The accuracy of the information in the Protein Data Bank (PDB) is of great importance for the myriad downstream applications that make use of protein structural information. Despite best efforts, the occasional introduction of errors is inevitable, especially where the experimental data are of limited resolution. A novel protein structure validation approach based on spotting inconsistencies between the residue contacts and distances observed in a structural model and those computationally predicted by methods such as AlphaFold2 has previously been established. It is particularly well suited to the detection of register errors. Importantly, this new approach is orthogonal to traditional methods based on stereochemistry or map–model agreement, and is resolution independent. Here, thousands of likely register errors are identified by scanning 3–5 Å resolution structures in the PDB. Unlike most methods, the application of this approach yields suggested corrections to the register of affected regions, which it is shown, even by limited implementation, lead to improved refinement statistics in the vast majority of cases. A few limitations and confounding factors such as fold-switching proteins are characterized, but this approach is expected to have broad application in spotting potential issues in current accessions and, through its implementation and distribution in CCP4, helping to ensure the accuracy of future depositions.

we introduce a novel approach for a real-time dual-frequency feedback system, which has been firstly used at the hard X-ray nanoprobe beamline of SSRF. The BiBEST can then efficiently stabilize X-ray beam position and stability in parallel, making use of different optical systems in the beamline.

; Credit: John Rabe/KPCC

Off-Ramp fan, KPCC member (!), and Tom Petty and Heartbreakers keyboardist Benmont Tench III joined John in his old Mercedes with his large, but portable Casio.

Tench has lived in the hills of Tarzana for decades, in a perfectly good house, but in the 100-degree heat, John outfitted his car with condenser mikes to record a farewell ode to Off-Ramp, Tench's "Like the Sun."

The full band version of Benmont Tench III's "Like the Sun"

"Like the Sun" helped Tench get back in the songwriting groove a decade ago after he burnt out on being professional songwriter in Nashville. He based the lyrics on tours of Los Angeles given to him by a friend, and takes the listener (with his Southern accent) from a restaurant called Michoacan to a hill top tent city. Tench also told John how he and his wife Alice explore Los Angeles.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Catawba County has been awarded one of only two grants presented across the nation, by Motorola and the National Association of Counties (NACo), to local governments that suggested innovative solutions to improve operations within their respective counties. The $30,000 grant will fund the wireless broadband internet capacity needed at Catawba County�s EcoComplex to allow for real-time monitoring between EcoComplex laboratories, universities and businesses.

The U.S. Environmental Protection Agency (EPA) should make changes to its integrated risk information system (IRIS) assessments handbook to ensure it provides clear operational instructions for those conducting assessments, and transparency regarding the assessment process, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The frozen breakfast category, anchored by waffles, pancakes and French toast, has produced its share of picks and pans over the past year, largely dominated by a handful of big-dollar items with little variation in sales.

Baked Grain Bites is a light, airy, and great-tasting snack made from brown rice, sorghum and amaranth.

The cream cheese brand transforms America’s favorite holiday dessert into this season’s “it” gift.

Breadblok recently introduced its Best Sellers Bundle, a bundle of its most popular products.

It's easy to fall prey to mediocrity. But, when you’re willing to put in the hard work and do what many people will not do, you'll find that the payoff is well worth it.

PACT has developed a specially designed, corrugated crate that some customers have been able to use over one hundred times.

By now, you may have heard that by July 2023, Google Analytics is shutting down for good, as Google replaces the analytics service with GA4. Why is this happening, and what does it mean for tracking my website analytics?

Hello, old friend. I’m writing today to say thanks, and to say farewell. This will be my last column.

Scheduled to premiere in May 2023 during AIHce EXP, AIHA’s annual conference, the series aims to introduce the public to the key role the occupational and environmental health and safety (OEHS) profession plays in creating healthier workplaces and communities.

ASSP recently published the third edition of the “Safety Professionals Handbook,” its flagship book that helps safety professionals expand their knowledge, advance their careers and improve safety at work.

Local Weather announced the launch of its newest flavor: Wildberry.

NextFoods’ GoodBelly unveiled its Prebiotic Sparkling Water available in three flavors: Mixed Berry, Lemon Lime and Mango Pineapple.

