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Long walk home ends in tragedy: Goods train mows down 16 migrants

Migrants fell asleep on railway track in Maharashtra




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World coronavirus dispatch: How the wealth management industry is changing

From US-China talks to end trade deadlock, to FDA nod for Moderna drug's Phase-II trials, and an Amsterdam restaurant with 'quarantine greenhouses' - read these and more in today's world dispatch




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Vande Bharat: Repatriation flights, ships bring over 700 Indians back home

Through Vande Bharat Mission, 64 flights and three Navy ships are to repatriate nearly 15,000 Indians stranded abroad




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Opposition leaders write to Prez expressing concern over workers' lives

In their letter to the President, the Opposition leaders raised the issue of labour laws being nullified and hard-won democratic rights of a vast majority of Indian people people being compromised




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Coronavirus LIVE: Testing scaled up to 95,000 per day, says Harsh Vardhan

Coronavirus India update: Stay tuned with Business Standard for latest news on COVID-19, world death toll, and cases across the world and in India




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Work on to neutralise remaining Styrene gas at LG Polymers' Vizag plant

The Chief Secretary said the gas leak resulted in 12 deaths, while 454 others had to be admitted to various hospitals




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OCI card holders' entry in India to remain suspended during lockdown: Govt

The government has kept in abeyance multiple-entry life-long visas given to OCI card holders till the time international travel resumes




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Lockdown 3.0: Odisha ups working hours to 12; staff to be paid for overtime

No female workers should be allowed or required to work in a factory between 7 pm and 6 am, unless specifically permitted by the government in this regard, the state govt order said




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Aurangabad train accident: Raised an alarm but to no avail, says eyewitness

As many as 16 migrant labourers were killed and five others injured when a freight train ran over them between Jalna and Aurangabad on Friday




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Vande Bharat Mission: Indians to arrive from Bangladesh, Gulf, UK today

India had on Monday announced it would begin a phased repatriation of its citizens stranded abroad starting May 7




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Lockdown impact: Fuel demand in India plunged to historic lows in April

In its latest report, the International Energy Agency has said India's annual fuel consumption will decline 5.6 per cent in 2020




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I am healthy, not suffering from any disease: Amit Shah issues statement

"I am totally healthy and I am not suffering from any disease," he said in the statement in Hindi which was posted on his Twitter handle




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Microfabricated electrochemical sensing devices

Lab Chip, 2020, 20,1358-1389
DOI: 10.1039/C9LC01112A, Critical Review
Fumihiro Sassa, Gokul Chandra Biswas, Hiroaki Suzuki
Electrochemistry provides possibilities to realize smart microdevices of the next generation with high functionalities.
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A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy

Lab Chip, 2020, 20,1418-1425
DOI: 10.1039/D0LC00149J, Paper
Chun-Miao Xu, Man Tang, Jiao Feng, Hou-Fu Xia, Ling-Ling Wu, Dai-Wen Pang, Gang Chen, Zhi-Ling Zhang
A system integrating diagnostic and therapeutic functions for cancer is presented using magnetically controlled microfluidics.
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Colorimetric absorbance mapping and quantitation on paper-based analytical devices

Lab Chip, 2020, 20,1441-1448
DOI: 10.1039/D0LC00028K, Paper
Open Access
Yoshiki Soda, Kye J. Robinson, Thomas J. Cherubini, Eric Bakker
A pixel-level colorimetric absorbance analysis can measure the total quantity of dye on paper, irrespective of shape and size.
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Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces

Lab Chip, 2020, 20,1410-1417
DOI: 10.1039/C9LC01256G, Paper
Rodi Abdalkader, Ken-ichiro Kamei
Human corneal epithelium coexists with tear fluids and shows its barrier functionality under the dynamic conditions of eye blinking. We developed a microfluidic platform enabling the dynamic culture of the human corneal barrier with recapitulation of eye blinking.
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An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

Lab Chip, 2020, 20,1390-1397
DOI: 10.1039/D0LC00021C, Communication
Bo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi “Leo” Liu, Pei-Shan Chung, Harold G. Monbouquette, Pei-Yu Chiou, Nigel T. Maidment
PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.
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Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing

