Little Richard obviously never released a heavy metal album, but it's safe to say without Little Richard heavy metal wouldn't...

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An Adams County Sheriff's deputy who fatally shot an armed man, who had fired multiple shots at the deputy while fleeing an arrest, was justified in his actions and will face no criminal charges in the shooting.

Officers from multiple jurisdictions were involved Wednesday morning in a fatal police shooting in Commerce City.

Investigators of a fatal hit-and-run incident are asking for the public's help in identifying a vehicle and its driver.

An Adams County Sheriff's deputy who fatally shot an armed man, who had fired multiple shots at the deputy while fleeing an arrest, was justified in his actions and will face no criminal charges in the shooting.

Elijah Blake looks for resolve between him and his dad.

The crash was with a car coming head-on

She lost control of her car and swerved lanes, report says

The 20-year-old rapper’s murder remains a mystery.

An officer was shot and killed.

Fat Joe joins Brett Berish to talk about his hustle.

Matt Prestbury talks about the organization's mission.

Larry Demery pleaded guilty to the 1993 crime.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

Пятого июня на Metal Blade состоится выпуск CD и виниловых версий альбомов MERCYFUL FATE, "Don't Break The Oath", "Melissa" и "Mercyful Fate", основой для которых были оригинальные мастер-ленты. Варианты изданий следующие:

Don't Break The Oath CD и LP:

- hardcover digisleeve "mini-LP" CD
- yellow w/ red flares vinyl
- clear w/ orange spots vinyl
- 180g black vinyl
- golden yellow marbled vinyl
- luminous orange marbled vinyl
- clear amber marbled vinyl
- opaque melon marbled vinyl
- flame splatter vinyl
- translucent red vinyl
- orange / red melt vinyl

Melissa CD и LP:

- hardcover digisleeve "mini-LP" CD
- yellow w/ black streaks vinyl
- highlighter yellow w/ red splatter vinyl
- 180g black vinyl
- opaque cherry red vinyl
- opaque golden yellow marbled vinyl
- dark green marbled vinyl
- olive green marbled vinyl
- green / blue color circle w/ red splatter vinyl
- translucent yellow vinyl
- red / black color circle w/ yellow splatter vinyl

Mercyful Fate CD и LP:

- hardcover digisleeve "mini-LP" CD
- black / white edge marbled vinyl
- clear w/ black smoke vinyl
- 180g black vinyl
- cool grey marbled vinyl
- clear ghost white vinyl
- white "blackdust" vinyl
- opaque red vinyl #Mercyful_Fate #MercyfulFate #HeavyMetal #Heavy_Metal

     Life really is like a box of chocolates. The really good kind is usually around 200 calories, and you can never consume just one. That becomes problematic, especially in a generation where one of anything is never enough.
     After my minor heart surgery in 2008, I became afraid to do anything but sit on the couch. Everything I did, from my job to my relationships, was settled and done by sitting, not acting. Now, three years later and over 110 pounds over weight, I feel like a new age rendition of The Blob. To conquer my weight gain, I have decided to train for a five mile swim of the Hoover Damn in October of this year. Going from couch to athlete will be a hard struggle, which I know will change my life forever. 
Being an active swimmer / water polo player and all around athlete in high school, weight was never an issue. Now, almost seven years later, I feel like I need an oxygen tank just to walk to my car some mornings. Motivation since high school has been a battle. How do you motivate yourself when you hate yourself? For almost two months now, I have been eating right and holding myself accountable for this mess I have caused myself. Almost eight pounds lighter than when I started, I feel triumphant. Eight pounds is not cause for celebration just yet, but I have this sense of accomplishment and energy—so much energy! I feel like I can do anything. My motivation will be to endure a five mile swim in less than ten months to change my life forever. 
     For your reading pleasure, (because we all love drama) I will be blogging every day about my struggles. Who knows what ten months will bring me, but weight loss is a life change and is hard to do. Follow me on my quest toward health, and I'll teach you the true skinny on being fat.