Although the progressive histologic steps leading to endometrial cancer (EndoCA), the most common female reproductive tract malignancy, from endometrial hyperplasia are well-established, the molecular changes accompanying this malignant transformation in a single patient have never been described. We had the unique opportunity to investigate the paired histologic and molecular features associated with the 12-yr development of EndoCA in a postmenopausal female who could not undergo hysterectomy and instead underwent progesterone treatment. Using a specially designed 58-gene next-generation sequencing panel, we analyzed a total of 10 sequential biopsy samples collected over this time frame. A total of eight pathogenic/likely pathogenic mutations in seven genes, APC, ARID1A, CTNNB1, CDKN2A, KRAS, PTEN, and TP53, were identified. A PTEN nonsense mutation p.W111* was present in all samples analyzed except histologically normal endometrium. Apart from this PTEN mutation, the only other recurrent mutation was KRAS G12D, which was present in six biopsy samplings, including histologically normal tissue obtained at the patient's first visit but not detectable in the cancer. The PTEN p.W111* mutant allele fractions were lowest in benign, inactive endometrial glands (0.7%), highest in adenocarcinoma (36.9%), and, notably, were always markedly reduced following progesterone treatment. To our knowledge, this report provides the first molecular characterization of EndoCA development in a single patient. A single PTEN mutation was present throughout the 12 years of cancer development. Importantly, and with potential significance toward medical and nonsurgical management of EndoCA, progesterone treatments were consistently noted to markedly decrease PTEN mutant allele fractions to precancerous levels.

PURPOSE

We undertook a trial to test the efficacy of a technology-assisted health coaching intervention for weight management, called Goals for Eating and Moving (GEM), within primary care.

Lung cancer is one of the leading causes of death worldwide. It can broadly be divided into small cell lung cancer (SCLC) and nonsmall cell lung cancer. There have been many advances over the recent years in both fields. The purpose of this review is to provide a concise summary of SCLC for the general respiratory readership.

Cassian's on a new mission to steal a familiar ship in the next season of his self-titled Star Wars show.

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HARI SREENIVASAN: The desire of the Kurds along Iraq’s northern border to govern themselves is receiving more resistance from Iraq’s central government. Iraqi army forces are demanding Kurdish troops withdraw from oil fields and military bases around Kirkuk, a city in the Kurdistan region that voted for independence last month. Kirkuk also has 10% of Iraq’s known oil reserves. Washington Post’s Loveday Morris is in Baghdad covering this standoff joins me now via Skype. First of all the significance of this. Why is it so important?

LOVEDAY MORRIS: There’s been a longtime conflict between Baghdad and Kurdistan over these disputed territories. Most significant of which is Kirkuk because of the oil reserves. But the referendum last month has really sharpened these disputes because you have Baghdad opposing independence and so it feels like they have to restate its territorial claims these areas. So that’s why we’re seeing a lot of tension right now.

HARI SREENIVASAN: And just to give people a little bit of a brief timeline – Iraqi forces control this area for a while and then in June ISIS took over the area and now it’s kind of back in Kurdish hands?

LOVEDAY MORRIS: Right. So in June 2014 Iraq lost control of a lot of the areas and we have this huge collapse in the face of an ISIS offensive. Over 100,000 soldiers fled and Kurdish forces moved in some of these areas – some of them maybe took from ISIS and others just moved into into the vacuum. And so Iraqi forces have been in these areas since June 2014. And that’s their main demand that they return to the areas.

HARI SREENIVASAN: What’s the likelihood that this standoff right now turns violent? Into some sort of a civil war?

LOVEDAY MORRIS:: I think at this point both sides don’t want violence. Al-Abadi, the prime minister, is really trying to defuse the situation by saying there’s going to be no military attack. But at the same time there is this buildup of forces so that I think they are trying to, in a way, intimidate the Kurds to withdraw from some areas but they don’t want to see a fight per say. But in this really tense situation there can be a small spark and things can turn violent quite easily.

HARI SREENIVASAN: Thank you.

The post Iraqi, Kurdish forces in standoff, weeks after Kurdish vote for independence appeared first on PBS NewsHour.

On this week's show, Chris is going through his failed Kickstarters; Anna Marie is off banging a ghost, which was fun; Kelley is collecting wheels of cheese in Skyrim; Josh is lookin' fly in his Yakuza shoes; and Alex wonders why he didn't just skip this week and write more E3 stories.