Lab Chip, 2020, 20,1461-1471
DOI: 10.1039/C9LC01097A, Paper
Open Access
Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R. A. Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A. Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F. Tedde, Hans P. Kiener, Peter Ertl
We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.
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Rapid lipolytic oscillations in ex vivo adipose tissue explants revealed through microfluidic droplet sampling at high temporal resolution

Lab Chip, 2020, 20,1503-1512
DOI: 10.1039/D0LC00103A, Paper
Juan Hu, Xiangpeng Li, Robert L. Judd, Christopher J. Easley
High temporal resolution sampling and quantitative detection of glycerol secretion dynamics from adipose tissue using our automated, droplet-based microfluidic system.
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Contact lens-based lysozyme detection in tear using a mobile sensor

Lab Chip, 2020, 20,1493-1502
DOI: 10.1039/C9LC01039D, Paper
Zachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan Ozcan
A rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.
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Mathematical modeling and computational analysis of centrifugal microfluidic platforms: a review

Lab Chip, 2020, 20,1318-1357
DOI: 10.1039/C9LC00775J, Critical Review
Open Access
Masoud Madadelahi, Luis F. Acosta-Soto, Samira Hosseini, Sergio O. Martinez-Chapa, Marc J. Madou
This paper focuses on theory and computational modelling of lab-on-a-disc devices of relevance for novel applications discovery and optimal designs.
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Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00051E, Paper
Jinxin Zhang, Jessica H. Hartman, Chuyi Chen, Shujie Yang, Qi Li, Zhenhua Tian, Po-Hsun Huang, Lin Wang, Joel N. Meyer, Tony Jun Huang
Acoustofluidic sorting of Caenorhabditis elegans in a high throughput manner.
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Nanoplasmon-enhanced drop-screen for high throughput single-cell nucleocytoplasmic miRNA profiling

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01226E, Paper
Jia Liu, Guoyun Sun, Shih-Chung Wei, Song Guo, Weikang Nicholas Lin, Chia-Hung Chen
Nanoplasmon-enhanced drop screen is developed to measure single-cell multiple miRNAs with high sensitivity of 0.1 nM, addressing cell nucleocytoplasmic profile in a throughput ∼100 cells per minute.
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Stretching DNA to twice the normal length with single-molecule hydrodynamic trapping

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01028A, Paper
Open Access
Yan Jiang, Theodore Feldman, Julia A. M. Bakx, Darren Yang, Wesley P. Wong
High-speed hydrodynamic trapping enables combined surface-free force spectroscopy and fluorescence imaging of single DNA molecules at extreme forces.
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ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00254B, Paper
Azusa Shimizu, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miura, Hiroaki Onoe
A perfusable and stretchable gelatin-based microfluidic system that can apply both simultaneous fluidic shear stress and stretch stress to in vitro endothelial 3D tissues is presented.
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Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01192G, Paper
Roman Mikhaylov, Fangda Wu, Hanlin Wang, Aled Clayton, Chao Sun, Zhihua Xie, Dongfang Liang, Yinhua Dong, Fan Yuan, Despina Moschou, Zhenlin Wu, Ming Hong Shen, Jian Yang, Yongqing Fu, Zhiyong Yang, Christian Burton, Rachel J. Errington, Marie Wiltshire, Xin Yang
We demonstrate a novel SAW device fabrication technique by mechanically clamping interdigital electrodes (IDEs) on the printed circuit board (PCB) to a LiNbO3 wafer. The novel PCB-SAW device is capable of performing all the functions of standard SAW devices.
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A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00263A, Paper
Jaime L. Korner, Elanna B. Stephenson, Katherine S. Elvira
A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.
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A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00059K, Paper
Open Access
Christian G. M. van Dijk, Maarten M. Brandt, Nikolaos Poulis, Jonas Anten, Matthijs van der Moolen, Liana Kramer, Erik F. G. A. Homburg, Laura Louzao-Martinez, Jiayi Pei, Merle M. Krebber, Bas W. M. van Balkom, Petra de Graaf, Dirk J. Duncker, Marianne C. Verhaar, Regina Luttge, Caroline Cheng
We present a microfluidic vascular device. Vascular cells in a 3D-ECM environment support hemodynamic flow and enable monocyte interaction.
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Current commercialization status of electrowetting-on-dielectric (EWOD) digital microfluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00144A, Critical Review
Jia Li, Chang-Jin “CJ” Kim
Electrowetting on EWOD surface: a droplet beading or spreading (left) or translating (right) by electric signals. The EWOD technology made the once-obscure electrowetting phenomenon practical, leading to the host of commercial products today.
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Direct loading of blood for plasma separation and diagnostic assays on a digital microfluidic device

