Andreas Nord, Arne Hegemann, and Lars P. Folkow

Animals in seasonal environments must prudently manage energy expenditure to survive the winter. This may be achieved through reductions in the allocation of energy for various purposes (e.g. thermoregulation, locomotion, etc.). We studied whether such trade-offs also include suppression of the innate immune response, by subjecting captive male Svalbard ptarmigan (Lagopus muta hyperborea) to bacterial lipopolysaccharide (LPS) during exposure to either mild temperature (0°C) or cold snaps (acute exposure to –20°C), in constant winter darkness when birds were in energy-conserving mode, and in constant daylight in spring. The innate immune response was mostly unaffected by temperature. However, energy expenditure was below baseline when birds were immune challenged in winter, but significantly above baseline in spring. This suggests that the energetic component of the innate immune response was reduced in winter, possibly contributing to energy conservation. Immunological parameters decreased (agglutination, lysis, bacteriostatic capacity) or did not change (haptoglobin/PIT54) after the challenge, and behavioural modifications (anorexia, mass loss) were lengthy (9 days). While we did not study the mechanisms explaining these weak, or slow, responses, it is tempting to speculate they may reflect the consequences of having evolved in an environment where pathogen transmission rate is presumably low for most of the year. This is an important consideration if climate change and increased exploitation of the Arctic would alter pathogen communities at a pace outwith counter-adaption in wildlife.

Addition of sodium bicarbonate (NaHCO₃) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus (MRSA) strains to be highly susceptible to β-lactams. We investigated the prevalence of this phenotype (NaHCO₃ responsiveness) to two β-lactams among 58 clinical MRSA bloodstream isolates. Of note, ~75% and ~36% of isolates displayed the NaHCO₃ responsiveness phenotype to cefazolin (CFZ) and oxacillin (OXA), respectively. Neither intrinsic β-lactam MICs in standard Mueller-Hinton broth (MHB) nor population analysis profiles were predictive of this phenotype. Several genotypic markers (clonal complex 8 [CC8]; agr I and spa t008) were associated with NaHCO₃ responsiveness for OXA.

Clinical benefit of immune checkpoint blockade in glioblastoma (GBM) is rare, and we hypothesize that tumor clonal evolution and the immune microenvironment are key determinants of response. Here, we present a detailed molecular characterization of the intratumoral and immune heterogeneity in an IDH wild-type, MGMT-negative GBM patient who plausibly benefited from anti-PD-1 therapy with an unusually long 25-mo overall survival time. We leveraged multiplex immunohistochemistry, RNA-seq, and whole-exome data from the primary tumor and three resected regions of recurrent disease to survey regional tumor-immune interactions, genomic instability, mutation burden, and expression profiles. We found significant regional heterogeneity in the neoantigenic and immune landscape, with a differential T-cell signature among recurrent sectors, a uniform loss of focal amplifications in EGFR, and a novel subclonal EGFR mutation. Comparisons with recently reported correlates of checkpoint blockade in GBM and with TCGA-GBM revealed appreciable intratumoral heterogeneity that may have contributed to a differential PD-1 blockade response.

The Responsive Home Project Overview

New York: Fathers tend to be more attentive and responsive to the needs of their toddler daughters than of their sons, finds a brain study that shows a toddler's gender influences the brain responses as well as the behaviour of fathers.

The findings showed that fathers of toddler daughters sang more often and spoke more openly about emotions, including sadness, whereas those with toddler sons engaged in more rough-and-tumble play.

"If the child cries out or asks for dad, fathers of daughters responded more than did fathers of sons," said lead researcher Jennifer Mascaro, Assistant Professor at Emory University.

Further, girls' fathers used more analytical language (words like all, below and much) which has been linked to future academic success, while with boys it was more achievement-related language (words such as proud, win and top).

This may be possibly because fathers are more accepting of girls' feelings than boys', the researchers said in the paper published in the journal Behavioral Neuroscience.

In addition, brain scans revealed that fathers of daughters had greater responses to their daughters' happy facial expressions in areas of the brain important for visual processing, reward, emotion regulation, and face processing than fathers of sons.

"The gender-biased paternal behaviour need not imply ill intentions on the part of fathers. These biases may be unconscious, or may actually reflect deliberate and altruistically motivated efforts to shape children's behaviour in line with social expectations of adult gender roles that fathers feel may benefit their children," added James Rilling anthropologist at Emory.

For the study, the team used data from 52 fathers of toddlers (30 girls, 22 boys), who agreed to clip a small handheld computer onto their belts and wear it for one weekday and one weekend day.

A sailor on board the USS Roosevelt - the COVID-19 infected Navy ship which a captain was fired from for sounding the alarm - has been found unresponsive in isolation in Guam after testing positive.

Take advantage of the new element and new features of in your next responsive website.

Thomas, Helene Maree, author

With the closure of school buildings fundamentally disrupting the way students receive services, the COVID-19 pandemic has changed the national conversation about education.

There is increased awareness and urgency within the research community to ensure that evaluation and assessment practices are sensitive to the cultures of people who are most impacted by those practices. Driven by changing demographics and the increasing complexity of problems that researchers and communities seek to address, new efforts are underway to develop research practices that better account for the unique perspectives and needs of the communities being studied. But there is hardly consensus on what culturally responsive research actually means or, more broadly, what implications such approaches could have on evidence-based policies and programs.

This webinar defined educational inequity and discussed its implications. It included a brief introduction to culturally responsive pedagogy and what broader systemic changes may be necessary to implement equity and culturally responsive pedagogy.

This webinar explored research on culturally responsive pedagogy and what is known about its effectiveness.

This webinar explored how a school and district have approached the challenge of implementing culturally responsive practice. It elaborated on programs, policies, and practices that were implemented to support efforts to achieve equity and use culturally responsive pedagogy.

This webinar explored how best to prepare educators to implement culturally responsive pedagogy, including and exploration of how programs train future teachers and school administrators and what changes programs may need to consider to effectively prepare these educators.

Pamental, Jason, author

Join the Regional Educational Laboratory Mid-Atlantic and stakeholders from the New Jersey and Delaware Departments of Education for a free four-part series on culturally responsive practices as a strategy for improving education outcomes.

Online Resource

Barker, Tom, 1977- author

Download the slides and view the demos for my presentation on practical flexbox progressive enhancement for RWD, "Enhancing Responsiveness with Flexbox" for the RWD Summit, as well as get links to related articles, tutorials, and tools on Flexible Box Layout.

You've been hard at work optimizing your site. You've already done things like lazy-loading Google Maps and been wondering if there was anything else you could do. For example, is there anything we can do to improve the loading of ads? Good news, there is some things you can do. You can respect user's mobile data plan by loading ads only when they are likely to appear in the viewport zone. You can also serve ads in the right size in accordance to the screen of the device. That would be nice of you. That would not only be responsive but also responsible.

I've written an article on that and got it published on CSS-Tricks.

Read the article

Try the Demo

You can also examine the demo on CodePen and contribute, follow the project on GitHub.

Hayden Library - T174.7.E965 2015

For this episode of On the Evidence, a principal and an education researcher share insights from research and the field on implementing culturally responsive practices.