The post RPG Cast – Episode 588: “Nintendo Leaked Themselves” appeared first on RPGamer.

Kelley is the master of the hunting horn. Chris is too old to play Solid Snake. Robert only steals from old people. And Ryan stuffs all the kids into the cannon.

The post RPG Cast – Episode 667: “Nintendo Has an Animal Crossing Jail?” appeared first on RPGamer.

Nintendo and The Pokémon Company in September filed a patent infringement lawsuit against Palworld developer Pocketpair. 

At the time Nintendo did not share which patents Palworld infringed on, however, Pocketpair has now revealed what patents Nintendo are claiming were infringed on.

"As announced on September 19, 2024, The Pokémon Company and Nintendo Co Ltd (hereinafter referred to as the Plaintiffs) have filed a patent infringement lawsuit against us," said Pocketpair. "We have received inquiries from various media outlets regarding the status of the lawsuit, and we would like to report the details and current status of this case as follows.

"The Plaintiffs claim that Palworld, released by us on January 19, 2024, infringes upon the following three patents held by the Plaintiffs, and are seeking an injunction against the game and compensation for a portion of the damages incurred between the date of registration of the patents and the date of filing of this lawsuit."

Nintendo and The Pokémon Company are each seeking an injunction and damages of five million yen plus late payment damages.

Pocketpair added, "We will continue to assert our position in this case through future legal proceedings. Please note that we will refrain from responding individually to inquiries regarding this case. If any matters arise that require public notice, we will announce them on our website, etc."

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463022/nintendo-and-the-pokemon-company-seeking-injunction-and-damages-from-pocketpair/

Nintendo announced it will host a Super Nintendo World Direct livestream on Monday, November 11 at 2:00 pm PT / 5:00 pm ET. You will be able to watch it on YouTube.

The Direct will be roughly 10 minutes and feature the Donkey Kong Country area of Super Nintendo World at Universal Studios Japan.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463031/super-nintendo-world-direct-set-for-november-11/

Nintendo today hosted a Super Nintendo World Direct livestream that featured Shigeru Miyamoto giving a deep dive look into the Donkey Kong Country-themed land.

The new land will feature a family roller coaster, called Mine-Cart Madness, congas you can hit to a rhythm, letters that can found throughout the land that can be scanned on the new Donkey Kong Power-Up Band, character meet and greets, and new food options.

Donkey Kong Country will open at Universal Studios Japan on December 11, 2024, and will also be a part of Super Nintendo World at Epic Universe in Florida when the theme park opens in May 2025.

View the Direct below:

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463038/super-nintendo-world-direct-dives-into-the-donkey-kong-country-themed-land/

Nintendo has announced its Black Friday 2024 deals. 

Dozens of games will be discounted including The Legend of Zelda: Tears of the Kingdom, Super Mario Maker 2, Animal Crossing: New Horizons, Pikmin 4, Nintendo Switch Sports, Kirby and the Forgotten Land, Super Mario Odyssey, Pikmin 1 + 2, and more.

The Neon Red and Neon Blue Joy-Con controllers and the Nintendo Switch Pro Controller will be discounted by $20, while the Nintendo Switch Carrying Case & Screen Protector - The Legend of Zelda: Tears of the Kingdom Edition will be discounted by $10.

The Nintendo Switch: Mario Kart 8 Deluxe Bundle will once again return for $299.99, while the new Nintendo Switch – OLED Model: Mario Kart 8 Deluxe Bundle will be available for $349.99. Both bundles include a digital download of Mario Kart 8 Deluxe and a 12-month Nintendo Switch Online Individual Membership.

The Nintendo Switch Lite: Hyrule Edition with Bonus Nintendo Switch Online + Expansion Pack will be available for $209.99. The bundle includes a 12-month Nintendo Switch Online + Expansion Pack Individual Membership.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463045/nintendos-black-friday-2024-deals-revealed/

Palworld developers Pocketpair have finally revealed which patents Nintendo and the Pokémon Company are suing them about. It looks like they're focusing on the act of throwing capsular items to catch or release monsters, together with the usage of monsters as mounts.

