ffi

Donald Trump announces immigration official Tom Homan as ‘border czar’




ffi

BREAKTHROUGH: KZN police arrest suspect for traffic officer’s murder




ffi

Education official in hot water after allegedly soliciting R5,000 bribe from teacher under investigation




ffi

Taiwan businessman Tsao to sue Chinese officials over sanctions

TAIPEI, TAIWAN — Taiwanese businessman Robert Tsao said on Monday he would sue in a Taiwan court senior Chinese officials over sanctions they had placed on him, saying he was seeking to counter China's intimidation of lawful activity. China, which claims Taiwan as its own territory, last month said it would punish and sanction Tsao, the retired founder of chipmaker UMC, for alleged criminal and pro-Taiwan independence activities. China's Taiwan Affairs Office said the "Black Bear Academy" that Tsao has helped fund was seeking to incite separatism that would endanger cross-strait ties. Tsao, one of Taiwan's richest men who has pledged to provide millions to two civilian defense training programs, told a press conference that China was threatening the lawful holding of political views in Taiwan, and his personal safety. The lawsuit will be lodged in a Taipei court against Song Tao, head of China's Taiwan Affairs Office, and also the office's spokesperson Chen Binhua. Taiwan courts have no jurisdiction in China and senior Chinese officials do not visit the island. China's Taiwan Affairs Office did not respond to a request for comment. Cheng Wen-lung, one of Tsao's lawyers, said they understood that neither Song nor Chen would come to Taiwan and there would be no way of enforcing any judgment, but the case was about sending a message to Beijing, given it has been seeking to use legal means to put pressure on Taiwanese persons it does not like. "Legally, we have to do this," Cheng said. "Taiwan is in a difficult spot, but we have to work hard. You cannot not do anything." Tsao's team is also looking at suing in a U.S. court under that country's Alien Tort Claims Act. China's announcement against Tsao came as the country's military staged a day of war games around Taiwan it said were a warning to "separatist acts." Taiwan's government rejects Beijing's sovereignty claims. UMC says Tsao has nothing to do with the company any longer having retired a decade ago.




