Nuclear architecture investigation provides insights into the role of nuclear bodies in RNA processing.

New 3D blueprints that highlight tumor complexity reveal several new discoveries, some of which challenge existing theories of cancer progression.

Agnès Lacreuse investigates cognitive aging and women’s health in nonhuman primates.

Alexander Fleming’s 1928 discovery of a mold with antibacterial properties was only the first serendipitous event on the long road to penicillin as a life-saving drug.

Dysfunctional neurons in the cerebellum, a brain region that controls motor functions, reduced REM sleep in mice.

In this webinar, Alex Rimmer, Samuel East, and Catriona Jamieson will discuss how they developed low-cost, animal-free culture media for cellular agriculture.

Almost every scientific presentation uses a slide deck, but little time is spent learning how to make or improve them. 

Scientists are reimagining the food system, turning to fungal fermentation as a sustainable method for transforming food byproducts into tasty treats.

Washington, D.C., police have arrested a suspect after recovering a stolen Salvation Army van used year-round every night to feed the homeless.

Dozens of beloved Washington restaurants closed this year, more than in 2022, according to the Restaurant Association of Metropolitan Washington.

If you're still wondering why Capitals general manager George McPhee signed defenseman John Erskine to a two-year, $3.925 million contract extension earlier this year, games like Tuesday's win over Winnipeg are your answer.

Former Idaho state Rep. Aaron von Ehlinger was sentenced Wednesday to 20 years behind bars for raping a 19-year-old intern.

$12 million -- That's the whopping number of dollars Oprah Winfrey handed over to the Smithsonian National Museum of African American History and Culture, the museum announced Tuesday, according to the Washington Post. Winfrey's name will adorn a 350-seat theater in the new museum, which is slated to open in 2015 on the National Mall. She already donated $1 million to the project in 2007 and has served on the museum's advisory council since 2004.

Jennifer Lopez wants D.C. to know she's still "Jenny From the Block," seeing as the multitasking superstar mentioned growing up in the Bronx within the first three minutes of her interview onstage Wednesday at the Cable Show taking place at the Washington Convention Center.

Hillary Clinton's first reality show pitch is "a go," according to Bravo executive Andy Cohen. The former secretary of state hit it out of the park with the "Project Pantsuit" idea she joked about earlier this month.

On Tuesday, Metro General Manager and CEO Randy Clarke proposed a budget for the next fiscal year that includes massive layoffs and dozens of service cuts as the agency faces a $750 million deficit.

An alliance of top automakers urged President Joe Biden to reconsider rules that would prop up electric vehicles at the expense of gas-powered ones.

KinectAir, an on-demand private air travel company, is now booking budget-friendly private planes.

With all of Washington consumed by the promise and perils of generative artificial intelligence and everything that comes with it, we risk neglecting the next technology revolution brewing under our very noses. Biotechnologies, built on our deepening understanding of how to read, write, and edit genetic code, the “code of life,” are not just transforming biomedicine but are generating better, more sustainable approaches to manufacturing, agriculture, and environmental health.

Both scientific ‘red herrings’ and flaws in human logic led to inaccurate ‘Pompeii effect’ hypothesis.

I was excited to see Microsoft bring the Windows Presentation Foundation (WPF) back from the dead this past year: At Build 2024 back in May, it announced that it would continue investing in this 20-year-old technology, starting with support for Windows 11 theming that would arrive as part of .NET 9. In fact, I was so excited about this that I brought my .NETpad project back from the dead as well, and I spent much of the summer modernizing my Notepad clone with the new features. I wrote 24 articles documenting this work, but I was stymied by the half-assed nature of the improvements.

Microsoft released exactly one WPF update during the several months of .NET 9 development, and it never added any of the features I discovered were missing. And so as we headed into today's release of .NET 9, my excitement was somewhat diminished. My assumption was that we wouldn't see those missing features implemented until .NET 10, if ever.

Well, Microsoft just released .NET 9. As part of that release, it published updated documentation for WPF (and all the other .NET technologies). And to my surprise, there are some updates to WPF that address at least one of those missing features.

So let's take a look.

