Business enterprises -- Computer networks -- Management.

Leipzig : F.C.W. Vogel, 1889.

Bonn : M. Cohen, 1869.

Berlin : A. Hirschwald, 1896.

Leipzig : G. Thieme, 1892.

Leipzig : W. Engelmann, 1868.

Amsterdam : J. Muller, 1895.

Stuttgart : F. Enke, 1895.

Leipzig : S. Hirzel, 1899.

London : H.K. Lewis, 1883.

[Paris] : Calcographie du Louvre, Musées Imperiaux, [1849?]

An idea that began when a classicist went to a brewery to sip beers and ponder the history of hops has brought to life an ancient ale.

The post Steampunk 1577 Changes Lives with Electric Wheelchair Kit Designed in SOLIDWORKS appeared first on SOLIDWORKS Education Blog.

Prenatal and postnatal organophosphate (cholinesterase inhibitor) pesticide exposure has been associated with delays in attention, memory, intelligence, and inhibitory control. Two recent studies reported decreased attention and working memory with greater exposure to organophosphates in boys but not in girls.

This is the first study to report associations between decreased acetylcholinesterase activity, a stable marker of cholinesterase inhibitor pesticide exposure, and lower overall neurodevelopment, attention, inhibitory control, and memory. These associations were present in boys but not in girls. (Read the full article)

Mailchimp is still leading the email marketing category, but it now adds CRM features and a website builder to help small to midsize businesses carry out marketing campaigns.

CNA Staff, Mar 30, 2020 / 02:30 pm (CNA).- The Church of the Holy Sepulchre was closed last week and has no definite timeline for reopening. This is the first time in nearly 700 years the holy site has closed for an extended period due to disease. 

The church building, which houses the tomb of Christ and the site of the crucifixion, was first closed to pilgrims and other visitors on Wednesday, March 25. Initially, the closure was only expected to last for one week, but religious and Israeli government officials agreed that due to the ongoing COVID-19 pandemic, the global pilgrimage destination should not reopen. 

"The initial understanding is that this order is valid for one week, although nobody knows how long this crisis will take," Wadie Abu Nassar, a spokesperson for the Assembly of Catholic Ordinaries of the Holy Land, told Reuters. 

Nassar said that if the church is still closed to the public at Easter, some sort of celebration will be arranged in line with the governmental guidelines and restrictions. Easter is celebrated on April 12 for Latin Rite Catholics and April 19 for Eastern Churches using the Julian calendar-- both dates are observed within the Church of the Holy Sepulchre. 

If this were to happen, said Nassar, pilgrims would still not be allowed inside, and the denominations that share custody of the church would coordinate to ensure that there are no more than 10 clerics and other leaders gathered inside at any time.

The Church of the Holy Sepulchre is unique among religious sites as it is partially controlled by several different Christian Churches. The Roman Catholic Church, Greek Orthodox Church, and Armenian Apostolic Church each share control of the building, and other Orthodox Churches also celebrate divine liturgy at the site. 

The last time the Church of the Holy Sepulchre was closed for an extended period was 1349, during an outbreak of the Black Death in Jerusalem. 

The church, which was first consecrated in the year 335, has been closed for short periods of time in the subsequent millennia due to war or other disputes. In 2018, to protest a proposed tax increase on churches, the site was closed to the public for about three days before reopening. 

Other religious sites, including the Western Wall and the Dome of the Rock, have also closed due to the Israeli government’s new restrictions aimed at preventing people from catching COVID-19. 

Authorities in Bethlehem, in the West Bank, closed the Church of the Nativity in early March after four cases of COVID-19 were diagnosed in the town. The Church of the Nativity was built over the birthplace of Jesus Christ. All tourists were subsequently banned from entering Bethlehem.

Israel has taken a proactive approach in its attempts to contain the spread of COVID-19. On March 9, Prime Minister Benjamin Netanyahu announced that anyone entering the country would be forced to quarantine for a 14-day period. That announcement resulted in the cancelation or abrupt end to many pilgrimages, as travelers scrambled to secure flights back to the United States. 

Israel has recorded more than 4,000 cases of COVID-19, with 15 deaths.

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As we celebrate the International Wheelchair Day this coming Sunday on March 1st, we are sharing the results of a report into the 'Most Wheelchair-Friendly Cities in Europe'. Prague ranked at spot #15 and was found to be more accessible than larger cities like Paris or London.

