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Regioselectivity switches between anthraquinone precursor fissions involved in bioactive xanthone biosynthesis

By pubs.rsc.org
Published On ::

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06369D, Edge Article
Open Access
Xiao Jing Lv, Chun Zhi Ai, Li Rong Zhang, Xiu Xiu Ma, Juan Juan Zhang, Jia Peng Zhu, Ren Xiang Tan
BruN and BTG13 cleave chrysophanol hydroquinone into monodictyphenone and cephalanone F, respectively, with the regioselectivities found tunable via the key amino acid (AA) substitution strategy.
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Differentiating carrier protein interactions in biosynthetic pathways using dapoxyl solvatochromism

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Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05499G, Edge Article
Open Access
Matthew G. Miyada, Yuran Choi, Kyle Rich, James J. La Clair, Michael D. Burkart
A highly sensitive solvatochromic system was developed to monitor the loading and interactivity of carrier proteins associated with fatty acid, polyketide and non-ribosomal peptide biosynthesis.
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A paper-in-polymer-pond (PiPP) hybrid microfluidic microplate for multiplexed ultrasensitive detection of cancer biomarkers

By pubs.rsc.org
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Lab Chip, 2024, 24,4962-4973
DOI: 10.1039/D4LC00485J, Paper
Sanjay S. Timilsina, XiuJun Li
A reusable and cost-effective paper-in-polymer-pond (PiPP) hybrid microfluidic microplate with unique features for ultrasensitive and high-throughput multiplexed detection of disease biomarkers within an hour without using specialized instruments.
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Microstring-engineered tension tissues: a novel platform for replicating tissue mechanics and advancing mechanobiology

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00753K, Paper
Zixing Zhou, Tingting Li, Wei Cai, Xiaobin Zhu, Zuoqi Zhang, Guoyou Huang
A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.
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Biomining of legacy waste at Kalamassery likely to begin soon

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 20:04:20 +0530


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CKCL, private players help fill gaps in non-biodegradable waste management in Ernakulam

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 19:46:17 +0530


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India and Brazil to collaborate on SAF, leverage biofuel expertise to decarbonise aviation

By www.thehindubusinessline.com
Published On :: Sat, 21 Sep 2024 15:27:56 +0530

The joint statement emphasised collaboration in technology exchange, joint research, and development initiatives to optimize SAF production processes and create frameworks encouraging investment in SAF production.


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India’s new biodiversity strategy aims to protect 30% of ecosystems, restore degraded habitats by 2030

By www.thehindubusinessline.com
Published On :: Fri, 01 Nov 2024 09:26:35 +0530

This plan aligns with the global targets set by the Kunming-Montreal Global Biodiversity Framework.


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NIH-funded scientists uncover clues to precancer and tumor biology

By www.cancer.gov
Published On :: Wed, 30 Oct 2024 12:00:00 +0000

New studies released by NCI’s Human Tumor Atlas Network explore the role of the tumor microenvironment and the immune system in promoting the spread of cancer and its resistance to treatment. The studies appear across several Nature journals.


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Trump expected to pick Marco Rubio for U.S. Secretary of State

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 09:37:03 +0530

Top role for Rubio could bolster Republicans' Latino gains; Rubio opposed $95 billion military aid to Ukraine


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Eluru Government Medical College named after biochemist Yellapragada SubbaRow

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 15:26:31 +0530

SubbaRow, born in 1895 in Bhimavaram, is credited with discovering drugs for Filariasis and the role of ATP in muscular activity


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Tirupati universities form cluster to work towards conserving biodiversity

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 20:43:10 +0530

IIT-T, IISER Tirupati, SPMVV and Dravidian University comes together to create campus biodiversity registers as part of APSCHE-IIC research programme


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Nitrogen-doped biomass-derived carbon dots for fluorescence determination of sunset yellow

By pubs.rsc.org
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Anal. Methods, 2024, 16,2063-2070
DOI: 10.1039/D3AY01944F, Paper
Qian Zhang, Xiaoqi Wang, Lili Yuan, Lina Yu, Congying Shao, Hongxing Jia, Shun Lu
Schematic of preparation of N-CDs and their sensing mechanism for sunset yellow.
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Response strategies and biological applications of organic fluorescent thermometry: cell- and mitochondrion-level detection