To add support for Windows 11 theming to a WPF project, you need to add a reference to the new Fluent theme resource dictionary in its App.xml file. It looks like so:

<Application.Resources>
    <ResourceDictionary>
      <ResourceDictionary.MergedDictionaries>
        <ResourceDictionary Source="pack://application:,,,/PresentationFramework.Fluent;component/Themes/Fluent.xaml" />
      </ResourceDictionary.MergedDictionaries>
    </ResourceDictionary>
</Application.Resources>

But with the shipping version of .NET 9, there's a second, more elegant way to add Windows 11 theming support. Now, you can access a new Application.ThemeMode property of a new styling API to toggle the app's theme mode between Light, Dark, System, and None. And that's fantastic, because it addresses one of those missing features: To date, .NETpad has adapted itself to the system theme (Light or Dark), but there was no way to let the user pick a theme mode. (For example, if the system was set to Dark and the user wanted the app to use Light mode.) With this change, I can implement that feature.

Fortunately, .NETpad is ready for this change, too: If you followed along with my work this past summer, you may remember that I implemented the user interface for switching the app theme into its settings interface, but left the UI hidden because it didn't do anything. But I always felt that Microsoft would need to implement this features, so I left the code in there. Granted, I didn't think it would happen this quickly.

The shipping version of .NET 9 also adds explicit support for the Windows 11 accent color (as configured by the user in the Settings app in Personalization > Accent color). As it is, .NETpa...

The post Modernizing .NETpad: .NET 9 Arrives with a Few (More) Small Improvements for WPF (Premium) appeared first on Thurrott.com.

Seattle's only news roundup. by Ashley Nerbovig

Ok weather to vote in! Should be a pretty nice day to stroll down to your nearest ballot box, with a high of 52 degrees and partly sunny, and a slight chance of rain after 2 p.m. 

So go vote! Don't let anything stop you. As Hannah said yesterday, you can still vote! I voted last year on the last possible day, and I hadn't registered yet at that point. I just jogged down to Lumen Field though and it was super easy to register, vote, and leave. Even if you're feeling left out because you're not in a swing state and the entirety of the country's future doesn't rest on your shoulders, the future of this state and city really does! Dropping some helpful links to make sure you have everything you need to make your voices heard. First, how to register to vote. Second, how to replace a lost ballot. Thirdly, ballot box locations. Finally, our handy cheat sheet for help filling out your ballot. 

Done your civic duty already? Well then sit back and enjoy the final hours of uncertainty at one of the many election night parties happening across the city tonight. The Stranger is throwing one at the Crocodile—it’s sold out, but we think it’s worth it to take your chances on standby tickets. There might be some no-shows, and we can squeeze you in. But if you don't wanna chance it, check out this list of parties you can attend from our sister publication Everout. Stranger reporters will be dotted around the city to bring you coverage of the election from various candidate election parties as well.

Speaking of voting: The Boeing machinists approved a contract last night ending their strike after 53 days, according to the Seattle Times. The latest contract, approved by 59% of membership, includes a 38% general wage increase over the next four years, which equates to 43% when you factor in raises on top of raises. The contract did not restore the pension that they lost in a contentious vote 10 years ago. Union president Jon Holden said the union should be proud of what they accomplished and that it was time to get back to building planes.

Alleged sex abuse in youth detention: An additional 176 people made allegations against Washington state for failing to protect them from sexual abuse while they were children at youth detention centers in the state, according to the Seattle Times. Combined with another lawsuit filed in September, that brings the total number of people claiming they were sexually abused in Washington's detention centers up to almost 400. Meanwhile, the Seattle Times Editorial Board continues to decry and complain about youth diversion programs meant to help kids avoid being sent into lock up.

Seattle Steel Pan Project Evicted: The Seattle Steel Pan Project, dedicated to teaching the art of steel plan music and performance, needs a new space to operate in after MLK FAME Community Center in the Central District evicted the group this week, according to an Instagram post from the project. In the post, the group accused MLK FAME of bowing to the demands of neighborhood "Karens" who complained about the groups weekly practice. I reached out to MLK FAME for a response, who did not immediately reply, but I'll update if they do. In the meantime, the project is asking everyone they know if they have any ideas where they can house their steel pan band. Their email address is steelpanproject@gmail.com. Here's a little taste of what they do:

Ok. Moving on. Let's talk about the presidential election: Let's be real, no one knows how this election will shake out. The polls are insanely tight in swing states. Dixville Notch, a tiny New Hampshire town that votes at midnight every year on Election Day, tallied up their six votes which resulted in a tie, with three votes for Vice President Kamala Harris, and three for former President Donald Trump. There is a very good chance we don't know the election result tonight, and maybe not for a couple days.

