Eversheds Sutherland is pleased to announce the appointment of a new Partner in the fields of data protection and IT law. As an attorney and 2012 certified Senior Project Manager IPMA Level B, Markus Naef advises companies on legal safeguards and ex...

Coronavirus and the related restrictive measures directly affect not only insolvency proceedings that are already in progress, but can also cause or accelerate financial problems that will lead to bankruptcy and subsequent beginning of insolvency pr...

Executive summary On 8 April 2020, the European Commission issued a Temporary Framework Communication enabling it to: issue “comfort letters” in respect of specific temporary competitor co-ordination projects; and explain the criteria it...

(MENAFN - Saudi Press Agency) Riyadh, May 9, 2020, SPA -- An official source at the Ministry of Interior stated that, in light of the health authoriti... ......

“Keep in mind that Abbas is a status quo man. He does not like to rock the boat and this is not something that he would do easily, to do what he threatens to do,” said Professor Khalil Shikaki.

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Loan agreements outline the terms of an agreement for a loan. This document dated 6 May 2020 is provided for the ADB project 54183-001 in Bhutan.

WASHINGTON: The United States on Friday accused China and Russia of stepping up cooperation to spread false narratives over the coronavirus pandemic, saying Beijing was increasingly adopting techniques honed by Moscow.

“Even before the Covid-19 crisis we assessed a certain level of coordination between Russia and the PRC (Peoples Republic of China) in the realm of propaganda,” said Lea Gabrielle, coordinator of the State Department’s Global Engagement Center, which tracks foreign propaganda.

“But with this pandemic the cooperation has accelerated rapidly,” she told reporters.

“We see this convergence as a result of what we consider to be pragmatism between the two actors who want to shape public understanding of the Covid pandemic for their own purposes,” she said.

The Global Engagement Center earlier said that thousands of Russian-linked social media accounts were spreading conspiracies about the pandemic, including charging that the virus first detected last year in the Chinese metropolis of Wuhan was created by the United States.

China outraged the United States when a foreign ministry spokesman tweeted a conspiracy that the US military brought the virus to Wuhan, but the two countries reached an informal rhetorical truce in late March after telephone talks between President Donald Trump and his counterpart Xi Jinping.

Tensions have again soared as Secretary of State Mike Pompeo pushes the theory that the virus originated in a Chinese laboratory, even though both the World Health Organisation and the US government’s top epidemiologist say there is no evidence of this.

According to the Global Engagement Centre, China has again intensified its online campaign to defend its handling of the pandemic, which has killed some 270,000 people worldwide, and criticise the United States.

“Beijing is adapting in real time and increasingly using techniques that have long been employed by Moscow,” Gabrielle said.

China has increasingly used bot networks to amplify its message, Gabrielle said.

She said that official Chinese diplomatic accounts suddenly witnessed a surge in late March, going from adding around 30 new followers daily to more than 720, often from freshly created accounts.

She said that China was first observed using such online methods to “sow political discord” in its autonomous territory of Hong Kong, which has witnessed major pro-democracy demonstrations.

Published in Dawn, May 9th, 2020

An alligator carcass dropped in the deep ocean reveals the bizarre ecosystems of the seabed - including zombie worms that fed on prehistoric reptiles

An alligator carcass dropped in the deep ocean reveals the bizarre ecosystems of the seabed - including zombie worms that fed on prehistoric reptiles

ABSTRACT

The cell cycle is a critical component of cellular proliferation, differentiation, and response to stress, yet its role in the regulation of intracellular symbioses is not well understood. To explore host-symbiont cell cycle coordination in a marine symbiosis, we employed a model for coral-dinoflagellate associations: the tropical sea anemone Aiptasia (Exaiptasia pallida) and its native microalgal photosymbionts (Breviolum minutum and Breviolum psygmophilum). Using fluorescent labeling and spatial point-pattern image analyses to characterize cell population distributions in both partners, we developed protocols that are tailored to the three-dimensional cellular landscape of a symbiotic sea anemone tentacle. Introducing cultured symbiont cells to symbiont-free adult hosts increased overall host cell proliferation rates. The acceleration occurred predominantly in the symbiont-containing gastrodermis near clusters of symbionts but was also observed in symbiont-free epidermal tissue layers, indicating that the presence of symbionts contributes to elevated proliferation rates in the entire host during colonization. Symbiont cell cycle progression differed between cultured algae and those residing within hosts; the endosymbiotic state resulted in increased S-phase but decreased G₂/M-phase symbiont populations. These phenotypes and the deceleration of cell cycle progression varied with symbiont identity and host nutritional status. These results demonstrate that host and symbiont cells have substantial and species-specific effects on the proliferation rates of their mutualistic partners. This is the first empirical evidence to support species-specific regulation of the symbiont cell cycle within a single cnidarian-dinoflagellate association; similar regulatory mechanisms likely govern interpartner coordination in other coral-algal symbioses and shape their ecophysiological responses to a changing climate.

