A look at the results of fDi’s rankings throughout 2019 finds that Singapore and New York dominated the year’s league tables, followed by Shanghai, Tokyo and London

This GFN Thursday, the GeForce NOW Priority membership is getting enhancements and a fresh name to go along with it. The new Performance membership offers more GeForce-powered premium gaming — at no change in the monthly membership cost. Gamers having a hard time deciding between the Performance and Ultimate memberships can take them both for Read Article

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

HAVANA — Rafael strengthened Wednesday into a powerful Category 3 hurricane ahead of its expected landfall in western Cuba, where it was forecast to bring "life-threatening" storm surges, winds and flash floods.  The storm, which knocked out power and dumped rain on the Cayman Islands and Jamaica, is expected to hit the Isle of Youth in the coming hours and make landfall later on Wednesday.  Classes and public transport were suspended on parts of the island as authorities issued an alarm for the incoming weather for the west of the country. Workers secured buildings and cleaned up garbage along Havana's coastline in preparation for floods. Authorities also canceled flights in certain areas like Havana and Varadero. Thousands of people in the west of the island were evacuated as a prevention measure.  "Preparations to protect life and property should be rushed to completion," warned the National Hurricane Center in Miami.  The storm was located about 65 kilometers (40 miles) east-southeast of the Isle of Youth and around 135 kilometers (84 miles) south-southeast of Havana. It had maximum sustained winds of 185 kph (115 mph) and was moving northwest at 22 kph (14 mph), according to the National Hurricane Center in Miami.  Forecasters expected the storm to later weaken over Cuba, but emerge in the southeastern Gulf of Mexico as a hurricane.  Cubans have already been struggling with blackouts while recovering from another hurricane two weeks ago that killed at least six people in the eastern part of the island.  The U.S. State Department issued an advisory for Cuba on Tuesday afternoon, offering departure flights to non-essential staff and American citizens, and advising others to "reconsider travel to Cuba due to the potential impact of Tropical Storm Rafael."  On Tuesday morning, the Cuban Civil Defense called on Cubans to prepare as soon as possible, because when the storm makes landfall "it's important to stay where you are."  Silvia Perez, a 72-year-old retiree living in a coastal area of Havana, was among those scrambling to prepare. As other neighbors moved appliances and other furniture from ground floor homes, worried about floods, Perez stocked up on water and food.  "This is a night I don't want to sleep through, between the battering air and the trees," Perez said. "I'm scared for my friends and family."  A hurricane warning was in effect on Wednesday for a portion of the Cayman Islands and the Cuban provinces of Pinar del Rio, Artemisa, La Habana, Mayabeque, Matanzas and the Isle of Youth.  A tropical storm warning was in effect for the Cuban provinces of Villa Clara, Cienfuegos, Sancti Spiritus and Ciego de Avila, as well as the lower and middle Florida Keys from Key West to west of the Channel 5 Bridge, and Dry Tortugas.  The storm on Tuesday knocked out power in parts of Jamaica and unleashed flooding and landslides. The Jamaica Public Service, the island's electricity provider, said in a statement late Tuesday that impassable roads were preventing crews from restoring power in some areas.  Power outages were reported across the Cayman Islands after a direct hit late Tuesday, and schools remained closed on Wednesday.  "While conditions have improved on Grand Cayman, residents are advised to exercise extreme caution on the roads and near coastlines as rough seas and residual flooding risks may persist," the government said in a statement.  Heavy rainfall also was expected to spread north into Florida and nearby areas of the southeast U.S. during the middle to late part of the week. The Hurricane Center predicted storm surges in Florida could reach 1 to 3 feet in Dry Tortugas and 1 to 2 feet in the Lower Florida Keys. A few tornadoes also were expected Wednesday over the Keys and southwestern Florida.  Rafael is the 17th named storm of the season.  The National Oceanic and Atmospheric Administration predicted the 2024 hurricane season was likely to be well above average, with between 17 and 25 named storms. The forecast called for as many as 13 hurricanes and four major hurricanes.  An average Atlantic hurricane season produces 14 named storms, seven of them hurricanes and three major hurricanes. 

[Dabanga] Airstrikes killed dozens and injured others in Nyala and neighbouring Beleil in South Darfur and Mellit, El Koma, and Kabkabiya in North Darfur on Saturday and Sunday, according to a Radio Dabanga listener. Multiple political actors and groups have condemned the "random" air raids.

Females perform better than males • Malta’s computer literacy score is within international average for computer literacy and substantially below average in computational thinking

Australia is a case study for how the West prioritizes fossil fuels and military intervention over developing alternative energy and regional accord.

Online gambling platforms are always open, meaning you can gamble when you feel like it

This paper examines enterprise performance in the North-East region of the People's Republic of China.

This paper is part of a cross-country study on corporate governance in Asia. A consensus has yet to be reached about exactly what factors were behind the crisis of 1998 and how these factors interacted in bringing about the crisis.

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This brief shows how India sparked a digital payments boom and boosted financial inclusion through the introduction of its Unified Payments Interface (UPI) and outlines ways countries in the region can ramp up their own digital transformation.