Battleground states prepare for certification fight: Given the resistance to certifying the vote in swing states in the last election cycle, many officials have already started to prepare to quash attempts by county officials to squabble over valid election results, according to Politico. Election officials fear if Trump loses, he won't just fade quietly into the night, and instead will mount another attempt to overturn election results.

Meanwhile, the two parties also are wrestling for control of congress. New York stands out as a battleground state for the House, as the congressional seats they lost in 2022 helped Republicans take the chamber back, according to Politico. Meanwhile in Texas, Democrats continue to try to take Senator Ted Cruz's seat, and while Cruz continues to lead, Representative Colin Allred is within spitting distance of him. But, it's wholly unpredictable who will control what in 2025.

But for some good news: One of my top five favorite creatures in the world continues to beat the odds. A cloned black-footed ferret mother in Virginia gave birth to two little baby ferrets in June, according to the Washington Post. Unclear why we're only hearing about it now. We should have rang the bells. If you don't know much about black-footed ferrets, you're really missing out. These little bandits scurry across our prairie lands, and has supposedly gone extinct twice, but they're resilient AF. Now with the cloning and the babies, we could continue to see this species soldier on. Ugh I love them so much, I've been obsessed with them ever since I lived in Montana. And I'm not a ferret girl, it's just they're little markings make them look like they have a tiny black Zorro mask across their smol faces. Here is a video of them being adorable:

I'm so excited about this cloning thing: Instead of a musical recommendation, another video about black footed ferrets.

Tuesday’s catastrophic results at the federal level mask a different, more durable, and deeply consequential result here in Seattle: Voters chose a public safety candidate from the left. by Kamau Chege

Tuesday’s catastrophic results at the federal level mask a different, more durable, and deeply consequential result here in Seattle: Voters chose a public safety candidate from the left.

For close observers, the result was no surprise: Alexis Mercedes Rinck, running on a strong message of smart, sensible, and progressive public safety and stability, won her primary handily, led in the polls in the lead up to the general election, and easily defeated an incumbent councilmember citywide with more votes than any city council candidate has ever won in a Seattle election.

The critical takeaway is how she won. Rinck, unlike other candidates from Seattle’s left wing in recent years, conceded to the obvious but difficult-to-navigate reality that Seattle voters view public safety as the single most important issue in local elections and, importantly, that those views actually reflect a material reality that bears serious public attention and public work. Missing from the campaign were efforts to browbeat voters for being concerned about public drug use, visible homelessness, and a pervasive sense of disorder in our streets. 

Unlike her opponent, however, Rinck’s policy proposals to tackle voters’ biggest concerns are evidence-based. She supports deep investments in affordable housing — and is willing to raise revenue to pay for it. She’ll work to expand mental health treatment opportunities for those who need it. She’ll fully fund critical municipal services that connect people to resources before they fall into crisis. And she’ll work to build more housing everywhere.

Woo’s campaign, meanwhile, felt rudderless and contradictory to itself. She was at once painting herself as an outsider seeking change, but also as an incumbent who got progressive results. But in facing a charismatic, competent opponent who conceded that Woo’s main issue was central but ran on doing something about it that might actually work, Woo’s campaign collapsed. 

At the beginning of the year, a campaign based on public safety seemed like fertile ground for Woo and her colleagues on the city council who won their elections hammering the same themes against a left that failed to counter pandemic-era attacks about defunding the police.

Rinck’s progressive campaign neutralized those attacks by recognizing a fundamental liberal principle: that when public spaces become private domains — whether through encampments or open air drug markets — they deny public amenities to the many while inadequately serving the few who are unhoused or in crisis. The solution most people want, as Tuesday’s results suggest, lies not in costly incarceration or aimless sweeps but in moving people from crisis to care.

