Eversheds Sutherland has advised the CEO and owner of Saracus group on the sale of the group to an investment fund managed by private equity investor Maxburg Capital Partners. The parties agreed to keep the purchase price confidential. The client wi...

The Swiss Federal Supreme Court recently considered whether a dividend distributed by a Swiss company that participated in a zero balancing financing arrangement had been distributed lawfully. The case refers back to 2001 when Swisscargo AG distribu...

In this case, the Court of Appeal provided a long awaited decision answering whether a charterer’s failure to pay an instalment of hire punctually is a breach of condition under a time charterparty thus enabling the shipowner to terminate the ...

Here is how staff and residents of group homes for people with disabilities are coping during COVID-19 in the Southern Tier of New York. ......

On May 9, a plea was submitted in India's Delhi High Court, for legal probe and arrest of those accused in the #BoisLockerRoom controversy that started earlier this week in the country. On May 3, leaked images from a private Instagram chat group went viral in India, drawing criticism for sharing nude images of underage girls. The petition says that members of the private Instagram group chat, 'Bois Locker Room', who belong to affluent families, have threatened to leak explicit photos and hack the accounts of the women who exposed the group chat, stirring up a social media storm across the country. The leaked screenshots had revealed that a group of teenage boys from...

Moscow sent over a dozen military transport planes with equipment and specialists to Italy back in March to help the country in its efforts to stop the spread of the COVID-19 infection. ......

Eversheds Sutherland has advised Doncasters Group on the sale of its UK Fabrications and Blaenavon Forgings businesses to Arlington Capital Partners as two separate transactions. The deals were led by Corporate partner Richard Kyle with support from...

With Japanese drumming group Kodo forced to cancel this year's tour, the group has made an appeal for donations and equipment.

No one caught breaking mandatory quarantine

Indian police are investigating an online chat group that made light of gang-rape and caused a backlash on social media over trivialising sexual assault, with one teenage boy questioned on Tuesday.An Instagram chat group called “bois locker room” was the top trending hashtag on Twitter in India, with many tweets using screenshots from the group to highlight derogatory comments made about women, sexism or victim blaming.Sexual violence against women has become a major issue in India since the…

Prague Daily Monitor

Along with spring comes Million Moments next protests, scheduled for March 1st in Prague. The planned gathering place is Hradčanská, from which the movement will take a scenic walk to Staroměstské náměstí and begin the official protest. The planned protests are the result of Wednesday's election of Stanislav Křeček as Ombudsman. The movement will inform the public on February 16th about dates for protests in other main cities across the country.

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Police dispersed lunchtime protesters with pepper spray in an upscale Hong Kong shopping centre just 12 hours after the government relaxed some coronavirus social-distancing measures and allowed people to gather in groups of eight on Friday.Shortly after dozens of anti-government demonstrators began yelling slogans and belting out their anthem, officers entered the IFC Mall in Central to cordon off their protest site, forcing the Apple store to lower its shutters.Later, police used pepper spray…

Two of four children found to have COVID-19 have recovered, while five of eight staff at group homes and youth detention centres who tested positive have recovered.

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Human Rights Watch (HRW) said on Saturday that Saudi Arabian authorities recently detained and are holding incommunicado Prince Faisal bin Abdullah, who had previously been netted in an anti-corruption drive and released in late 2017.

The US-based rights group, citing a source with ties to the royal family, said Prince Faisal bin Abdullah, a son of late monarch King Abdullah, was detained by security forces on March 27 while self-isolating due to the coronavirus pandemic at a family compound northeast of the capital Riyadh.

Reuters could not immediately independently verify the detention. The Saudi government media office did not immediately respond to a detailed Reuters request for comment.

Earlier in March, authorities had detained King Salman’s brother, Prince Ahmed bin Abdulaziz, and former crown prince Mohammed bin Nayef, who was replaced in a 2017 palace coup and placed under house arrest, sources had told Reuters.

Sources with royal connections said at the time that the move was a preemptive effort to ensure compliance within the ruling Al Saud family ahead of an eventual succession to the throne by Crown Prince Mohammed bin Salman upon the king’s death or abdication.

