pe

Image forming apparatus storing a stylus pen

Disclosed is an image forming apparatus provided with an operation panel receiving instructions from a user by touch operations, a stylus pen used to perform the touch operations, and a pen holder holding the stylus pen, the pen holder including an opening for insertion of the stylus pen from outside of the pen holder, and a storage section storing the stylus pen. The storage section includes a first hollow portion with a first bottom and a second hollow portion with a second bottom lower than the first bottom. The stylus pen is stored in the storage section by being inserted through the opening, proceeding along the first bottom to enter the second hollow portion, and slanting, upon a center of gravity of the stylus pen passing a boundary between the first bottom and the second bottom, so that a tip of the stylus pen points downwards.




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Apparatus pertaining to physically-discrete sign components

A physically-discrete sign component comprises an internally-electrically-illuminated alphabetic character having a front-facing profile and at least one connecting bar disposed at least substantially horizontally with respect to the front-facing profile of the alphabetic character and at least partially within the front-facing profile of that alphabetic character. By one approach the physically-discrete sign component includes two of the connecting bars. If desired, these two connecting bars are disposed at least substantially parallel to one another. By one approach, a first one of the connecting bars extends partially, but not wholly, above an upper periphery of the aforementioned front-facing profile while the second connecting bar extends partially, but not wholly, below a lower periphery of the front-facing profile. The connecting bars can include a connecting-bar interface configured to physically and electrically interconnect to an adjacent sign component.




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Apparatus for internally restoring a pipe

A method of internally restoring a pipe preferably includes the steps of isolating a leaking pipe from a system of pipes; drying an interior of a leaking pipe; measuring the airflow through the leak; cleaning the interior of the leaking pipe; presealing a leak with a leak sealing media, measuring the leak flow rate after the pre-sealing; applying an internal protective coating process; and pressure testing the leaking pipe for leaks. The pipe restoration method preferably uses a control box, a media injection system, an air compressor and a coating dispensing system at an inlet of the leaking pipe. The pipe restoration method preferably uses a coating overflow receiver, a muffler and a dust collector at an exit of the leaking pipe. After the treatments, the leaking pipe becomes a restored pipe. The restored pipe is pressure tested for leaks at a working pressure rating of the pipe.




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Substrate processing apparatus for maintaining a more uniform temperature during substrate processing

A substrate processing apparatus that includes a process tank having a pair of opposed sidewalls for storing a chemical liquid, and processing a plurality of substrates by the chemical liquid; a substrate holding mechanism including a holding part for holding the plurality of substrates, and a back part connected to the holding part and interposed between the substrates held by the holding part and one sidewall of the pair of opposed sidewalls when the substrate holding mechanism is loaded into the process tank. A heating device is disposed on the process tank for heating the stored chemical liquid. The heating device includes at least a first heater disposed on the one sidewall, and a second heater disposed on the other sidewall of the pair of opposed sidewalls. Energy outputs of the first heater and the second heater are independently controlled.




pe

Substrate treatment systems using supercritical fluid

Substrate treatment systems are provided. The substrate treatment systems may include a treating device configured to treat a substrate with a supercritical fluid, and a supplying device configured to supply the supercritical fluid to the treating device. The treating device may include a supercritical process zone in which the substrate is treated with the supercritical fluid, and a pre-supercritical process zone in which the supercritical fluid is expanded and then provided into the supercritical process zone to create a supercritical state in the supercritical process zone.




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Substrate clean solution for copper contamination removal

Embodiments of the invention generally relate to a method for selectively etching or otherwise removing copper or other metallic contaminants from a substrate, such as a gallium arsenide wafer. In one embodiment, a method for selectively removing metallic contaminants from a substrate surface is provided which includes exposing a substrate to a peroxide clean solution, exposing the substrate to a hydroxide clean solution, and exposing the substrate to a selective etch solution containing potassium iodide, iodine, sulfuric acid, and water during a selective etch process. The substrate generally contains gallium arsenide material, such as crystalline gallium arsenide, and is usually a growth substrate for an epitaxial lift off (ELO) process. The copper or other metallic contaminants disposed on the substrate may be selectively etched at a rate of about 500 times, about 1,000 times, about 2,000 times, or about 4,000 times or greater than the gallium arsenide material.




