pe Confederate president's name to disappear from Biloxi school By www.edweek.org Published On :: Wed, 02 Dec 2020 00:00:00 +0000 Full Article Mississippi
pe State Auditor's Battle Cry: Open the Books on K-12 Spending By www.edweek.org Published On :: Fri, 02 Aug 2019 00:00:00 +0000 A West Virginia official turns up the heat on financial disclosure for the state’s beleaguered schools, and ruffles feathers in the process. Full Article West_Virginia
pe Educational Opportunities and Performance in West Virginia By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article West_Virginia
pe West Virginia Superintendent Announces Resignation By blogs.edweek.org Published On :: Fri, 23 Sep 2016 00:00:00 +0000 Michael Martirano led the state's schools through dramatic budget cuts, academic challenges, and a state-versus-local battle over school construction. Full Article West_Virginia
pe States Dependent on Natural Resources Face Tricky Path on K-12 Revenue By blogs.edweek.org Published On :: Thu, 28 Dec 2017 00:00:00 +0000 Governors in several natural resource-dependent states said recently they will have to continue to cut public education funding because prices for oil and coal have not rebounded. Full Article West_Virginia
pe Educational Opportunities and Performance in West Virginia By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article West_Virginia
pe How Layoffs Upend Life for Educators, Students, and Districts By www.edweek.org Published On :: Tue, 14 Jul 2020 00:00:00 +0000 Pandemic-inflicted budget cuts have cost thousands of educators their jobs. Here’s how that’s playing out in five districts around the country. Full Article Michigan
pe Educational Opportunities and Performance in Michigan By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Michigan
pe GOP senator: Let high schools decide about opening By www.edweek.org Published On :: Fri, 04 Dec 2020 00:00:00 +0000 Full Article Michigan
pe Federal Judge Denies Relief in Challenge to New Mexico School Reopening Rules By blogs.edweek.org Published On :: Tue, 06 Oct 2020 00:00:00 +0000 In a case that has drawn the involvement of the Trump administration, a federal judge holds that state rules limiting in-person instruction are not infringing on federal constitutional rights. Full Article New_Mexico
pe Santa Fe schools end in-person learning experiment By www.edweek.org Published On :: Wed, 11 Nov 2020 00:00:00 +0000 Full Article New_Mexico
pe AASA Selects Illinois Educator as Superintendent of the Year By www.edweek.org Published On :: Tue, 27 Feb 2018 00:00:00 +0000 David Schuler, the superintendent of Township High School District 214 in Arlington Heights, Ill., has been named 2018 National Superintendent of the Year. Full Article Illinois
pe Illinois High Court Backs Pension for One-Day Teacher Substitute By www.edweek.org Published On :: Tue, 16 Apr 2019 00:00:00 +0000 A union lobbyist who worked just one day as a substitute teacher is entitled to a pension worth potentially tens of thousands of dollars annually, the Illinois supreme court has ruled. Full Article Illinois
pe In Illinois, New Budget Caps Raises and Limits Pensions for Teachers By blogs.edweek.org Published On :: Tue, 05 Jun 2018 00:00:00 +0000 The state's budget bill, which Republican Gov. Bruce Rauner signed into law this week, caps annual raises for end-of-career-teachers, lowering the pension they can receive. Full Article Illinois
pe State-District Tensions Swell Over School Pensions By www.edweek.org Published On :: Tue, 01 Oct 2019 00:00:00 +0000 There’s a tussle over the right balance for who should pick up the tab for teacher retirements and how that affects wealthier and less-wealthy districts. Full Article Illinois
pe Educational Opportunities and Performance in Illinois By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Illinois
pe Educational Opportunities and Performance in Illinois By www.edweek.org Published On :: Tue, 21 Jan 2020 00:00:00 +0000 This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Illinois
