and a positive regulator of salicylic acid-primed cell death, undergoes an absolute NTA on the initiator Met; Nt-acetyltransferase B (NatB) partly contributes to this modification. While NTA results in destabilization of certain target proteins, our genetic and biochemical analyses revealed that plant NatB-involved NTA instead renders SIB1 more stable. Given that the ubiquitin/proteasome system stimulates SIB1 degradation, it seems that the NTA-conferred stability ensures the timely expression of SIB1-dependent genes, mostly related to immune responses. Taking our findings together, here we report a noncanonical NTA-driven protein stabilization in land plants.

Extreme elongation distinguishes about one-fourth of cotton (Gossypium sp.) seed epidermal cells as "lint" fibers, useful for the textile industry, from "fuzz" fibers (<5 mm). Ligon lintless-2 (Li₂), a dominant mutation that results in no lint fiber but normal fuzz fiber, offers insight into pathways and mechanisms that differentiate spinnable cotton from its progenitors. A genetic map developed using 1,545 F2 plants showed that marker CISP15 was 0.4 cM from Li₂, and "dominant" simple sequence repeat (SSR) markers (i.e. with null alleles in the Li₂ genotype) SSR7 and SSR18 showed complete linkage with Li₂. Nonrandom distribution of markers with null alleles suggests that the Li₂ phenotype results from a 176- to 221-kb deletion of the terminal region of chromosome 18 that may have been masked in prior pooled-sample mapping strategies. The deletion includes 10 genes with putative roles in fiber development. Two Glycosyltransferase Family 1 genes showed striking expression differences during elongation of wild-type versus Li₂ fiber, and virus-induced silencing of these genes in the wild type induced Li₂-like phenotypes. Further, at least 7 of the 10 putative fiber development genes in the deletion region showed higher expression in the wild type than in Li₂ mutants during fiber development stages, suggesting coordinated regulation of processes in cell wall development and cell elongation, consistent with the hypothesis that some fiber-related quantitative trait loci comprise closely spaced groups of functionally diverse but coordinately regulated genes.