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Method and apparatus for cleaning a film seperating device

A method for cleaning a film separating device involves: a) performing positive-direction water cleaning when the ratio between the film filter resistance and the preliminary film filter resistance is less than 1.2; b) performing reverse water cleaning when the ratio between the film filter resistance and the preliminary film filter resistance is greater-than or equal-to 1.2; c) performing reverse chemical cleaning when the ratio between the film filter resistance and the preliminary film filter resistance is greater-than or equal-to 2; d) performing positive-direction chemical cleaning when the ratio between the film filter resistance and the preliminary film filter resistance is greater-than or equal-to 3.




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Controlling temperature of a faraday shield

A method for controlling thermal cycling of a faraday shield in a plasma process chamber is provided. The method includes: performing a first plasma processing operation on a first wafer in the plasma process chamber; terminating the first plasma processing operation; performing a first wafer transfer operation to transfer the first wafer out of the chamber; and, during the first wafer transfer operation, applying power to a TCP coil under a plasma limiting condition.




pe

Dishwasher with booster agent dispersal system

A dishwasher includes a shiftable rack provided with a washing agent dispersal system including a housing into which washing fluid is delivered. When the rack is shifted to a retracted position within a tub of the dishwasher, a tube feed system is employed to selectively distribute washing fluid from a pump assembly to each of multiple spray arms, the housing of the washing agent dispersal system and an auxiliary spray unit carried by the upper rack.




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High performance low viscoelasticity foaming detergent compositions employing extended chain anionic surfactants

The invention meets the needs above by providing a surfactant system, mixture or blend that can be used as a part of a soaking composition. The surfactant system is capable of forming emulsions with, and thus removing, oily and greasy stains. In a preferred embodiment the surfactant compositions of the invention can remove non-trans fat and fatty acid stains. The invention involves foaming soaking compositions that have some or part of the anionic surfactant present in the same replaced with an extended chain anionic surfactant.




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Tools and methods for processing microelectronic workpieces using process chamber designs that easily transition between open and closed modes of operation

Strategies for tool designs and their uses wherein the tools can operate in either closed or open modes of operation. The tools easily transition between open and closed modes on demand. According to one general strategy, environmentally controlled pathway(s) couple the ambient to one or more process chambers. Air amplification capabilities upstream from the process chamber(s) allow substantial flows of air to be introduced into the process chamber(s) on demand. Alternatively, the fluid pathways are easily closed, such as by simple valve actuation, to block egress to the ambient through these pathways. Alternative flows of nonambient fluids can then be introduced into the process chamber(s) via pathways that are at least partially in common with the pathways used for ambient air introduction. In other strategies, gap(s) between moveable components are sealed at least with flowing gas curtains rather than by relying only upon direct physical contact for sealing.




pe

Sawing rope

A sawing rope (270) with abrasive elements (506) fixed on a steel rope (502) with a polymer jacket (504) is described and claimed. The abrasive elements (506) are made of a metallic sleeve on which an abrasive layer is deposited by means of electrolytic deposition, by means of sintering or by means of cladding for example laser cladding. Characteristic about this sawing rope (270) in view of the prior known sawing ropes is that each sleeve shows a connection or closure. Such a connection makes it possible to attach abrasive elements (506) on the rope without having to thread them on the rope (270) as is needed when making prior-art sawing ropes. The inventive sawing rope (270) can therefore be made in long lengths in a very efficient way.