ffi

US Senate Democrats rush to confirm judges before Trump takes office

The U.S. Senate's Democratic majority began a crusade on Tuesday to confirm as many new federal judges nominated by President Joe Biden as possible to avoid leaving vacancies that Republican Donald Trump could fill after taking office on Jan. 20. With Republicans set to take control of the chamber on Jan. 3, the Senate on Tuesday held a confirmation vote on one of Biden's judicial nominees - former prosecutor April Perry - for the first time since Trump won the Nov. 5 presidential election. The Senate voted 51-44 in favor of her becoming a U.S. district court judge in Illinois. All told, Biden has announced another 30 judicial nominees who are awaiting Senate confirmation votes. Sixteen have already have been reviewed by the Senate Judiciary Committee and are awaiting a final confirmation vote by the full Senate. Another 14 nominees are awaiting committee review. The U.S. Constitution assigns to the Senate the power to confirm a president's nominees for life-tenured seats on the federal judiciary. "We are going to get as many done as we can," Democratic Senate Majority Leader Chuck Schumer said in a statement. Trump made 234 judicial appointments during his first four years in office, the second most of any president in a single term, and succeeded in moving the judiciary rightward - including building a 6-3 conservative majority on the U.S. Supreme Court with three appointees. Biden has appointed a host of liberal judges. Since the beginning of his presidency in 2021, the Senate has confirmed 214 Biden judicial nominees, including liberal Supreme Court Justice Ketanji Brown Jackson. About two-thirds were women, and the same share were racial minorities. Senate Democrats are under pressure to swiftly confirm the remaining nominees, along with any new picks Biden may name in the waning weeks of his presidency. How many nominees Senate Democrats will be able to confirm remains to be seen. Trump in a social media post on Sunday called on the Senate to halt approving Biden's nominees, saying, "Democrats are looking to ram through their Judges." Billionaire Trump backer Elon Musk on Tuesday wrote on social media that "activist" judicial nominees are "bad for the country." Mike Davis, a Trump ally at the conservative judicial advocacy group Article III Project, in another post urged Senate Republicans to vote down all judicial appointments until January. "The American people voted for monumental change," Davis wrote on social media last week. "Grind the Senate to a halt." Current Senate Republican leader Mitch McConnell's office declined comment. McConnell has consistently opposed Biden's nominees and, as majority leader, was instrumental in getting Trump's previous nominees confirmed. Trump's judicial appointees have been involved in major decisions welcomed by conservatives including Supreme Court rulings rolling back abortion rights, widening gun rights, rejecting race-conscious collegiate admissions and limiting the power of federal regulatory agencies. Judicial nominees require a simple majority for confirmation. Democrats currently hold a slim 51-49 majority, meaning that they can ill afford any defections or absences if Republicans show up in force to oppose Biden's nominees during the chamber's post-election "lame duck" session. West Virginia Senator Joe Manchin, an independent who caucuses with the Democrats, has said he would not vote for any nominee who does not garner at least one Republican vote. Must-pass legislation like a spending bill to avert a government shutdown also may consume precious time during the session. 'Every possible nominee' Biden's allies have said a concerted push to confirm his remaining nominees would allow him to build on his legacy of helping to diversify a federal bench long dominated by white men. He is not done nominating judges. On Friday, Biden announced his first post-election nominee, Tali Farhadian Weinstein, who after unsuccessfully running in the 2021 Democratic primary to be Manhattan district attorney was picked for a job as a federal district judge in New York. A spokesperson for Senator Dick Durbin, the No. 2 Senate Democrat and chair of the Judiciary Committee, said in a statement that he "aims to confirm every possible nominee before the end of this Congress." White House spokesperson Andrew Bates on Monday noted that during Trump's first term, the Republican-controlled Senate confirmed 18 judges after Biden had won the 2020 election but before he took office. Pending nominees include five to the influential federal appeals courts. Republicans said before the election that they had the votes to block two of them: Adeel Mangi, who would become the first Muslim federal appellate judge, and North Carolina Solicitor General Ryan Park, who unsuccessfully defended the race-conscious admissions policies before the Supreme Court. There are several others nominated to serve as trial court judges like Perry, a former prosecutor now working at Chicago-headquartered GE HealthCare who would join the bench in Illinois. Biden nominated her to a judgeship in April after her prior nomination to become Chicago's top federal prosecutor was blocked by Republican Senator JD Vance. Vance began placing a hold on Biden's nominees to the U.S. Justice Department in 2023 after Special Counsel Jack Smith secured the first of two federal indictments against Trump, who subsequently picked the senator as his vice presidential running mate.




ffi

North Korean troops start fighting alongside Russians, say US, Ukraine officials

North Korea troops have begun fighting alongside Russians, a U.S. State Department spokesman said during a briefing on Tuesday. "Over 10,000 DPRK (North Korean) soldiers have been sent to eastern Russia, and most of them have moved to the far western Kursk Oblast, where they have begun engaging in combat operations with Russian forces," spokesperson Vedant Patel told reporters. A day earlier, Ukrainian President Volodymyr Zelenskyy said Ukrainian troops were facing 50,000 troops, including 11,000 North Korean troops deployed by Russia to its Kursk region, although Moscow will neither confirm nor deny their involvement. U.S. Defense Secretary Lloyd Austin spoke Tuesday with his Ukrainian counterpart Rustem Umerov “to discuss battlefield dynamics and provide an update on U.S. security assistance” for the Eastern European country, according to Pentagon press secretary Major General Pat Ryder. Ryder said, "the secretary reaffirmed President [Joe] Biden's commitment to surge security assistance to Ukraine." The Pentagon also clarified the amount of money that remains available for Ukraine's military assistance. There is about $7.1 billion left in the Presidential Drawdown Authority, which includes $4.3 billion approved by Congress in April, plus $2.8 billion that became available after recalculations. Additionally, there is about $2.2 billion available under the Ukraine Security Assistance Initiative program. Ryder again underscored that the U.S. would rush aid to Ukraine and use all available funds. Ryder said the two defense leaders also talked about the implications of the thousands of North Korean troops now assessed to be mostly in western Kursk Oblast. Airstrike kills mother, children A Russia airstrike on Ukrainian President Zelenskyy’s hometown killed a mother and her three children and left 14 people wounded, officials said Tuesday. Interior Minister Igor Klymenko said rescue and recovery operations were complete after the residential building in Kryvyi Rig was hit a day earlier. The office of the prosecutor general said a 32-year-old woman and children who were 10 years, 2 years and 2 months old were killed. In Russia’s Belgorod region, a Ukrainian drone attack started a fire at an oil depot, regional governor Vyacheslav Gladkov posted on the Telegram messaging app. He said a tank caught fire and 10 fire crews responded in the Starkooskolsky District near the Ukrainian border. The Russian defense ministry also said 13 Ukrainian drones were destroyed overnight, all in regions bordering Ukraine. Ukraine’s air force said it shot down 46 Russian drones overnight. In addition, Ukrainian’s military was “holding back a fairly large grouping of Russian troops – 50,000 of the occupier’s army personnel,” in the Kursk region, Zelenskyy said in his address to the nation Monday. “Our forces' strikes on Russian arsenals have reduced the amount of artillery used by the occupier, and this is noticeable at the front. That is why we need decisions from our partners – America, Britain, Germany – on long-range capabilities,” Zelenskyy said. “This is vital. The further our missiles and drones can hit, the less real combat capability Russia will have.” North Korea defense pact The forces in Kursk include 11,000 North Korean troops deployed by Russia to Kursk, Zelenskyy has said, although Moscow will neither confirm nor deny their involvement. State media in North Korea reported that country ratified a defense agreement with Russia on Tuesday, formalizing months of deepening security ties. The deal "was ratified as a decree" of leader Kim Jong Un, the Korean Central News Agency (KCNA) said Tuesday. The notice comes after Russian lawmakers voted unanimously last week to ratify the deal, which President Vladimir Putin later signed. "The treaty will take effect from the day when both sides exchanged the ratification instruments," KCNA said. Putin and Kim signed the strategic pact in June, during Putin’s visit to North Korea. Material from The Associated Press, Reuters and Agence France-Presse was used in this report.