IMPORTANCE Biomass regulation is critical to the overall health of cnidarian-dinoflagellate symbioses. Despite the central role of the cell cycle in the growth and proliferation of cnidarian host cells and dinoflagellate symbionts, there are few studies that have examined the potential for host-symbiont coregulation. This study provides evidence for the acceleration of host cell proliferation when in local proximity to clusters of symbionts within cnidarian tentacles. The findings suggest that symbionts augment the cell cycle of not only their enveloping host cells but also neighboring cells in the epidermis and gastrodermis. This provides a possible mechanism for rapid colonization of cnidarian tissues. In addition, the cell cycles of symbionts differed depending on nutritional regime, symbiotic state, and species identity. The responses of cell cycle profiles to these different factors implicate a role for species-specific regulation of symbiont cell cycles within host cnidarian tissues.

Daniel J. Tobiansky, Meredith C. Miles, Franz Goller, and Matthew J. Fuxjager

Performance trade-offs can dramatically alter an organism's evolutionary trajectory by making certain phenotypic outcomes unattainable. Understanding how these trade-offs arise from an animal's design is therefore an important goal of biology. To explore this topic, we study how androgenic hormones, which regulate skeletal muscle function, influence performance trade-offs relevant to different components of complex reproductive behaviour. We conduct this work in golden-collared manakins (Manacus vitellinus), a Neotropical bird in which males court females by rapidly snapping their wings together above their back. Androgens help mediate the snap displays by radically increasing the twitch speed of a dorsal wing muscle [scapulohumeralis caudalis (SH)], which actuates the bird's wing-snap. Through hormone manipulations and in situ muscle recordings, we test how these positive effects on SH speed influence trade-offs with endurance. Indeed, this trait impacts the display by shaping signal length. We find that androgen-dependent increases in SH speed incur a cost to endurance, particularly when this muscle performs at its functional limits. Moreover, when behavioural data are overlaid on our muscle recordings, displaying animals appear to balance display speed with fatigue-induced muscle fusion (physiological tetanus) to generate the fastest possible signal while maintaining an appropriate signal duration. Our results point to androgenic hormone action as a functional trigger of trade-offs in sexual performance—they enhance one element of a courtship display, but in doing so, impede another.

Background

Positive serology for cytomegalovirus (CMV) has been associated with all-cause mortality risk but its role in COPD mortality is unknown. The objective of the present study was to assess the relationship between CMV serology and COPD mortality.

Background:

In Canada, First Nations populations experience a higher incidence of diabetes and diabetes-related complications than other people. Given the paucity of information on use of preventive eye examinations and the need for interventional care for severe retinopathy among First Nations people, we carried out a population-based study to compare rates of eye examinations and interventional therapies to treat vision-threatening stages of diabetic retinopathy among First Nations people and other people with diabetes in Ontario.

Background:

The success of multisite collaborative research relies on effective data collection, harmonization, and aggregation strategies. Data Coordination Centers (DCC) serve to facilitate the implementation of these strategies. The utility of a DCC can be particularly relevant for research on rare diseases where collaboration from multiple sites to amass large aggregate datasets is essential. However, approaches to building a DCC have been scarcely documented.

Brown dwarfs, which are halfway between huge planets and small stars, have extremely powerful winds whipping around them at speeds of about 650 metres per second

An analysis of the fossilized teeth of Deinonychus antirrhopus, a species of wolf-sized dromaeosaurid dinosaur that lived between 115 and 108 million years ago (Cretaceous period) in what is now the United States, adds to the growing evidence that this and other raptors were not complex social hunters by modern mammalian standards. The image of [...]

The House of Commons echoed with peals of laughter today as Matt Hancock complimented a fellow Tory MP on his lockdown hairdo.

Today's extraordinary projections of the course of the economy over the rest of the year from the Bank of England are, bizarrely, both worse and better than might be feared.

Matt Hancock has slammed Professor Neil Ferguson for his "extraordinary" breach of coronavirus lockdown rules, adding he was left "speechless" by his actions.

