invasive Florida is measuring its invasive python problem by the ton By www.mnn.com Published On :: Tue, 22 Mar 2016 11:48:14 +0000 In the latest Python Challenge, researchers bagged over 2,000 pounds of the problematic snakes and discovered some of the species' secrets. Full Article Animals
invasive How tiny wasps could save the Christmas Island red crab from invasive crazy ants By www.mnn.com Published On :: Thu, 15 Dec 2016 12:00:15 +0000 Conservationists are hoping for a Christmas (Island) miracle. Full Article Animals
invasive Why invasive plants love climate change By www.mnn.com Published On :: Wed, 03 May 2017 11:06:13 +0000 As climate change affects the world, invasive species are finding new, more hospitable places to call home. Full Article Wilderness & Resources
invasive Invasive plant that can cause blindness pops up in Virginia for first time By www.mnn.com Published On :: Mon, 18 Jun 2018 14:10:31 +0000 Touching a giant hogweed can cause burns and even blindness. Full Article Wilderness & Resources
invasive Samurai wasps could be our secret weapon against invasive stink bugs By www.mnn.com Published On :: Wed, 20 Mar 2019 12:30:57 +0000 While stink bugs ravage our food crops, samurai wasps — another sneaky insect from Japan — are helping us keep them in check. Full Article Animals
invasive This invasive 20-pound rodent could devastate California's agriculture industry By www.mnn.com Published On :: Fri, 27 Sep 2019 12:42:16 +0000 Non-native nutria have made their way to the Golden State, and Californians are rushing to find a solution to this ROUS-sized problem. Full Article Animals
invasive 5 invasive species that may have won the war By www.mnn.com Published On :: Fri, 11 Nov 2016 17:02:57 +0000 Is it time to throw in the towel on the fight against these invasive foes? Here are some non-native species that humans just can't seem to beat. Full Article Wilderness & Resources
invasive Capturing Florida's chameleons, one small invasive reptile at a time By www.mnn.com Published On :: Wed, 26 Jul 2017 19:18:55 +0000 Herpers are people who search for chameleons at night and remove the invasive species from the wild. What happens next, though, is controversial. Full Article Animals
invasive Calospa Rejuvenation Center Offers First-of-its-kind Non-invasive Body Sculpting Treatment, Emsculpt® By www.24-7pressrelease.com Published On :: Sun, 28 Oct 2018 07:00:00 GMT Louisville Medical Spa Offers Revolutionary New Technology Offers Dual Treatment to Address Abdominal Fat and Muscle Tone Full Article
invasive New Patent Provides Non-Invasive Method to Study Gene Expression By www.24-7pressrelease.com Published On :: Tue, 18 Jun 2019 07:00:00 GMT Institute of Noetic Sciences Dr. Garret Yount patents an easy-to-use oral rinse to harvest RNA, DNA's essential partner in gene expression and regulation. Full Article
invasive SCCM Pod-280 Evolution of Non-Invasive Mechanical Ventilation Use in the PICU By sccm-audio.s3.amazonaws.com Published On :: Thu, 11 Jun 2015 10:27:00 -0500 Margaret Parker, MD, MCCM, speaks with Andrea Wolfler, MD Full Article Medicine
invasive Grand Canyon National Park Resource Management Staff to Apply Herbicide to Invasive Plants in Developed Areas of North Rim By www.nps.gov Published On :: Fri, 10 May 2019 06:51:00 EST From Tuesday, May 16 to Wednesday, May 17 the Grand Canyon National Park Division of Science and Resource Management (SRM) will apply minor spot spray treatments of herbicide around the Grand Canyon Lodge and campground in the North Rim Developed Area to aid in the control of an especially invasive grass species for which mechanical removal is ineffective. https://www.nps.gov/grca/learn/news/grca-apply-herbicide-on-nr-2019.htm Full Article
invasive Meeting the challenge: invasive plants in Pacific Northwest ecosystems By www.fs.fed.us Published On :: Thu, 16 Aug 2007 09:00:00 PST During September 19-20, 2006, a conference was held at the University of Washington Botanic Gardens, Seattle, WA, with the title "Meeting the challenge: invasive plants in Pacific Northwest Ecosystems." The mission of the conference was to create strategies and partnerships to understand and manage invasions of non-native plants in the Pacific Northwest. The audience included over 180 professionals, students, and citizens from public and private organizations responsible for monitoring, studying, or managing non-native invasive plants. This proceedings includes twenty-seven papers based on oral presentations at the conference plus a synthesis paper that summarizes workshop themes, discussions, and related information. Topics include early detection and rapid response; control techniques, biology, and impacts; management approaches; distribution and mapping of invasive plants; and partnerships, education, and outreach. Full Article