ffi

PML-Q Affirms Independence and Tractor Symbol for Upcoming Elections

In Lahore on Sunday, Chaudhry Shafay Hussain, the leader of Pakistan Muslim League-Quaid (PML-Q), asserted that his party has no intentions of merging with any other political group. Hussain clarified, “While seat adjustments may occur in specific constituencies with the Pakistan Muslim League-Nawaz, the PML-Q is committed to maintaining its independent identity.” PML-Q’s commitment to ... Read more

The post PML-Q Affirms Independence and Tractor Symbol for Upcoming Elections appeared first on Pakistan Tribune.




ffi

Bolivia's Morales barred from running for political office

LA PAZ, BOLIVIA — A constitutional court in Bolivia has barred former President Evo Morales from running again for office, ushering in a new phase in the country's long-running political crisis. Morales, who led Bolivia from 2006 to 2019, had been vying for the candidacy of his MAS party, alongside his former mentee-turned-rival, President Luis Arce. But, in a decision last week that was reported on Friday, Bolivia's constitutional court ruled that presidents were limited to serving two terms, whether consecutive or nonconsecutive. After his first two terms, a court ruling allowed Morales to serve a third term because his first preceded a constitutional rewrite. He ran for a fourth term in the 2019 elections but fled the country after the results were disputed and unrest ensued. Arce was elected in 2020. "Without a doubt, this ushers in a new era of politics in Bolivia," opposition lawmaker Marcelo Pedrazas told journalists Friday. "In 2025, we'll have an election without Evo Morales on the ballot." Morales' lawyer, Orlando Ceballos, called the court's ruling politically motivated. "What are they trying to do? To get rid of MAS, to disqualify Evo, that's the point," Ceballos said in a radio interview, adding that they would take up the matter with the Inter-American Commission on Human Rights. Morales and Arce have increasingly butted heads in past weeks, with Morales supporters using roadblocks to halt commerce and raiding military bases. Morales has called for peaceful talks with the government but went on a nearly weeklong hunger strike in protest of what he considers political persecution by Arce's administration. On Friday, lawmakers loyal to Morales caused chaos in Congress, shouting and throwing flowers at the vice president ahead of Arce's planned yearly address and forcing him to deliver his speech from the presidential palace.




ffi

East-West Center Student Affiliate Program

East-West Center Student Affiliate Program

fairfieb




ffi

Gauteng police arrest seven suspected victims of human trafficking linked to counterfeit food




ffi

Commuters face heavy traffic as SiGMA convention kicks off

This event is expected to draw around 25,000 attendees, leading to significant delays on key routes across the island




ffi

Election Officials in the Top 30 Most Populous U.S. Counties

With an average of only one in five voters participating in local elections, voting results are easily swayed by just one vote. Voting in local elections has never been more critical.





