EV sales rose 65% in California in the first half of the year, led by Tesla. But that doesn't mean consumers are suddenly in love with electric cars.

Salsa music, with its large bands and close dancing, has a devoted following in L.A., but its very nature makes it especially susceptible to the ravages of the coronavirus.

The second installment of ESPN's Michael Jordan documentary series tells the story of the birth of the Chicago Bulls' dynasty and its two star rebels.

Over 40 years ago, rich country governments agreed to give 0.7% of their GNI (Gross National Income) as official aid to poor countries for development assistance.

The average aid delivered each year has actually been between 0.2 to 0.4%. The shortfall has therefore accumulated to almost $5 trillion dollars at 2012 prices, while total aid delivered in that same time frame has reached $3.6 trillion.

This update includes updated charts and graphs that look into this further.

Read full article: Official global foreign aid shortfall: $4 trillion

Travelling to Antarctica is usually a once in a lifetime experience, and one many people have on their bucket lists. It’s not surprising, considering the dramatic icebergs, huge areas of wilderness and sensational lagoons. Just...

The post 5 Ways To Get The Most Out Of A Trip To Antarctica appeared first on Geeky Traveller.

Lionel Messi boasts the most viewed goal on YouTube, according to a new study that has analysed the most iconic strikes on the internet.

THANKFULLY, the Government is still encouraging us to get out and exercise - as long as we keep the two-metre distance rule.

Manchester United are one of the biggest football clubs in the world, but the Red Devils are not considered among the most influential Premier League sides according to new research.

The January transfer window is just around the corner, so which players are most likely to move?

Approximately 32 kilometres of Seattle streets will permanently close to most vehicles by the end of May, Mayor Jenny Durkan said Thursday.

Manchester United hero Wayne Rooney has been named as the most influential Premier League player of all time, but who else makes the top 20?

About 10% of Southern Utah workers have filed for unemployment amid the coronavirus, which doesn't include self-employed and many non-profit workers.

News of Little Richard's death sent shockwaves across social media Saturday as tributes started pouring in from celebrities and musicians.

Indianapolis native Doug Jones takes his creature craft to new heights in Guillermo del Toro's "The Shape of Water."

The 22-year-old rider from Brownsburg became the youngest time trial winner — with the biggest margin — in the history of road cycling's World Championships.

Most Marion County public schools will close Friday and all public schools in the county will close by Monday.

Mapa interativo mostra medidas que países vizinhos vêm tomando desde primeiros casos registrados de covid-19 para restringir movimento dos cidadãos.

Batizada de covid-19, a doença é uma infecção respiratória que começa com sintomas como febre e tosse seca e, ao fim de uma semana, pode provocar falta de ar. Cerca de 80% dos casos são leves, e 5%, graves.

Em estudo clínico randomizado controlado, pessoas que receberam as substâncias interferon beta 1-b, lopinavir-ritonavir e ribavirin tiveram tempo menor para alta e desaparecimento do vírus, na comparação com o grupo controle.

Gibson Southern quarterback Brady Allen remains one of the most coveted Indiana recruits in the Class of 2022

IU basketball coaching legend got to see Michael Jordan up close as part of the 1984 U.S. Olympic team; Knight came away quite impressed.

An anonymous reader quotes a report from NPR: As hospitals were overrun by coronavirus patients in other parts of the world, the Army Corps of Engineers mobilized in the U.S., hiring private contractors to build emergency field hospitals around the country. The endeavor cost more than $660 million, according to an NPR analysis of federal spending records. But nearly four months into the pandemic, most of these facilities haven't treated a single patient. Public health experts said this episode exposes how ill-prepared the U.S. is for a pandemic. They praised the Army Corps for quickly providing thousands of extra beds, but experts said there wasn't enough planning to make sure these field hospitals could be put to use once they were finished. "It's so painful because what it's showing is that the plans we have in place, they don't work," said Robyn Gershon, a professor at New York University's School of Global Public Health. "We have to go back to the drawing board and redo it." But the nation's governors -- who requested the Army Corps projects and, in some cases, contributed state funding -- said they're relieved these facilities didn't get more use. They said early models predicted a catastrophic shortage of hospital beds, and no one knew for sure when or if stay-at-home orders would reduce the spread of the coronavirus. "All those field hospitals and available beds sit empty today," Florida Gov. Ron DeSantis, a Republican, said last month. "And that's a very, very good thing." Michigan Gov. Gretchen Whitmer, a Democrat, said: "These 1,000-bed alternate care sites are not necessary; they're not filled. Thank God." Senior military leaders also said the effort was a success -- even if the beds sit empty.

