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SAP’s India lab fastest-growing and second-largest, says company CEO

The company deepened its investments in the country with the new campus, aiming to create 15,000 new jobs in Bengaluru




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Freshworks asks 660 employees to leave as part of ‘global realignment’

The move is expected to result in $11 million to $13 million in charges in the fourth quarter of 2024, consisting primarily of cash expenditure for separation-related payments, employee benefits and related costs




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KPMG in India forms strategic alliance with SecurityBridge to enhance SAP security and compliance

KPMG in India, one of the country’s leading professional services firms, has announced a strategic alliance with SecurityBridge GmbH, a renowned provider of SAP-native cybersecurity solutions. This collaboration aims to enhance SAP security and compliance offerings for clients by integrating SecurityBridge’s cutting-edge technology into KPMG’s comprehensive service portfolio




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With Trump win, DoT gears up to sort out issues related to Elon Musk’s Starlink

The department of telecommunications is looking into security aspects while considering the demands made by two American companies — Starlink and Amazon (project Kuiper), say sources




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AI adoption: 74% companies struggle to achieve and scale value, says BCG

Report to assess firms’ AI maturity is based on a survey of 1,000 CxOs and senior executives from over 20 sectors, spanning 59 countries




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Good triumphs over evil

July 31 and August 1 are important days for the people living in Zanskar mountains as they celebrate Karsha Gustor.




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Exploring the self-assembly dynamics of novel steroid–coumarin conjugates: a comprehensive spectroscopic and solid-state investigation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00192C, Paper
Open Access
Claudia M. Ramírez-Lozano, Ma. Eugenia Ochoa, Pablo Labra-Vázquez, Arturo Jiménez-Sánchez, Norberto Farfán, Rosa Santillan
The design, synthesis, and characterization of seven novel steroid–coumarin conjugates with diverse steroidal nuclei as lipophilic fluorescent materials for bioimaging applications are presented.
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Siloxane-containing phosphine (oxide) ligands for enhanced catalytic activity of cobalt complexes for hydrosilylation reactions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00333K, Paper
Peng Liu, Jiajian Peng, Ying Bai, Jiayun Li
A series of siloxane-containing phosphine (oxide) ligands have been designed and synthesized.
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Click synthesis of dendronized malonates for the preparation of amphiphilic dendro[60]fullerenes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D3OB01986A, Paper
Carlos Cruz-Hernández, Perla Y. López-Camacho, Gustavo Basurto-Islas, Aaron Rojas, Patricia Guadarrama, Melchor Martínez-Herrera
Click chemistry is a valuable methodology for obtaining dendronized malonate derivatives to derivatize C60 using the Bingel–Hirsch reaction.
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Metal- and light-free decarboxylative direct C–H alkylation of heteroarenes at room temperature

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00187G, Paper
Tong-Bo Zhang, Xi-Dong Guan, Yan Gao, Shi-Chao Lu, Bing-Long Li
This study reports a metal- and light-free decarboxylative C–H alkylation of heteroarenes at room temperature.
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A water mediated multicomponent reaction for the synthesis of novel spirooxindole derivatives and their antifungal activity

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00256C, Paper
Min Zhang, Liang Shi, Li Chen, Zhengyu Liu, Ting Zhao, Chunyin Zhu, Liuqing Yang
A total of 27 novel spirooxindoles were synthesized through a water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds. Several compounds showed excellent antifungal activity against Physalospora piricola.
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An efficient synthesis of mono-, di-, and tri-substituted 1,3-thiazoles employing functionalized thioamides as thiocarbonyl precursors

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00229F, Paper
Kalleshappa Sheela, Chikkappaiahnayaka Santhosh, Krishna Ravi Singh, Kalleshappa Sharath, Maralinganadoddi P. Sadashiva
Herein, we report an efficient strategy to synthesize functionalized 1,3-thiazoles using alkyl 2-amino-2-thioxoacetates.
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HFIP-mediated C-3-alkylation of indoles and synthesis of indolo[2,3-b]quinolines & related natural products

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00414K, Paper
Auqib Rashid, Waseem I. Lone, Preeti Dogra, Showkat Rashid, Bilal A. Bhat
An expeditious metal free C-3 alkylation of indoles and its NIS-mediated deviation to indolo[2,3-b]quinolines is reported. Applications of these strategies in accessing bioactive natural products have also been demonstrated.
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Structural flexibility of favipiravir and its structural analogues in solutions: experimental and computational insight

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00404C, Paper
Tatiana P. Gerasimova, Almaz A. Zagidullin, Anastasiia N. Nikolaeva, Robert R. Fayzullin, Aliya M. Saitova, Vasili A. Miluykov, Stefan Grimme, Sergey A. Katsyuba
Keto-enol transformations of 6-R-3-hydroxy-2-pyrazinecarboxamides in solutions are accompanied by deprotonation of enol tautomers and the formation of corresponding anionic species. The key factors determining these processes have been identified.
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Reduction of sulfoxides catalyzed by the commercially available manganese complex MnBr(CO)5

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00204K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Daniel Leal Lourenço, Ana Cristina Fernandes
A new methodology for the reduction of a wide variety of aliphatic and aromatic sulfoxides catalyzed by the air-stable, cheap and commercially available manganese catalyst MnBr(CO)5 with excellent yields is...
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Charge-transfer inclusion complex formation of the tropylium cation with prism[6]arenes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00423J, Communication
Guojiao Zhang, Channi Cheng, Zhengxiang Li, Dezhi Zhao, Chengyou Han
We report that charge-transfer (CT) inclusion complexes were formed between prism[6]arenes and tropylium cation. Additionally, the CT complex showed Cl/Ag+ responsiveness which can be easily monitored by the naked eye.
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Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00432A, Paper
Peng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu
2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...
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Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
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TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
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An FeCl3-catalyzed three-component reaction for the synthesis of β-(1,2,3-triazolyl)-ketones using DMF as a one-carbon source