It was not clear if the reported detention of Prince Faisal was related to those in early March, which also saw Ahmed’s son Nayef and Mohammed bin Nayef’s brother Nawaf detained.

Saudi authorities have not commented on those detentions, which follow crackdowns on dissent in which clerics, intellectuals and rights activists have been arrested, and an anti-corruption drive launched in 2017 that netted scores of royals, ministers and businessmen.

Critics have said the campaigns were part of moves by Crown Prince Mohammed, the king’s son and the kingdom’s de facto ruler, to consolidate his grip on power.

“Now we have to add Prince Faisal to the hundreds detained in Saudi Arabia without a clear legal basis,” said Michael Page, deputy Middle East director at HRW.

The kingdom has regularly denied allegations of unfair detention.

Authorities said last year the government was winding down the anti-corruption campaign after 15 months, but would continue to go after graft.

HRW said Prince Faisal’s whereabouts or status are not known.

“The source said that Prince Faisal has not publicly criticised authorities since his December 2017 arrest and that family members are concerned about his health as he has a heart condition,” it added.

In late December 2017, a senior Saudi official said Prince Faisal and another royal, Prince Meshaal bin Abdullah, were released from Riyadh’s Ritz-Carlton hotel, where people nabbed in the anti-corruption drive were being held, after reaching an undisclosed financial settlement with the government.

CHANDIGARH: TDI Investors Association, which includes 70 member investors from Chandigarh, on Wednesday created a row, alleging that the owners had cheated them of Rs 150 crore. The association, in a press conference, alleged that a legal agreement was signed between the company and the members in 2005 after which they paid 80% of the cost for showrooms in the mall and were promised possession by 2008. The members blamed the company of not giving them possession till date and neither paying them the returns. The project includes 70 shops varying from 400 sq ft to 1,000 sq ft. TDI chairman Ravinder Taneja, however, trashed the allegations, blaming the authorities […]

Dentons’ Real Estate team advised CPI Property Group (CPI), the largest commercial property owner in the Czech Republic, Berlin and the CEE region, on the acquisition of a 50.3% share in the ownership of Chałubińskiego 8 office building in Warsaw. The divestment was made by First Property Group, an investment company and the manager of real estate funds operating in Great Britain and Central Europe.

NEW DELHI: Realty firm Logix group plans to raise Rs 250 crore from foreign investors for the development of its ongoing mixed-use commercial project in Noida. The company is developing this commercial project at an investment of Rs 1,000 crore and is looking to raise FDI to complete this project. The 6-acre project ‘Noida City Center’ includes a 7 lakh sq ft shopping mall, 2.5 lakh sq ft office towers, two hotels with combined 400 rooms and 100 service apartments. “Total project cost of this commercial project is Rs 1,000 crore,” Logix group CMD Shakti Nath said. The investments are largely met through internal accruals, he said, adding that the […]

NEW DELHI: Unitech Corporate Parks, a Unitech group firm listed in London, has received bids of up to Rs 2,700 crore from six companies, including Blackstone, for sale of its IT Special economic Zone (SEZ) in Gurgaon. Listed on London’s Alternative Investment Market and set up to invest in commercial real estate of India, UCP has 60 per cent stake in the Gurgaon SEZ comprising 3.6 million sq ft commercial space. Unitech has remaining stake in the SEZ. UCP has given the mandate to property consultant Jones Lang LaSalle India to find out potential buyers. According to sources, UCP, which has put the Gurgaon SEZ on the block, has received […]

U.S. brokers should not be forced to sign an agreement that could make them liable for breaches of a massive new industry trading database that they have no control over, a leading financial industry...

Human Rights Watch (HRW) said on Saturday that Saudi Arabian authorities recently detained and are holding incommunicado Prince Faisal bin Abdullah, who had previously been netted in an anti-corruption drive and released in late 2017.