Read more of this story at Slashdot.

Wagyu steak, baby lamb chops, dumplings, pie and more were served with fine wine at the IndyStar Wine & Food Experience at Clay Terrace in Carmel.

During the coronavirus pandemic, it's business as usual at Mug-N-Bun restaurant, and Historic Steer In embraces its drive-in roots.

Running back who scored 4 touchdowns in the NFC championship game picks up another score in the sport's biggest game

The Edinburgh Lancers head into the tournament 17-5 after winning just eight games last season.

Math is beautiful and, sometimes, math becomes even more beautiful with the help of a bit of computer science. My favorite proof of all time combines the two in just such a way. Goal: prove that the cardinality of the … Continue reading →

Wagyu steak, baby lamb chops, dumplings, pie and more were served with fine wine at the IndyStar Wine & Food Experience at Clay Terrace in Carmel.

Find out which cricketer you are most like - with our entirely unscientific personality quiz.

Some 80% of state voters support employers providing full replacement wages to farmworkers to stay home when sick with COVID-19, poll finds.

Most Montrealers are not on board with sending children back to school May 18 according to a new survey from the Quebec English School Boards Association (QESBA) and the Association for Canadians Studies (ACS).

"Half Life: Alyx" will transport you to an incredibly vivid science fiction world.

Darth Maul could have saved the galaxy in 'Star Wars: The Clone Wars," and lived on in the movies. Neither happened.

Discover the (sometimes surprising!) things you can no longer do on a cruise and cruise ship. How many of these did you know about? Got any to add that I missed? I look forward to you listening (or watching the video version: https://youtu.be/zas6F4wMD0Q )

What are the unusual, surprising and even rude theme cruises that you can go on? I look at 9 of the theme cruises on the seas that you could go on (if they appeal!). Many groups and organisations charter entire cruise ships and run themed cruise vacations - some of which you may find very remarkable. Discover the 9 types of theme cruises many travellers may find surprising and unusual.

** Buy my Cruise T-shirts: http://bit.ly/TFTStore
** USA cruisers get great cruise deals CRUISEDIRECT.COM: http://bit.ly/TFTBookCruise
** UK Cruisers get great cruise deals with CRUISE.CO.UK: http://bit.ly/BookCruiseUK

Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

Follow Tips For Travellers on:
- Instagram: http://www.instagram.com/garybembridge
- Facebook: http://www.facebook.com/tipsfortravellers
- Twitter: http://www.twitter.com/garybembridge

A new policy is keeping hundreds of families from obtaining visas

Reopening the country may be bad from a public health standpoint, but the president is pushing for it anyway.

In the past five years, mobile games have exploded in popularity. With the advent of Apple’s App Store, mobile app developers have jumped on the opportunity to create mobile games from scratch on the most popular devices in the world. What Makes a Mobile Game Go Viral? Why is it that some mobile games become […]

The post From Concept to Design: How Developers Create Today’s Most Popular Mobile Games appeared first on SpyreStudios.

Want to know what the most well-loved recipes for the month of April were? You know the ones: the recipes our Simply sous chefs (that’s you!) have been cooking, sharing, and talking about nonstop. Read on to see what made the cut!

Continue reading "The Most Popular Recipes in April" »

Najibullah Quraishi has covered the war in Afghanistan for more than a decade, but embedding with ISIS fighters who've recently emerged there "was the most risky and dangerous job ever I've done in my life," he says.

Most Realtors® Don’t Expect Steep Price Declines in...

Finding a good system to be organized can be intimidating. There are so many options! Useful tips on how to get your life together are all over the internet. From minimalist planners to detailed systems, something is bound to draw you in. Choosing the best system to use will be the biggest decision you’ll have […]

The post The Simplest Hack to Be Your Most Organized Self appeared first on Dumb Little Man.

Planning a little solo jaunt across the land? If this is your first time planning your virgin solo adventure, I understand completely how excited and nervous you are. I was once in your shoes.

Before you slap on your backpack and march out that door, here’s a small checklist of things you might want to do to ensure a better trip.

