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Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification [RNA]

pncRNA-D is an irradiation-induced 602-nt long noncoding RNA transcribed from the promoter region of the cyclin D1 (CCND1) gene. CCND1 expression is predicted to be inhibited through an interplay between pncRNA-D and RNA-binding protein TLS/FUS. Because the pncRNA-D–TLS interaction is essential for pncRNA-D–stimulated CCND1 inhibition, here we studied the possible role of RNA modification in this interaction in HeLa cells. We found that osmotic stress induces pncRNA-D by recruiting RNA polymerase II to its promoter. pncRNA-D was highly m6A-methylated in control cells, but osmotic stress reduced the methylation and also arginine methylation of TLS in the nucleus. Knockdown of the m6A modification enzyme methyltransferase-like 3 (METTL3) prolonged the half-life of pncRNA-D, and among the known m6A recognition proteins, YTH domain-containing 1 (YTHDC1) was responsible for binding m6A of pncRNA-D. Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS–pncRNA-D interaction. CRISPR/Cas9-mediated deletion of candidate m6A site decreased the m6A level in pncRNA-D and altered its interaction with the RNA-binding proteins. Of note, a reduction in the m6A modification arrested the cell cycle at the G0/G1 phase, and pncRNA-D knockdown partially reversed this arrest. Moreover, pncRNA-D induction in HeLa cells significantly suppressed cell growth. Collectively, these findings suggest that m6A modification of the long noncoding RNA pncRNA-D plays a role in the regulation of CCND1 gene expression and cell cycle progression.




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Unending Cycles of Abuse: The Practice of Bacha Bazi in Afghanistan

Research Event

6 February 2020 - 6:00pm to 7:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Charu Lata Hogg, Associate Fellow, Asia-Pacific Programme, Chatham House
Hameed Hakimi, Research Associate, Asia-Pacific Programme and Europe Programme, Chatham House
Chair: Champa Patel, Head of Asia-Pacific Programme, Chatham House

Afghanistan has suffered decades of armed conflict resulting in a heavily armed and militarized society involving multiple armed actors and with children being disproportionately affected by the conflict. In March 2019, the Afghanistan government criminalized the harmful practice of bacha bazi, or ‘boy play’, which triggers a range of human rights violations against boys and young men. However, recent research conducted by the All Survivors Project and Youth Health and Development Organisation demonstrates that the practice is widely prevalent due to poverty, prevailing gender norms and widespread impunity. This event will look at research that was conducted in the four provinces of Balkh, Herat, Kandahar and Kabul following interviews with over 100 key informants, 24 survivors and with 13 focus group discussions. 

The event will be preceded by the screening of a documentary on the practice of bacha bazi in Afghanistan which includes interviews with survivors, key government officials and NGOs. The speakers will discuss how an increase in the intensity of conflict in recent years has removed protection mechanisms and increased the vulnerability of all children to conflict-related sexual violence.

Event attributes

Chatham House Rule

Lucy Ridout

Programme Administrator, Asia-Pacific Programme
+44 (0) 207 314 2761




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Asia’s Internet Shutdowns Threaten the Right to Digital Access

18 February 2020

Vasuki Shastry

Associate Fellow, Asia-Pacific Programme
Internet shutdowns by Asian governments are curbing their citizens’ space for debate and tougher global regulation is needed, writes Vasuki Shastry.

2020-02-18-Kashmir-Internet.jpg

People look at their mobile phones after authorities restored low speed mobile internet services in Kashmir Valley on 25 January 2020. Photo: Getty Images.

Internet shutdowns in Asia have become frequent and persistent, an ominous sign of shrinking public space for debate and discourse. The shutdowns have become an irresistible option for governments of all stripes and ideological affiliations. Democratic India, Sri Lanka, Indonesia and the Philippines are prodigious offenders. So are Asia’s more repressive regimes, notably China.

In their defence, governments have offered real and imagined threats to national security as reasons for shutting down the pipes. It is useful to examine these claims as well as to objectively frame the issue. Are internet shutdowns in Asia legitimate and can be defended and explained as threats to national security? Or should we take a broader approach where international law, norms, values, rights and indeed economic stability could be invoked to curb this invidious practice?

Let’s start with the shutdown in Kashmir, where Indian authorities clamped down on internet access for a straight 165 days, described by rights group Access Now as the ‘longest shutdown ever in a democracy’. The Kashmir Chamber of Commerce and Industry estimates that the shutdown had huge economic costs, estimated at over £1.9 billion.

The economic cost of the continuing surveillance and shutdown in China’s Xinjiang province is likely to be higher. But India is a democracy and could be a role model, which is why the recent assertion of Communications and Information Technology Minister Ravishankar Prasad is worrying. He asserted in Parliament that the Indian citizen’s right to the internet was not a fundamental right. ‘While right of internet is important, security of the country is equally important…Can we deny (that) the internet is abused by terrorists…?’.