By pubs.rsc.org
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Anal. Methods, 2024, 16,1968-1984
DOI: 10.1039/D4AY00117F, Minireview
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Shuai Li, Yaoxuan Li, Shiji Zhang, Haixiao Fang, Ze Huang, Duoteng Zhang, Aixiang Ding, Kajsa Uvdal, Zhangjun Hu, Kai Huang, Lin Li
In this review, we primarily summarized four temperature-response strategies. Then, we further analyzed the chemical modifications and biological applications of the probes. Finally, we have provided a prospective on the future development of probes.
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A novel isophorone-based fluorescent probe for recognizing Al3+ and its bioimaging in plants

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Anal. Methods, 2024, 16,2120-2126
DOI: 10.1039/D4AY00023D, Paper
Yanna Zhao, Yuqi Wang, Yingying Zhang, Xiaowei Bai, Wentong Hou, Yuqing Huang
Aluminium ions (Al3+) are widely present in industries and daily life and are closely related to human health and environmental protection.
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An on-line SPE-LC-MS/MS method for quantification of nucleobases and nucleosides present in biological fluids

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00100A, Paper
Yi-Ming Liu, Shuguan Wang, Amani Dickenson, Jinghe Mao, Xiaolin Bai, Xun Liao
A facile on-line SPE-LC-MS/MS method for quantification of nucleobases and nucleosides in urine and saliva.
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One-step electrodeposited hybrid nanofilms in amperometric biosensor development

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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00290C, Tutorial Review
Yuliya E. Silina
This review summarizes developments in amperometric biosensors with electrodeposited sensing films. It was shown how the analytical merit of one-step designed biosensors can be controlled by the change of chemical factors within the same engineering platform.
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A Rapid and Sensitive Aptamer-Based Biosensor for Beta-lactoglobulin in milk

By pubs.rsc.org
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00460D, Paper
Anqi Liu, Meng Jiang, Yuyin Wu, Han Guo, Ling Kong, Zhiwei Chen, Zhaofeng Luo
β-Lactoglobulin, a naturally occurring milk protein and a major cause of milk allergy in infants, was the focus of this study. A highly selective, sensitive, and cost-effective BLI biosensor was...
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A Multimode Biosensor Based on Prussian Blue Nanoparticle Loaded with Gold Nanoclusters for the Detection of Aflatoxin B1

By pubs.rsc.org
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02330C, Paper
zhaodi Fu, juan Huang, Wei Wei, zhihui Wu, Xingbo Shi
Herein, a novel fluorescent/colorimetric/photothermal biosensor is proposed for aflatoxin B1 (AFB1) detection in food based on Prussian blue nanoparticles (PBNPs) (~50 nm), gold nanocluster (AuNCs) and aptamer (Apt) within three...
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A simple, fast and inexpensive approach to quantify low concentrations of iron in biodiesel by voltammetry after extraction induced by microemulsion breaking

By pubs.rsc.org
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00342J, Paper
Cristian Henrique Krause, Alexandre Batista Schneider, Leandro Kolling, Lauren Thauani Teixeira Oliveira, Márcia M. Silva
An alternative approach to assay iron (Fe) in biodiesel by differential pulse adsorptive cathodic stripping voltammetry (DPAdCSV) is presented herein. The sample treatment involved a simple, rapid, but effective extraction...
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An overview of electrochemical biosensors used for COVID-19 detection

By pubs.rsc.org
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Anal. Methods, 2024, 16,2164-2176
DOI: 10.1039/D3AY02042H, Minireview
Tatiana Lima Valerio, Raquel Anastácio, Stella Schuster da Silva, Carolina Camargo de Oliveira, Marcio Vidotti
This short review presents the latest advances in the field of electrochemical biosensors, focusing particularly on impedimetric biosensors for the direct measurement of analytes.
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A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00146J, Paper
Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan Ding
A fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.
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Electroanalysis overview: additive manufactured biosensors using fused filament fabrication