ffi

Somalia's Intelligence Agency Arrests Two Al-Shabaab Affiliates in Mogadishu

[Shabelle] Mogadishu, Somalia -- The National Intelligence and Security Agency (NISA) of Somalia announced on Thursday the arrest of two men with ties to the militant group Al-Shabaab in the capital city of Mogadishu.





ffi

Saudi armed forces chief of staff in Iran for talks with officials


Iran's state media said al-Ruwaili headed a high-level Saudi military delegation in Tehran and met Armed Forces Chief of Staff Major General Mohammad Bagheri.




ffi

Defense officials fear Iran will act against Israel before Trump returns to WH


Intelligence services have begun intensifying intelligence sharing and situational assessments with the US military to prevent overlooking critical developments.




ffi

Trump says Musk, Ramaswamy will form outside group to advise White House on government efficiency

Trump says Musk, Ramaswamy will form outside group to advise White House on government efficiency




ffi

Senior Ombuds Programs Officer

ADB has a vacancy for the position of Senior Ombuds Programs Officer in the Office of the Ombudsperson. The deadline for submitting applications is on 13-NOV-2024.




ffi

Senior IT Officer (Change Lead)

ADB has a vacancy for the position of Senior IT Officer (Change Lead) in the Information Technology Department . The deadline for submitting applications is on 13-NOV-2024.




ffi

Senior Compliance Review Officer

ADB has a vacancy for the position of Senior Compliance Review Officer in the Office of the Compliance Review Panel. The deadline for submitting applications is on 21-NOV-2024.




ffi

Associate IT Officer (Technology Operations Governance and Service Management)

ADB has a vacancy for the position of Associate IT Officer (Technology Operations Governance and Service Management) in the Information Technology Department . The deadline for submitting applications is on 19-NOV-2024.




ffi

Associate Climate Change Officer

ADB has a vacancy for the position of Associate Climate Change Officer in the Climate Change and Sustainable Development Department. The deadline for submitting applications is on 23-NOV-2024.




ffi

Project Officer (Transport)

ADB has a vacancy for the position of Project Officer (Transport) in the Sectors Group. The deadline for submitting applications is on 26-NOV-2024.




ffi

(Associate) Human Resource Officer

ADB has a vacancy for the position of (Associate) Human Resource Officer in the Budget, People, and Management Systems Department. The deadline for submitting applications is on 20-NOV-2024.





ffi

Greeley police officer kills mountain lion near school

The mountain lion was considered a public threat and had activated a shelter-in-place order for nearby residents.




ffi

22 drown as bus plunges into river in Diamer: rescue officials

Twenty-two people drowned, while one person was saved on Tuesday after a bus carrying them plunged into a river in Gilgit-Baltistan’s Diamer district on Tuesday, according to rescue officials.

“Sixteen dead bodies have been recovered from the river, while the search for the remaining persons continues,” Senior Superintendent of Police Diamer, Sher Khan, told Dawn.com.

He added that a woman, who was a bride, had sustained injuries and was receiving treatment at a hospital.

Sharing details of the accident earlier, Rescue 1122 spokesperson Shaukat Riaz told Dawn.com that a bus coming from Astore fell into the Indus River from Telchi bridge in the limits of Diamer district in Gilgit-Baltistan on Tuesday afternoon.

“The vehicle was part of a wedding procession heading towards Punjab’s Chakwal district,” he said.

He added the passengers who were onboard the bus had been identified and women were among the drowned.

“Nineteen of them belonged to Astore while four were from the Chakwal district of Punjab,” he said.

The district administration officials were also present on the spot and supervised the search operation in the river, Riaz added.

President Asif Ali Zardari expressed his grief and conveyed his condolences to the victims’ relatives.

Road accidents are frequent in KP and GB, exacerbated by harsh weather, rugged terrain, poorly maintained roads, overloaded vehicles, and minimal traffic regulations.

The narrow, winding routes and driver fatigue further elevate risk, making these regions especially accident-prone.