invasive Invasive plant species and the Joint Fire Science Program By www.fs.fed.us Published On :: Wed, 07 Nov 2007 08:00:00 PST Invasive nonnative plants may be responsible for serious, long-term ecological impacts, including altering fire behavior and fire regimes. Therefore, knowing how to successfully manage invasive plants and their impacts on natural resources is crucial. We present a summary of research on invasive plants and fire that has been generated through the Joint Fire Science Programfocusing specifically on ecology of species invasions, the interactions between fire and invasives, and the responses of invasives to different management practices. Selected findings include (1) prescribed fire may increase invasive species in some ecosystems; (2) fuel treatments that leave some overstory canopy, minimize exposure of bare ground, and target sites that already host species capable of resprouting may be less likely to promote invasives; and (3) postfire seeding should be approached with caution, as it can increase invasives. Full Article
invasive Nonnative invasive plants of Pacific coast forests: a field guide for identification. By www.fs.fed.us Published On :: Thu, 18 May 2011 10:38:00 PST Nonnative plants affect the composition and function of natural and managed ecosystems and have large economic effects through lost or degraded land use and eradication costs. In spite of their importance, very little comprehensive information on the abundance, distribution, and impact of nonnative invasive plants is available. Full Article
invasive Methods and processes for non-invasive assessment of genetic variations By www.freepatentsonline.com Published On :: Tue, 14 Jun 2016 08:00:00 EDT Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations. Full Article
invasive Device for collapsing and loading a heart valve into a minimally invasive delivery system By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A device is provided for collapsing a stented bioprosthetic valve, including first section and second sections, each spanning between first and second ends of the device. The second section of the device is associated with the first section to at least partially enclose an internal cavity formed by the first and second sections, the internal cavity tapering from an open insertion portion at a first end of the device to an open exit portion at a second end of the device. The insertion portion has a larger dimension than the exit portion. When the first section and second section are substantially enclosing the internal cavity, a stented bioprosthetic valve may be inserted into the insertion portion and collapsed as it is moved toward and through the exit portion. The valve may then be loaded on an apparatus for insertion into the body. Full Article
invasive Robotic apparatus for minimally invasive surgery By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A robotic arm especially suited for laparoscopic surgery, having a torsional joint and a flexural joint forming serially arranged joints is described. The joints provide respective degrees of freedom for the arm, which further receives drive means for such joints. The robotic arm also has transmission means placed between the drive means have and the joints. The transmission means a first and a second assembly of three gear wheels, preferably conical gear wheels, and a train of three additional gear wheels, preferably straight-cut gear wheels, which couple the first and second assembly to form a differential mechanism. Full Article
invasive NON-INVASIVE SYSTEMS AND METHODS FOR IDENTIFYING RESPIRATORY DISTURBANCES EXPERIENCED BY A SUBJECT By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT An example method for detecting respiratory disturbances experienced by a subject can include receiving an airflow signal and at least one of an acoustic or vibration signal, where the airflow, acoustic, and/or vibration signals are associated with the subjects breathing. At least one feature can be extracted from the airflow signal and at least one feature can be extracted from at least one of the acoustic or vibration signal. Based on the extracted features, at least one respiratory disturbance can be detected. The respiratory disturbance can be flow limited breath or inspiratory flow limitation (“IFL”). Full Article
invasive Aircraft to spray insecticide for invasive moths in Everett, Woodway By www.seattletimes.com Published On :: Tue, 14 Apr 2020 07:56:52 -0700 The $300,000 effort could take place between now and June depending on weather conditions and the moths' hatching season, officials said. Full Article Agriculture Boeing & Aerospace Local News Northwest