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Hand-operated implement comprising a cutting chain for cutting mineral and metal materials

A hand-operated implement has a guide bar on which is fitted a cutting chain for cutting mineral and metal materials. The cutting chain is driven around the guide bar by a chain sprocket. The chain sprocket is arranged in a chain sprocket chamber which is delimited by a chain sprocket cover. A cutting element has an outer side facing a sidewall of the chain sprocket cover which lies in a first notional plane. The distance between the sidewall and the first notional plane measured perpendicular to the first notional plane and centrally between the top of the cutting element and the peripheral wall is less than approximately 0.8 cm over at least 30% of the section between a second notional plane containing the central axis of a fixing bolt on the guide bar and the exit opening at which the cutting chain leaves the chain sprocket chamber.




pe

Wire saw with tension detecting means and guide roller speed control

The present invention provides a wire saw which cuts a workpiece using a cutting wire and is capable of adjusting wire tension with high responsiveness. The wire saw includes first and second workpiece cutting units 1A and 1B. Each of the workpiece cutting units 1A and 1B includes a pair of guide rollers 10a and 10b around which a wire W is wound to form a workpiece-cutting wire group. The wire saw further includes a tension detector 18 which detects tension in the wire W between the workpiece cutting units 1A and 1B, and a control device 50. The control device 50 changes a rotational speed of the guide rollers 10a and 10b of at least one of the workpiece cutting units based on the tension detected by the tension detector 18 so as to keep the tension within an acceptable range.




pe

Cutting chain for a hand-operated implement and hand-operated implement

A cutting chain for a hand-operated implement for cutting metal and mineral materials such as a stone cutter has central connecting links which are connected to one another by lateral connecting links. The central connecting links comprise first central connecting links which each have a drive tooth. The cutting chain has two central connecting links with drive teeth shaped differently to the drive teeth on the first central connecting links; or located a different distance from the leading drive teeth; or having no drive teeth. A hand-operated implement for cutting mineral materials has a drive motor which drives the cutting chain around a guide bar by a drive sprocket. The cutting chain is guided round part of the circumference of the drive sprocket and round a nose sprocket on the guide bar. The drive sprocket or nose sprocket have different first and second areas matched to the cutting chain.




pe

Supply device for spraying a cutting tool of a handheld power tool and a power tool of this type

A supply device for a handheld power tool for a cutting grinder includes a cutting tool and a protective cover which at least partially surrounds the cutting tool. The supply device includes a U-shaped element which can be arranged on the protective cover and via which a fluid medium can be supplied to the cutting tool. The U-shaped element has a connection piece on which a coupling element can be arranged. On the coupling element a pipeline can be connected via which the fluid medium can be supplied to the U-shaped element through the connection piece. The coupling element can be turned about the axis of rotation of the connection pieces.




pe

Independently supported concrete saw apparatus and method

A saw apparatus for sawing paving slabs has a frame mounted on a ground contacting propulsion member such that the frame may move above a slab to be cut without touching the slab. A first saw support assembly disposes a blade of a saw in cutting engagement with the slab for a transverse cut. A second saw support assembly disposes a blade of another saw in cutting engagement with the slab for a longitudinal cut. The saws are mounted on the saw assemblies and the saw assemblies are mounted on the frame and the frame is mounted on the ground contact propulsion members such that no part of said frame need contact the slab during cutting.




pe

Dressing device for a grinding wheel and its use in a centreless nuclear fuel pellet grinder

The invention relates to a device for dressing a grinding wheel, comprising a sleeve to hold a corundum rod laterally and to guide it along its longitudinal axis, a ram to apply constant thrust force onto the corundum rod held in place and guided in the sleeve, to bring it into contact with the grinding wheel, means of rigidly connecting the ram shaft to the end of the corundum rod, and linear guide means for the sleeve for translating the corundum rod parallel to the axis of the grinding wheel while keeping the rod pressed against the grinding wheel with a constant force. Application to a centerless grinder in which the grinding wheel is used to grind nuclear fuel pellets.