read more

Kei Jokura, Junko M. Nishino, Michio Ogasawara, and Atsuo Nishino

Ciliary movement is a fundamental process to support animal life, and the movement pattern may be altered in response to external stimuli under the control of nervous systems. Juvenile and adult ascidians have ciliary arrays around their pharyngeal gill slits (stigmata), and continuous beating is interrupted for seconds by mechanical stimuli on other parts of the body. Although it has been suggested that neural transmission to evoke ciliary arrest is cholinergic, its molecular basis has not yet been elucidated in detail. We herein attempted to clarify the molecular mechanisms underlying this neurociliary transmission in the model ascidian Ciona. Acetylcholinesterase histochemical staining showed strong signals on the laterodistal ciliated cells of stigmata, hereafter referred to as trapezial cells. The direct administration of acetylcholine (ACh) and other agonists of nicotinic ACh receptors (nAChRs) onto ciliated cells reliably evoked ciliary arrest that persisted for seconds in a dose-dependent manner. Only one isoform among all nAChR subunits encoded in the Ciona genome, called nAChR-A7/8-1, a relative of vertebrate α7 nAChRs, was expressed by trapezial cells. Exogenously expressed nAChR-A7/8-1 on Xenopus oocytes responded to ACh and other agonists with consistent pharmacological traits to those observed in vivo. Further efforts to examine signaling downstream of this receptor revealed that an inhibitor of phospholipase C (PLC) hampered ACh-induced ciliary arrest. We herein propose that homomeric α7-related nAChR-A7/8-1 mediates neurociliary transmission in Ciona stigmata to elicit persistent ciliary arrest by recruiting intracellular Ca²⁺ signaling.

VOLUME 295 (2020) PAGES 4079–4092There was an error in the abstract. “The pyridinium cation hampers uptake of OPs into the central nervous system (CNS)” should read as “The pyridinium cation hampers uptake into the central nervous system (CNS).”

Treatments for cognitive deficits associated with central nervous system (CNS) disorders such as Alzheimer disease and schizophrenia remain significant unmet medical needs that incur substantial pressure on the health care system. The α7 nicotinic acetylcholine receptor (nAChR) has garnered substantial attention as a target for cognitive deficits based on receptor localization, robust preclinical effects, genetics implicating its involvement in cognitive disorders, and encouraging, albeit mixed, clinical data with α7 nAChR orthosteric agonists. Importantly, previous orthosteric agonists at this receptor suffered from off-target activity, receptor desensitization, and an inverted U-shaped dose-effect curve in preclinical assays that limit their clinical utility. To overcome the challenges with orthosteric agonists, we have identified a novel selective α7 positive allosteric modulator (PAM), BNC375. This compound is selective over related receptors and potentiates acetylcholine-evoked α7 currents with only marginal effect on the receptor desensitization kinetics. In addition, BNC375 enhances long-term potentiation of electrically evoked synaptic responses in rat hippocampal slices and in vivo. Systemic administration of BNC375 reverses scopolamine-induced cognitive deficits in rat novel object recognition and rhesus monkey object retrieval detour (ORD) task over a wide range of exposures, showing no evidence of an inverted U-shaped dose-effect curve. The compound also improves performance in the ORD task in aged African green monkeys. Moreover, ex vivo ¹³C-NMR analysis indicates that BNC375 treatment can enhance neurotransmitter release in rat medial prefrontal cortex. These findings suggest that α7 nAChR PAMs have multiple advantages over orthosteric α7 nAChR agonists for the treatment of cognitive dysfunction associated with CNS diseases.

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of ¹⁸F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.

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Pamela H. Smith finds scientific inspiration in manuscripts and other artifacts. “So much exploration, experimentation, and innovation happens in craft."

Two different groups of researchers have shown that electrical stimulation of the spinal cord, combined with months of intense training, can allow some people who have been paralyzed to regain some walking ability.

A Chicago police officer pleaded guilty today to violating the federal civil rights of a man whom the officer struck repeatedly with a dangerous weapon while the man was handcuffed and shackled in a wheelchair.

An indictment was filed today charging seven individuals -- three former shareholders of the Jenkens & Gilchrist law firm (J&G), the former Chief Executive Officer and a former tax partner from the BDO Seidman accounting firm (BDO), and two former bankers from a foreign bank with headquarters in New York (Bank A) -- with tax fraud conspiracy and related crimes arising out of tax shelters promoted by J&G, BDO, and the bank.

William Cozzi, a Chicago police officer, was sentenced today to 40 months in federal prison for violating the federal civil rights of a man whom the officer struck repeatedly with a dangerous weapon while the man was handcuffed and shackled in a wheelchair.

A federal jury in Los Angeles convicted a Fresno woman late Friday after it found that she committed Medicare fraud by recruiting patients for the purpose of receiving unnecessary power wheelchairs.

A federal jury in Houston today convicted Helen Etinfoh, 50, and Paula Whitfield, 43, for their roles in a Medicare fraud conspiracy involving, among other things, fraudulent claims of hurricane damage to power wheelchairs.

Maria Nela Moreno, 57, was also sentenced by U.S. District Judge John F. Walter of the Central District of California to three years of supervised release and was ordered to pay $110,000 in restitution.

Paula Whitfield, a patient recruiter for a Houston durable medical equipment company, was sentenced today to 21 months in prison in connection with a $3 million power wheelchair fraud scheme.

Three individuals pleaded guilty today in connection with a Medicare fraud scheme operated out of a Houston-area durable medical equipment (DME) company.

