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Glasgow Coma Scale on Presentation Predicts Outcome in Endovascular Treatment for Acute Posterior Large-Vessel Occlusion [INTERVENTIONAL]

SUMMARY:

Use of mechanical thrombectomy for stroke has increased since the publication of trials describing outcome improvement when used in the anterior circulation. These results, however, cannot be directly translated to the posterior circulation. While a high NIHSS score has demonstrated an association with poor outcomes in posterior stroke, the NIHSS is weighted toward hemispheric disease, and complex scores potentially delay definitive imaging diagnosis. We performed a retrospective analysis to ascertain whether any rapidly obtainable demographic or clinical and imaging data have a correlation with patient outcome postthrombectomy. Seventy-three cases were audited between September 2010 and October 2017. Presenting with a Glasgow Coma Scale score of >13 meant that the odds of reaching the primary end point of functional independence (defined as a 90-day modified Rankin Scale score of 0–2) were 5.70 times greater; similarly, presenting with a posterior circulation ASPECTS of >9 resulted in the odds of reaching the primary end point being 4.03 times greater. Older age correlated to a lower odds of independence (0.97, p = .04).




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MRI Vessel Wall Imaging after Intra-Arterial Treatment for Acute Ischemic Stroke [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Vessel wall imaging is increasingly performed in the diagnostic work-up of patients with ischemic stroke. The aim of this study was to compare vessel wall enhancement after intra-arterial thrombosuction with that in patients not treated with thrombosuction.

MATERIALS AND METHODS:

From 2009 to 2017, forty-nine patients with an ischemic stroke underwent 7T MR imaging within 3 months after symptom onset as part of a prospective intracranial vessel wall imaging study. Fourteen of these patients underwent intra-arterial treatment using thrombosuction (intra-arterial treatment group). In the intra-arterial treatment group, vessel walls were evaluated for major vessel wall changes. All patients underwent pre- and postcontrast vessel wall imaging to assess enhancing foci of the vessel wall using coregistered subtraction images. A Wilcoxon signed rank test was performed to test for differences.

RESULTS:

In the intra-arterial treatment group, 11 of 14 patients (79%) showed vessel wall enhancement compared with 17 of 35 patients without intra-arterial treatment (49%). In the intra-arterial treatment group, more enhancing foci were detected on the ipsilateral side (n = 18.5) compared with the contralateral side (n = 3, P = .005). Enhancement was more often concentric on the ipsilateral side (n = 8) compared with contralateral side (n = 0, P = .01). No differences were found in the group without intra-arterial treatment between the number and configuration of ipsilateral and contralateral enhancing foci.

CONCLUSIONS:

Patients with intra-arterial treatment by means of thrombosuction showed more (concentric) enhancing foci of the vessel wall ipsilateral compared with contralateral to the treated artery than the patients without intra-arterial treatment, suggesting reactive changes of the vessel wall. This finding should be taken into account when assessing vessel wall MR images in patients with stroke.




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Cho thuê phòng 70m2 có bể bơi tại resort 5 sao Naman Retreat từ ngày 1/6 - 7/6/2020 giá 1,5 triệu/ngày. Điện thoại liên hệ 0949183160....




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It's time to retreat from the tyranny of lockdown tech

People in lockdown are no longer trying to use technology to get their old lives back and that's a good thing, says Annalee Newitz




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RPGCast – Episode 485: “The Christmas Zone Treaty”

Happy Holidays! We wrap up the final podcast of the year affirming it's OK for Anna Marie to play casual games, even if Chris disagrees. While Josh and Kelley are making New Year's resolutions, Chris also disagrees about what should be a brief story. We'll see everyone in 2019!




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Obesity is linked to gut microbiota disturbance, but not among statin-treated individuals

Scientists set out to investigate a potential role of the gut microbiota in the development of cardio-metabolic diseases. They ended up identifying the common cholesterol-lowering drug statins as a potential microbiota-modulating therapeutic.




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Focused ultrasound opening brain to previously impossible treatments

Focused ultrasound, the researchers hope, could revolutionize treatment for conditions from Alzheimer's to epilepsy to brain tumors -- and even help repair the devastating damage caused by stroke.