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***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***Cold chamber die casting of amorphous alloys using cold crucible induction melting techniques

Various embodiments provide systems and methods for casting amorphous alloys. Exemplary casting system may include an insertable and rotatable vessel configured in a non-movable induction heating structure for melting amorphous alloys to form molten materials in the vessel. While the molten materials remain heated, the vessel may be rotated to pour the molten materials into a casting device for casting them into articles.




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Counter-gravity casting of hollow shapes

The embodiments described herein relate to methods and apparatus for counter-gravity formation of BMG-containing hollow parts. In one embodiment, the BMG-containing hollow parts may be formed by first feeding a molten metal alloy in a counter-gravity direction into a mold cavity to deposit the molten metal alloy on a surface of the mold cavity and then solidifying the deposited molten metal alloy.




pe

Temperature regulated melt crucible for cold chamber die casting

Disclosed is a vessel for melting and casting meltable materials. The vessel may be a surface temperature regulated vessel for providing a substantially non-wetting interface with the molten materials. In one embodiment, the vessel may include one or more temperature regulating channels configured to flow a fluid therein for regulating a surface temperature of the vessel such that molten materials are substantially non-wetting at the interface with the vessel. Disclosed also includes systems and methods for melting and casting meltable materials using the vessel.




pe

Non-electroslag remelting type clean metal ingot mold

A non-electroslag remelting type clean metal ingot mold includes an ingot mold body and a insulating riser arranged on the ingot mold body; an insulated heating and heat preservation device is vertically arranged in the ingot mold body and divides the space in the ingot mold body into a plurality of independent cavity units; and the cavity units are distributed in two rows in the ingot mold body. Because the insulated heating and heat preservation device is arranged in the ingot mold body and divides the space in the ingot mold body into a plurality of independent cavity units, most of impurities and segregates in liquid metals are enriched in the part in contact with the isolation and heat insulation mechanism during the directional solidification and crystallization of the liquid metals and the enriched alloy segregates, and the impurities can be easily eliminated by utilizing flame or other processing methods.




pe

Copper alloy and copper alloy manufacturing method

A copper alloy having an electrical resistivity lower than those of current copper alloys and a tensile strength higher than those of current copper alloys and a method of manufacturing such a copper alloy are provided. The copper alloy is produced by adding a predetermined amount of carbon to a molten copper in a high-temperature environment of a temperature in the range of 1200° C. to 1250° C. such that the copper alloy has a carbon content in the range of 0.01% to 0.6% by weight.




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Insert molding of bulk amorphous alloy into open cell foam

Provided in one embodiment is a method of making use of foams as a processing aid or to improve the properties of bulk-solidifying amorphous alloy materials. Other embodiments include the bulk-solidifying amorphous alloy/foam composite materials made in accordance with the methods.




pe

Aluminium-copper alloy for casting

An aluminium-copper alloy comprising substantially insoluble particles which occupy the interdendritic regions of the alloy, provided with free titanium in quantity sufficient to result in a refinement of the grain structure in the cast alloy.




pe

Production of die cast rotors with copper bars for electric motors

A rotor core for an electric motor includes a stack of laminations having peripherally spaced openings receiving copper bars with opposite end portions projecting from the stack. The core is mounted on an arbor and is inserted into a mold on a vertical die cast press having a shot chamber. The mold has upper and lower mold members defining annular cavities receiving end portions of the bars. Molten copper or aluminum is poured into the shot chamber and forced upwardly by a shot piston through passages in the lower mold member and into the cavity around the lower end portions of the bars. The pressurized molten metal solidifies and shrinks around the bar end portions to form an endring for the rotor. The core, endring and arbor are inverted and confined in the mold, and the casting steps are repeated to form the opposite endring.




pe

Optimizing feed mixer performance in a paraffinic froth treatment process

The invention relates to improved bitumen recovery processes and systems. One process provides for operation of a bitumen froth treatment plant at optimum shear rates in the feed pipe carrying the bitumen froth to the froth settling unit. Another process provides for optimizing the design of a bitumen froth treatment plant by optimizing the diameter of the feed pipe to impart an optimum shear rate to the bitumen froth mixture and further optimizing the volume of the feed pipe to impart an optimum residence time for the bitumen froth stream in the feed pipe. An optimal plant design is also disclosed, the plant including optimal diameter and volume of the feed pipe.