invasive Expanding Miami Zika Zone: Time To Wipe Out Invasive Mosquito By www.futurepundit.com Published On :: 2016-09-17T18:01:02-08:00 The Miami Beach danger zone for mosquitoes carrying Zika virus is expanding. This isn't just about microcephaly in developing fetuses. Since Zika attacks neural progenitor cells it might cause lasting damage in adults too. A case of acute sensory polyneuropathy in an adult caused symptoms that lasted for months. It is suspected that Zika causes inflammation of sensory nerves and possibly an auto-immune response. So Zika is bad. What should we do about it? Wipe out the mosquitoes that carry it. Totally drive them to extinction. These mosquitoes are invasive in the Western Hemisphere. If a mosquito causes major health problems for the human species we should just wipe it out. Wiping out a mosquito species could be done with... Full Article
invasive Invasive "murder hornets" arrive in US, threaten honeybees By inhabitat.com Published On :: Thu, 07 May 2020 16:30:00 +0000 If you’ve been itching to get back to the outside world, two words might make you think again: murder hornets. For the first time, these gigantic, invasive hornets have been spotted in the U.S., which could be a problem for both humans and honeybees.[...] Full Article bees invasive species honeybees hornets Animals
invasive Invasive, flammable grasses now blanket much of the United States By www.pbs.org Published On :: New research quantifies the fire risks of eight species of invasive grass. Full Article
invasive CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Eighth Meeting of the Bern Convention Group of Experts on Invasive Alien Species, 5-7 May 2009, Brijuni, Croatia. By www.cbd.int Published On :: Tue, 05 May 2009 00:00:00 GMT Full Article
invasive CBD Communiqué: Struggle against invasive species remains important goal for global Strategic Plan for Biodiversity: Secretariat of the Convention on Biological Diversity supports recent statement by conservation organizations By www.cbd.int Published On :: Mon, 01 Aug 2011 00:00:00 GMT Full Article
invasive CBD Communiqué: CBD Secretariat and IUCN sign supplementary agreement for the implementation of the Strategic Plan for Biodiversity 2011-2020 regarding invasive species By www.cbd.int Published On :: Tue, 08 Nov 2011 00:00:00 GMT Full Article
invasive CBD News: Statement by Mr. Braulio F. de Souza Dias, CBD Executive Secretary, to the Subregional Capacity-Building Workshop to Address Invasive Alien Species and to Achieve Aichi Biodiversity Target 9 in the Arab Region, 11 - 14 February 2013, Dubai, Unit By www.cbd.int Published On :: Mon, 11 Feb 2013 00:00:00 GMT Full Article
invasive CBD News: The guidance addresses a major pathway for introduction and spread of invasive alien species, as a significant percentage of global invasive introductions result from pets, aquarium and terrarium species that escape from confined conditions and By www.cbd.int Published On :: Fri, 10 Oct 2014 00:00:00 GMT Full Article
invasive CBD News: Seminar-Workshop on Harmonizing Methods in Risk Assessment and Management of Forest Invasive Alien Plant Species in South East Asia, 2-5 December 2014, Bogor, Indonesia By www.cbd.int Published On :: Tue, 02 Dec 2014 00:00:00 GMT Full Article
invasive CBD News: Governments, non-governmental organizations and local communities have taken up the Honolulu Challenge and agreed to take bold actions to counter invasive alien species that harm biodiversity. By www.cbd.int Published On :: Tue, 29 Nov 2016 00:00:00 GMT Full Article
invasive CBD News: First 23 validated checklists from the Global Register of Introduced and Invasive Species highlighted in paper, signaling major step in delivering information to support national action against biological invasions. By www.gbif.org Published On :: Tue, 23 Jan 2018 00:00:00 GMT Full Article
invasive CBD News: Statement by Ms. Elizabeth Maruma Mrema, Acting Executive Secretary, Convention on Biological Diversity, on the occasion of the meeting of the Ad Hoc Technical Expert Group on Invasive Alien Species, Montreal, 2-4 December 2019 By www.cbd.int Published On :: Mon, 02 Dec 2019 00:00:00 GMT Full Article
invasive Geschichte der Appendizitis : von der Entdeckung des Organs bis hin zur minimalinvasiven Appendektomie / Mali Kallenberger. By search.wellcomelibrary.org Published On :: Berlin : Peter Lang [2019] Full Article
invasive Engineering researcher’s non-invasive aid to monitoring pressure in the skull wins gold medal By www.raeng.org.uk Published On :: Wed, 11 Mar 2020 11:49:33 +00:00 Full Article