The public’s fixation on safety and stability in this election should not surprise us. Fears about safety flourish in populist moments, in cities divided between haves and have-nots, and in places grappling with widening inequality. As zoning laws continue to strangle our ability to build, crisis care programs are starved for funding, and democratic institutions strain under populist pressure, voters gravitate to a basic need for physical and psychological security.

Rinck’s campaign offers us a model and a playbook for organizing with hope and meeting people where they are — even if that is initially a place of fear and contradiction. Her campaign, and those we hope will follow it in winning back the City Council for progressives, offers abundance in the face of scarcity and hope in the face of despair.

We’re facing bleak times as a country. Perhaps it’s precisely because things are so bad right now that we can't give in to despair, whose pernicious power is its ability to narrow our attention to narratives that only encourage more despair. Its impact results in our inaction. 

As implausible as it seems, this moment demands hope, and specifically, hope as action. We must remind ourselves and each other of our own agency, and our ability to imagine a better future, a better system. Despair calls on us to retreat. Hope asks: what if we win? Then demands we go out and make it happen. On Tuesday, Rinck did just that.

Kamau Chege is a democracy reform advocate. Rian Watt is an economic justice advocate.

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SEO, or search engine optimization, is a buzzword these days. Lots of people know what it means; however, fewer understand what it all entails. Unfortunately, there’s not an Easy Button for boosting your website’s traffic, but there are some relatively basic steps you can take to start moving in the right direction. If you are […]

Elegant all-sheer support pantyhose from Propeds. 20 deniers. Combine striking sheerness with support for full day use. Sandal toe. Freesize. Colors Beige,Silk Beige,Suntan,Sparrow. See Sizechart. Price: USD4.45

Support ankle highs from Propeds;. 15 deniers. Extra sheerness makes you feel pampered and sexy. Ideal for day or evening, you get the support you need while enhancing the beauty of your leg. 2 pair pack. Freesize. Colors Beige,Toffee,Nutmeg,Peach,Suntan,Honey,Sparrow. See Sizechart. Price: USD3.70

Women fashion ankle high socks from Propeds. Young fashion socks in metallic brilliance color. For casual and outdoor. Freesize (size 3-7), 6 colors. Colors Metallic Silver,Metallic Gold,Metallic Orange,Metallic Brown,Metallic Blue,Metallic Black. See Sizechart. Price: USD5.96

Floral lace French-cut support, extra sheers. Freesize. Sandal toe. Luxurious floral lace together with extra-sheerness and silkiness makes you feel pampered and sexy. Ideal for day and evening, you get the support and control you need while enhancing the beauty of your legs. Colors Nude,Honey,Peach,Silk Beige,Suntan,Toffee,Midnight. See Sizechart. Price: USD4.90

Propeds five-toes fashion cotton toesocks. Ankle high without heel pockets. Thick cool cotton is moisture absorbent. Freesize (men size 6-10). Unstretch socks length is 15½inches (40cm). Multi-colored toes. See Sizechart. Price: USD5.96

Ultra-fine scented cotton seamless footcovers. Lowcut for a fashionable look. 2 pair pack. Nude color only. Propeds Footcovers knitted with ultra-fine scented cotton blended with spandex and nylon to give you a comfortable fit, with a lowcut for a fashionable look. They wick moisture away from the feet, keep your feet fresh and prolong the lie of shoes. Nude color only. Sizes S,M,L,Q. See Sizechart. Price: USD5.28

Propeds women daysheer knee highs. Provides soft Nylon comfort for everyday wear. Soft elastic top. Reinforced toe for extra durability. 3 pair pack. Freesize. Colors Nude,Beige,Suntan,Toffee,Nutmeg,Sparrow,Midnight,Black. See Sizechart. Price: USD4.45

100% fine cotton tailored-to-fit footcovers from Propeds. Lowcut for a fashionable bare leg look. 2 pair pack. Nude color only. Propeds footcovers are made of 100% fine combed cotton, and tailored to fit your size. Natural cotton is absorbent, providing cool comfort in hot weather. Perfect for loafers, sneakers and leather shoes.Nude color only. Sizes S,M,L,Q. See Sizechart. Price: USD5.96

