We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology platform. The configuration of this gene fusion predicts the production of a kinase-activating JAK2 fusion protein, which would normally lead to a diagnosis of Philadelphia chromosome–like B-ALL (Ph-like B-ALL). However, the unusual presentation of eosinophilia led us to demonstrate the presence of this gene fusion in nonlymphoid hematopoietic cells by fluorescence in situ hybridization (FISH) studies with morphologic correlation. Therefore, we believe this disease, in fact, represents blast crisis arising from an underlying myeloid neoplasm with JAK2 rearrangements. This case illustrates the difficulty in differentiating Ph-like B-ALL and myeloid/lymphoid neoplasm with eosinophilia and gene rearrangements (MLN-EGR) in blast crisis. As currently defined, the diagnosis of MLN-EGR relies on the hematologic presentations and the identification of marker gene fusions (including PCM1-JAK2, ETV6-JAK2, and BCR-JAK2). However, these same gene fusions, when limited to B-lymphoblasts, also define Ph-like B-ALL. Yet, our case does not conform to either condition. Therefore, the assessment for lineage restriction of gene rearrangements to reflect the pathophysiologic difference between B-ALL and MLN-EGR in blast crisis is likely a more robust diagnostic approach and allows the inclusion of MLN-EGR with novel gene fusions.

It all boils down to how resilient the region is, says an urban planner and designer based in Manila.

Tens of thousands of new apartments enter the Ho Chi Minh City market every year, putting pressure on investors who want to reap returns from rental apartments.

If you didn’t feel challenged enough by Indivisible‘s main platforming and punching campaign, here’s some good news for ya. Lab Zero have released a new DLC for their turn-ish-based RPG today that promises the “forty specially crafted levels await to test your platforming and combat skills.” The Razmi’s Challenges DLC is available now, so you […]

Get ready for the first scored event in DARPA's latest Grand Challenge

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Bill Maher said Republicans "don't care" about Tara Reade's sexual assault allegations, saying such claims are simply used as a "unilateral weapon" against Democrats.

The Roses are Red Challenge has caught the internet and has become a fad now as the netizens are coming up with a hilarious line which rhyme with roses are red. It is the netizens who have started this trend amid lockdown and most of them are making their own versions of their poems. Most of them tickle your funny bone with the one-liners which have caught the attention of the Internet users.

Arsenal and England midfielder Jordan Nobbs will be a columnist for 90min & BBC Sport pundit at the Women's World Cup in France this summer, as Phil Neville's Lionesses' look to secure a maiden World Cup triumph. Two wins from our first two games is obviously what we were all hoping for. The first game of a World Cup, or any other major tournament, is never going to be one where you're playing at your absolute best. But the 2-1 win over was Scotland was great given the pre-match hype, the..

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Follow our live coronavirus updates HERE Coronavirus: The symptoms

Follow our live coronavirus updates here Coronavirus: the symptoms

A group of parents who were challenged by police over a trip to the beach during the coronavirus lockdown claimed their children needed a "change of air".

A one-minute silence for the fallen heroes of the NHS was backed by the Government today.

A pregnant doctor and her husband are bringing a legal challenge against the Government which questions the lawfulness of current guidance and a failure to source PPE.

The nine-year-old was inspired by hero fundraiser Captain Tom Moore's £30 million fundraiser

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The Budd family hopes to raise £20,000 for charities including The Felix Project You can donate at virginmoneygiving.com/fund/FoodforLondonNOW

Damien Conrad from The Felix Project shares his story You can donate here virginmoneygiving.com/fund/FoodforLondonNOW

Low staff numbers and a lack of PPE are among the challenges facing schools as they draw together plans to reopen.

Boris Johnson has paid his respects to fallen soldiers ahead of the 75th anniversary of Victory in Europe (VE) Day on a visit to Westminster Abbey.

The travel industry has sifted through the BBC show’s many sex scenes to showcase shots of Ireland’s landscape

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NASA has awarded the University of Washington a $499,864 grant to develop a competition that calls on students to turn a simulated lava tube into a habitat suitable for harboring humans on the moon or Mars. The exploration and habitation skills competition will be funded as part of NASA's Artemis Student Challenges program, which plays off the themes of the Artemis moon program to inspire the next generation of explorers and engineers. The competition will involve navigating a rover through a facsimile lava tube and surface structures, generating maps, identifying valuable resources and deploying an airtight barrier to seal the… Read More

The third time's the charm for the Allen Institute for Brain Science's 3-D atlas of the mouse brain. Version 3 of the atlas, known as the Allen Mouse Brain Common Coordinate Framework or CCFv3, is the subject of a research paper published today in the journal Cell. It builds on a partial brain map that focused on the mouse cortex and was released in 2016. Previous versions of the atlas were rendered with lower-resolution 3-D maps. The latest high-resolution maps are fine enough to pinpoint the locations of individual brain cells — which is crucial for interpreting datasets that contain thousands… Read More

These are trying times, not least because corporate life needs to go on, which for millions of businesses means delivering compute resources…

The health care sector has cut 1.4 million jobs in April. And as COVID-19 has consumed health care resources, other essential routine procedures — like screenings for strokes — have gone down.

It seems like Lily Allen confirmed her engagement with her partner David Harbour. Lily shared an Instagram photo showing off her abs, but accidentally (or maybe not?) gave a glimpse of the diamond ring. Allen was referring to the line from “Fight Club” movie. “The first rule of Fight Club is: You do not talk […]

The post Lily Allen Hints About Engagement With David Harbour appeared first on Chart Attack.

He invited Sylvester Stallone and Arnold Schwarzenegger to also take part.

Adam Silver outlined a potentially grim future for the NBA in a call with players, calling the pandemic the "single greatest challenge of all our lives."

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The Nigerian musician was a restless creator who embraced the physicality of drumming and innovated until the end

• Tony Allen’s 10 best tracks
• News report: Afrobeat co-founder Tony Allen dies aged 79

Few musicians can claim to have invented a revolutionary rhythm, but then few are quite like the late Afrobeat pioneer Tony Allen. Brian Eno called him “the greatest drummer that ever lived”, citing his style alongside James Brown’s funk breakbeat and the constant pulse of German band Neu! as the “three great beats of the 1970s”. Allen’s swirl of jazz, Yoruba and highlife was unlike anything the world had ever heard: a full-body polyrhythmic workout that would give most drummers sore wrists just thinking of it.

Allen came to prominence in Lagos alongside Fela Kuti. He started drumming in the late 50s while working at a radio station, looking to jazz icons such as Art Blakey and Max Roach for inspiration as he taught himself to play. In 1964 he met Kuti and they spent the next half-decade fine-tuning their fusion of west African party music and American funk and jazz, in the bands Koola Lobitos and, by 1969, Africa ’70. While Kuti, who died in 1997, is more well-known than his musical soulmate, he said that “without Tony Allen there would be no Afrobeat”.

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The singer posted the sweet snap on what should have been the start of the summer term

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The Smile singer has often talked candidly about her previous alcohol and drug use

Pioneering Afrobeat drummer Tony Allen has died at the age of 79.

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