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00302F, Paper
Christopher Dixon, Julian Lamanna, Aaron R. Wheeler
The integration of 3D porous membranes in a digital microfluidic device enables the generation of cell-free plasma from finger-stick volumes of blood with in-line, on-chip analysis.
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A new polymer lab-on-a-chip (LOC) based on a microfluidic capillary flow assay (MCFA) for detecting unbound cortisol in saliva

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00071J, Paper
Vinitha T. U., Sthitodhi Ghosh, Alexander Milleman, Thinh Nguyen, Chong H. Ahn
A new polymer lab-on-a-chip with on-chip dried reagents for microfluidic capillary flow assay (MCFA) detection of unbound cortisol in saliva.
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Photonic crystal-based smart contact lens for continuous intraocular pressure monitoring

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01268K, Paper
Bohee Maeng, Hyung-kwan Chang, Jungyul Park
A powerless smart contact lens enabling to monitor intraocular pressure (IOP) by checking the visual color change in photonic crystal structure with a microhydraulic amplification system has been realized.
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Spatially isolated reactions in a complex array: using magnetic beads to purify and quantify nucleic acids with digital and quantitative real-time PCR in thousands of parallel microwells

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00069H, Paper
W. Hampton Henley, Nathan A. Siegfried, J. Michael Ramsey
Encoded beads carrying primer pairs for nucleic acid targets are used for sample preparation and multiplexed-in-space digital PCR quantification.
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Multiplexed homogeneous digital immunoassay based on single-particle motion analysis

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00079E, Paper
Kenji Akama, Hiroyuki Noji
Homogeneous digital immunoassay is a powerful analytical method for highly sensitive biomarker detection with a simple protocol. By using this method, we demonstrated the simultaneous multiple protein detection.
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In-air EIS sensor for in situ and real-time monitoring of in vitro epithelial cells under air-exposure

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01064E, Paper
Seungbeom Noh, Hanseup Kim
This paper reports in-air monitoring of in vitro monolayer cells under air-exposure utilizing electrochemical impedance spectroscopy (EIS).
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Nanocrystal synthesis, μfluidic sample dilution and direct extraction of single emission linewidths in continuous flow

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00213E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ioannis Lignos, Hendrik Utzat, Moungi G. Bawendi, Klavs F. Jensen
We present a flow-based system coupled with an optical interferometry setup for the extraction of single nanocrystal properties.
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Acoustic separation of living and dead cells using high density medium

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00175A, Paper
Open Access
Karl Olofsson, Björn Hammarström, Martin Wiklund
A novel, simple and robust route for binary separation of viable and dead cells using a density modified medium which takes advantage of the compromised cell membrane of dead cells.
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Capacitive Sensing of Triglyceride Film Reactions: A Proof-of-Concept Demonstration for Sensing in Simulated Duodenal Contents with Gastrointestinal Targeting Capsule System

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00133C, Paper
George Banis, Luke Beardslee, Justin Stine, Rajendra Mayavan Sathyam, Reza Ghodssi
Ingestible capsule systems continue evolving to overcome drawbacks associated with traditional gastrointestinal (GI) diagnostic and therapeutic processes, such as location restrictions or insufficient sensitivity measures when obtaining information on local...
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Catalytic exchange of hydrogen isotopes intensified by two-phase stratified flow in wettability designable microchannels

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00250J, Paper
Yuexiao Song, Feng Xin, Yongsheng Xu
This work develops a reliable method to achieve stratified flow in squared cross-section microchannels by endowing the four channel walls with very different wettabilities. The gas–liquid flows are studied experimentally...
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PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology

Lab Chip, 2020, 20,1628-1638
DOI: 10.1039/C9LC01165J, Paper
Jose A. Wippold, Han Wang, Joseph Tingling, Julian L. Leibowitz, Paul de Figueiredo, Arum Han
Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents.
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Auto-affitech: an automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method

Lab Chip, 2020, 20,1577-1585
DOI: 10.1039/D0LC00024H, Paper
Jingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong Yang
An automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.
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Microfluidic device to study flow-free chemotaxis of swimming cells

Lab Chip, 2020, 20,1639-1647
DOI: 10.1039/D0LC00045K, Paper
Nicolas Garcia-Seyda, Laurene Aoun, Victoria Tishkova, Valentine Seveau, Martine Biarnes-Pelicot, Marc Bajénoff, Marie-Pierre Valignat, Olivier Theodoly
Permeable agarose barriers allow flow-free gradient generation, applicable to adherent and non-adherent (swimming) cells, as well as co-culture experiments.
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Monitoring the two-dimensional concentration profile of toluene vapors by using polymer-stabilized nematic liquid crystals in microchannels

Lab Chip, 2020, 20,1687-1693
DOI: 10.1039/C9LC01021A, Paper
Zongdai Liu, Dan Luo, Kun-Lin Yang
The concentration of toluene vapor is obtained based on polymer-stabilized liquid crystals by viewing a colourful gamut under a polarized optical microscope.
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A microfluidic platform for functional testing of cancer drugs on intact tumor slices

Lab Chip, 2020, 20,1658-1675
DOI: 10.1039/C9LC00811J, Paper
A. D. Rodriguez, L. F. Horowitz, K. Castro, H. Kenerson, N. Bhattacharjee, G. Gandhe, A. Raman, R. J. Monnat, R. Yeung, R. C. Rostomily, A. Folch
We have developed a digitally-manufacturable microfluidic platform that allows for multiplexed drug testing of intact tumor slices.
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Selective cell propagation via micropatterning of a thermally-activated hydrogel

Lab Chip, 2020, 20,1544-1553
DOI: 10.1039/C9LC01230C, Communication
Jeffrey C. Y. Chiu, Joyce A. Teodoro, Jeong Hyun Lee, Kerryn Matthews, Simon P. Duffy, Hongshen Ma
Inverse gelation of methylcellulose enables hydrogel micropatterning to selectively propagate cells identified by microscopy.
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In-flow measurement of cell–cell adhesion using oscillatory inertial microfluidics

Lab Chip, 2020, 20,1612-1620
DOI: 10.1039/D0LC00089B, Paper
Baris R. Mutlu, Taronish Dubash, Claudius Dietsche, Avanish Mishra, Arzu Ozbey, Kevin Keim, Jon F. Edd, Daniel A. Haber, Shyamala Maheswaran, Mehmet Toner
Cell–cell adhesion strength of freely suspended cell clusters can be measured using an oscillatory inertial microfluidic system.
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3-Step flow focusing enables multidirectional imaging of bioparticles for imaging flow cytometry

Lab Chip, 2020, 20,1676-1686
DOI: 10.1039/D0LC00244E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Andreas Kleiber, Anuradha Ramoji, Günter Mayer, Ute Neugebauer, Jürgen Popp, Thomas Henkel
The control of the focus plane allows multi-directional imaging flow cytometry.
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Acoustic erythrocytometer for mechanically probing cell viscoelasticity

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC00999J, Paper
Open Access
A. Link, T. Franke
Novel microfluidic platform to determine the viscoelastic fingerprint of a red blood cell population using surface acoustic waves.
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Particle/cell separation using sheath-free deterministic lateral displacement arrays with inertially focused single straight input

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00354A, Paper
Naotomo Tottori, Takasi Nisisako
We propose sheath-free microfluidic deterministic lateral displacement devices with inertially focused single straight input.
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A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredient

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00153H, Paper
Zhening Su, Jinxu He, Peipei Zhou, Lu Huang, Jianhua Zhou
Crystallization of active pharmaceutical ingredients (APIs) is a crucial process in the pharmaceutical industry due to its great impact in drug efficacy. However, conventional approaches for screening the optimal crystallization...
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