If you've somehow yet to encounter Palworld, it's a bestselling survival game that takes hefty - some would say, scandalous - inspiration from Pokémon, with players poaching Pokésque critters using magic spheres, and deploying them as soldiers and minions.

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The books, TV, games and more that New Scientist staff have enjoyed this week

Archaeologists have discovered a "remarkable" section of one of Britain's most important Roman roads in southeast London.

Ryzen and Epyc chips have two main issues; L3 cache latency, and 'preferred core' tech.

An intricate atlas of the inner lining of the uterus could help researchers better understand conditions like endometriosis, infertility and abnormal menstruation

A chemical produced by gut bacteria could be the basis for a non-invasive test for endometriosis – and mouse experiments suggest it might also help treat the condition

Senate Republicans met on Tuesday night to hear from the three candidates to succeed Mitch McConnell, and Rick Scott left with two new endorsements.

Home users can opt in for a single year of updates at $30 per PC—not 3 years.

Microsoft works to make Recall "secure and trusted" after security complaints.

In today’s complex business environment, organizations rely heavily on external vendors for essential services and resources. Managing these relationships effectively is crucial for operational efficiency, cost control, and risk management. To achieve this, many companies turn to Vendor Management Software to streamline vendor interactions, ensuring that the right processes and tools are in place for […]

The post Optimizing Vendor Portfolio with Vendor Management Software appeared first on Chart Attack.

Whoopi Goldberg told her co-hosts Tuesday on ABC's "The View" that she agrees with Vice President Kamala Harris voters who want to avoid family members who voted for President-elect Donald Trump during the holidays.

The post Whoopi Goldberg Endorses Harris Voters Avoiding Holidays with Trump-Supporting Family — ‘It Might Not Be the Time to Gather’ appeared first on Breitbart.

Hours after mischief charges were dropped against a London, Ont., doctor who protested the Liberal government’s Israel policy by squirting ketchup at a member of parliament’s constituency office, Dr. Tarek Loubani repeated the protest.

Work on Asahi's Vulkan GPU driver and various translation layers is paying off.

Now is the time to check out this free total conversion of Fallout 4.

Subscription music app gives Nintendo new reason to crack down on third-party music uploads.

"More software has been played on Nintendo Switch than on any other Nintendo hardware."

Los Angeles Dodgers star Shohei Ohtani is a finalist for his first National League MVP award after winning the AL honor twice, joined among the top three in NL voting by New York Mets shortstop Francisco Lindor and Arizona second baseman Ketel Marte.

For our next dive into the retro games available on Switch, we’re going all the way back to 1989. Er, …

Continue reading "The 10 Best Game Boy and Game Boy Color Games on Nintendo Switch, Plus 5 We’d Like to See – SwitchArcade Special"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 27th, 2024. In today’s article, we kick things off …

Continue reading "SwitchArcade Round-Up: Today’s Nintendo Direct, Full Review of ‘EGGCONSOLE Star Trader’, Plus New Releases and Sales"

About two and a half years ago we were treated to a lovely gaming experience titled Dungeons of Dreadrock from …

Continue reading "‘Dungeons of Dreadrock 2’ Announced, Launching on Nintendo Switch in November with Mobile and PC Versions to Follow"

In our tour through retro games available to buy on Switch, we’ve worked our way through the NES, Game Boy, …

Continue reading "The 10 Best Super NES Games on Nintendo Switch, Plus 5 We’d Like to See – SwitchArcade Special"

It’s that time again: eShop sale time! Nintendo’s calling this one the Blockbuster Sale, so I’m sure we can expect …

Continue reading "The Best Nintendo Switch eShop Sales From The ‘Blockbuster Sale’"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for September 2nd, 2024. I think it’s a holiday today in …

Continue reading "SwitchArcade Round-Up: Reviews Featuring ‘Bakeru’ & ‘Peglin’, Plus Highlights From Nintendo’s Blockbuster Sale"

In the latest look at retro game offerings on the Nintendo Switch, I’ve opted to take a different approach. You …

Continue reading "The 10 Best Game Boy Advance & Nintendo DS Games on Nintendo Switch – SwitchArcade Special"

Well here it is, friends. This will be the last of my retro game eShop lists, mostly because I am …

Continue reading "The 10 Best PlayStation 1 Games on Nintendo Switch – SwitchArcade Special"

Indonesia's National Disaster Management Agency said Monday that at least 10 people have died as a series of volcanic eruptions widens on the remote island of Flores.