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ABSTRACT

Recent global advocacy efforts have highlighted the importance of development of a vaccine against group A Streptococcus (GAS). Combo5 is a non-M protein-based vaccine that provides protection against GAS skin infection in mice and reduces the severity of pharyngitis in nonhuman primates. However, Combo5 with the addition of aluminum hydroxide (alum) as an adjuvant failed to protect against invasive GAS infection of mice. Here, we show that formulation of Combo5 with adjuvants containing saponin QS21 significantly improves protective efficacy, even though all 7 adjuvants tested generated high antigen-specific IgG antibody titers, including alum. Detailed characterization of Combo5 formulated with SMQ adjuvant, a squalene-in-water emulsion containing a TLR4 agonist and QS21, showed significant differences from the results obtained with alum in IgG subclasses generated following immunization, with an absence of GAS opsonizing antibodies. SMQ, but not alum, generated strong interleukin-6 (IL-6), gamma interferon (IFN-), and tumor necrosis alpha (TNF-α) responses. This work highlights the importance of adjuvant selection for non-M protein-based GAS vaccines to optimize immune responses and protective efficacy.

IMPORTANCE Availability of a group A Streptococcus vaccine remains an unmet public health need. Here, we tested different adjuvant formulations to improve the protective efficacy of non-M protein vaccine Combo5 in an invasive disease model. We show that novel adjuvants can dramatically shape the type of immune response developed following immunization with Combo5 and significantly improve protection. In addition, protection afforded by Combo5 is not mediated by opsonizing antibodies, believed to be the main correlate of protection against GAS infections. Overall, this report highlights the importance of adjuvant selection in raising protective immune responses against GAS invasive infection. Adjuvants that can provide a more balanced Th1/Th2-type response may be required to optimize protection of GAS vaccines, particularly those based on non-M protein antigens.

ABSTRACT

Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibiotic to which GBS is intrinsically resistant. Reductions in the MIC of TMP reached as high as 512-fold across a diverse panel of isolates. To better understand HMOs’ mechanism of action, we characterized the metabolic response of GBS to HMO treatment using ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UPLC-HRMS/MS) analysis. These data showed that when challenged by HMOs, GBS undergoes significant perturbations in metabolic pathways related to the biosynthesis and incorporation of macromolecules involved in membrane construction. This study represents reports the metabolic characterization of a cell that is perturbed by HMOs.

IMPORTANCE Group B Streptococcus is an important human pathogen that causes serious infections during pregnancy which can lead to chorioamnionitis, funisitis, premature rupture of gestational membranes, preterm birth, neonatal sepsis, and death. GBS is evolving antimicrobial resistance mechanisms, and the work presented in this paper provides evidence that prebiotics such as human milk oligosaccharides can act as adjuvants to restore the utility of antibiotics.

Group II introns are mobile genetic elements that perform both self-splicing and intron mobility reactions. These ribozymes are comprised of a catalytic RNA core that binds to an intron-encoded protein (IEP) to form a ribonucleoprotein (RNP) complex. Splicing proceeds through two competing reactions: hydrolysis or branching. Group IIC intron ribozymes have a minimal RNA architecture, and splice almost exclusively through hydrolysis in ribozyme reactions. Addition of the IEP allows the splicing reaction to form branched lariat RNPs capable of intron mobility. Here we examine ribozyme splicing, IEP-dependent splicing, and mobility reactions of a group IIC intron from the thermophilic bacterium Thermoanerobacter italicus (Ta.it.I1). We show that Ta.it.I1 is highly active for ribozyme activity, forming linear hydrolytic intron products. Addition of purified IEP switches activity to the canonical lariat forming splicing reaction. We demonstrate that the Ta.it.I1 group IIC intron coordinates the progression of the forward splicing reaction through a –' interaction between intron domains II and VI. We further show that branched splicing is supported in the absence of the IEP when the –' interaction is mutated. We also investigated the regulation of the two steps of reverse splicing during intron mobility into DNA substrates. Using a fluorescent mobility assay that simultaneously visualizes all steps of intron integration into DNA, we show that completion of reverse splicing is tightly coupled to cDNA synthesis regardless of mutation of the –' interaction.