Two nankeen kestrels have been filmed flying in a wind tunnel to learn how the raptors keep their heads in a fixed position under turbulent conditions

Experiments show that illuminating the underside of a decoy seal reduces attacks by great white sharks, revealing a possible strategy to protect surfers and swimmers

Our arm of the Milky Way is filled with older, metal-rich stars. New research suggests these might provide the best conditions for life to form on their planets

The lifestyle choices you make in middle age play a particularly important role in how your brain ages

The Linac Coherent Light Source in California fired an X-ray pulse that lasted only a few hundred billionths of a billionth of a second but carried nearly a terawatt of power

When I heard Stephen Hawking extol the mysteries of black holes, I knew theoretical physics was what I wanted to do. There is still so much to learn about these strange regions, says Chanda Prescod-Weinstein

Droplets of fluid have been known to hover above a hot surface, but a new experiment suggests the same can happen to tiny jets of liquid too

A small world in the outer solar system appears to have volcanic activity possibly spurred by liquid water

Experiments show that illuminating the underside of a decoy seal reduces attacks by great white sharks, revealing a possible strategy to protect surfers and swimmers

Droplets of fluid have been known to hover above a hot surface, but a new experiment suggests the same can happen to tiny jets of liquid too

Title: Good Nutrition Can Boost School Performance, Expert Says
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Title: Rheumatoid Factor (RF)
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Category: Health News
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Objective:

In this study, we sought to comprehensively evaluate GPT-4 (Generative Pre-trained Transformer)’s performance on the 2022 American Board of Family Medicine’s (ABFM) In-Training Examination (ITE), compared with its predecessor, GPT-3.5, and the national family residents’ performance on the same examination.

The world of cancer science is moving toward a paradigm shift in making connections with neuroscience. After decades of research on genetic instability and mutations or on the tumor microenvironment, emerging evidence suggests that a malignant tumor is able to hijack and use the brain and its network of peripheral and central neurons as disrupters of homeostasis in the body. Whole-body homeostasis requires brain–body circuits to maintain survival and health via the processes of interoception, immunoception, and nociception. It is now likely that cancer disturbs physiological brain–body communication in making bidirectional brain tumor connections.

Our approaches toward understanding cancer have evolved beyond cell-intrinsic and local microenvironmental changes within the tumor to encompass how the cancer interfaces with the entire host organism. The nervous system is uniquely situated at the interface between the brain and body, constantly receiving and sending signals back and forth to maintain homeostasis and respond to salient stimuli. It is becoming clear that various cancers disrupt this dialog between the brain and body via both neuronal and humoral routes, leading to aberrant brain activity and accelerated disease. In this outlook, I discuss this view of cancer as a homeostatic challenge, emphasize cutting-edge work, and provide outstanding questions that need to be answered to move the field forward.

Introduction

Exacerbation of COPD complicated by respiratory acidaemia is the commonest indication for noninvasive ventilation (NIV). The NIV outcomes (NIVO) score offers the best estimate of survival for those ventilated. Unfortunately, two-thirds of cases of COPD are unrecognised, and patients may present without COPD having been confirmed by spirometry.

In this study, the nonclinical pharmacokinetics of OLX702A-075-16, an RNA interference therapeutic currently in development, were investigated. OLX702A-075-16 is a novel N-acetylgalactosamine conjugated asymmetric small-interfering RNA (GalNAc-asiRNA) used for the treatment of an undisclosed liver disease. Its unique 16/21-mer asymmetric structure reduces nonspecific off-target effects without compromising efficacy. We investigated the plasma concentration, tissue distribution, metabolism, and renal excretion of OLX702A-075-16 following a subcutaneous administration in mice and rats. For bioanalysis, high-performance liquid chromatography with fluorescence detection was used. The results showed rapid clearance from plasma (0.5 to 1.5 hours of half-life) and predominant distribution to the liver and/or kidney. Less than 1% of the liver concentration of OLX702A-075-16 was detected in the other tissues. Metabolite profiling using liquid chromatography coupled with high-resolution mass spectrometry revealed that the intact duplex OLX702A-075-16 was the major compound in plasma. The GalNAc moiety was predominantly metabolized from the sense strand in the liver, with the unconjugated sense strand of OLX702A-075-16 accounting for more than 95% of the total exposure in the rat liver. Meanwhile, the antisense strand was metabolized by the sequential loss of nucleotides from the 3'-terminus by exonuclease, with the rat liver samples yielding the most diverse truncated forms of metabolites. Urinary excretion over 96 hours was less than 1% of the administered dose in rats. High plasma protein binding of OLX702A-075-16 likely inhibited its clearance through renal filtration.

A STING (stimulator of interferon genes) agonist GSK3996915 under investigation in early discovery for hepatitis B was orally dosed to a mouse model for understanding the parent drug distribution in liver, the target organ. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) was used to quantify the distribution of GSK3996915 in liver collected from mice administered a single oral dose at 90 mg/kg. GSK3996915 was detected with a zonal distribution localized in the portal triad and highly concentrated in the main bile ducts, indicating clearance through biliary excretion. High spatial resolution imaging showed the distribution of the parent drug localized to the cellular populations in the sinusoids, including the Kupffer cells. Additionally, a series of drug-related metabolites were observed to be localized in the central zones of the liver. These results exemplify the potential of utilizing MALDI IMS for measuring not only quantitative drug distribution and target exposure but also drug metabolism and elimination in a single suite of experiments.

The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. Methods: The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). Results: The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5–4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23–2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56–4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101–400 (unadjusted HR, 3.09; 95% CI, 2.57–3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41–6.05) were at increased risk of MACEs. Conclusion: The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging.

BACKGROUND AND PURPOSE:

Hemangioblastoma is a rare vascular tumor that occurs within the central nervous system in children. Differentiating hemangioblastoma from other posterior fossa tumors can be challenging on imaging, and preoperative diagnosis can change the neurosurgical approach. We hypothesize that a "lightbulb sign" on the arterial spin-labeling (ASL) sequence (diffuse homogeneous intense hyperperfusion within the solid component of the tumor) will provide additional imaging finding to differentiate hemangioblastoma from other posterior fossa tumors.