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• Top 10 Films of 2012
• Movies We Wish We Saw In Theatres
• Most Overrated Movie
• Guilty Pleasure
• Biggest Disappointment
• Best Movie Poster
• Most Memorable Scene
• Best Movie You Saw In 2012 That Didn't Come Out In 2012

Many chemicals and cellular processes cause oxidative stress that can damage lipids, proteins, or DNA (1). To quickly sense and respond to this ubiquitous threat, organisms have evolved enzymes that neutralize harmful oxidants such as reactive oxygen species and electrophilic compounds (including xenobiotics and their breakdown products) in cells.These antioxidant enzymes include GSH S-transferase (GST),2 NADPH:quinone oxidoreductase 1, thioredoxin, hemeoxygenase-1, and others (2, 3). Many of these proteins are commonly expressed in cells exposed to oxidative stress.The antioxidant response element (ARE) is a major regulatory component of this cellular stress response. The ARE is a conserved, 11-nucleotide-long DNA motif present in the 5'-flanking regions of many genes encoding antioxidant proteins. The laboratory of Cecil Pickett (Fig. 1) at the Merck Frosst Centre for Therapeutic Research in Quebec discovered ARE, a finding reported in the early 1990s in two JBC papers recognized as Classics here (4, 5).jbc;295/12/3929/F1F1F1Figure 1.Cecil Pickett (pictured) and colleagues first described the ARE motif, present in the 5' regions of many genes whose expression is up-regulated by oxidative stress and xenobiotics. Photo courtesy of Cecil Pickett.ARE's discovery was spurred in large part by Pickett's career choice. After completing a PhD in biology and a 2-year postdoc at UCLA in the mid-1970s, he began to work in the pharmaceutical industry.Recruited to Merck in 1978 by its then head of research and development (and later CEO), Roy Vagelos, “I became interested in how drug-metabolizing enzymes were induced by various xenobiotics,” Pickett says.According to Pickett, Vagelos encouraged researchers at the company...

Our ongoing celebration of the Library of Congress National Book Festival continues with Poets Laureate Tracy K. Smith and Robert Hass discussing the making of poetry, the position of Poet Laureate and their new books, "American Journal: Fifty Poems for Our Time" (edited by Smith) and "A Little Book on Form: An Exploration into the Formal Imagination of Poetry" (Hass), on the Poetry & Prose stage at the 2018 Festival.

Our ongoing celebration of the Library of Congress National Book Festival continues with presidential scholar Annette Gordon-Reed discussing "The Hemingses of Monticello: An American Family" on the Special Programs stage at the 2015 Festival.

Our ongoing celebration of the Library of Congress National Book Festival continues with crime writer Patricia Cornwell discussing "Red Mist,” her 19th Kay Scarpetta novel, on the Fiction & Mystery stage at the 2012 Festival.

Our ongoing celebration of the Library of Congress National Book Festival continues with young adult and fantasy author Leigh Bardugo discussing "Crooked Kingdom" on the Genre Fiction stage at the 2018 Festival. This post includes prompts for writing and thinking that young readers, families and teachers can use to explore the author and the author’s work—recommended for ages 13+.

Our ongoing celebration of the Library of Congress National Book Festival continues with former Secretary of State Condoleezza Rice discussing "Democracy: Stories from the Long Road to Freedom" on the Main Stage at the 2017 Festival.

Our ongoing celebration of the Library of Congress National Book Festival continues with two-time Pulitzer Prize-winning novelist Colson Whitehead discussing "Zone One" on the Poetry & Prose stage at the 2012 Festival.

Our ongoing celebration of the Library of Congress National Book Festival continues with historian Michael Beschloss discussing “Presidents of War” on the Main Stage at the 2019 Festival.

Our ongoing celebration of the Library of Congress National Book Festival continues with crime and mystery writer Karin Slaughter discussing "Broken," part of her Will Trent series, on the Fiction & Mystery stage at the 2010 Festival.

Our ongoing celebration of the Library of Congress National Book Festival continues with actor and author Neil Patrick Harris discussing "The Magic Misfits: The Minor Third." The event, part of the new year-long National Book Festival Presents series, took place in the Library’s Coolidge Auditorium. This post includes prompts for writing and thinking that young readers, families and teachers can use to explore the author and the author’s work—recommended for ages 8+.

OK, most of us will never be able to enjoy the first growths from Bordeaux, but you don't have to spend a grand on a bottle to realise that when it comes to cabernet and merlot blends, Bordeaux is still the region to beat.

Seven goals in Ljubljana made Portugal winger Ricardinho the all-time top UEFA Futsal EURO finals top scorer: we look at the numbers and the skills behind the man that lifted the trophy, 'O Mágico',

21 downgrades a day since January compared with 15 between January and mid-March.

