Police Detective Superintendent Nicholas Pedro, Officer in Charge of the Crime Division, today [Sept 26] announced that a suspect has been arrested in connection with the recent sexual assault, with a 37-year-old male taken into custody. Image of the suspect provided by the police: Detective Superintendent Pedro said, “What we have learned so far however, […]

A 36-year-old suspect has been arrested in relation to the aggravated burglary and sexual assault at a Smiths Parish residence yesterday [Oct 19], the police have confirmed, adding that the investigation continues and anyone with any information should contact them. A police spokesperson said, “A 36-year-old suspect has been arrested in relation to the aggravated […]

A  20-year-old man was arrested in connection with the aggravated burglary and sexual assault in Smiths on October 19th, marking the second arrest in connection with the matter. A police spokesperson said, “The Bermuda Police Service [BPS], would like to thank the public for their continued assistance with the investigation into the aggravated burglary/sexual assault which […]

A 58-year-old Mexican national was arrested at the airport “after he was found in possession of a large quantity of cash” and the police also executed search warrants at residences in Devonshire and Paget and “more than $17,000 in cash was seized and two persons arrested.” A police spokesperson said, “On Saturday, July 20th, 2024, […]

A 31 year old man — who is alleged to have run through Somerset Long Bay totally naked — was arrested for indecent exposure during the first day of Cup Match. A police spokesperson said, “A 31 year old man was arrested for indecent exposure on Somerset Long Bay on Thursday. He was bailed to […]

[Updated] The police have arrested two suspects following an armed robbery at the Rubis service station on St. John’s Road in Pembroke today. A police spokesperson said, “At around 12.45pm today, Thursday 28th May, police received a report of an armed robbery at the Rubis service station at 61 St. John’s Road, Pembroke. “Reports are […]

The police have arrested two suspects — a 16-year-old male and a 17-year-old male — after an 18-year-old male was “robbed of his motorcycle at knifepoint.” A police spokesperson said, “Around 11:00 p.m. on Sunday, July 2nd, 2023, an 18-year-old male attended Hamilton Police Station and reported that he was robbed of his motorcycle at […]

“Two male suspects were arrested in connection with the ongoing investigations into the murders of Razi Garland and Amon Robinson,” the police said. A police spokesperson said, “On Thursday, July 25th, 2024, the Bermuda Police Service Serious Crime Unit, supported by the Criminal Investigation, Gang Targeting and Police Support Units, executed two warrants in the […]

“The policing plan implemented over the just concluded Cup Match holiday weekend, was in the main, successful in preventing any major criminal activity,” the police said, adding that there “were thirty-six arrests for various offences, the majority being for outstanding warrants.” A police spokesperson said, “However of particular concern, among them were ten persons arrested for […]

A 59-year-old minibus driver was arrested and passengers were transferred to another vehicle, with the incident going viral on social media as passengers posted images. A police spokesperson said, “Around 8:50 a.m. on Monday, August 5th, 2024 police officers had cause to stop a minibus driven by a 59-year-old male, on Middle Road Southampton. “Upon being […]

Police have arrested three men as part of Operation Athelstan, an “operational response to the firearm incident that occurred on August 24,” with an 18-year-old male “arrested in connection with the firearm incident” and two other men “arrested on suspicion of possession of controlled drugs and drug equipment.” A police spokesperson said, “Around 3:00pm on […]

A second man has now been arrested in connection with the firearm incident that occurred on August 24th, the police have confirmed. A police spokesperson said, “Around 1:00 p.m. on Wednesday, September 4, 2024, the Bermuda Police Service [BPS] continued Operation Athelstan, which is the BPS response to the police shooting that occurred on Saturday, […]

Police “attended a residence in Warwick and recovered what appears to be a firearm and ammunition” and “three persons have been arrested in connection with this matter.” A police spokesperson said, “Shortly before noon today, Friday, September 13, 2024, acting on information received, police attended a residence in Warwick and recovered what appears to be […]

A 42-year-old man was arrested in connection with the shooting in Warwick that injured a 48-year-old man, the police have confirmed. A police spokesperson said, “A suspect has been arrested in connection with the firearms incident which occurred on Thursday, September 12, 2024 at Quarry Hill Road Warwick and which left a 48-year-old male with […]

A 29-year-old man wanted in connection with the recent seizure of firearms, drugs, and ammunition turned himself in to police and “another male has also since been arrested in relation to this matter, making it five suspects arrested as part of this operation.” A police spokesperson said, “Around 10:40 a.m. on Wednesday, October 2nd, 2024, […]