Rachelle and Kelly Swan bought their house in Spiritwood two years ago. They gave up their keys to the bank voluntarily in May, closing the door on the bat-infested house.  

Nintendo has filed a lawsuit against a streamer called EveryGameGuru, accused of streaming gameplays of pirated games before they were even released — and of providing viewers access to piracy tools and illegal copies of the games.

EveryGameGuru allegedly streamed Mario & Luigi: Brothership across five days, weeks before its official release on November 7. After Nintendo had the videos taken down from various platforms, including YouTube, they continued live streaming on Loco and even included a QR code for their CashApp handle.

Nintendo said EveryGameGuru sent the company an email, saying it has “a thousand burner channels” and “can do this all day.”

Don’t anger the house of Mario! The company is asking for $150,000 in damages per violation of its copyright. 404media did the math: That could add up to millions, seeing as the suit cites at least 10 games, streamed on at least 50 occasions.

— Mat Smith

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Sony has sold 65 million PS5s

Andor season two will hit Disney+ in April

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HTC Vive Focus Vision review

An average-performing premium VR headset.

Sure, it’s not for most of us. The Vive Focus Vision isn’t for the same people as the PSVR2 or Meta Quest 3. This is meant to be high-end VR for businesses and creators: a cross between the Focus 3 and last year’s goggle-like XR Elite. The build quality is excellent, but it’s running on aging hardware. Worse, it’s riddled with software issues and is rather expensive compared to the Meta Quest 3.

Continue reading.

The voice of AOL’s You’ve got mail! dies aged 74

He recorded four phrases for $200 in 1989.

If you’re aged 30 and up, you know the voice of Elwood Edwards, realize it or not. He recorded the phrase, “You’ve got mail!” and three other lines for Quantum Computer Services in 1989. That company became America Online (AOL), Meg Ryan made the movie with Tom Hanks and everything else. (AOL is currently owned by Yahoo, Engadget’s parent company.)

Continue reading.

Latest God of War Ragnarok patch tells the son to be quiet

It reduces all the hints from Kratos’ offspring.

The latest patch for the PS5 version of God of War Ragnarok adds the option first seen in the PC port to tone down the boy’s excessive and unsolicited hints when Kratos is contemplating the game’s many puzzles. Enough, Atreus! (The patch also includes PS5 Pro upgrades, for smooth 60 fps and better visuals. But that’s not as funny.)

Continue reading.

Nintendo is set to show off the Donkey Kong Country expansion of its Super Nintendo World theme park today (Monday, November 11) at 5PM ET, the company revealed in a post on X. That means the new Universal Studios Japan area might finally open soon, after being delayed from the previously announced launch window of Spring 2024. 

The new park attraction featuring Mario's barrel-throwing nemesis was first revealed in 2021. The centerpiece is a ride called Mine Cart Madness, named after the best level in the 1994 SNES game Donkey Kong Country. After being blasted out of a barrel cannon, you'll take a mine cart ride through the jungle that includes a "leap across a collapsed track" as Nintendo showed in a render earlier this year.  

The direct livestream appears to be focused on Donkey Kong world alone, and Nintendo specifically pointed out that "no game information will be featured" — so don't expect any news on the next-gen Switch 2 console either. 

Donkey Kong Country will expand the park size by up to 70 percent, Nintendo said when it was announced. Current attractions at the Japan park are the Mario Kart: Kuppa's Challenge rollercoaster and Yoshi Adventure. Nintendo recently announced that it would open a Super Nintendo World attraction at Universal Studios Orlando on May 22nd, 2025 with the same attractions as the park in Osaka. 

As the world turns, so do the console generations. The Nintendo Switch is over seven years old, so it’s due for a refresh. Nintendo Switch 2 rumors have been swirling for years, but now they are really heating up. A sequel to Nintendo's most successful home console ever is coming and it’s likely coming sooner rather than later.

Will it be a straight up sequel to the Switch with updated specs while retaining the same hybrid functionality or will Nintendo get weird with it? Will it even be called the Switch 2, or will the company go with something like the Super Switch or even the New Nintendo Switch? You can never tell with Nintendo. Heck, maybe it’ll call the thing the Switch U.