invasive Invasive Snails Might Save Coffee Crops From Fungus, but Experts Advise Caution By www.smithsonianmag.com Published On :: Wed, 11 Mar 2020 17:46:34 +0000 The snails are an invasive crop pest that are known to eat more than just coffee rust Full Article
invasive Noninvasive Ventilation for Respiratory Distress Syndrome: A Randomized Controlled Trial By pediatrics.aappublications.org Published On :: 2011-01-24T04:01:22-08:00 Nasal continuous positive airway pressure (NCPAP) has been the initial respiratory support for many preterm infants with respiratory distress syndrome (RDS). Nasal intermittent positive-pressure ventilation (NIPPV) seems to increase the beneficial effects of NCPAP by combining it with ventilatory inflations. This study suggests that NIPPV, as an intial respiratory support for preterm infants with RDS, is feasible and safe and may have beneficial effects, when compared with NCPAP. (Read the full article) Full Article
invasive Bovine Lactoferrin Prevents Invasive Fungal Infections in Very Low Birth Weight Infants: A Randomized Controlled Trial By pediatrics.aappublications.org Published On :: 2011-12-19T00:08:42-08:00 Lactoferrin is a glycoprotein with anti-infective activities being part of the innate defensive network. Bovine and human lactoferrin share high homology. Bovine lactoferrin can prevent late-onset sepsis in preterm very low birth weight neonates.In preterm very low birth weight infants, bovine lactoferrin is able to prevent not only late-onset sepsis but also systemic fungal infections. This protection is achieved independently from their colonization status. (Read the full article) Full Article
invasive Prevention of Invasive Cronobacter Infections in Young Infants Fed Powdered Infant Formulas By pediatrics.aappublications.org Published On :: 2012-10-08T00:07:34-07:00 Invasive Cronobacter infection is a rare but devastating disease known to affect hospitalized premature or immunocompromised infants fed powdered infant formulas (PIFs). PIF labels imply that powdered formulas are safe for healthy, term infants if the label instructions are followed.Cronobacter can also infect healthy, term infants in the first months of life, even if PIF label instructions are followed. Invasive Cronobacter infection is extremely rare in exclusively breastfed infants or those fed commercially sterile, ready-to-feed formulas. (Read the full article) Full Article
invasive Invasive Pneumococcal Disease in Infants Younger Than 90 Days Before and After Introduction of PCV7 By pediatrics.aappublications.org Published On :: 2013-06-03T00:07:04-07:00 Introduction of the pneumococcal conjugate vaccine was associated with decreased invasive pneumococcal disease (IPD) in children. Few data exist on the impact in infants aged 1 to 90 days, who are too young to be fully immunized.The incidence and proportion of IPD in Utah infants aged 1–90 days remained stable after vaccine introduction. IPD caused by PCV7 serotypes decreased significantly in the post-vaccine period. Serotype 7F emerged as the predominant serotype and commonly resulted in meningitis. (Read the full article) Full Article
invasive Trends in Invasive Methicillin-Resistant Staphylococcus aureus Infections By pediatrics.aappublications.org Published On :: 2013-09-23T08:26:06-07:00 Invasive methicillin-resistant Staphylococcus aureus (MRSA) in children is associated with high morbidity and mortality. Although reductions in health care–associated MRSA infection among adults are documented, it is unclear if a similar trend is occurring among children.Data from population-based surveillance were analyzed to assess changes in invasive MRSA infection incidence over time. This analysis describes the epidemiology and trends of invasive MRSA infections among children in 9 US metropolitan areas and estimates national burden. (Read the full article) Full Article
invasive Invasive Procedures in Preterm Children: Brain and Cognitive Development at School Age By pediatrics.aappublications.org Published On :: 2014-02-17T00:07:23-08:00 Greater numbers of invasive procedures from birth to term-equivalent age, adjusted for clinical confounders, are associated with altered brain microstructure during neonatal care and poorer cognitive outcome at 18 months’ corrected age in children born very preterm.Altered myelination at school age is associated with greater numbers of invasive procedures during hospitalization in very preterm children without severe brain injury or neurosensory impairment. Greater numbers of invasive procedures and altered brain microstructure interact to predict lower IQ. (Read the full article) Full Article