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Most critically ill patients with COVID-19 survive with standard treatment, study reveals

Clinicians from two hospitals in Boston report that the majority of even the sickest patients with COVID-19 -- those who require ventilators in intensive care units -- get better when they receive existing guideline-supported treatment for respiratory failure.




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For better migraine treatment, try adding some downward dogs

Adding yoga to your regularly prescribed migraine treatment may be better than medication alone, according to a new study. The new research suggests yoga may help people with migraines have headaches that happen less often, don't last as long and are less painful.




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Novel way to treat snakebite

Scientists demonstrate a completely new way of treating snakebites. The team have shown that the repurposing of an existing medicine, commonly used to treat mercury poisoning, is an effective oral therapy for the treatment of certain hemotoxic snakebites.




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China approves Novartis' multiple sclerosis treatment Mayzent

BEIJING (Reuters) - Chinese regulators have approved Novartis' Mayzent to treat relapsing multiple sclerosis in adults, the Swiss drug maker said in a statement on Saturday. Other drugs approved by China's National Medical Products Administration to treat MS include Novartis' Gilenya, Bayer's Betaferon and Sanofi's Aubagio. China has an estimated 30,000 patients with MS. (Reporting by Roxanne Liu and Kevin Yao in Beijing; Editing by Edwina Gibbs





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Hepatitis C infection rates are being cut by testing and treatment

The infection is being eliminated as a public health threat by countries that introduce widespread testing and treatment for those at risk




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Coronavirus treatment: What drugs could work and when can we get them?

To fight the new coronavirus, researchers are investigating more than 60 drugs, including remdesivir and hydroxychloroquine and brand new ones. Here’s a breakdown of progress so far




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What would a game-changing treatment for coronavirus look like?

Even if we find drugs that are effective against the coronavirus, that doesn't necessarily mean they will change the wider situation and help end lockdowns




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Electrical devices implanted in the brain may help treat anorexia

In a small trial, implanting electrodes into the brain helped women with severe anorexia gain weight and feel less anxious and depressed




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Even for Bill Barr, the DOJ's treatment of Michael Flynn is a corrupt new low

There is absolutely no legitimate basis in law or in fact to dismiss Flynn’s guilty plea.




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How Evolution Helps Us Understand and Treat Cancer

A new book argues that controlling cancer is within reach if scientists are able to anticipate the evolution of resistance to traditional treatments




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Accurate 3D imaging of sperm cells moving at top speed could improve IVF treatments

Researchers have developed a safe and accurate 3D imaging method to identify sperm cells moving at a high speed. The new method has the potential to significantly improve IVF treatments.




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Belgian, U.S. scientists look to llama in search for COVID-19 treatment

A llama called Winter could prove useful in the hunt for a treatment for COVID-19, according to U.S. and Belgian scientists who have identified a tiny particle that appears to block the new coronavirus.




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Boris Johnson 'watching Withnail and I and playing sudoku' in hospital while being treated for coronavirus

Read our live coronavirus updates HERE




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War veteran, 99, applauded out of hospital after being successfully treated for Covid-19

Follow our live coronavirus updates HERE Coronavirus: the symptoms




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Parents of NHS nurse from New Zealand who treated Boris Johnson 'exceptionally proud' of daughter

Follow our live updates here Coronavirus: the symptoms




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Nurse who treated Boris Johnson 'thought he'd done something wrong' when he was urgently called back to work

Follow our live Covid-19 updates HERE Coronavirus: The symptoms




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Ten US nurses 'suspended after refusing to treat patients without face masks'

Follow our live coronavirus updates HERE Coronavirus: The symptoms




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NHS medics fear life or death decisions in treating coronavirus patients amid PPE row

RAF plane still awaiting go-ahead for flight to Turkey to collect supplies




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NHS staff asked to treat Covid-19 patients without gowns amid 'critical' PPE shortage

NHS doctors and nurses on the frontline are now being asked to treat coronavirus patients without full-length gowns if necessary, ahead of expected shortages.




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Adverts for IV drips claiming to treat Covid-19 banned by watchdog

Adverts promoting IV drips that claimed to boost patients' immunity to Covid-19 have been banned by the advertising watchdog.




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Woman being treated for coronavirus symptoms 'spat at and threw contents of sick bowl over nurse'

A woman allegedly spat at and threw the contents of a sick bowl over a nurse while being treated for Covid-19 symptoms.




