CONTEXT:

Pneumococcal conjugate vaccines (PCVs) (pneumococcal 13-valent conjugate vaccine [PCV-13] and pneumococcal 10-valent conjugate vaccine [PCV-10]) are available for prevention of pneumococcal infections in children.

The Delaware Invasive Species Council (DISC), a non-profit organization dedicated to limiting the introduction and spread of non-native and invasive plant and animal species, has adopted an election year theme for its annual meeting and conference on Oct. 19 at the Delaware Agricultural Museum in Dover (866 N. DuPont Highway, Dover, DE 19901). This year's conference agenda will explore the ways that land and natural resource managers, conservationists, and others that want their voices heard are keeping up with the fight on invasive species by voting them out! Registration opens at 8:30 am and the conference will kick off at 9:00 am. Lunch and an annual membership are included in the registration fee of $40.00.

Title: Progress in Predicting Invasive Breast Cancer
Category: Health News
Created: 4/29/2010 10:21:00 AM
Last Editorial Review: 4/29/2010 10:21:45 AM

Title: Less-Invasive Surgery for Esophageal Cancer Might Be Safer
Category: Health News
Created: 4/30/2012 8:06:00 PM
Last Editorial Review: 5/1/2012 12:00:00 AM

Title: New Earlier, Noninvasive Paternity Test Developed
Category: Health News
Created: 5/3/2012 11:00:00 AM
Last Editorial Review: 5/3/2012 12:00:00 AM

Title: Less Invasive Heart Valve Replacement Works for Elderly: Study
Category: Health News
Created: 5/2/2012 6:05:00 PM
Last Editorial Review: 5/3/2012 12:00:00 AM

ABSTRACT

Recent global advocacy efforts have highlighted the importance of development of a vaccine against group A Streptococcus (GAS). Combo5 is a non-M protein-based vaccine that provides protection against GAS skin infection in mice and reduces the severity of pharyngitis in nonhuman primates. However, Combo5 with the addition of aluminum hydroxide (alum) as an adjuvant failed to protect against invasive GAS infection of mice. Here, we show that formulation of Combo5 with adjuvants containing saponin QS21 significantly improves protective efficacy, even though all 7 adjuvants tested generated high antigen-specific IgG antibody titers, including alum. Detailed characterization of Combo5 formulated with SMQ adjuvant, a squalene-in-water emulsion containing a TLR4 agonist and QS21, showed significant differences from the results obtained with alum in IgG subclasses generated following immunization, with an absence of GAS opsonizing antibodies. SMQ, but not alum, generated strong interleukin-6 (IL-6), gamma interferon (IFN-), and tumor necrosis alpha (TNF-α) responses. This work highlights the importance of adjuvant selection for non-M protein-based GAS vaccines to optimize immune responses and protective efficacy.

IMPORTANCE Availability of a group A Streptococcus vaccine remains an unmet public health need. Here, we tested different adjuvant formulations to improve the protective efficacy of non-M protein vaccine Combo5 in an invasive disease model. We show that novel adjuvants can dramatically shape the type of immune response developed following immunization with Combo5 and significantly improve protection. In addition, protection afforded by Combo5 is not mediated by opsonizing antibodies, believed to be the main correlate of protection against GAS infections. Overall, this report highlights the importance of adjuvant selection in raising protective immune responses against GAS invasive infection. Adjuvants that can provide a more balanced Th1/Th2-type response may be required to optimize protection of GAS vaccines, particularly those based on non-M protein antigens.

An strange, invasive species of jellyfish in Europe eats its own young when food is low, a new study claims.

The impact on human health of an invasive ragweed plant may be "seriously underestimated".

From foxes and falcons to otters and owls, the USDA program is doing away with wildlife in droves.

Scientists find that scary fish robots can quickly stress invasive fish species into reduced reproduction.

Few things make as much sense as eating a harmful species, while sparing the threatened ones.

These organisms are destroying ecosystems across the globe, costing humans billions of dollars in damages.

Bloody red shrimp are invasive, but yummy for some native Great Lakes fish. A first-time find by Canadian researchers.

Non-native species like zebra mussels make national news, but the dangerous plant variable milfoil is rarely discussed outside of lake communities.

Nicknaming plants. Now there's a good job to have. The invasive plant in this tale, called "cheatgrass," is being fought off by a native

Commonly thought to be a byproduct of economic distress, a new report suggest that dollar stores are a cause of it.

Unconventional sushi made out of Japanese knotweed, Asian carp and lionfish are the draw here.

Spectral salivary biomarkers identified using univariate and multivariate analysis may provide a novel robust alternative for monitoring diabetes using

Information gathered from routine visits to the doctor is enough to accurately predict a person's risk of developing Alzheimer's disease and related dementias,

Dr. Simon Ourian, a Beverly Hills-based dermatologist, works with A-list clients including Kim Kardashian West, Khloe Kardashian, and Jenna Dewan.

The app, due to be rolled out next week, will record the Bluetooth connections a phone makes with others to identify someone's contacts if they catch the virus.

The cannibalistic animal in question is a species called Mnemiopsis leidyi, which is also known as the warty comb jelly. It regularly washes up on Baltic shores.

Cham, Switzerland : Springer, 2019.

Cham : Palgrave Macmillan, c2019.

Agricultural scientists from ten states have embarked on a hunt to trace and isolate five harmful "invasive weeds" which made their...

Darmstadt : Steinkopff, [2005]

Interview with Benjamin D. Smith, MD, author of Association Between Treatment With Brachytherapy vs Whole-Breast Irradiation and Subsequent Mastectomy, Complications, and Survival Among Older Women With Invasive Breast Cancer

Interview with Diana W. Bianchi, MD, author of Noninvasive Prenatal Testing and Incidental Detection of Occult Maternal Malignancies

Weber, Ewald, 1960- author

Online Resource

In mice, surgery-free technique inhibits region implicated in memory formation