The Bermuda Police Service confirmed that “two male suspects have been arrested in connection with the murder of 17-year-old Ethan Arruda.” A police spokesperson said, “Mr. Arruda died after he sustained a stab wound to the chest. He had reportedly attended a party at a residence on Devonshire Bay Road, Devonshire, where approximately 100 people […]

German law enforcement authorities have announced the disruption of a criminal service called dstat[.]cc that made it possible for other threat actors to easily mount distributed denial-of-service (DDoS) attacks. "The platform made such DDoS attacks accessible to a wide range of users, even those without any in-depth technical skills of their own," the Federal Criminal Police Office (aka

Canadian law enforcement authorities have arrested an individual who is suspected to have conducted a series of hacks stemming from the breach of cloud data warehousing platform Snowflake earlier this year. The individual in question, Alexander "Connor" Moucka (aka Judische and Waifu), was apprehended on October 30, 2024, on the basis of a provisional arrest warrant, following a request by the

Police bodycam footage of Trump 2020 campaign Advisor Brad Parscale’s arrest was released on Monday showing officers bodyslamming Parscale once he emerged outside his home shirtless with a beer in his hand during a tense scene after his wife told the police that he was suicidal. “Listen, I’m not trying to kill myself. She’s lying, I didn’t […]

The post Police Bodycam Footage Released Shows Trump 2020 Adviser Brad Parscale Bodyslammed During Arrest appeared first on Hispolitica.

A tram is vandalised in new rioting in Amsterdam, days after the attacks on Israeli football fans.

Cape Town police have arrested two suspects in connection with the murder of Noem My Skollie actor David Manuel and his friend, Alfonso Fisher, in Gugulethu last month.

G protein–coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (βarr). βarr-dependent actions begin with recruitment of βarr to the phosphorylated receptor tail and are followed by engagement with the receptor core. βarrs are known to act as adaptor proteins binding receptors and various effectors, but it is unclear whether in addition to the scaffolding role βarrs can allosterically activate their downstream targets. Here we demonstrate the direct allosteric activation of proto-oncogene kinase Src by GPCR–βarr complexes in vitro and establish the conformational basis of the activation. Whereas free βarr1 had no effect on Src activity, βarr1 in complex with M2 muscarinic or β2-adrenergic receptors reconstituted in lipid nanodiscs activate Src by reducing the lag phase in Src autophosphorylation. Interestingly, receptor–βarr1 complexes formed with a βarr1 mutant, in which the finger-loop, required to interact with the receptor core, has been deleted, fully retain the ability to activate Src. Similarly, βarr1 in complex with only a phosphorylated C-terminal tail of the vasopressin 2 receptor activates Src as efficiently as GPCR–βarr complexes. In contrast, βarr1 and chimeric M2 receptor with nonphosphorylated C-terminal tail failed to activate Src. Taken together, these data demonstrate that the phosphorylated GPCR tail interaction with βarr1 is necessary and sufficient to empower it to allosterically activate Src. Our findings may have implications for understanding more broadly the mechanisms of allosteric activation of downstream targets by βarrs.

Rhodopsin is a canonical class A photosensitive G protein–coupled receptor (GPCR), yet relatively few pharmaceutical agents targeting this visual receptor have been identified, in part due to the unique characteristics of its light-sensitive, covalently bound retinal ligands. Rhodopsin becomes activated when light isomerizes 11-cis-retinal into an agonist, all-trans-retinal (ATR), which enables the receptor to activate its G protein. We have previously demonstrated that, despite being covalently bound, ATR can display properties of equilibrium binding, yet how this is accomplished is unknown. Here, we describe a new approach for both identifying compounds that can activate and attenuate rhodopsin and testing the hypothesis that opsin binds retinal in equilibrium. Our method uses opsin-based fluorescent sensors, which directly report the formation of active receptor conformations by detecting the binding of G protein or arrestin fragments that have been fused onto the receptor's C terminus. We show that these biosensors can be used to monitor equilibrium binding of the agonist, ATR, as well as the noncovalent binding of β-ionone, an antagonist for G protein activation. Finally, we use these novel biosensors to observe ATR release from an activated, unlabeled receptor and its subsequent transfer to the sensor in real time. Taken together, these data support the retinal equilibrium binding hypothesis. The approach we describe should prove directly translatable to other GPCRs, providing a new tool for ligand discovery and mutant characterization.

The police have arrested an individual in the probe surrounding two bags of cash that allegedly fell from a Beryllium security vehicle en route to the Norman Manley International Airport in Kingston last week. 

A Remembrance Day ceremony in Sarnia, Ont., was disrupted Monday, police say, by the presence and arrest of multiple alleged members of an outlaw motorcycle gang.  

The three Somerville High School juniors allegedly entered a freshman cabin and sexually assaulted three victims.