The owner and operator of a Los Angeles durable medical equipment company was sentenced to 46 months in prison in connection with a power wheelchair scheme to defraud Medicare.

On Monday, after a one-week trial in federal court in Los Angeles, a jury found Donna K. Wells, 52, guilty of one count of health care fraud.

The office manager of a Los Angeles durable medical equipment (DME) company pleaded guilty today to conspiring with her former church pastor to run a power wheelchair scheme that defrauded Medicare of more than $6 million, the Departments of Justice and Health and Human Services (HHS) announced.

Helen Etinfoh, the former owner and operator of a Houston durable medical equipment (DME) company was sentenced today to 41 months in prison in connection with a $3 million power wheelchair fraud scheme.

An Oakland, Calif., woman was sentenced today to 57 months in prison for her role in a scam to bill Medicare for more than $1.2 million in claims for expensive, high-end power wheelchairs and other durable medical equipment (DME) that were not medically necessary.

Paul M. Daugerdas, Donna M. Guerin, Denis M. Field and David Parse were convicted today in Manhattan federal court for their roles in a tax shelter scheme in which they designed, marketed and implemented fraudulent tax shelters used by wealthy individuals to avoid paying taxes to the Internal Revenue Service.

Marion Beverly Metoyer, a patient recruiter for a Houston durable medical equipment (DME) company, was convicted today by a Houston federal jury of health care fraud related to a power wheelchair fraud scheme.

Marion Beverly Metoyer, 57, of Dayton, Texas, was sentenced by U.S. District Judge Gray Miller in the Southern District of Texas. Metoyer was convicted by a jury on May 26, 2011, of one count of conspiracy to commit health care fraud, three counts of health care fraud, one count of conspiracy to defraud the United States and to receive health care kickbacks and two counts of receiving kickbacks.

The Justice Department, at the request of the Food and Drug Administration (FDA), today filed a complaint and a proposed consent decree in the U.S. District Court for the Northern District of Ohio against Invacare Corp., Gerald B. Blouch and Ronald J. Clines.

A Los Angeles-area doctor and a patient recruiter pleaded guilty today for their roles in a power wheelchair fraud scheme that defrauded Medicare of over $10.1 million.

Deputy Assistant Attorney General Ronald A. Cimino for the Tax Division of the Department of Justice and U.S. Attorney Preet Bharara for the Southern District of New York announced that Paul M. Daugerdas, 63, a tax attorney and certified public accountant, was sentenced today in Manhattan federal court to serve 15 years in prison for orchestrating a massive fraudulent tax shelter scheme in which he and his co-conspirators designed, marketed and implemented fraudulent tax shelters used by wealthy individuals to evade over $1.6 billion in taxes owed to the Internal Revenue Service (IRS).

Just what we've been waiting for - an automated home fermentation device that can turn fruit or honey into wine, mead, or cider.

Veterinarians built this sweet mini-wheelchair for a turtle with a shattered shell.

Episode 4 was previously delayed to May 8

While many polling stations were bereft of facilities for the physically challenged and senior citizens, the situation was refreshingly different in Palghar district, where arrangements were made to bring in physically challenged voters and drop them back to their homes.

The voters had a car to take them to the polling stations, where they didn't have to wait in queue to cast their votes, and drop them back home once they were done. This process had begun as a part of the run-up to the polls.

Explaining the same, the district's social development officer Vibha Jadhav said, "We had conducted a survey and made a list of physically challenged voters before the election. Now, we have been calling them to know when they would be able to come to the polling stations to vote."

Election 2019: Prominent personalities, other Mumbaikars come out to caste vote!

The voters had a car to take them to the polling stations, where they didn’t have to wait in queue to cast their votes, and drop them back home once they were done

Virar resident Suresh Pawar, 43, thanked the government for the initiative, "I am visually challenged person, as is my wife. Until last year, we had to take an auto rickshaw to reach the polling booth. But this time, the government has given us relief by arranging vehicles for us.

The polling booths also had representatives stationed to help physically challenged voters. Jidnyasa Polekar, from the National Service Scheme, who was one of the assistants, said, "We kept wheelchairs for physically challenged and senior citizens. We also assisted visually challenged voters to understand the process of voting so that they can cast their ballot sans any hassle."

Bolstering voter turnout

Palghar collector Dr. Prashant Narnaware told mid-day that they had taken a number of initiatives to bolster voters' turnout in the district. "We had carried out campaigns to spread awareness among voters. We reached out to 13 lakh voters during our 25-day campaign titled 'I Shall Vote.' We also involved school students in the initiative by asking them to write letters to their parents, urging them to cast their vote," said Narnavare. On voting day, however, the district was hit with a slight EVM glitch. "There are 2,170 polling booths in Palghar, out of which the EVMs of 50 booths faced glitches. But they were changed within 10 minutes, as all the zonal officials were given additional EVMs to tackle the crisis," said Narnavare.

Salman Khan, SRK, Ranveer Singh, Kangana, Bachchans step out for voting

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