Research, Research, Research

It doesn’t matter if you’re headed into uncharted territory or a bustling metropolis, it only helps if you already know what to expect when you set foot in your destination. A quick google search should give you enough information on things like the local culture, geography, weather and political climate to start with. Oh, and do not forget to check out the local laws, either-written and unwritten. People have in the past gotten into trouble for using the wrong gesture or for looking the wrong person in the eye. Did you also know that shaking your head can be interpreted as ‘yes’ in India?

“Hi, would you like to buy some drugs?

– Nervously shakes head –

“Great! Here’s two kilograms of cocaine!”

Kuh-Myoo-Nick-Ashion

Learn a few words and phrases from the local language and the appropriate situations to use them in. You would be surprised at how much a ‘Yallah’ or a ‘Habibi’ can get people to warm up to you in the Middle East. Also, knowing the language makes ordering food that much easier. Just saying.

Who Ya’ Gonna Call?

It’s very useful to have in hand a bunch of contacts that you can get in touch with if-knock on wood- you should ever find yourself in trouble, eg: Your home country’s Embassy/Consulate(stolen passports are a thing in some countries you know?), local emergency numbers etc. If you have friends or relatives in the country/area, make sure you have their numbers as well. There’s no telling what kind of emergency you might encounter on the road.

Link Up With Other Travellers And Locals!

This is for many people, the single greatest reward of solo travel-meeting new people. There’s so much you discover from engaging with people from different cultures and backgrounds. Yes, I’m being captain obvious here, but it’s a point that just had to be reiterated.  Being alive in the internet age has its perks.

A slew of apps and websites have made it that much easier for travelers to get in touch with people at their destinations. It doesn’t matter if you’re just hanging out with your host from ‘AirBnB’ and ‘Couchsurfing’ or finding fellow travelers to share in your adventure from ‘Penroads’, you’re guaranteed to meet some cool people on your journey. As a matter of fact, Penroads is the best way for you to connect with international travellers coming in from all over the world, so it’s definitely a useful tool to have (It’s a shameless plug. I am so sorry. But it really works!).

Stay Healthy!

Last but never the least, take care of your body. Stay hydrated. It’s no good if your mind yells “Onward!” and your body groans “Hell no!”. Find out if you need to get vaccinated before setting off. Carry some basic medicines and bandages if you can, especially if you’re venturing into the wilderness. On occasion you might have to be careful about where and what you eat as well. Talk to someone who has travelled to India and you just might hear the story about how the delicious chicken Tikka from a street vendor gave them a bad case of ‘Delhi Belly’.

Happy tripping!

Parag Murali is the Marketing & Happiness Manager at penroads.com. He combines his love for travelling and people into a daily passion for bringing travellers together. You can contact him at parag@penroads.com for just about anything, so feel free!

The province is investing $1.5 million to support a housing project in Muskoka to help people with no place to call home.

Tamar Geiger
Mar 1, 2012; 11:M111.014050-M111.014050
Special Issue: Prospects in Space and Time

7 November 2019

Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and other xenobiotics, a feature that is valuable in a biotechnology setting. However, extant P450 enzymes are typically relatively unstable, with T50 values of ∼30–40 °C. Reconstructed ancestral cytochrome P450 enzymes tend to have variable substrate selectivity compared with related extant forms, but they also have higher thermostability and therefore may be excellent tools for commercial biosynthesis of important intermediates, final drug molecules, or drug metabolites. The mammalian ancestor of the cytochrome P450 1B subfamily was herein characterized structurally and functionally, revealing differences from the extant human CYP1B1 in ligand binding, metabolism, and potential molecular contributors to its thermostability. Whereas extant human CYP1B1 has one molecule of α-naphthoflavone in a closed active site, we observed that subtle amino acid substitutions outside the active site in the ancestor CYP1B enzyme yielded an open active site with four ligand copies. A structure of the ancestor with 17β-estradiol revealed only one molecule in the active site, which still had the same open conformation. Detailed comparisons between the extant and ancestor forms revealed increases in electrostatic and aromatic interactions between distinct secondary structure elements in the ancestral forms that may contribute to their thermostability. To the best of our knowledge, this represents the first structural evaluation of a reconstructed ancestral cytochrome P450, revealing key features that appear to contribute to its thermostability.

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