pe Supreme Court Declines Appeal Backed by Illinois School Districts on Tax Remedies By blogs.edweek.org Published On :: Mon, 16 Nov 2020 00:00:00 +0000 The court declined to take up an appeal backed by school groups of a ruling allowing some property taxpayers challenge their assessments in federal court. Full Article Illinois
pe Notre Dame WBB puts up highlight-reel performance in dominating Purdue By notredame.rivals.com Published On :: Mon, 11 Nov 2024 04:44:06 GMT Dazzling first with a relentless hawking defense that helped force 22 turnovers, then adding an almost frantic-paced offensive assault, the 2-0 No. 6-ranked Irish overwhelmed Purdue (1-1), 102-58, at Mackey Arena in West Lafayette, Ind. Dynamo guard Hannah Hidalgo was slapping, diving and picking pockets all night, making life miserable for any Boilermaker stuck bringing the ball up the floor. ► Snap Counts: Here's who played for Notre Dame football against Florida St. Full Article article Sports
pe South Carolina a unanimous No. 1 in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings By sports.yahoo.com Published On :: Mon, 11 Nov 2024 16:59:09 GMT South Carolina a unanimous No. in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings. Full Article article News
pe No. 4 Texas Women’s Basketball Dominates SEMO in Home Opener By sports.yahoo.com Published On :: Mon, 11 Nov 2024 19:21:10 GMT The No. 4 Texas Longhorns kicked off their season with a 119-47 win over Southeast Missouri State (SEMO) on Sunday at Moody Center. This victory marked Texas' 13th consecutive home opener win, establishing a strong start to the 2024-2 Full Article article Sports
pe Girls basketball: No. 1 Lady Pirates roll in opener By sports.yahoo.com Published On :: Tue, 12 Nov 2024 01:16:00 GMT Nov. 11—Class 3A preseason No. 1 Greensburg opened the season Friday with an 81-23 victory over Jac-Cen-Del. The Lady Pirates opened the scoring with a steal and layup by Mylie Wilkison. After buckets by Clarie Larrison, Mary Harmon, Wilkison and Leah West, the Lady Pirates led 10-0. JCD got on the board with a 3-pointer by Brooklyn Simon. It was all Greensburg from there in the first quarter. ... Full Article article Sports
pe Lady Vols basketball schedule for 2025-26 season will open vs NC State in Greensboro By sports.yahoo.com Published On :: Tue, 12 Nov 2024 16:51:31 GMT Tennessee Lady Vols basketball will open the 2025-26 season with a neutral-site matchup against NC State in Greensboro at First Horizon Coliseum Full Article article Sports
pe Lady Vols basketball vs MTSU: Final score, Talaysia Cooper logs double-double By sports.yahoo.com Published On :: Tue, 12 Nov 2024 20:30:17 GMT The Lady Vols beat Middle Tennessee 89-75 on Tuesday at Food City Center. Talaysia Cooper led Tennessee with 18 points Full Article article Sports
pe Barker, Betts lead No. 5 UCLA women over Pepperdine 91-54 By sports.yahoo.com Published On :: Tue, 12 Nov 2024 21:59:34 GMT Janiah Barker had 18 points and 11 rebounds, Lauren Betts had 17 points and 12 rebounds and the No. 5 UCLA women rolled past Pepperdine 91-54 on Tuesday. The Bruins (3-0) started the game with an 18-0 run. Ornela Muca, who led Pepperdine (1-2) with 20 points, made a 3-pointer to stop the run. Full Article article Sports
pe Lady Vols rely on best 3-point shooting performance of season to beat Middle Tennessee By sports.yahoo.com Published On :: Wed, 13 Nov 2024 01:30:10 GMT Lady Vols basketball relied on its best 3-point shooting night of the season to close out a win over Middle Tennessee State on Tuesday Full Article article Sports
pe Blugolds men’s and women’s basketball have home opener, first games in the new Sonnentag Event Center By sports.yahoo.com Published On :: Wed, 13 Nov 2024 02:46:00 GMT EAU CLAIRE— This weekend saw the first basketball games for Blugold men’s and women’s basketball during the Market & Johnson Blugold Tip-Off Tournament. The games were the first to be played at the Sonnentag Event Center, a part of the new $122 million multi-purpose facility which opened earlier this year. The event center has a capacity of 3,500 people for sporting events as compared to the ... Full Article article Sports