In October, two people were killed and 36 others were injured when a Rawalpindi-bound passenger bus fell into a ravine in Khyber Pakhtunkhwa’s Upper Kohistan area.




ffi

Nadra will have to hike fees to open more offices

ISLAMABAD: The National Database and Registration Authority (Nadra) chief has told a National Assembly panel that the fees for identity cards will have to be increased if it opens up more offices.

In a briefing to the National Assembly’s Standing Committee on Interior on Tuesday, Nadra Chairman Lt General Munir Afsar said the authority has no office in 61 tehsils of Khyber Pakhtunkhwa and Balochistan.

The committee, which met for the second consecutive day with Raja Khurram Nawaz in the chair, was told that 26 National Registration Centres (NRCs) and three mega NRCs were currently operational in Karachi.

The authority is planning to open one more NRC and four mega NRCs in Karachi next year.

Chairman tells NA body six employees were sacked over data breaches

While talking about the security of Nadra’s infrastructure, Lt Gen Afsar said the agency monitors three to four hundred individuals daily to detect data leaks and unauthorised identity card issuances.

He said six Nadra employees, including a grade-19 officer, have been dismissed over their alleged involvement in a data breach.

The breach compromised the data of around 2.7 million citizens between 2019 and 2023.

A joint investigation team formed to probe the data leak in March submitted a report to the Interior Ministry revealing that Nadra officers in Karachi, Multan and Peshawar were involved in the data theft.

The NA committee was informed that Nadra had dismissed 202 hired and 60 officers during the last five years.

The authority’s revenue has increased from Rs23.55billion in 2019-20 to Rs57bn in 2023-24.

FIA DG briefs committee

The Federal Investigation Agency (FIA) director general, Ahmad Ishaque Jehangir, briefed the committee about human smuggling networks recently uncovered by his organisation.

He said smugglers in Lahore, Rawalpindi and Karachi lure people with the prospects of overseas employment.

He said the agency was probing the case further, and the investigation is expected to conclude in six to seven months as this is a cross-border crime, and additional information is required from law enforcement agencies in Romania.

An additional inspector general (AIG) of Punjab police briefed the participants on rape cases involving minors reported in the province over the past five years.

From 2020 to 2024, 8,306 such cases were registered, with 6,950 accused arrested. Of these, 299 were convicted, 1,736 acquitted, 1,088 discharged, and 3,827 cases were still under trial, the lawmakers were told.

The committee also discussed the new “Criminal Law (Amendment) Bill, 2024 and directed the ministry to include a clause permitting the filing of an FIR against Discos and employees responsible for overbilling.

The members said that electricity usage and theft slabs should be specified in the bill and that the proposed law should differentiate between residential, commercial, and industrial users.

Published in Dawn, November 13th, 2024




ffi

8100 officejet pro service manual

8100 officejet pro service manual




ffi

6500 officejet printer manual

6500 officejet printer manual




ffi

6500 officejet wireless manual

6500 officejet wireless manual




ffi

4500 officejet wireless guide

4500 officejet wireless guide




ffi

4500 manual officejet

4500 manual officejet




ffi

Loan No. 49423-BAN: Bangladesh Power System Enhancement and Efficiency Improvement Project [URIDS-G-04]




ffi

Grant No. 0183-NEP: Energy Access and Efficiency Improvement Project [ICB No. CFL-068/69-01]




ffi

Loan No. 2830-IND: Madhya Pradesh Energy Efficiency Improvement Investment Program – Tranche 2 [MD / WZ / 06 / PUR / ADB /993]




ffi

Meghna Energy-Efficient Flour Milling Project

The transaction involves a senior secured loan of up to $20,000,000 to Tanveer Dal Mill and Flour Mills Limited (Tanveer) for the Meghna Energy-Efficient Flour Milling Project in Bangladesh. Tanveer is part of Meghna group.




ffi

GSA Energy-Efficient Green Data Center Project

The proposed project will support the development of a 25.6 MW Tier-III/Rated 3, LEED Gold certified, green data center in Samut Prakan, Thailand. This financing will align with the Green Loan Principles and marks ADB's first data center financing, supporting Thailand's green growth and innovation agenda. The project aims to expand green data center capacity in Thailand, demonstrate the potential for green data centers, and support the digital economy while aligning with ADB's climate finance targets. This financing will align with the Green Loan Principles and marks ADB's first data center financing, supporting Thailand's green growth and innovation agenda. The project aims to expand green data center capacity in Thailand, demonstrate the potential for green data centers, and support the digital economy while aligning with ADB's climate finance targets.