"A Life of Giving" is back with "Show By Your Example" featuring host Rev. Richard Klingeisen spreading positivity and inspiration worldwide. Tune in for heartfelt stories of faith, generosity, and family values on Ash Wednesday, February 14th, 2024.

Henry Halladay, Ph.D, PE is premiering today the latest installment of his celebrated podumentary, Learn Learn Learn, along with an exclusive Q&A bonus show and confirmation that season three is slated for 2022.

Crimson Phoenix believes in the value of mentoring and supporting the community. We are proud to offer this program as a service to the community. Applicants can sign up on the Crimson Phoenix SPY Program website.

The BG-EXH-100C6 capitalizes on HDBaseT 3.0 enhancements in addition to its robust feature set.

Initial pilot program testing to launch immediately with select NaLA members to ensure Lifeline and ACP customers can access broadcast programming.

Fight digital eye strain in the most stylish way possible with zFORT® lenses, designed to maximize comfort and minimize the effects of blue light

GrandBilliards Invites You To Win A Lap Top

Joseph Ponnoly, DBA, is a distinguished expert in cybersecurity and data analytics with 25 years of experience

Jan M. Lundberg is a retired pharmaceutical researcher with over 30 years of professional success

Renowned physician, Dr. Tasheema Fair launches "Ladydoc Lifestyle", a four-episode web series empowering women to prioritize their health and well-being, streaming now!

The World's Slimmest Dolby Atmos 2.1 Soundbar

"My skincare routine is simple, I only use soap and water," said Greg Lindberg. "My skin doesn't need anything else because it's soft and rejuvenated due to my anti-aging program.

Andrea K. Hopf, DBA, is an experienced industrial engineer and the director at Cabinetworks Group

Chardae Rodgers-Gamble, DBA, is a seasoned expert and founder of CR Clinical and Jackson Taylor Therapeutics

Lindberg discusses his journey of transforming his life through fasting and how the wellness regimen affected his health, body and mind.

Christopher G. Thompson is recognized for his expertise as a general manager for WCRN AM 830

Sunil Jagani, a prominent figure in Philadelphia's technology landscape and founder of AllianceTek, is making waves in the AI industry with his pioneering work on Retrieval-Augmented Generation (RAG)

'Guru of Ganja' Ed Rosenthal's book is the definitive guide for all marijuana cultivators — from first-time home-growers to experienced commercial business owners

LGBTQ+ Podcast DB Honeybutter features gay pastor, The Reverend Steve Pieters, on surviving AIDS, being portrayed in the new Jessica Chastain movie The Eyes of Tammy Faye, fairy wands and hope.

Books Illuminated is proud to make available to school libraries and public institutions the hardbound version of their popular climate fiction, "BAMBOO: A Post-Apocalyptic Odyssey."

In its mission to advance boating to a sustainable future, Ingenity and its partners are inviting guests to experience their fully-electric multisport towboat on the scenic waters of Lake Tahoe.

Smart sports equipment brand, HAKII, announces plans to launch the HAKII Mix Smart Headband Headphones, a groundbreaking type of wearable stereo open-ear headphones

The team at Atelier Studio has been hard at work to create a functional and sustainable living space that can easily adapt to various needs, providing a seamless integration into homeowners' lives.

RouteGenie will host a conference in Niagara Falls, NY. It is an event designed for NEMT professionals.

Carl Woodby is noted for his proficiency in bus maintenance procedures as a distinguished transit consultant

Haro-Lund introduces a new static mixing technology, which combines significantly better mixing, with an order of magnitude reduction in costs compared to the industry standard helical element by utilizing die cutting equipment for manufacturing.

Hussein Tarraf serves as the owner of Tarraf and Associates PC

Rothstein Publishing Wins 2 Top Books of the Year by ASIS International

Available for one day only

The National Institutes of Health is funding a study through SilverBills and the University of Denver's Knoebel Institute for Healthy Aging to provide a free year of bill management help & services for dementia or Alzheimer's caregivers.

Lifestyle Adventure Show "Getting Sassy with Samantha Goldberg" Will Debut in Mid-Spring

This trailblazing report illuminates the huge and untapped climate impact of the U.S. financial system, how it is undermining leading companies' climate action, and why companies' financial management may be their greatest lever for climate progress.