invasive Invasive Pneumococcal Disease After Implementation of 13-Valent Conjugate Vaccine By pediatrics.aappublications.org Published On :: 2014-07-07T05:07:01-07:00 Invasive pneumococcal disease causes enormous morbidity in children. The spectrum and severity of illness caused by pneumococcal serotypes not present in the current vaccine, and whether the clinical profile and severity of disease have changed, are largely unknown.Initial data suggest that nonvaccine serotypes are more common in children with underlying conditions, who have greater morbidity from disease. In the post-PCV13 era, a larger proportion of patients are hospitalized, but mortality rates are unchanged. (Read the full article) Full Article
invasive Neuroinvasive Arboviral Disease in the United States: 2003 to 2012 By pediatrics.aappublications.org Published On :: 2014-08-11T00:06:55-07:00 Arthropod-borne viruses are important causes of neurologic infections among children in the United States. The epidemiology of these diseases is complex and relates to multiple factors, including vector biology, animal reservoirs, weather, and human behavior.National surveillance data from 2003 to 2012 will improve understanding of the geographic, temporal, and clinical trends in pediatric neuroinvasive arboviral disease, and will inform decision-making for clinicians, public health authorities, and the general public. (Read the full article) Full Article
invasive Use of Neonatal Chest Ultrasound to Predict Noninvasive Ventilation Failure By pediatrics.aappublications.org Published On :: 2014-09-01T00:06:19-07:00 Lung ultrasound outperforms conventional radiology in the emergency diagnosis of pneumothorax and pleural effusions. In the pediatric age, lung ultrasound has been also successfully applied to the fluid-to-air transition after birth and to rapid pneumonia diagnosis.Nasal ventilation has dramatically decreased the need for invasive mechanical respiratory support. This study demonstrates that, after a short trial on nasal continuous positive airway pressure, lung ultrasonography reliably predicts the failure of noninvasive ventilation unlike the conventional chest radiogram. (Read the full article) Full Article
invasive Vaccination, Underlying Comorbidities, and Risk of Invasive Pneumococcal Disease By pediatrics.aappublications.org Published On :: 2015-02-02T00:05:26-08:00 Universal use of conjugated pneumococcal vaccines has resulted in dramatic decline in vaccine-type invasive pneumococcal disease. However, disease is not evenly distributed, and children with underlying clinical conditions are disproportionately represented, especially among children >5 years of age.Invasive pneumococcal disease among children with comorbidity results in higher morbidity and mortality, and a large proportion of disease is due to serotypes not included in current conjugate vaccines. (Read the full article) Full Article
invasive Noninvasive Ventilation Strategies for Early Treatment of RDS in Preterm Infants: An RCT By pediatrics.aappublications.org Published On :: 2015-02-09T00:05:27-08:00 Noninvasive ventilation (NIV) reduced the need of intubation in preterm infants with RDS. However, randomized studies comparing nasal synchronized intermittent positive pressure ventilation and bilevel continuous positive airway pressure are still lacking.The present study shows no differences in short-term outcomes between 2 different NIV strategies, nasal synchronized intermittent positive pressure ventilation and bilevel continuous positive airway pressure, in preterm infants for the initial treatment of RDS. (Read the full article) Full Article
invasive Pneumococcal Conjugate Vaccine and Clinically Suspected Invasive Pneumococcal Disease By pediatrics.aappublications.org Published On :: 2015-06-15T00:06:46-07:00 Conventional invasive pneumococcal disease (IPD) definition using laboratory confirmation lacks sensitivity. Using a vaccine-probe design, the FinIP trial showed that IPD disease burden and vaccine-preventable disease incidence were fourfold higher when a more sensitive outcome, clinically suspected IPD, was used.Vaccine-preventable disease incidence (ie, absolute reduction due to PCV10 vaccination) during routine vaccination program was threefold with the more sensitive outcome of clinically suspected IPD compared with the conventional IPD definition. This has major implications for cost-effectiveness of PCVs. (Read the full article) Full Article