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00207E, Communication
Ruilin Fang, Lei Zheng, Xuyang Chen, Can Wang, Yunfeng Chen
FeCl3-catalyzed oxidative condensation of NH-1,2,3-triazoles and aryl methyl ketones and DMF has been reported.
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Facile synthesis of tetrahydroquinoline containing dithiocarbamate derivatives via one-pot sequential multicomponent reaction

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00490F, Communication
SIDDHARTHA KUMAR SENAPATI, Anit Pal, Animesh Das
An efficient sequential multi-component method for the synthesis of tertrahydroquinoline containing dithiocarbamate has been developed. This reaction involved a boronic acid-catalyzed reduction of quinoline to tertrahydroquinoline, followed by nucleophilic addition...
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Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00171K, Review Article
Bor-Cherng Hong, Ranadheer Reddy Indurmuddam
This review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.
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Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00363B, Paper
Si-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong Xie
A three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.
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Empathy is the need of the hour

Demand for proactive customer services




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Why do planes dump excess fuel in the sky?




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Compliance with regulation: Staying ahead is key




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Google to develop AI that takes over computers: Report

Google is developing AI technology that takes over a web browser to complete tasks such as research and shopping, The Information reported




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Google’s moneymaking machine still pumping out massive profits despite multiple threats

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire




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Amazon's improving retail sales boost third-quarter profit, revenue beats estimates

Like its tech peers, Amazon said it expected higher capital expenditures for the foreseeable future to help develop artificial intelligence software




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OpenAI CEO Sam Altman says next big AI model launch pushed due to compute challenges

Altman also said that the next update for DALL-E was still in the works with no release date yet




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Dietary restriction or good genes: new study tries to unpack which has greater impact on lifespan

If we know that genetics and lifestyle affect how long you live, which one is more important? And how do they interact?




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Sexual harassment rampant in Maharashtra medical colleges, finds survey

The survey also found that a majority of students believed that reporting these events could negatively affect their grades and future prospects; it highlighted the need for better safety mechanisms on campus




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Rapid assessment of pulse polio campaign shows high vaccine coverage, highlights gaps in Chennai

Chennai accounted for nearly 21% of the non-vaccinated children, highlighting the gaps in an urban area and the need for targeted community outreach




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Drugs regulator finds 49 samples not of standard quality, manufacturers asked to withdraw their products

Four spurious drugs were also found and action has been initiated against the makers, the DCGI said




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Polio in Pakistan: Another vaccination campaign begins after worrying surge

Pakistan regularly launches such campaigns, but violence targeting the health workers and police assigned to escort them is common




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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




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Roll back approval to import used medical devices, med-tech industry urges PM

The group said the move puts at risk patient safety and undermines the domestic med-tech sector. It said that refurbished machines are not subject to stringent quality checks applicable to new devices.




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As breast cancer incidence rises, doctors raise importance of early detection, need for women to be breast aware

Chennai accounts for highest crude incidence rate of breast cancer in T.N., data shows; a number of factors have led to this, say doctors




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Air passenger with suspected mpox symptoms isolated at Tiruchi govt. hospital

When contacted, a senior hospital official told The Hindu that the patient’s blood sample has been sent for further testing




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Third phase of polio vaccination campaign to resume in northern Gaza: WHO-UNICEF

“Despite the lack of access to all eligible children in northern Gaza, the Polio Technical Committee for Gaza has taken the decision to resume the campaign,” a joint statement by UNICEF and WHO said




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More than 50,000 vaccinated against mpox in DR Congo, Rwanda: WHO

The outbreak is still not under control, the African Union’s health watchdog has warned, appealing for resources to avoid a “more severe” pandemic than Covid-19




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Tiruchi man with mpox symptoms: Sample has returned negative, says Tamil Nadu Health Minister

The man, who had returned from Sharjah on October 31, was found to have fever during screening on arriving at the Tiruchi airport.




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Doctors urge National Medical Commission to simplify centralised registration process

The register is a centralised repository that contains the name, address, and qualifications of licensed medical practitioners; however the registration process is complex and cumbersome, say doctors




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Symposium stresses on the urgent need for integrated health strategies




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Can mid-level healthcare providers compensate for physician shortages in rural India?

To make up for doctor shortages, several countries around the world have introduced a cadre of MLHPs into their health systems; however, in India, mainstreaming of MLHPs has time and again been met with resistance from organised medicine 




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Why I Won't Mind Campaigning For Kangana

'Since we are in the same party now, there has to be political camaraderie if nothing more.'




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'Social Media Has Complicated Everything'

'I would have become a big star 11 years ago if things had worked as per my plans.'




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'Comparisons With Vicky Used To Irritate'

'That comparison, "Oh look at Vicky, do you also see yourself being that successful in life?"' 'Vicky has seen a lot and done a lot and he is where he is. I feel really happy about it.''But I have my own journey.'




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Expert clinic director successfully implements half-hour scheduling system, boosting therapist productivity

As word spread about the success of the half-hour schedule, some early adopters became curious after the clinic director and the team showcased the benefits.




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Empowering Pharma with AI, Analytics: Accelerating Drug Discovery, Optimizing Healthcare Outcomes By Rajesh Munirathnam

While AI is making significant strides in healthcare, it is also transforming other industries, such as insurance.