pe Women's basketball notebook: Gonzaga got the best from a motivated Stanford team, a sign of respect for Bulldogs By sports.yahoo.com Published On :: Wed, 13 Nov 2024 03:03:00 GMT Nov. 12—The Gonzaga women's basketball team has much to learn after a challenging loss at Stanford on Sunday. Losses have a way of exposing a team's shortcomings. And there is much to learn from the worst loss (89-58) in coach Lisa Fortier's 11 seasons. Stanford, unranked in the preseason poll for the first time since 1999-2000, is unranked no more. The Cardinal (3-0) entered at No. 24 in the ... Full Article article Sports
pe New underground gallery & auditorium to open beneath historic Mitchell Library building By www.sl.nsw.gov.au Published On :: Thu, 26 Oct 2023 22:10:49 +0000 Friday, 27 October 2023 Sydneysiders and visitors will soon experience the State Library on a whole new level. Full Article
pe Openbook summer out now! By www.sl.nsw.gov.au Published On :: Tue, 28 Nov 2023 04:33:27 +0000 Tuesday 28 November 2023 Fishing for a great summer read? Full Article
pe Openbook’s autumn edition showcases diverse talents of Australia’s creative community By www.sl.nsw.gov.au Published On :: Thu, 07 Mar 2024 23:05:18 +0000 Wednesday 6 March 2024 Showcasing diverse talents of Australia’s creative community. Full Article
pe Precious personal sketchbooks of artist Michael Kelly find new home By www.sl.nsw.gov.au Published On :: Mon, 11 Mar 2024 23:17:34 +0000 Monday 11 March 2024 65 personal sketchbooks have just been donated to the State Library and will go on public display for the first time. Full Article
pe Wagga Wagga students first in the state to experience new immersive learning program By www.sl.nsw.gov.au Published On :: Mon, 18 Mar 2024 23:51:18 +0000 Friday 15 March 2024 Wagga Wagga students first in the state to experience new immersive learning program. Full Article
pe Psychedelics and Neural Plasticity: Therapeutic Implications By www.jneurosci.org Published On :: 2022-11-09 Steven F. GriecoNov 9, 2022; 42:8439-8449Symposium and Mini-Symposium Full Article
pe Intracranially Administered Anti-A{beta} Antibodies Reduce {beta}-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation By www.jneurosci.org Published On :: 2003-05-01 Donna M. WilcockMay 1, 2003; 23:3745-3751Development Plasticity Repair Full Article
pe Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central Nervous System By www.jneurosci.org Published On :: 2024-10-23 Xinying GuoOct 23, 2024; 44:e0727242024-e0727242024Cellular Full Article
pe Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type By www.jneurosci.org Published On :: 1998-12-15 Guo-qiang BiDec 15, 1998; 18:10464-10472Articles Full Article
pe Right Temporoparietal Junction Underlies Avoidance of Moral Transgression in Autism Spectrum Disorder By www.jneurosci.org Published On :: 2021-02-24 Yang HuFeb 24, 2021; 41:1699-1715BehavioralSystemsCognitive Full Article
pe Aperiodic EEG Predicts Variability of Visual Temporal Processing By www.jneurosci.org Published On :: 2024-10-02 Michele DeodatoOct 2, 2024; 44:e2308232024-e2308232024BehavioralSystemsCognitive Full Article
pe Musical Training Shapes Structural Brain Development By www.jneurosci.org Published On :: 2009-03-11 Krista L. HydeMar 11, 2009; 29:3019-3025Development Plasticity Repair Full Article
pe The Salience Network: A Neural System for Perceiving and Responding to Homeostatic Demands By www.jneurosci.org Published On :: 2019-12-11 William W. SeeleyDec 11, 2019; 39:9878-9882Progressions Full Article
pe Targeting Cre Recombinase to Specific Neuron Populations with Bacterial Artificial Chromosome Constructs By www.jneurosci.org Published On :: 2007-09-12 Shiaoching GongSep 12, 2007; 27:9817-9823Toolbox Full Article
pe A Recurrent Network Mechanism of Time Integration in Perceptual Decisions By www.jneurosci.org Published On :: 2006-01-25 Kong-Fatt WongJan 25, 2006; 26:1314-1328BehavioralSystemsCognitive Full Article