In any event, recent weeks have brought feverish speculation regarding all aspects of the forthcoming gaming console. It’s important to note, however, that very little information has been confirmed by Nintendo. The company operates on its own timetable. With that said, here are all of the rumors that are most likely to come true, given industry analysis.

When will the Nintendo Switch 2 be announced?

As previously mentioned, Nintendo marches to the beat of its own drum. We don’t exactly know when it’ll hold an event to reveal the console. It likely won't be in 2024, as the tech year is winding down and it's rare to get announcements of new harder in late November and December. 

Even Nintendo has trouble keeping the lid on a major console release, so we could learn something before the official reveal. There are parts that have to be sourced and shipments that have to be made. A senior analyst at MST Financial noted a spike in production equipment spending by Nintendo assembler Hosiden.

When will the Nintendo Switch 2 come out?

Once again, this is more or less a mystery. We aren’t totally in the dark, but it’s mostly rumor and speculation. One thing we know for sure is that Nintendo will announce the Nintendo Switch 2 (or whatever it chooses to call it) by March 2025, as the company confirmed back in May. Some are saying there will be a March release date, which makes sense given the OG Switch came out on March 17, 2017. However, other reports put the console’s release window later in 2025.

We can infer a lot from the announcement date. If the console is announced this year, March would be a safe bet, given that the original Switch was officially confirmed in October of 2016. However, the console likely won't be announced until next year, at this point, so expect a late 2025 release. 

Will it even be a proper Switch sequel?

Nintendo has a weird track record here. The baffling Wii U followed the massive success of the Wii. The Wii itself followed the more traditional GameCube. In other words, it’s possible it’ll be something out of left field and not exactly a true sequel to the Switch. However, this is unlikely this time around. As much as I would love to see wacky VR glasses or a completely bonkers console concept, all points indicate a more traditional approach.

Developers have already seen the hardware, though in a much earlier form, and it seems to be a regular old console. While Nintendo hasn't confirmed hybrid functionality, it’d be a weird omission given the absolute financial firestorm of the Switch. We’ve also heard rumors of a Mini-LED display, which would track for a hybrid console. It’s highly likely this will be a straight-up Switch 2, or something like it, calling to mind the Super Nintendo.

To that end, recent rumors suggest a design that recalls the original Switch. According to reporting by VGC, photos of the console have appeared online and they show an 8-inch screen and magnetic Joy-Con controllers. There looks to be SL/SR buttons and front-facing player LEDs on these controllers. 

Is the Nintendo Switch 2 backwards compatible?

If it’s a sequel to the Switch, the next question has to be about backwards compatibility. The Switch’s library is absolutely massive, and continues to grow, so gamers would be rightfully peeved if they couldn’t play Tears of the Kingdom on their new next-gen console. There’s good news on this front.

The company has officially announced in a recent earnings report that the console will be fully backwards compatible. It will also feature access to Nintendo Online, so users will be able to play all of those old retro titles. 

What about specs?

The rumors regarding specs are all over the place, so it’s tough to pin down. We know one thing for sure: It’ll be more powerful than the ancient Switch hardware, which was already antiquated back in 2017. One analyst allegedly got a hold of a spec sheet from the Korean United Daily News that said the Switch 2 would boast an eight-core Cortex-A78AE processor, 8GB of RAM, and 64GB of internal eMMC storage. This tracks for me, as these specs are about as underpowered in 2024 as the original Switch was in 2017. However, some reports do indicate that the console would include 12GB of RAM. 

Another source suggests that the eight-core CPU will be packaged inside an NVIDIA-produced Tegra239 SoC (system on a chip). Given the current Switch runs on an NVIDIA chip, that makes a lot of sense. The CPU will be more powerful, but it's the Switch 2's new GPU that will be a major differentiator. It's all-but-confirmed that the Switch 2 will support DLSS, NVIDIA's "deep learning supersampling" upscaling tech, which would allow the console to render games at a low resolution internally while outputting a high-resolution image. (Fun fact: We actually wrote about how perfect DLSS was for the Nintendo Switch 2 when the technology was announced alongside the RTX 20 series back in 2018.)

