Advocate General of the Court of Justice of the European Union (“CJEU”) publishes his opinion (the “Opinion”) questioning the validity of Safe Harbor The Opinion in summary On 23 September 2015 Advocate General (“AG&rdq...

The Court of Justice of the European Union (“CJEU”) publishes its ruling (the “Ruling”) on Maximillian Schrems v Data Protection Commissioner (the “Case”)   The Ruling in summary This morning (6 October 2015)...

Prostate-specific membrane antigen (PSMA)–targeting α-radiation therapy (TAT) is an emerging treatment modality for metastatic castration-resistant prostate cancer. There is a subgroup of patients with poor response despite sufficient expression of PSMA in their tumors. The aim of this work was to characterize PSMA-TAT–nonresponding lesions by targeted next-generation sequencing. Methods: Of 60 patients treated with ²²⁵Ac-PSMA-617, we identified 10 patients who presented with a poor response despite sufficient tumor uptake in PSMA PET/CT. We were able to perform CT-guided biopsies with histologic validation of the nonresponding lesions in 7 of these nonresponding patients. Specimens were analyzed by targeted next-generation sequencing interrogating 37 DNA damage-repair–associated genes. Results: In the 7 tumor samples analyzed, we found a total of 15 whole-gene deletions, deleterious or presumably deleterious mutations affecting TP53 (n = 3), CHEK2 (n = 2), ATM (n = 2), and BRCA1, BRCA2, PALB2, MSH2, MSH6, NBN, FANCB, and PMS1 (n = 1 each). The average number of deleterious or presumably deleterious mutations was 2.2 (range, 0–6) per patient. In addition, several variants of unknown significance in ATM, BRCA1, MSH2, SLX4, ERCC, and various FANC genes were detected. Conclusion: Patients with resistance to PSMA-TAT despite PSMA positivity frequently harbor mutations in DNA damage-repair and checkpoint genes. Although the causal role of these alterations in the patient outcome remains to be determined, our findings encourage future studies combining PSMA-TAT and DNA damage-repair–targeting agents such as poly(ADP-ribose)-polymerase inhibitors.

We characterized 29 bla_CTX-M-27-harboring plasmids of Escherichia coli sequence type 131 (ST131) sublineage C1/H30R isolates from healthy individuals and long-term-care facility (LTCF) residents. Most (27/29) plasmids were of the FIA, FIB, and FII multireplicon type with the same plasmid multilocus sequence typing (pMLST). Several plasmids (7/23) from LTCF residents harbored only bla_CTX-M-27 as the resistance gene; however, their fundamental structures were very similar to those of previously isolated bla_CTX-M-27/F1:A2:B20 plasmids, suggesting their prevalence as a newly arising public health concern.

A team of researchers at the Massachusetts Institute of Technology (MIT) has demonstrated that single-celled microorganisms such as Escherichia coli and Saccharomyces cerevisiae that normally do not inhabit hydrogen-rich environments can survive and grow in a 100% hydrogen atmosphere. “There’s a diversity of habitable worlds out there, and we have confirmed that Earth-based life can [...]

The pandemic has left many unable to leave harbor, creating a window for fishing grounds to recover from years of overfishing

With the U.S. death toll from the coronavirus mounting, President Trump on Monday took aim at MSNBC's Joe Scarborough. The cable news host responded by telling Trump to let Vice President Mike Pence “run things for the next couple of weeks.”

Soripada Lubis, a naturalized American citizen originally from Indonesia, pleaded guilty today to harboring illegal aliens for commercial advantage and private financial gain. Lubis’ wife, Siti Chadidjah Siregar, a citizen of Indonesia, pleaded guilty to making false statements to federal agents who were investigating the scheme.

“It is critical that Medicare providers base their DME purchasing decisions on what is in the best interests of their patients,” stated Tony West, Assistant Attorney General for the Civil Division.

The Department filed a lawsuit against the owner and property manager of a 48-unit apartment complex in Ann Arbor, Mich., alleging that the defendants discriminated on the basis of race or color in the rental of apartments.