In a twist worthy of a Bollywood movie, the 24-year-old lyricist of a song in an upcoming Salman Khan film has been arrested for issuing a death threat - purportedly from the Lawrence Bishnoi gang - to the actor and himself.

Lawrence Bishnoi first grabbed headlines when he publicly threatened to kill Bollywood actor Salman Khan in 2018.

A Newark man has been indicted and arrested for a 2009 homicide following a cold case investigation. On April 24, 31-year-old Ricardo J. Vega was indicted on two counts of Murder 1st Degree for the killing of 19-year-old Justin Trnka. Trnka, also of Newark, was killed during an armed robbery on March17,2009. Potential charges for the armed robbery are subject to a statute of limitations […]

A Seaford pastor has been arrested and charged with 10 felony counts of Dealing in Child Pornography, Attorney General Kathy Jennings announced Thursday.  James R. Dryden, 74, was arrested February 15 following an Internet Crimes Against Children Task Force (ICAC) investigation led by the Delaware Department of Justice and Delaware State Police. ICAC’s investigation was spurred […]

DOVER, DE (Jan. 20, 2023) –   The Delaware Division of Public Health’s (DPH) Office of Animal Welfare (OAW) announces the arrest of a sixth man involved in a Seaford dog fighting incident from January 8. OAW charged Laurel, DE, resident Ronnell Jacobs, age 45, with three felony counts related to dog fighting, and two misdemeanor counts […]

Delaware Animal Services (DAS), the enforcement unit within the Office of Animal Welfare, announces the arrest of a man and a woman involved in an animal cruelty case.  On Aug. 25, 2023, Delaware State Police (DSP) Troop 7 received a tip from a concerned citizen that Dillon Hensey, age 32, and his wife, Chelsie Puckett, age 33, were seen […]

Delaware Natural Resources Police investigation leads to the arrest of a 16-year-old male of Wilmington, DE, for an attempted carjacking at Bellevue State Park.

Delaware Natural Resources Police arrested two men on June 22, 2024 following an investigation into the assault at Cape Henlopen State Park.

Attorney General Kathy Jennings announced on Monday that a Maryland resident was arrested for allegedly stealing the identity of a registered nurse (“RN”), and then trying to use those credentials to fraudulently obtain employment in Delaware nursing homes.  “The licensing system for healthcare professionals is crucial to patient safety,” Attorney General Jennings said.  “The Delaware Department of […]

The Thoothukudi police in Tamil Nadu have arrested a physical education teacher at a private school for allegedly harassing girl students sexually and forcing them to take liquor.

The Supreme Court on Tuesday extended the interim protection from arrest granted to Malayalam film actor Siddique in an alleged rape case.

A man has been arrested here in connection with the murder of a 50-year-old beautician in Rajasthan's Jodhpur whose body was chopped and buried in a pit by the accused, an official has said.

One person was killed and two others were injured when three men on a motorcycle opened fire on three friends returning home on a scooter last night in the Kabir Nagar area of North East Delhi.

Police on Monday arrested Manisha, wife of jailed gangster Kaushal Chaudhary, for allegedly trying to extort Rs 2 crores from a hotel owner, officials said.

A man was arrested in Noida on Monday for allegedly fabricating a Transfer Certificate (TC) for his son to show that he was a juvenile when he was arrested in a rape and murder case in 2016, police said.

[SAPS] - Polokwane based Hawks Serious Commercial Crime Investigation in collaboration with National Traffic Anti-corruption Unit arrested 11 suspects between the ages of 27 and 57 for alleged fraud at various Provinces during operation "SISFIKILE".

[SAPS] One hundred and seventy one (171) murder suspects, 261 attempted murder suspects and 250 suspected rapists were among 12 593 suspects who were arrested during various operations by police in KwaZulu-Natal in the month of October. During such operations police also managed to recover 345 firearms and 2 998 rounds of ammunition of various calibre of firearms. Among the recovered firearms were 23 rifles and 17 homemade illegal guns.

The Enugu State Government has strongly condemned the bullying and physical assault of a student at the Federal Government College, Enugu, describing it as “deeply troubling and emotionally distressing.” The state Commissioner for Education, Prof Ndubueze Mbah, in a statement on Tuesday, emphasised the government’s zero-tolerance policy for bullying, abuse, and dehumanising treatment in all

The Ondo State Police Command, on Tuesday, said it had arrested one prophetess, Mrs Folashade Adekola, over the death of a woman, Jumoke Adesuwa and her newborn baby inside the church. Our correspondent gathered on Tuesday that the deceased bled to death from complications after childbirth inside the suspect’s church located in the Oke-Aro area