The minister’s primary defence of the shutdown – that the internet was being abused by terrorists and others to foment unrest – has some merit. Our starting point therefore is that big tech platforms should be doing a significantly better job in monitoring content and in removing material designed to provoke violence and hatred. This is the original sin and Asian governments are right to worry about messaging platforms, for example, becoming preferred channels for venom and hate speech.

To date, the big tech firms have made the right noises about monitoring and moderating content, but they have not gone far enough, providing governments with the excuse to routinely shut down access. To be blunt, self-regulation of the platforms is not working and tougher global regulation, enforcement and sanctions, possibly via the G20, would help.

At the same time, better policing of the platforms will not resolve the issue entirely because governments regard internet shutdowns as a useful way to restrict human rights and to consolidate political control and surveillance over citizens. The international community – including nation-states, NGOs and the private sector – needs to come together and embrace two overarching principles:

First, digital access is a fundamental human right and integrated into global declarations and norms.

Second, to protect fragmentation and Balkanization of the internet, the digital pipes which carry data across national boundaries should be embedded into international law as being part of the global commons (just like oceans are under maritime law). This would raise the bar on countries which frequently restrict digital access to their citizens.

Sensible though these recommendations might seem, it is obvious that many Asian governments would be loath to sign up to global declarations which would limit their policy options at home. There is an economic dimension to internet shutdowns, as the Kashmir case makes clear, which could be addressed by naming and shaming, just as the OECD’s Financial Action Task Force does for countries falling foul of money laundering regulations. Recommendations include:

  • Digital access should be included in the UN’s Human Development Index.
  • The World Bank’s closely followed Doing Business Index (DBI) should score countries favourably based on their commitment to offering unimpeded access to the internet. China and India watch the DBI rankings very closely and will be forced to pursue a more liberal approach if their rankings fall precipitously.
  • Since internet shutdowns have a clear economic cost, particularly in payments and financial services, the International Monetary Fund (IMF) should make an annual determination of member countries (as part of its surveillance mandate) of the impact of shutdowns on economic activity and financial stability.

Finally, all Asian governments have declared a public commitment to drive financial inclusion by providing digital access and identity to the poor and vulnerable. This mandate is at odds with frequent internet disruptions. A small vendor in Kashmir, Xinjiang or elsewhere in the region has limited or no recourse when the pipes are shut down. Central banks in the region need to step in by offering some level of protection, just like deposit insurance coverage.

It is clear that many of these recommendations would be rejected outright by many Asian governments. They regard internet shutdowns as part of their policy toolkit to deal with external and internal threats to national security. In pursuing such a rigid approach, governments are wilfully curbing their citizens’ space for debate and ignoring a much broader issue of rights to digital access.

Armed with a hammer, it is tempting for governments to regard the internet as a nail. The international community and citizens’ groups have an obligation to make such hammering very expensive.




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Bangladesh: The Trade-Off Between Economic Prosperity and Human Rights

Research Event

11 March 2020 - 1:00pm to 2:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

K. Anis Ahmed, Publisher, Dhaka Tribune and Bangla Tribune; Author of Good Night, Mr. Kissinger, Co-director, Dhaka Literary Festival
Meenakshi Ganguly, South Asia Director, Human Rights Watch
Chair: Ed Cumming, Writer, The Independent

Bangladesh's recent gains in economic and social indices, set against its record of corruption and poor civil rights, has at times been termed the ‘Bangladesh Paradox’. Yet this label is overly simplistic; the current situation proves that these trends can coexist.

The Awami League government, in power since 2009, has increased political stability, delivered unprecedented economic and social advances, and adopted a counter-terrorism strategy to stamp out extremist groups. At the same time, it is criticized for curbing civil rights and failing to hold credible elections. However, as the two previous regimes have demonstrated, the rights situation is unlikely to improve even if the Awami League were replaced.

How did worsening rights become a feature of the state irrespective of its political dispensation? An unresolved contest between political and non-political state actors may hold the key to that puzzle. The perils of the current dispensation have recently manifested in weakening economic indicators, which jeopardize the very stability and social progress for which the country has garnered much praise.