Souvenir fashion pantyhose / tights from Sarah Borghi. 50 deniers. With Microfibre and Lycra. Sheer to waist, gusset. Meryl labelled. Colors Noce,Ottanio,Ribes. Sizes 1,2,3,4. See Sizechart. Price: USD10.49

Solid-color ankle high cotton socks from Propeds. Available in 12 colors. The fancy scallop top and wide lively assorted color choices are specially designed for the lively young. Freesize (size 3-6). Colors Cream,White,Grey,Powder Blue,Navy Blue,DarkGrey,Black,Mustard,Apple Green,Tan,Maroon,Light Pink. See Sizechart. Price: USD4.45

Cool, comfort cotton socks from Propeds. Low cuff cushion socks for sports and casual wear Freesize (size 3-7). Colors Lilac,Red,Turquoise. See Sizechart. Price: USD3.70

Knee high comfort sheers. Sag-free with stay-up top. 15 deniers. 2-pair pack + 1-Pair Bonus. This style has been discontinued. Sales while stock lasts. Colors Beige,Toffee,Nutmeg,Nude,Honey,Suntan,Sparrow,Black. Freesize. See Sizechart. Price: USD6.72

Microfibre ankle high support socks from Propeds, giving you the soft and comfortable fit. Big diamond fishnet mesh fashion design. Tailored to stay in place and to retain shape. Great with loafers, sneakers and high-cut shoes. Quick dry. Colors: Summer Nude,Peach,Silk Beige,Suntan. Freesize. Price: USD5.21

2-color ankle high cotton socks from Propeds. Available in 5 color combinations. The fancy scallop top and lively color combinations are specially designed for the lively young. Freesize (size 3-6). Colors Maroon/Black,Mustard/Tan,Black/Mustard,P.Blue/L.Pink,Tan/Maroon. See Sizechart. Price: USD4.45

Foglie fashion pantyhose / tights from Sarah Borghi. 50 deniers. With Microfibre and Lycra. Meryl labelled. Colors Mosto,Nero. Sizes 1,2,3. See Sizechart. Price: USD10.49

Fine calf high cotton socks from Propeds Suitable for sports and casual wear. Cool and comfortable socks. Freesize (size 6-10). Colors White,Navy,Grey,Black,Coffee. See Sizechart. Price: USD4.45

Microfibre ankle high support socks from Propeds, giving you the soft and comfortable fit. Small criss-cross fishnet mesh fashion design. Tailored to stay in place and to retain shape. Great with loafers, sneakers and high-cut shoes. Quick dry. Microfibre provides a drapeable, soft and comfortable fit. Color chart. Colors Peach,Suntan. Freesize. Price: USD5.21

Ladies color fashion socks from Propeds. Lowcut cotton socks. Freesize (size 4-7). Colors Solid Pink, Solld Blue, Solid Black, White/Pink, White/Lilac, White/Dark Blue, White/PowderBlue, White/Black. See Sizechart. Price: USD4.45

Fashion ankle high socks from Propeds. Color cotton socks available in 3 assorted color combination and comes in 5 choices. The fancy scallop top and lively color combinations are specially designed for the active people. Freesize (size 3-6). Colors Black/AG/Cr,Grey/PB/LP,White/Gr/Bk,Light Pink/Cr/Bk,A.Green/LP/PB. See Sizechart. Price: USD4.45

Sheer footcovers from Sleek. 30 deniers. Multi-packs offer: 5-pair pack with each item individually packed. Size S-L only. Nude color only. Price: USD5.21

Strong and sheer knee highs. With Comfort band. Comes with a multi-packs offer of 3-pair pack. Size S-L only. Colors Nude, Honey and Black. Price: USD5.96

Albert Andre graduated medical compression knee high cotton socks, with Lycra. Helps to tone the legs, reduce fatigue and prevent DVT. Popular with cabin crew and tourists. Suitable for people who drives and works long hours standing up. Strong compression 18-22mmHg, class 1. See Sizechart. Price: USD21.88

Support knee highs from Propeds. 15 deniers. Extra sheerness makes you feel pampered and sexy. Ideal for day or evening, you get the support and control you need while enhancing the beauty of your legs. Shadow toe. Freesize. Colors Peach,Honey,Beige,Suntan,Toffee,Sparrow,Dusk,Midnight,Black. See Sizechart. Price: USD4.45