A look at the best, the worst and the spiciest of the latest weekend of esports, which saw Sebastian Vettel making his long-awaited online racing debut.

Here's why Clemson, Ohio State, Oklahoma and 22 more teams will have the top offenses through the next three seasons.

Australians have developed groundbreaking medtech with the potential to transform lives around the world. Read more about the innovations featured on Australia Unlimited this year.

Microchip Honored with Best of Show Award at Flash Memory Summit 2019

Your weekly selection of awesome robot videos

Brazil and Real Madrid legend Ronaldo has hailed former team-mate David Beckham as "one of the best of all time".

The new decade of football is on lockdown after the coronavirus pandemic brought the sport to standstill.

As you may know, I maintain an extensive list of book recommendations for the biotech enthusiast on a "Amazon Influencer" page. After the latest update there are well over 100 titles! I recently analyzed the data to come up with the most popular titles among my followers (perhaps the full list is a bit intimidating):​Genentech: The Birth of BiotechThe Biotech Trader HandbookThe Pharmagellan Guide to Biotech Forecasting & ValuationValuation in Life Sciences: A Practical GuideThe Antidot [...]

Robert Kubica continued his impressive season for Renault after finishing as the 'best of the rest' behind the big three teams at the German Grand Prix

1)The ultimate in greenwashing chutzpah for the year goes to the Fur Council of Canada for their

This year's nominees include amazing concept gadgets, biomimicry in robotics, crowd-sourced projects and more. Vote for your favorites here.

Everywhere you look for the next week in London there is an arty billboard.

The beauty of culture is it's more a part of your life than you know. Artists, writers, musicians, and filmmakers can use their fame and star power to get the green message out in their favorite medium, whether its on a Web site, Twitter feed, book page,

We love seeing celebrities use their influence for good--especially when it's for the green good. With their fame and star power, they can encourage fans to eat less meat, cut their consumption, and pay attention to what's

Is keeping up with TreeHugger too much work? Let us help with our newsletters. We have a daily, edited by me, and a weekly, edited by Warren McLaren. Today I muse about how Amazon is Now Selling More Digital Kindle Books Than Print Books. Have a look

Our friends over at the design blog Dezeen have launched a pop-up shop in the smartest part of town. Calling it Temporium, because it is only up for 10 days, it features the best of new British design.

Who are the best ambassadors for clean energy, energy industry innovators, activists, and more? Vote here.

Whlle TreeHugger has covered energy issues since its founding, Energy as a Best of Green category is new for 2012. Find out the best energy project, energy ambassador, activist group, and more.

The point of having a booth at Greenbuild is to attract attention, and like with everything else, design matters. I immediately fell in love with the Kohler booth; In some ways it is so 2005 green, with its recycled materials

It is a fascinating product, glazing that darkens at the flip of a switch, eliminating the

What can one say about a show that attracts 23,000 green building professionals across the border to Toronto? It could only beGreenbuild, the grand spectacle put on by theU.S. Green Building Council (USGBC). This was its tenth

There were inspiring people and some neat new things at Greenbuild, and my biggest ever Best of Show.

Lessons from the kitchens at Le Corbusier's Unité d’Habitation in Marseille.

What's the cutest tiny shed or building, best single family house, or best new furniture design? Vote on these and more.

From the best U.S.-based fashion brand to the best volunteer vacation, eco-savvy (and oh-so-clever) shoes, cheeky t-shirt, and more, read on for our Best of Green 2012 winners in the Living category.

If you've been following the world of architecture, you've probably feasted your eyes on the Metropol Parasol, which has been one of the most popular and talked about structures of 2011. Currently the world's largest wooden structure, the Parasol's

+ Inhabitots just turned three years old! My how quickly baby blogs... and babies grow up! Celebrating your little one's third birthday? Here are six green gifts your tot will love!

As you may have seen on every major news channel out there, Hurricane Irene is barreling up towards eastern cities like NYC and Washington DC and from the looks of it, it ain't gonna be pretty. Many New Yorkers are evacuating and those who are staying

+ Overwhelmed by all the gear your kid needs to head back to school? We'll streamline your shopping endeavors with the best eco-friendly back to school supply basics.

The competition between the hottest solar homes in the nation at the 2011 Solar Decathlon in Washington, DC has been heating up all week and the winners will finally be announced tomorrow. Green design experts will be judging these student-built houses

+ Indulge your budding foodie with LoooLo Textiles organic munchy toys, which in addition to being beautifully designed, are biodegradable. A set of bagel, lox and cream cheese, a fresh PB & J, and a burger piled high with the works will infuse

NBCUniversal's Peacock launches for Comcast subscribers on Wednesday. With more people staying at home streaming content, one analyst says the environment is primed for Peacock's rollout.