Lucy Ridout

Programme Administrator, Asia-Pacific Programme
+44 (0) 207 314 2761




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Tripping the Light-Fantastic

Invisibility is no longer confined to fiction. In a recent experiment, microwaves were bent around a cylinder and returned to their original trajectories, rendering the cylinder almost invisible at those wavelengths. This doesn't mean that we're ready for invisible humans (or spaceships), but by using Maxwell's equations, which are partial differential equations fundamental to electromagnetics, mathematicians have demonstrated that in some simple cases not seeing is believing, too. Part of this successful demonstration of invisibility is due to metamaterials electromagnetic materials that can be made to have highly unusual properties. Another ingredient is a mathematical transformation that stretches a point into a ball, "cloaking" whatever is inside. This transformation was discovered while researchers were pondering how a tumor could escape detection. Their attempts to improve visibility eventually led to the development of equations for invisibility. A more recent transformation creates an optical "wormhole," which tricks electromagnetic waves into behaving as if the topology of space has changed. We'll finish with this: For More Information: Metamaterial Electromagnetic Cloak at Microwave Frequencies, D. Schurig et al, Science, November 10, 2006.




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Working It Out. Math solves a mystery about the opening of "A Hard Day's Night."

The music of most hit songs is pretty well known, but sometimes there are mysteries. One question that remained unanswered for over forty years is: What instrumentation and notes make up the opening chord of the Beatles. "A Hard Day.s Night"? Mathematician Jason Brown - a big Beatles fan - recently solved the puzzle using his musical knowledge and discrete Fourier transforms, mathematical transformations that help decompose signals into their basic parts. These transformations simplify applications ranging from signal processing to multiplying large numbers, so that a researcher doesn.t have to be "working like a dog" to get an answer. Brown is also using mathematics, specifically graph theory, to discover who wrote "In My Life," which both Lennon and McCartney claimed to have written. In his graphs, chords are represented by points that are connected when one chord immediately follows another. When all songs with known authorship are diagrammed, Brown will see which collection of graphs - McCartney.s or Lennon.s - is a better fit for "In My Life." Although it may seem a bit counterintuitive to use mathematics to learn more about a revolutionary band, these analytical methods identify and uncover compositional principles inherent in some of the best Beatles. music. Thus it.s completely natural and rewarding to apply mathematics to the Fab 4 For More Information: Professor Uses Mathematics to Decode Beatles Tunes, "The Wall Street Journal", January 30, 2009..




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Some of the latest climate models provide unrealistically high projections of future warming

A new study from University of Michigan climate researchers concludes that some of the latest-generation climate models may be overly sensitive to carbon dioxide increases and therefore project future warming that is unrealistically high.




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Wildlife through the window: what readers have spotted during lockdown

We asked Guardian readers living in cities and towns across the world to share their images of the wildlife they can see from their homes. You answered in your droves, from Canada to Cardiff, and here are some of the best.




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HIGH QUALITY LOGO DESIGNING SERVICES




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What Are The Highest Paying Affiliate Programs?




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Report of the eighth meeting of the Compliance Committee




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Report of the eighth Coordination Meeting for Governments and Organizations Implementing and/or Funding Biosafety Capacity-building Activities




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CBD News: Statement of Ahmed Djoghlaf, Executive Secretary, at the Opening Session of the Ninth Meeting of the Conference of the Parties to the Convention on Biological Diversity, Bonn, 19 May 2008.<br><br><table width=120> <tr>&




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CBD News: The Executive Secretary of the Convention, Dr. Ahmed Djoghlaf, is pleased to invite you to the second CBD Linnaeus Lectures series highlighting major issues related to biological diversity - and our collective efforts to protect it worldwide. Sp




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CBD News: Message from the Executive Secretary Ahmed Djoghlaf to the participants of the Conference of the Competence Network Urban Ecology "Urban Biodiversity & Design - Implementing the Convention on Biological Diversity in towns and Cities&quo




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CBD News: Message from Ahmed Djoghlaf, Executive Secretary, to the G8 Environment Ministers Meeting, Kobe, Japan, 24-26 May 2008.




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CBD News: Statement from the Executive Secretary, Ahmed Djoghlaf, on the occasion of the 2008 CIC Markhor Award Ceremony for Outstanding Conservation Performance, 27 May 2008, Bonn, Germany.




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CBD News: 3 Heads of State, 87 Ministers to Open Biodiversity High Level Conference.




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CBD News: Statement by Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity at the Closure of the High Level Segment of the Ninth Meeting of the Conference of the Parties to the Convention.




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CBD News: Statement by Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity at the closing session of the Ninth Meeting of the Parties to the Convention on Biological Diversity, Bonn, 30 May 2008.




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CBD News: Message from Executive Secretary, Ahmed Djoghlaf, on the occasion of the High-Level Conference on World Food Security and the Challenges of Climate Change and Bioenergy FAO, Rome, 3 June 2008.




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CBD News: Statement by Dr. Ahmed Djoghlaf, Executive Secretary, Secretariat of the Convention on Biological Diversity, for the UN Treaty Event: Seminar/Panel Discussion, 4 June 2008.