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Boris Johnson's ICU nurse Jenny McGee reveals she thought it was a joke when he praised her as she speaks for first time about treating him for coronavirus

A nurse from New Zealand who cared for Boris Johnson as he battled coronavirus says he "absolutely needed" intensive care treatment after his symptoms worsened.




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Trump bizarrely suggests injecting disinfectant as coronavirus treatment before experts quickly debunk claim

Donald Trump has told a coronavirus press conference that the idea of injecting Covid-19 patients with disinfectant "sounds interesting to me".




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Do NOT try injecting disinfectant as coronavirus treatment, Dettol warns following Donald Trump suggestion

Disinfectants must never be injected, the company which makes Dettol has stressed, after Donald Trump mused on its potential as a treatment for coronavirus.




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Donald Trump says his remarks on injecting disinfectant to treat coronavirus were 'sarcastic'

Donald Trump has said his remarks on injecting disinfectant to treat coronavirus were "sarcastic".




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Blood plasma trial could lead to treatment for thousands of NHS coronavirus patients




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Labour leader Sir Keir Starmer steps up demand for lockdown 'exit strategy': the British public deserve to be treated like adults

Labour leader Sir Keir Starmer has called for a coronavirus lockdown "exit strategy" with the Government facing increasing pressure to reveal its next steps.




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Streatham crash: Woman in her 80s fighting for life after being hit by van in front of shocked witnesses

A woman in her 80s is fighting for her life after she was hit by a van in front of shocked onlookers on a major south London road.




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Trump blasted by medical experts over call for study of disinfectant injections to treat virus

Medical experts have hit out at Donald Trump after he suggested that research should be carried out into whether the coronavirus might be treated by injecting disinfectant into the body.




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Drug trial gives hope for treatment of coronavirus as global study sees patient recovery time reduced

A drug used to treat Ebola patients has shown "very promising" early results in a trial of people admitted to hospital with coronavirus.




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UK to trial new blood plasma coronavirus treatment as US approves use of Ebola drug to fight Covid-19

The United States has authorised the emergency use of the Ebola drug remdesivir for treating coronavirus, clearing the way for the potential treatment of 140,000 patients around the country.




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Oxygen almost ran out at first NHS trust to treat Covid patients

The hospital trust that treated London's first coronavirus cases almost ran out of oxygen as hundreds of patients fought for their lives, it can be revealed.




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More than 40 children treated in London for 'hyper inflammatory new disease after seemingly contracting coronavirus'

More than 40 children have been treated in a specialist London hospital for a "hyper inflammatory" new disease after apparently contracting coronavirus, the Standard has been told.




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Streatham crash: Cyclist, 16, fighting for life after 'double hit-and-run' in south London





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Coronavirus: Researchers 'a few weeks away' from concluding clinical trials of treatment

Australian scientists also working to evaluate extent of immunity to virus among public




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Doctors fear serious conditions could go untreated

Doctors are worried that with routine operations cancelled or postponed - and people frightened to come near hospitals - serious conditions could go untreated or undiagnosed.





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Val Kilmer opens up about cancer treatment that lost him the use of his voice

Kilmer, a follower of Christian Science calls it: the “suggestion of throat cancer.”




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Dentists warn 'desperate' people will try 'DIY dentistry' if the government doesn't give access to emergency treatment

'It's inevitable many desperate patients will resort to 'DIY dentistry'




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Boris Johnson discharged from hospital as fiancee Carrie Symonds hails 'magnificent' NHS and reveals 'dark times' during PM's treatment

Follow our live coronavirus updates HERE Fiancee Carrie Symonds said: "There were times last week that were very dark indeed"




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Boris Johnson tested negative for Covid-19 after needing 'significant level of treatment' to overcome coronavirus

The PM's spokesman confirmed Boris Johnson has tested negative for Covid-19 Coronavirus: the symptoms Follow our live coronavirus updates here




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Hydroxychloroquine still being used to treat coronavirus

Hydroxychloroquine, the much-touted, much-maligned drug initially championed by President Trump as a “game changer” against the coronavirus, but which was later shown to have potential risks to patients, is still being used to combat the pandemic in hospitals across the country.