OBJECTIVE

Daily foot self-inspection may permit earlier detection and treatment of a foot lesion, reducing the risk of infection and lower-limb amputation (LLA). Though race and ethnicity are strongly associated with LLA risk, with higher risk seen in African Americans (AA), American Indians/Alaska Natives (AI/AN), and Native Hawaiians/Pacific Islanders (NH/PI), associations between foot self-inspection and racial and ethnic groups are inconsistent. We aimed to assess differences in foot self-inspection among people with diabetes by race/ethnicity.

The Stenotrophomonas maltophilia complex (Smc) comprises opportunistic environmental Gram-negative bacilli responsible for a variety of infections in both humans and animals. Beyond its large genetic diversity, its genetic organization in genogroups was recently confirmed through the whole-genome sequencing of human and environmental strains. As they are poorly represented in these analyses, we sequenced the whole genomes of 93 animal strains to determine their genetic background and characteristics. Combining these data with 81 newly sequenced human strains and the genomes available from RefSeq, we performed a genomic analysis that included 375 nonduplicated genomes with various origins (animal, 104; human, 226; environment, 30; unknown, 15). Phylogenetic analysis and clustering based on genome-wide average nucleotide identity confirmed and specified the genetic organization of Smc in at least 20 genogroups. Two new genogroups were identified, and two previously described groups were further divided into two subgroups each. Comparing the strains isolated from different host types and their genogroup affiliation, we observed a clear disequilibrium in certain groups. Surprisingly, some antimicrobial resistance genes, integrons, and/or clusters of attC sites lacking integron-integrase (CALIN) sequences targeting antimicrobial compounds extensively used in animals were mainly identified in animal strains. We also identified genes commonly found in animal strains coding for efflux systems. The result of a large whole-genome analysis performed by us supports the hypothesis of the putative contribution of animals as a reservoir of Stenotrophomonas maltophilia complex strains and/or resistance genes for strains in humans.

IMPORTANCE Given its naturally large antimicrobial resistance profile, the Stenotrophomonas maltophilia complex (Smc) is a set of emerging pathogens of immunosuppressed and cystic fibrosis patients. As it is group of environmental microorganisms, this adaptation to humans is an opportunity to understand the genetic and metabolic selective mechanisms involved in this process. The previously reported genomic organization was incomplete, as data from animal strains were underrepresented. We added the missing piece of the puzzle with whole-genome sequencing of 93 strains of animal origin. Beyond describing the phylogenetic organization, we confirmed the genetic diversity of the Smc, which could not be estimated through routine phenotype- or matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF)-based laboratory tests. Animals strains seem to play a key role in the diversity of Smc and could act as a reservoir for mobile resistance genes. Some genogroups seem to be associated with particular hosts; the genetic support of this association and the role of the determinants/corresponding genes need to be explored.

Background:

Asian Americans are at higher risk for noncardia gastric cancers (NCGC) relative to non-Hispanic Whites (NHW). Asian Americans are genetically, linguistically, and culturally heterogeneous, yet have mostly been treated as a single population in prior studies. This aggregation may obscure important subgroup-specific cancer patterns.

BACKGROUND AND PURPOSE:

Endovascular embolization only has been advocated for treatment of brain arteriovenous malformations in recent trials. Our aim was to evaluate the results of embolization only in a cohort of patients who were enrolled in the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) study at 39 clinical sites in 9 countries.

BACKGROUND AND PURPOSE:

Flow diversion for the posterior circulation remains a promising treatment option for selected posterior circulation aneurysms. The Flow-Redirection Intraluminal Device (FRED) system has not been previously assessed in a large cohort of patients with posterior circulation aneurysms. The purpose of the present study was to assess safety and efficacy of FRED in this location.

The International Astronomical Union has concluded a review of satellite mega constellations such as SpaceX's Starlink satellites and found they will have a major impact on large telescopes, but not naked eye astronomy

Desmond Mombeyarara, 34, was with his son when officers shot him with a stun gun

Anti-racism protesters have gathered outside a petrol station in Greater Manchester to demonstrate against the stun gun shooting by police of a black man in the company of his distressed son.

Desmond Mombeyarara, 34, was shot with a stun gun by police on Wednesday evening after officers stopped him for allegedly speeding.