pe A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3{alpha} Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses By www.jneurosci.org Published On :: 2024-10-09T09:30:20-07:00 α-Neurexins are essential and highly expressed presynaptic cell-adhesion molecules that are frequently linked to neuropsychiatric and neurodevelopmental disorders. Despite their importance, how the elaborate extracellular sequences of α-neurexins contribute to synapse function is poorly understood. We recently characterized the presynaptic gain-of-function phenotype caused by a missense mutation in an evolutionarily conserved extracellular sequence of neurexin-3α (A687T) that we identified in a patient diagnosed with profound intellectual disability and epilepsy. The striking A687T gain-of-function mutation on neurexin-3α prompted us to systematically test using mutants whether the presynaptic gain-of-function phenotype is a consequence of the addition of side-chain bulk (i.e., A687V) or polar/hydrophilic properties (i.e., A687S). We used multidisciplinary approaches in mixed-sex primary hippocampal cultures to assess the impact of the neurexin-3αA687 residue on synapse morphology, function and ligand binding. Unexpectedly, neither A687V nor A687S recapitulated the neurexin-3α A687T phenotype. Instead, distinct from A687T, molecular replacement with A687S significantly enhanced postsynaptic properties exclusively at excitatory synapses and selectively increased binding to neuroligin-1 and neuroligin-3 without changing binding to neuroligin-2 or LRRTM2. Importantly, we provide the first experimental evidence supporting the notion that the position A687 of neurexin-3α and the N-terminal sequences of neuroligins may contribute to the stability of α-neurexin–neuroligin-1 trans-synaptic interactions and that these interactions may specifically regulate the postsynaptic strength of excitatory synapses. Full Article
pe Recent Visual Experience Reshapes V4 Neuronal Activity and Improves Perceptual Performance By www.jneurosci.org Published On :: 2024-10-09T09:30:20-07:00 Recent visual experience heavily influences our visual perception, but how neuronal activity is reshaped to alter and improve perceptual discrimination remains unknown. We recorded from populations of neurons in visual cortical area V4 while two male rhesus macaque monkeys performed a natural image change detection task under different experience conditions. We found that maximizing the recent experience with a particular image led to an improvement in the ability to detect a change in that image. This improvement was associated with decreased neural responses to the image, consistent with neuronal changes previously seen in studies of adaptation and expectation. We found that the magnitude of behavioral improvement was correlated with the magnitude of response suppression. Furthermore, this suppression of activity led to an increase in signal separation, providing evidence that a reduction in activity can improve stimulus encoding. Within populations of neurons, greater recent experience was associated with decreased trial-to-trial shared variability, indicating that a reduction in variability is a key means by which experience influences perception. Taken together, the results of our study contribute to an understanding of how recent visual experience can shape our perception and behavior through modulating activity patterns in the mid-level visual cortex. Full Article
pe Brief and Diverse Excitotoxic Insults Increase the Neuronal Nuclear Membrane Permeability in the Neonatal Brain, Resulting in Neuronal Dysfunction and Cell Death By www.jneurosci.org Published On :: 2024-10-09T09:30:20-07:00 Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca2+-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca2+ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca2+ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca2+-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain. Full Article