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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00278D, Minireview
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Robert D. Crapnell, Craig E. Banks
Additive manufacturing (3D-printing), in particular fused filament fabrication, presents a paradigm shift in the way electrochemical based biosensing platforms are produced, giving rise to a new generation of personalized and on-demand biosensors.
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Polymeric membrane potentiometric sensors based on template-removal-free imprinted receptors for determination of antibiotics

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00263F, Paper
Xinyao Wang, Guohua Cui, Rongning Liang, Wei Qin
Currently, Nernstian-response-based polymeric membrane potentiometric sensors using the molecularly imprinted polymers (MIPs) as the receptors have been successfully developed for determination of organic ionic species. However, the preparation of these...
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Biology transformed: On the Nobel Prize in chemistry

By www.thehindu.com
Published On :: Mon, 14 Oct 2024 00:28:00 +0530

Nobel for determining protein structure recognises a big advance


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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
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The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

By pubs.rsc.org
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RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
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Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation

By pubs.rsc.org
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RSC Med. Chem., 2024, 15,3529-3557
DOI: 10.1039/D4MD00481G, Research Article
Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai Adel
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
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Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3485-3494
DOI: 10.1039/D4MD00246F, Research Article
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
A novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.
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Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
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Design and Synthesis of coumarin-based amphoteric antimicrobials with the biofilm interference and immunoregulation effects

By pubs.rsc.org
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00721B, Research Article
Qun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan Han
Bacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00383G, Research Article
Open Access
Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia Oueis
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism

By pubs.rsc.org
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RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article
Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
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Unlocking renewable energy from industrial waste: Biogas production from spent wash

By www.thehindubusinessline.com
Published On :: Sun, 13 Oct 2024 15:51:29 +0530

It is a sustainable solution for industrial waste management and renewable energy generation


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RPG Life Sciences to sell biotech unit to Intas Pharma

By www.thehindu.com
Published On :: Fri, 27 May 2016 00:00:00 +0530


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Biomimetic mineralization of positively charged silica nanoparticles templated by thermoresponsive protein micelles: applications to electrostatic assembly of hierarchical and composite superstructures

By pubs.rsc.org
Published On ::

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00907J, Paper
Nada Y. Naser, William C. Wixson, Helen Larson, Brandi M. Cossairt, Lilo D. Pozzo, François Baneyx
Exploiting the ability of a solid-binding elastin-like peptide to micellize, we mineralize monodisperse silica nanoparticles whose positive surface charge enables one-step electrostatic assembly of various mono- and bi-material superstructures.
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Effects of Hydration Water on Bioresponsiveness of Polymer Interfaces Revealed by Analysis of Linear and Cyclic Polymer–Grafted Substrates

By pubs.rsc.org
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Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00977K, Paper
Open Access
Shin-nosuke Nishimura, Naoya Kurahashi, Shohei Shiomoto, Yoshihisa Harada, Masaru Tanaka
Given that the hydration water of polymer matrices may differ from that of outermost polymer surfaces, processes at biomaterial–biofluid interfaces and role of hydration water therein cannot be adequately examined...
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Reliance Industries to invest ₹65,000 crore in A.P. to set up compressed biogas projects

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 20:23:10 +0530

The project will result in the creation of 2.50 lakh jobs, and earn an estimated ₹57,650 crore in taxes and duties for Andhra Pradesh over a period of 25 years, according to the Memorandum of Understanding signed on Tuesday


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Symbiosis launches dual degree MBA in partnership with Macquarie University and Aston University

By www.thehindu.com
Published On :: Thu, 24 Oct 2024 18:55:30 +0530


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Sulfenylation of bioactive maleimides, acrylates and cyclohexenones under ambient organophotocatalysis