pe

Filter device, method for its operation and use thereof

A filter device for filtering a suspension includes at least one filter for continuous creation of a filter cake including particles from the suspension, at least one dispensing device configured to apply at least one first wash liquid to the filter cakes, at least one steaming unit configured to steam the filter cake using steam; at least one removal device configured to remove a surface layer of the filter cake facing away from the at least one filter, wherein the filter device is configured to convey the filter cake to the at least one removal device, the at least one dispensing device and the at least one steaming device, and at least one transport device configured to transport the removed surface layer of the filter cake away from the filter device.




pe

Method and apparatus for converting coal to petroleum product

The present invention provides a method of converting coal to a petroleum product. The method includes the steps of mixing the coal and water to form a mixture, and heating the mixture to approximately 500 degrees Fahrenheit. The method further includes separating the mixture in a first separator into a liquid stream of a water bearing minerals and a solid stream of coal, and transferring the coal from the first separator to a coking reactor wherein the temperature is raised to approximately 1,000 degrees Fahrenheit to drive off lighter fractions of the coal as a gas. The method also includes transferring the gas to a fourth separator to separate water and liquid petroleum product from the gas.




pe

Method and apparatus for processing of spent lubricating oil

The present invention provides a method and an apparatus for recovery of spent lubricating oil. The evaporation of hydrocarbon fractions from spent lubricating oil is carried out in three steps. The first step is at approximately 150-1030 mbar and between 70-240° C. in which is greater than 99% water, greater than 99% of ethylene glycol and greater than 50% of hydrocarbon molecules with normal boiling point up to 310° C. are evaporated from spent oil. The second step is operated at 6-30 mbar and 200-2900 C in which predominantly gasoil and light vacuum gasoil fractions are evaporated. The third step is operated at 250-320° C. and 0.5-15 mbar in which mainly heavy vacuum gasoil (boiling range of 425 to 570° C. on ASTM D-1160 test) is evaporated from spent oil.




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Method of making a knit apparel with a tie dyed appearance and an apparel made by the method

A knit apparel is made using a decorating pattern that is generated to give the apparel the appearance of tie dyed apparel. The decorating pattern includes a main element, a secondary element and intermediate zones have the same color but gradually lighter shades as the main element.




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Dial of circular hosiery knitting machine of the type with cylinder and dial with yarn cutting device

A dial of a circular hosiery knitting machine of the type with a cylinder and dial with yarn cutting device. The dial comprises a dial body which is substantially disk-shaped. The dial is provided with a cutting device, which comprises a plurality of cutting sectors which are distributed around the axis of the dial body and have cutting edges. The cutting sectors are arranged at sectors of the dial body which are intended to be free from needles. The cutting device comprises a cutter which is adapted to abut against the cutting edges of the cutting sectors to cut at least one yarn engaged by one of the cutting sectors in its rotary motion about the axis of the dial body with respect to the cutter.




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Orthopedic padding

An orthopedic padding including an elongate spacer fabric having spaced faces interconnected and separated by an intermediate spacer area, the spaced faces having a knitted construction different from a knitted construction of the intermediate spacer area, and the elongate fabric constructed at least in part of hydrophobic monofilament yarn knitted in an open construction for breathability.