pe TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation By www.jneurosci.org Published On :: 2024-10-16T09:30:18-07:00 Vertebrate nervous systems use the axon initial segment (AIS) to initiate action potentials and maintain neuronal polarity. The microtubule-associated protein tripartite motif containing 46 (TRIM46) was reported to regulate axon specification, AIS assembly, and neuronal polarity through the bundling, or fasciculation, of microtubules in the proximal axon. However, these claims are based on TRIM46 knockdown in cultured neurons. To investigate TRIM46 function in vivo, we examined male and female TRIM46 knock-out mice. Contrary to previous reports, we find that TRIM46 is dispensable for axon specification and AIS formation. TRIM46 knock-out mice are viable, have normal behavior, and have normal brain structure. Thus, TRIM46 is not required for AIS formation, axon specification, or nervous system function. However, we confirm that TRIM46 is required for microtubule fasciculation. We also show TRIM46 enrichment in the first ~100 μm of axon occurs independently of ankyrinG (AnkG) in vivo, although AnkG is required to restrict TRIM46 only to the AIS. Our results highlight the need for further investigation of the mechanisms by which the AIS and microtubules interact to shape neuronal structure and function. Full Article
pe Mu-Opioid Receptor (MOR) Dependence of Pain in Chemotherapy-Induced Peripheral Neuropathy By www.jneurosci.org Published On :: 2024-10-16T09:30:18-07:00 We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared with inflammatory pain, the cross talk between nociceptor TLR4 and mu-opioid receptors (MORs), and that MOR and TLR4 agonists induce hyperalgesic priming (priming), which also occurs in CIPN, we determined, using male rats, whether (1) antisense knockdown of nociceptor MOR attenuates CIPN, (2) and attenuates the priming associated with CIPN, and (3) CIPN also produces opioid-induced hyperalgesia (OIH). We found that intrathecal MOR antisense prevents and reverses hyperalgesia induced by oxaliplatin and paclitaxel, two common clinical chemotherapy agents. Oxaliplatin-induced priming was also markedly attenuated by MOR antisense. Additionally, intradermal morphine, at a dose that does not affect nociceptive threshold in controls, exacerbates mechanical hyperalgesia (OIH) in rats with CIPN, suggesting the presence of OIH. This OIH associated with CIPN is inhibited by interventions that reverse Type II priming [the combination of an inhibitor of Src and mitogen-activated protein kinase (MAPK)], an MOR antagonist, as well as a TLR4 antagonist. Our findings support a role of nociceptor MOR in oxaliplatin-induced pain and priming. We propose that priming and OIH are central to the symptom burden in CIPN, contributing to its chronicity and the limited efficacy of opioid analgesics to treat neuropathic pain. Full Article
pe Erratum: Spencer et al., "Regulation of the Mouse Ventral Tegmental Area by Melanin-Concentrating Hormone" By www.jneurosci.org Published On :: 2024-10-23T09:30:30-07:00 Full Article
pe Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central Nervous System By www.jneurosci.org Published On :: 2024-10-23T09:30:29-07:00 Perivascular mural cells including vascular smooth cells (VSMCs) and pericytes are integral components of the vascular system. In the central nervous system (CNS), pericytes are also indispensable for the blood–brain barrier (BBB), blood–spinal cord barrier, and blood–retinal barrier and play key roles in maintaining cerebrovascular and neuronal functions. However, the functional specifications of pericytes between CNS and peripheral organs have not been resolved at the genetic and molecular levels. Hence, the generation of reliable CNS pericyte-specific models and genetic tools remains very challenging. Here, we report a new CNS pericyte marker in mice. This putative cation-transporting ATPase 13A5 (Atp13a5) marker was identified through single-cell transcriptomics, based on its specificity to brain pericytes. We further generated a knock-in model with both tdTomato reporter and Cre recombinase. Using this model to trace the distribution of Atp13a5-positive pericytes in mice, we found that the tdTomato reporter reliably labels the CNS pericytes, including the ones in spinal cord and retina but not peripheral organs. Interestingly, brain pericytes are likely shaped by the developing neural environment, as Atp13a5-positive pericytes start to appear around murine embryonic day 15 (E15) and expand along the cerebrovasculature. Thus, Atp13a5 is a specific marker of CNS pericyte lineage, and this Atp13a5-based model is a reliable tool to explore the heterogeneity of pericytes and BBB functions in health and diseases. Full Article