Ingram also called ITV's new drama about his cheating scandal 'terrifyingly accurate' and 'excruciatingly enjoyable'

Expert skincare advice is just a click away

When truth is stranger than fiction

ES design columnists Att Pynta on mastering clashing prints and colour

Rio Ferdinand believes that Paul Pogba should be the one talking about his future at Manchester United - not his agent Mino Raiola.

Rio Ferdinand has revealed his relationship with former England team-mate John Terry has never improved after the former Chelsea captain allegedly racially abused his brother Anton in 2011.

Rio Ferdinand has urged Manchester United to sign Jadon Sancho and warned rival clubs that it would be "over" for them if the Borussia Dortmund star links up with Marcus Rashford.

Rio Ferdinand has given Manchester United five new transfer targets as Ole Gunnar Solskjaer looks to refresh his squad.

Former Manchester United and England stalwart Rio Ferdinand says any Government decision regarding the fate of the 2019-20 domestic football season must be respected.

Rio Ferdinand has launched an impassioned defence of Paul Pogba, claiming he should be 'the jewel in the crown' at Manchester United and accusing the club of failing to build around him.

Rio Ferdinand believes both relentless criticism and a desire for trophies may eventually drive Paul Pogba away from Manchester United.

The national coordinator is charged with formulating and implementing a national strategy to combat child exploitation, and with submitting the strategy and relevant reports to Congress.

The position was established as part of the Department’s ongoing efforts, initiated last year at the direction of the Attorney General, to review and improve its criminal discovery and case management policies and procedures.

The settlement requires the companies to pay a total of $900,000 in civil penalties for violating premerger waiting period requirements.

The Justice Department’s plan identifies the steps it will take to develop a comprehensive consultation and coordination policy with tribal nations, after robust tribal input.

"We at the Justice Department have recommitted ourselves to this work. We’re strengthening civil rights protections in employment, housing, voting, and sentencing, and we’ve launched a new initiative aimed at expanding access to justice."

Cardinal Health Inc. has agreed to pay the United States $8 million to resolve claims that it violated the False Claims Act by making payments to induce referral orders for its prescription drugs in violation of the Anti-Kickback Statute.

The Departments of Justice, Homeland Security and Labor announced today the selection of Pilot Anti-Trafficking Coordination Teams (ACTeams) as part of a nationwide Human Trafficking Enhanced Enforcement Initiative designed to better coordinate federal criminal investigations and prosecutions of human trafficking offenses.

The Department of Justice, Federal Trade Commission (FTC) and the European Commission today issued an updated set of “best practices” that they use to coordinate their merger reviews.

"Today, I am firmly committed – as I know everyone here is committed – to keep the promises we’ve made to the American people, and especially to survivors and victims’ families in communities like Newtown," said Attorney General Holder.

A former program coordinator at the defunct health provider Health Care Solutions Network Inc. (HCSN) was sentenced in Miami to 70 months in prison today for her role in a $63 million fraud scheme.

Building on the work of the original and successful Defending Childhood Task Force and efforts across the Department of Justice in Indian country, the American Indian and Alaska Native Task Force will consist of two groups – an Advisory Committee and a Federal Working Group.

Attorney General Eric Holder, Health and Human Services (HHS) Secretary Kathleen Sebelius, and Federal Trade Commission (FTC) Chairwoman Edith Ramirez met at the White House to kick off a comprehensive interagency initiative to prevent, protect against, and where necessary prosecute consumer fraud and privacy violations in the Health Insurance Marketplace.

For at-risk young people—and particularly those affected by violence—the services provided by the Affordable Care Act represent more than an insurance policy; they are a lifeline. They are the tools of prevention and reorientation that can mean the difference between a life of fulfillment, and one that perpetuates a cycle of trauma and violence.

The Department of Justice, the Federal Trade Commission (FTC), and the Competition Bureau Canada today issued a set of “best practices” to make more transparent how they coordinate merger reviews that affect the United States and Canada.

"...we're here because 60,000 young people are still confined in juvenile detention and correction facilities on any given day and when they are released they will need support to successfully make that transition to productive adulthood and stable lives."

Care coordination is considered a hallmark of patient-centered treatment and has been shown to improve health outcomes and patient satisfaction as well as reduce costs. Defined as organizing patient care activities and sharing information among all participants concerned with an individual’s treatment plan in order to achieve safer and more effective results, care coordination is increasingly...