eu

Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




eu

IIT-M students develop robot for O.P. Jindal university’s Constitution Museum

It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says




eu

Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




eu

The globally-acclaimed Candlelight Concert is now in Chennai. Listen to classical and contemporary music at Museum Theatre, amidst thousands of candles

The first concert on November 15 will feature tunes from Tamil and Hindi films, followed by tributes to Coldplay, Mozart, Queen, and Abba in the upcoming months



  • Life & Style

eu

MRPL gets special award for innovation by Petroleum Ministry




eu

India’s first Constitution Museum to have semi-humanoid guide robot

The interactive robot will provide visitors a guided tour of the museum




eu

Nifty slumps 10% from peak, Bank Nifty weekly contracts bid adieu

Inflation, firm dollar add to volatility amid FPI selling spree




eu

Pediatric Euthanasia

Fr. Barnabas Powell welcomes back Wesley J. Smith, a lawyer and award winning author as well as a Senior Fellow at the Discovery Institute’s Center on Human Exceptionalism.




eu

Transient Permian-Triassic euxinia in the southern Panthalassa deep ocean

Grasby, S E; Bond, D P G; Wignall, P B; Yin, R; Strachan, L J; Takahashi, S. Geology vol. 49, no. 8, 2021 p. 889-893, https://doi.org/10.1130/G48928.1
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210010.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210010.jpg" title="Geology vol. 49, no. 8, 2021 p. 889-893, https://doi.org/10.1130/G48928.1" height="150" border="1" /></a>




eu

Overpressure detection from geophysical, drilling and well testing data for petroleum exploration wells in the Beaufort-Mackenzie Basin, Yukon and Northwest Territories

Hu, K; Issler, D R; Chen, Z. Geological Survey of Canada, Open File 6692, 2021, 37 pages, https://doi.org/10.4095/327948
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327948.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327948.jpg" title="Geological Survey of Canada, Open File 6692, 2021, 37 pages, https://doi.org/10.4095/327948" height="150" border="1" /></a>




eu

Geochemical variation in the Jurassic-Cretaceous strata of the Baccalieu I-78 well, Flemish Pass Basin, Canada: chemostratigraphic and paleoenvironmental implications

Bingham-Koslowski, N; Azmy, K. Geoscience Canada; Geoscience Canada vol. 49, no. 2, 2022 p. 75, https://doi.org/10.12789/geocanj.2022.49.188
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210643.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210643.jpg" title="Geoscience Canada; Geoscience Canada vol. 49, no. 2, 2022 p. 75, https://doi.org/10.12789/geocanj.2022.49.188" height="150" border="1" /></a>




eu

Overview of the age, evolution, and petroleum potential of the Eagle Plain Basin, Yukon

Re-release; Lane, L S; Bell, K M; Issler, D R. Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential; by Lavoie, D (ed.); Dewing, K (ed.); Geological Survey of Canada, Bulletin 609, 2022 p. 77-89, https://doi.org/10.4095/326092
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326092.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326092.jpg" title="Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential; by Lavoie, D (ed.); Dewing, K (ed.); Geological Survey of Canada, Bulletin 609, 2022 p. 77-89, https://doi.org/10.4095/326092" height="150" border="1" /></a>




eu

Highly fractionated Hg isotope evidence for dynamic euxinia in shallow waters of the Mesoproterozoic ocean

Wu, Y; Tian, H; Yin, R; Chen, D; Grasby, S E; Shen, J; Li, T; Ju, S; Peng, P. Earth and Planetary Science Letters 616, 118211, 2023 p. 1-9, https://doi.org/10.1016/j.epsl.2023.118211
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20230261.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20230261.jpg" title="Earth and Planetary Science Letters 616, 118211, 2023 p. 1-9, https://doi.org/10.1016/j.epsl.2023.118211" height="150" border="1" /></a>




eu

SF: we have been repeatedly impressed by how resourceful GLS is in the European market

GLS and SF, China's largest integrated logistics service provider, are excited to announce a bilateral network partnership.




eu

Ochama Expands in Europe

Ochama, the European omni-channel retail brand of JD.com, Inc. (also known as JINGDONG), has announced the launch of a new automated warehouse in Poland.




eu

Deutsche Post: the transport of letters by plane within Germany can no longer be justified in times of climate change

After 63 years, Deutsche Post is discontinuing its night airmail network in Germany.




eu

Volleyball: Bermuda Defeat St. Eustatius

The Bermuda men’s national volleyball team were back in action competing in the 2024 ECVA senior men’s championships. Bermuda took on St. Eustatius and picked up a 3 – 0 victory to move to 1 & 1. Bermuda won the first set 25-11, before winning the second set 25-18, and then they closed it out […]




eu

Joell Wins Amateur Bowlers Tour Fall Nationals

Dennis Joell has achieved a significant victory on the International Bowling stage, claiming the title at the 2024 Amateur Bowlers Tour Fall Nationals in Las Vegas. Joell delivered a commanding performance in the final match, defeating American Rick Mayber with a score of 247 – 200 to secure the championship. Related Stories Bowling: Under, Astronauts, […]














eu

Samsung introduceert de Galaxy A16-serie, met twee nieuwe toestellen - Samsung Newsroom België