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, 11,6503-6509
DOI: 10.1039/D4QO01342E, Research Article
Debanjana Bag, Rajjakfur Rahaman, Anindya S. Manna, Subhasis Pal, Rajesh Nandi, Shobhon Aich, Narendra Nath Ghosh, Dilip K. Maiti
A novel visible light-induced sulfenylation of biologically important maleimides, acrylates and cyclohexenones has been developed using cheap and easily available organophotoredox catalyst Eosin Y with thiols under ambient conditions.
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Integrating electrocatalysis with biocatalysis for asymmetric synthesis

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01899K, Highlight
Yuqi Lin, Jiage Yu, Ke-Yin Ye
This highlight presents recent advances in asymmetric synthesis that integrate electrocatalysis with biocatalysis and discusses future development directions in this field.
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Synthesis and antibiotic potential of myxocoumarin-inspired chromene dione analogs

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,35215-35219
DOI: 10.1039/D4RA05941G, Paper
Open Access
Antonia Behnsen, Gesa Hertrampf, Sandra Vojnović, Jasmina Nikodinović-Runić, Tobias A. M. Gulder
The myxocoumarins are natural products with strong antibiotic activity. We herein explored structural simplification of the myxocoumarins while aiming to retain their antibacterial properties. This led to the discovery of potent myxochromene diones.
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Design, synthesis, biological evaluation, and in silico studies of novel N-substituted-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carboxamides as promising anticancer agents

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,35323-35335
DOI: 10.1039/D4RA04492D, Paper
Open Access
Navid Dastyafteh, Manica Negahdaripour, Mohammad Hosein Sayahi, Mina Emami, Younes Ghasemi, Elham Safaei, Homa Azizian, Zahra Pakrouh Jahromi, Mehdi Asadi, Mohammad Reza Mohajeri-Tehrani, Fateme Zare, Minoo Shahidi, Zahra Pooraskari, Sayed Mahmoud Sajjadi-Jazi, Bagher Larijani, Mohammad Mahdavi, Sara Ranjbar
Synthesis and cytotoxicity evaluation of novel benzimidazoles were explained. The most potent derivative was subjected to cell cycle, apoptosis, and in silico investigations. Compound 5o proved to be a promising anticancer agent.
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N-doped carbon quantum dots for the selective detection of OCl− ions, bioimaging, and the production of Fe3O4 nanoparticles utilized in the synthesis of substituted imidazole

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,35448-35459
DOI: 10.1039/D4RA06474G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Namrata Priyadarshini Hota, Sathiyanarayanan Kulathu Iyer
Nitrogen-doped quantum dots (NCQD) were synthesized by solvothermal means using o-phenylenediamine and L-tartaric acid.
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In vitro bioactivity, mechanical, and cell interaction of sodium chloride-added calcium sulfate–hydroxyapatite composite bone cements

By pubs.rsc.org
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RSC Adv., 2024, 14,35460-35474
DOI: 10.1039/D4RA06034B, Paper
Open Access
Pharatree Jaita, Chamnan Randorn, Anucha Watcharapasorn, Parkpoom Jarupoom
In this research, sodium chloride-added calcium sulfate–hydroxyapatite composite bone cements (0.70CaS–0.30HAP)/xNaCl were studied.
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Design, synthesis, and in vitro and in vivo biological evaluation of triazolopyrimidine hybrids as multitarget directed anticancer agents

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RSC Adv., 2024, 14,35239-35254
DOI: 10.1039/D4RA06704E, Paper
Open Access
Heba A. Adawy, Samar S. Tawfik, Abdullah A. Elgazar, Khalid B. Selim, Fatma E. Goda
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.
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Zeolitic imidazolate framework-67 in chitosan-grafted hydrogel as an effective catalyst for peroxymonosulfate activation to degrade antibiotics and dyes

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,35628-35637
DOI: 10.1039/D4RA06537A, Paper
Open Access
Atipong Nachaichot, Kunlarat Phonlakan, Supinya Nijpanich, Soraya Pornsuwan, Surangkhana Budsombat
Zeolitic imidazolate framework-67 (ZIF-67) was synthesized in situ in the hydrogel of chitosan-grafted poly(acrylic acid) (chitosan-g-PAA) to activate peroxymonosulfate (PMS) and degrade tetracycline (TC).
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