ffi

Chimps do better at difficult tasks when they have an audience

An analysis of thousands of cognitive tests carried out by chimpanzees finds that the number of spectators influenced their performance in different ways depending on the difficulty of the task




ffi

Hybrid design could make nuclear fusion reactors more efficient

Two types of fusion reactor called tokamaks and stellarators both have drawbacks – but a new design combining parts from both could offer the best of both worlds




ffi

We might officially enter the Anthropocene epoch in 2024

Scientific bodies are due to make an official decision in the coming year about whether to declare a new geochronological unit precipitated by the impact of humans on Earth




ffi

Chimps do better at difficult tasks when they have an audience

An analysis of thousands of cognitive tests carried out by chimpanzees finds that the number of spectators influenced their performance in different ways depending on the difficulty of the task




ffi

New Blood Thinner Effient No Better Than Plavix at Preventing Heart Trouble: Study

Title: New Blood Thinner Effient No Better Than Plavix at Preventing Heart Trouble: Study
Category: Health News
Created: 8/26/2012 10:05:00 AM
Last Editorial Review: 8/27/2012 12:00:00 AM




ffi

Two Ebola Patients Who Received Experimental Treatment Have Recovered: Congo Officials

Title: Two Ebola Patients Who Received Experimental Treatment Have Recovered: Congo Officials
Category: Health News
Created: 8/27/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM




ffi

Traffic Noise Is (Bad) for the Birds

Title: Traffic Noise Is (Bad) for the Birds
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM




ffi

Scientists Challenge Key Survival Stat Cited by U.S. Officials in Plasma Approval

Title: Scientists Challenge Key Survival Stat Cited by U.S. Officials in Plasma Approval
Category: Health News
Created: 8/25/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM




ffi

Michigan Officials Puzzled by Mysterious Deaths of 30 Dogs

Title: Michigan Officials Puzzled by Mysterious Deaths of 30 Dogs
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM




ffi

Reply to Letter to Editor Concerning “Nocturnal Pressure Controlled Ventilation Improves Sleep Efficiency in Patients Receiving Mechanical Ventilation”




ffi

Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice [Behavioral Pharmacology]

Low-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relative to high-efficacy opioids. This study used a recently validated assay of pain-depressed behavior in mice to evaluate a novel series of MOR-selective C9-substituted phenylmorphan opioids with graded MOR efficacies. Intraperitoneal injection of dilute lactic acid (IP acid) served as a noxious stimulus to depress locomotor activity by mice in an activity chamber composed of two compartments connected by an obstructed door. Behavioral measures included (1) crosses between compartments (vertical activity over the obstruction) and (2) movement counts quantified as photobeam breaks summed across compartments (horizontal activity). Each drug was tested alone and as a pretreatment to IP acid. A charcoal-meal test and whole-body-plethysmography assessment of breathing in 5% CO2 were also used to assess gastrointestinal (GI) inhibition and respiratory depression, respectively. IP acid produced a concentration-dependent depression in crosses and movement that was optimally alleviated by intermediate- to low-efficacy phenylmorphans with sufficient efficacy to produce analgesia with minimal locomotor disruption. Follow-up studies with two low-efficacy phenylmorphans (JL-2-39 and DC-1-76.1) indicated that both drugs produced naltrexone-reversible antinociception with a rapid onset and a duration of ~1 h. Potency of both drugs increased when behavior was depressed by a lower IP-acid concentration, and neither drug alleviated behavioral depression by a non-pain stimulus (IP lithium chloride). Both drugs produced weaker GI inhibition and respiratory depression than fentanyl and attenuated fentanyl-induced GI inhibition and respiratory depression. Results support further consideration of selective, low-efficacy MOR agonists as candidate analgesics.

SIGNIFICANCE STATEMENT

This study used a novel set of mu opioid receptor (MOR)-selective opioids with graded MOR efficacies to examine the lower boundary of MOR efficacy sufficient to relieve pain-related behavioral depression in mice. Two novel low-efficacy opioids (JL-2-39, DC-1-76.1) produced effective antinociception with improved safety relative to higher- or lower-efficacy opioids, and results support further consideration of these and other low-efficacy opioids as candidate analgesics.