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Independently controlled rollers for take-down assembly of knitting machine

A knitting machine includes a take-down assembly that includes a first take-down roller and a second take-down roller. The first take-down roller is configured to rotatably contact and apply tension to a first portion of a knit component. The second take-down roller is configured to rotatably contact and apply tension to a second portion of the knit component. The knitting machine further includes a first actuator that actuates to selectively adjust tension applied by the first take-down roller on the first portion of the knit component. Furthermore, the knitting machine includes a second actuator that actuates to selectively adjust tension applied by the second take-down roller on the second portion of the knit component. Additionally, the knitting machine includes a controller that is operably coupled to the first actuator and the second actuator to selectively and independently control actuation of the first actuator and the second actuator.




pe

Knitted component for an article of footwear including a full monofilament upper

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




pe

Independently controlled rollers for take-down assembly of knitting machine

A knitting machine includes a take-down assembly that includes a first take-down roller and a second take-down roller. The first take-down roller is configured to rotatably contact and apply tension to a first portion of a knit component. The second take-down roller is configured to rotatably contact and apply tension to a second portion of the knit component. The knitting machine further includes a first actuator that actuates to selectively adjust tension applied by the first take-down roller on the first portion of the knit component. Furthermore, the knitting machine includes a second actuator that actuates to selectively adjust tension applied by the second take-down roller on the second portion of the knit component. Additionally, the knitting machine includes a controller that is operably coupled to the first actuator and the second actuator to selectively and independently control actuation of the first actuator and the second actuator.




pe

Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




pe

Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




pe

Sandwich cookie dipper

A sandwich cookie dipper for dipping sandwich cookies in milk includes a handle, a cookie cradle and a transition element that interconnects to and sets off the cookie cradle from the handle. The cookie cradle comprises a thin, resilient rod-like member configured to substantially conform to a part of an outer circumference of a crème layer sandwiched between two disk-like cookie members of a sandwich cookie. The sandwich cookie secured thereby is less likely to dislodge as it is dipped and brought to the cookie eater's mouth.




pe

Beverage brewing apparatus with pump dispensing system

A beverage machine for preparing and dispensing a hot beverage having a pump dispensing system. Hot water passes through a water distributor to infuse material in a filter basket. A coffee tank receives the brewed beverage and maintains it at an appropriate temperature. On demand, a pump dispensing system delivers the beverage through an outlet chamber and spout into a user's cup. The user manipulates a switch to vary the rate at which the pump dispensing system dispenses the beverage.




pe

Novel method for preparing pH dependent Ultra Small Polymeric Nanoparticles for topical and/or Transdermal delivery

The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 mn and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.




pe

CANCER TARGETING BY ANTI-EGFR PEPTIDES AND APPLICATIONS THEREOF

A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.




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MULTI-SPECIFIC ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES AND USES THEREOF

This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.




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CD123 SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.




pe

Cysteine engineered antibodies for site-specific conjugation

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.




pe

METHODS OF INHIBITING PATHOLOGICAL ANGIOGENESIS WITH DOPPEL-TARGETING MOLECULES

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.




pe

BCMA (CD269) SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.




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Monoclonal Antibodies That Specifically Block Biological Activity Of A Tumor Antigen

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.




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APPARATUS FOR SENSING THE UNSTRESSED SHAPE OF A THIN STRIP SUBJECTED TO HIGH TENSILE STRESS

A cold rolling mill is described wherein the unstressed shape of metal sheet is continuously sensed during rolling by a plurality of negligible displacement force sensors perpendicularly disposed relative to the pass line at a mill location producing a tensile stress above 4,000 p.s.i. in the metal sheet being rolled. The output signals from those sensors underlying opposite edges of the metal sheet are compared to equalize reduction at the sheet edges while the difference between the force measured by a centrally situated sensor and the average force measured by the sensors underlying opposite edges of the sheet provide a signal indicative of the roll bending force required to produce flat sheet.




pe

Wireless surround sound speaker system

Disclosed is a wireless surround sound speaker system wherein a transmitter broadcasts a variety of FM signals that correspond to the individual speaker channels commonly found in a surround sound system. Receivers, individually equipped with signal receiving, conditioning and amplification components, are configured to receive any one of the broadcast signals in a remote location and are used to drive a conventional loudspeaker in that location. Powered by wall socket or via DC battery packs, the receivers, used in conjunction with the transmitter, provide surround sound capabilities without the need for complex and difficult wiring.