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CBD News: Message from the Executive Secretary, Ahmed Djoghlaf, to the participants of the 38th biennial World Farmers' Congress in Warsaw, Poland, Friday 6 June 2008.




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CBD News: Sustaining the Blue Planet: Our Ocean Our Future - Message of Dr Ahmed Djoghlaf, Executive Secretary, on the occasion of the World Ocean Day, 8 June 2008.




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CBD News: Statement on behalf of Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the 24th Session of the North American Forestry Commission (NAFC), San Juan, Puerto Rico, 9-12 June 2008.




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CBD News: Statement from Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Twelfth Regular Session of the African Ministerial Conference on the Environment, Johannesburg, South Africa, 7-12 June 2008




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CBD News: Message from Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity to the Business and Biodiversity Conservation Seminar




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CBD News: Statement by Ahmed Djoghlaf, Executive Secretary, at the G8 Dialogue Series convened by the Institute of Advanced Studies of the United Nations University (UNU-IAS): "Climate Change and Biodiversity or the Unprecedented Planetary Environmen




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CBD News: Statement by Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, to the International Model Forest Network Global Forum - 16-21 June 2008 - Alberta, Canada.




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CBD News: Message from Mr. Ahmed djoghlaf, Executive Secretary, on the occasion of the World Day to Combat Desertification: Combating Land Degradation for Sustainable Agriculture.




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CBD News: Message from Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of World Refugee Day, 20 June 2008.




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CBD News: Statement by Executive Secretary, Ahmed Djoghlaf, on the occasion of the World Cities Summit, Singapore, 23-25 June 2008.




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CBD News: Message du Secrétaire exécutif Ahmed Djoghalf à l'occasion de la Conférence sur l'agriculture maghrébine: défis et perspectives Du 30 juin au 2 juillet 2008, Fès, Maroc.




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CBD News: Statement by the Executive Secretary, Ahmed Djoghlaf, at the Annual Ministerial Review of the High-level Segment of the 2008 Substantive Session of the Economic and Social Council, United Nations, New York, 1 July 2008




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CBD News: Message from the Executive Secretary, Ahmed Djoghlaf, on the Occasion of the Fourth International Conference on Sustainable Agriculture for Food, Energy and Industry, Sapporo, Japan, 2-5 July 2008




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CBD News: Déclaration de M. Ahmed Djoghlaf, Secrétaire exécutif, à l'occasion de la Conférence de haut niveau sur « L'Union Européenne et l'Outre-Mer : Stratégies face au changement climatique et 




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CBD News: Message of the Executive Secretary, Dr. Ahmed Djoghlaf, on the occasion of the Technical Workshop on Protected Areas in the Amazon, 14-16 July 2008, Amacayacú National Park, Colombia.




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CBD News: Innovative Green Wave/Airbus Partnership Takes Flight.




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CBD News: Message from Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity on the occasion of the International Day of the World's Indigenous Peoples, 9 August 2008.




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CBD News: Message from Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of International Youth Day, 12 August 2008.




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CBD News: Intervention du Dr. Ahmed Djoghlaf lors du Cycles de Conférences 2008 « Relever le défi de la Biodiversité » organisés par l'Institut de Formation de l'Environnement et le Ministère français de l&#




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CBD News: Message from Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of International Literacy Day, 08 September 2008.




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CBD News: Statement by the Executive Secretary Mr. Ahmed Djoghlaf on "Biological Diversity, Well-being and Sustainable Society" at the Sixth International Conference on Science and Technology for Sustainability 2008, 12 September 2008, Tokyo, Ja




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CBD News: Statement by the Executive Secretary Mr. Ahmed Djoghlaf on "Biodiversity challenges and responses: Towards the Nagoya Summit on Biodiversity" at the Sixteenth Environment Congress for Asia and the Pacific, 14 September 2008, Nagoya, Ja




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CBD News: Message from Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the World Habitat Day 06 October 2008.




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CBD News: Statement from Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the IUCN World Conservation Congress, Barcelona, 6 October 2008.




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CBD News: Intervention du Secrétaire exécutif M. Ahmed Djoghlaf à l'occasion de la Soirée francophone de l'Organisation internationale de la francophonieau Congrès mondial de la nature, 6 octobre 2008, Barcelone, Espagne.




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CBD News: Statement from Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity on the occasion of the High Level Roundtable on Local and Regional Authorities, IUCN World Conservation Congress, Barcelona, 7 October 2008.




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CBD News: "Meeting the 2010 biodiversity target: A contribution to poverty alleviation and the benefit of life on Earth", Statement by Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity at the IUCN World Conservati




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CBD News: "Sustainable Development: Which way next", Statement by Executive Secretary, Dr. Ahmed Djoghlaf, on the occasion of the Global Indian Diaspora Conference towards a Dynamic Indian Diaspora, Singapore, 9-11 October 2008.