invasive Racial and Regional Differences in Rates of Invasive Pneumococcal Disease By pediatrics.aappublications.org Published On :: 2015-10-12T00:07:19-07:00 Previous studies have shown racial differences in invasive pneumococcal disease (IPD) rates. Recent studies demonstrated a national decline in IPD rates after 13-valent pneumococcal conjugate vaccine (PCV13) introduction. The impact of PCV13 on racial and regional differences in IPD rates among Tennessee children is unknown.After introduction of PCV13, pediatric IPD rates, including disease due to antibiotic-resistant strains, declined substantially. Racial and regional differences in IPD rates were no longer significant. Our study illustrates the impact of PCV13 and the importance of continued IPD surveillance. (Read the full article) Full Article
invasive Combination Therapy with Ibrexafungerp (formerly SCY-078), a First-in-Class Triterpenoid Inhibitor of (1->3)-{beta}-D-Glucan Synthesis, and Isavuconazole for Treatment of Experimental Invasive Pulmonary Aspergillosis [Experimental Therapeutics] By aac.asm.org Published On :: 2020-03-16T08:17:36-07:00 Ibrexafungerp (formerly SCY-078) is a semisynthetic triterpenoid and potent (1->3)-β-D-glucan synthase inhibitor. We investigated the in vitro activity, pharmacokinetics, and in vivo efficacy of ibrexafungerp (SCY) alone and in combination with anti-mould triazole isavuconazole (ISA) against invasive pulmonary aspergillosis (IPA). The combination of ibrexafungerp and isavuconazole in in vitro studies resulted in an additive and synergistic interactions against Aspergillus spp. Plasma concentration-time curves of ibrexafungerp were compatible with linear dose proportional profile. In vivo efficacy was studied in a well established persistently neutropenic NZW rabbit model of experimental IPA. Treatment groups included untreated rabbits (UC) and rabbits receiving ibrexafungerp at 2.5(SCY2.5) and 7.5(SCY7.5) mg/kg/day, isavuconazole at 40(ISA40) mg/kg/day, or combinations of SCY2.5+ISA40 and SCY7.5+ISA40. The combination of SCY+ISA produced in vitro synergistic interaction. There was significant in vivo reduction of residual fungal burden, lung weights, and pulmonary infarct scores in SCY2.5+ISA40, SCY7.5+ISA40, and ISA40-treatment groups vs that of SCY2.5-treated, SCY7.5-treated and UC (p<0.01). Rabbits treated with SCY2.5+ISA40 and SCY7.5+ISA40 had prolonged survival in comparison to that of SCY2.5-, SCY7.5-, ISA40-treated or UC (p<0.05). Serum GMI and (1->3)-β-D-glucan levels significantly declined in animals treated with the combination of SCY7.5+ISA40 in comparison to those treated with SCY7.5 or ISA40 (p<0.05). Ibrexafungerp and isavuconazole combination demonstrated prolonged survival, decreased pulmonary injury, reduced residual fungal burden, lower GMI and (1->3)-β-D-glucan levels in comparison to those of single therapy for treatment of IPA. These findings provide an experimental foundation for clinical evaluation of the combination of ibrexafungerp and an anti-mould triazole for treatment of IPA. Full Article
invasive Performance of the Modified Boston and Philadelphia Criteria for Invasive Bacterial Infections By pediatrics.aappublications.org Published On :: 2020-04-01T01:00:57-07:00 BACKGROUND: The ability of the decades-old Boston and Philadelphia criteria to accurately identify infants at low risk for serious bacterial infections has not been recently reevaluated. METHODS: We assembled a multicenter cohort of infants 29 to 60 days of age who had cerebrospinal fluid (CSF) and blood cultures obtained. We report the performance of the modified Boston criteria (peripheral white blood cell count [WBC] ≥20 000 cells per mm3, CSF WBC ≥10 cells per mm3, and urinalysis with >10 WBC per high-power field or positive urine dip result) and modified Philadelphia criteria (peripheral WBC ≥15 000 cells per mm3, CSF WBC ≥8 cells per mm3, positive CSF Gram-stain result, and urinalysis with >10 WBC per high-power field or positive urine dip result) for the identification of invasive bacterial infections (IBIs). We defined IBI as bacterial meningitis (growth of pathogenic bacteria from CSF culture) or bacteremia (growth from blood culture). RESULTS: We applied the modified Boston criteria to 8344 infants and the modified Philadelphia criteria to 8131 infants. The modified Boston criteria identified 133 of the 212 infants with IBI (sensitivity 62.7% [95% confidence interval (CI) 55.9% to 69.3%] and specificity 59.2% [95% CI 58.1% to 60.2%]), and the modified Philadelphia criteria identified 157 of the 219 infants with IBI (sensitivity 71.7% [95% CI 65.2% to 77.6%] and specificity 46.1% [95% CI 45.0% to 47.2%]). The modified Boston and Philadelphia criteria misclassified 17 of 53 (32.1%) and 13 of 56 (23.3%) infants with bacterial meningitis, respectively. CONCLUSIONS: The modified Boston and Philadelphia criteria misclassified a substantial number of infants 29 to 60 days old with IBI, including those with bacterial meningitis. Full Article