The owners and operators of Ivanhoe House Apartments, an apartment complex in Ann Arbor, Mich., have agreed to pay $82,500 to settle a lawsuit filed by the Justice Department alleging that they had discriminated against African-American home-seekers, in violation of the Fair Housing Act.

The Justice Department announced today that the evidence does not reveal a violation of the applicable federal criminal civil rights statute or warrant further federal criminal investigation in the death of Imam Luqman Ameen Abdullah, a Detroit Muslim cleric, who was shot during an Oct. 28, 2009, arrest by FBI agents in Dearborn, Mich.

Javier Arce, 58, and Cristina Mier Arce, 55, were indicted by a federal grand jury for conspiracy and harboring of an undocumented Bolivian national for their financial gain.

consent decree, valued at approximately $5.5 million, was filed today in the U.S. District Court for the Northern District of Ohio.

The Department of Justice, on behalf of the U.S. Environmental Protection Agency, along with the Massachusetts Attorney General’s Office, on behalf of the Massachusetts Department of Environmental Protection, have reached a settlement with AVX Corp. for $366.25 million plus interest regarding the New Bedford Harbor Superfund Site, in New Bedford, Mass.

The Department of Justice announced today that a federal criminal complaint has been filed in the Eastern District of Virginia charging defendants Abdelkader and Hnia Amal with immigration offenses in connection with allegations that they held a woman in their home as a domestic servant for three years.

The Department of Justice announced today that Abdelkader and Hnia Amal pleaded guilty to one count of alien harboring in the U.S. District Court for the Eastern District of Virginia.

By Karin F.R. Moore —

These busy filter-feeders clean the water, attract biodiversity, and offer protection from storms.

Nicolas Laisné's vast project is a very different kind of office development.

In the US, Arbor Day is April 27, 2007. When this writer was a child, our grade school class planted trees on Arbor Day, told that when we grew up that "our" trees might well still be there, beholden to our childhood actions. We even had an

Doubletree Hotels with the Arbor Day Foundation kicked

The Triumph Elm is being set up on Michigan Avenue in downtown Chicago in honor of Arbor Day this Friday (and you thought the fun ended with Earth Day!). The tree is part of a project by the Morton Arboretum to enlighten

Instead of buying some new "green" products for Earth Day, start a legacy for your community by planting trees for Arbor Day.

Whether they are growing to be thousands of years old, making life-long friendships or confounding us with their resilience, trees provide to us invaluable material resources.

A tree-planting campaign that's as easy as a click, text or tweet seeks to reach a million before December 31.

Planting trees is one of the most effective things we can do to fight climate change. Too bad Arbor day is missing the opportunity.

When it comes to potentially infectious microbes, beards beat the dogs.

As the novel coronavirus becomes pandemic, people are focused on stopping the spread of germs through largescale quarantines and everyday best practices like hand washing.

iKlebsiella pneumoniae/i carbapenemase (KPC) is commonly found in sinks located near patients toilets in hospital rooms. These sinks act as reservoirs

In the paper, published in the Journal of Investigative Dermatology, researchers found that 50% of skin rashes in patients with lupus contained an abnormally

MIKE DICKSON ON CENTRE COURT: It was all there again for Jo Konta - another Grand Slam semi-final, this time against a possibly vulnerable Serena Williams.

Marco Rubio's campaign says the candidate's latest ad has struck a chord with American voters and that's why 'elitist members of the media' like MSNBC's Joe Scarborough aren't liking it.

Morning Joe hosts Joe Scarborough and Mika Brzezinski lashed out at the president in claiming he is 'not well' and should let Vice President Mike Pence take over while he gets checked out.

Senator Ted Cruz and MSNBC host Joe Scarborough Friday engaged in a bitter war of words on Twitter Friday evening.

Transaction expected to close in Q3 2020

Washington, May 06: President Donald Trump on Wednesday said that fallout from the novel coronavirus pandemic has hit the United States harder than Pearl Harbor in World War II or the 9/11 attacks. "This is worse than Pearl Harbor. This is

West, Brady T

Online Resource

Dearborn, Jenny, author

Hayden Library - QP551.P69594 2019

Wohlstetter, Roberta

Barker Library - TL725.3.M2 B467 2019