  1. Samsung introduceert de Galaxy A16-serie, met twee nieuwe toestellen  Samsung Newsroom België
  2. Samsung A16 4G kost 199 euro, 30 euro minder dan 5G-variant - Tablets en telefoons - Nieuws  Tweakers
  3. De nieuwe Samsung Galaxy A16 van €199 heeft wat de iPhone 16 niet heeft  Bright.nl
  4. Samsung lanceert nog goedkopere Galaxy A16 met zes jaar ondersteuning  TechPulse






eu

Aantal abonnees Spotify groeit met 12 procent in een jaar - Beeld en geluid - Nieuws - Tweakers

  1. Aantal abonnees Spotify groeit met 12 procent in een jaar - Beeld en geluid - Nieuws  Tweakers
  2. Spotify klimt naar record  De Tijd
  3. Spotify niet langer verliesgevend, maakt voor het derde kwartaal op rij winst  NU.nl
  4. Muziekstreamer Spotify wipt over kwart miljard betalende gebruikers  De Tijd
  5. Spotify winst derde kwartaal 2024 overtreft verwachtingen  Business AM













eu

Transition Releases New Youth MTB Lineup



A new 20” hardtail, a redesigned 24” full suspension, and a 27.5” young adult full suspension bike.
( Photos: 8, Comments: 40 )




eu

10 best winter hiking holidays in Europe for snowshoeing, winter sun and mountain climbs

From trekking the foothills of Mont Blanc to snowshoeing in Oulanka National Park, here are some of the best European trails to tread this winter




eu

Call for a review of services for people with neurological disorders




eu

A real opportunity to improve neurology services in England




eu

Australian neuroscientist given two year suspended sentence for falsifying Parkinson&#039;s research




eu

Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons

A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs to VTA VGluT2+VGaT+ neurons are unknown, limiting our understanding of their functional capabilities. By coupling monosynaptic rabies tracing with intersectional genetic targeting in male and female mice, we found that VTA VGluT2+VGaT+ neurons received diverse brainwide inputs. The largest numbers of monosynaptic inputs to VTA VGluT2+VGaT+ neurons were from superior colliculus (SC), lateral hypothalamus (LH), midbrain reticular nucleus, and periaqueductal gray, whereas the densest inputs relative to brain region volume were from the dorsal raphe nucleus, lateral habenula, and VTA. Based on these and prior data, we hypothesized that LH and SC inputs were from glutamatergic neurons. Optical activation of glutamatergic LH neurons activated VTA VGluT2+VGaT+ neurons regardless of stimulation frequency and resulted in flee-like ambulatory behavior. In contrast, optical activation of glutamatergic SC neurons activated VTA VGluT2+VGaT+ neurons for a brief period of time at high frequency and resulted in head rotation and arrested ambulatory behavior (freezing). Stimulation of glutamatergic LH neurons, but not glutamatergic SC neurons, was associated with VTA VGluT2+VGaT+ footshock-induced activity and inhibition of LH glutamatergic neurons disrupted VTA VGluT2+VGaT+ tailshock-induced activity. We interpret these results such that inputs to VTA VGluT2+VGaT+ neurons may integrate diverse signals related to the detection and processing of motivationally salient outcomes.




eu

Behavioral and Neural Mechanisms of Face-Specific Attention during Goal-Directed Visual Search

Goal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific regions of the visual field while filtering out irrelevant information. However, given the domain specificity of social behaviors, it remains unclear whether attention to faces versus nonfaces recruits different neurocognitive processes. In this study, we simultaneously recorded activity from temporal and frontal nodes of the attention network while macaques performed a goal-directed visual search task. V4 and inferotemporal (IT) visual category-selective units, selected during cue presentation, discriminated fixations on targets and distractors during the search but were differentially engaged by face and house targets. V4 and IT category-selective units also encoded fixation transitions and search dynamics. Compared with distractors, fixations on targets reduced spike–LFP coherence within the temporal cortex. Importantly, target-induced desynchronization between the temporal and prefrontal cortices was only evident for face targets, suggesting that attention to faces differentially engaged the prefrontal cortex. We further revealed bidirectional theta influence between the temporal and prefrontal cortices using Granger causality, which was again disproportionate for faces. Finally, we showed that the search became more efficient with increasing target-induced desynchronization. Together, our results suggest domain specificity for attending to faces and an intricate interplay between visual attention and social processing neural networks.




eu

Monocyte Invasion into the Retina Restricts the Regeneration of Neurons from Mu&#x0308;ller Glia

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.