There are still questions about the Switch 2 and DLSS: Will the system support newer DLSS features like frame generation? Will existing games be automatically tidied up by NVIDIA's algorithm? Regardless of the exact implementation, DLSS upscaling will be a huge leap over the rudimentary techniques available to Nintendo Switch developers.

As for the display, there are many conflicting rumors. Early reports from solid sources suggested the Switch 2 would have an 8-inch display LCD display, but there have also been rumors about an 7-inch display with a 120Hz refresh rate. Some analysts have suggested this would be an OLED screen, while others have said it would be a Mini-LED display. A Mini-LED display is basically an LCD display that has a backlight made of (surprise!) mini-LEDs rather than edge lighting. This allows for local dimming, making the blacks more black. I’m hedging my bets here. I think it’ll be a standard LCD, to cut costs, with an OLED or Mini-LED model coming later down the line. However, Mini-LED screens are slightly cheaper than OLED displays, so that’s certainly a possibility at launch.

As for resolution, recent reporting suggests that the console will output 1080p in handheld and 4K when docked. That's much better than the OG Switch. 

How much will the Nintendo Switch 2 cost?

We don't have too much information regarding price but we do have plenty of history to work with. The original Nintendo Switch launched at $300, which is pretty much the "magic number" when it comes to Nintendo console releases in recent years. The Wii U also came in at $300. 

However, there are plenty of rumors circulating that Nintendo could be upping the asking price for the Switch 2. Numerous outlets have reported it'll be $400, or potentially even more expensive. However, the same analysts who say the console will be $400 were also fairly certain it would be out by the end of 2024 and, well, it looks like that ain't happening. 

Dipping back into history, there is some precedence for a price uptick. The GameCube was $200 and the Wii was $250. The Wii U and Switch increased to $300 and, well, numbers like to go up. A $400 price tag would make it nearly as expensive as a PS5 and Xbox Series X. That would also put it at the same price as the 256GB LCD Steam Deck. 

Do we know about any launch games?

Nope! But it’s certainly been a long time since we’ve gotten a proper 3D Mario adventure, right? That would be one heck of a system seller. Other than that, your guess is as good as mine. Past as prologue, we can expect something from Ubisoft and an off-the-wall title like 1-2-Switch. 

If there’s a gimmick or hook involved with the console, we’ll also get a game that takes advantage of that. A dual release of Metroid Prime 4, just like Breath of the Wild and Twilight Princess before that, is also a possibility.

That's everything we know about the Nintendo Switch 2 today. We'll update this article with rumors we trust and with information we gather directly from sources. Any changes made to the article after its initial publishing will be listed below.

Update, November 11, 2024, 9:00 AM ET: This story has been updated with details about the Switch 2's backwards compatibility as well as more details about the current expected announcement and release timeline.

While buzzy social media moments, massive celebrity endorsements and viral memes were everywhere during the U.S. election campaign, those who study social media and pop culture say it's likely that smaller social media interactions had a larger impact on the outcome.

Les White Stripes ont abandonné leur plainte sur les droits d'auteur contre le président des États-Unis nouvellement réélu, Donald Trump.

The U.S. Food and Drug Administration posted a video:

Quizás sepa que la FDA es responsable de aprobar los medicamentos nuevos, como medicamentos de receta, genéricos, biosimilares y de venta libre, y de garantizar que esos medicamentos sean seguros, de alta calidad y funcionen como se supone que deben hacerlo. Pero nuestro trabajo no termina ahí. Continuamos monitoreando la seguridad y calidad de los medicamentos aprobados en los años venideros. Aprenda más sobre nuestro papel en la regulación de estos medicamentos.

Para obtener más información sobre el papel de la FDA en la regulación y la aprobación de medicamentos, visite nuestro sitio web en www.fda.gov/drugs/information-consumers-and-patients-drug...

The U.S. Food and Drug Administration posted a video:

Los medicamentos de receta pasan por muchos pasos y fases importantes antes de que los aprobemos. Las investigaciones, los datos y la evidencia deben demostrar que el medicamento es seguro y eficaz para el uso previsto. Aprenda más sobre el proceso de aprobación de la FDA de principio a fin.

Para obtener más información sobre el papel de la FDA en la regulación y la aprobación de medicamentos, visite nuestro sitio web en www.fda.gov/drugs/information-consumers-and-patients-drug...