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Eversheds Sutherland advises CEO and owner of Sarcus group on the sale to private equity investor Maxburg Capital Partners

Eversheds Sutherland has advised the CEO and owner of Saracus group on the sale of the group to an investment fund managed by private equity investor Maxburg Capital Partners. The parties agreed to keep the purchase price confidential. The client wi...




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Retail groups with Swiss financing arrangements

The Swiss Federal Supreme Court recently considered whether a dividend distributed by a Swiss company that participated in a zero balancing financing arrangement had been distributed lawfully. The case refers back to 2001 when Swisscargo AG distribu...




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Spar Shipping A.S v Grand China Logistics Holding (Group) Co. Ltd [2016] EWCA CIV 982

In this case, the Court of Appeal provided a long awaited decision answering whether a charterer’s failure to pay an instalment of hire punctually is a breach of condition under a time charterparty thus enabling the shipowner to terminate the ...




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Everest Re Group, Ltd. (RE) CEO Juan Andrade on Q1 2020 Results - Earnings Call Transcript




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Coronavirus is added challenge for group homes: How they are dealing with pandemic

Here is how staff and residents of group homes for people with disabilities are coping during COVID-19 in the Southern Tier of New York. ......




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#BoisLockerRoom: Members threaten women who exposed the group chat, states plea submitted in India's Delhi High Court

On May 9, a plea was submitted in India's Delhi High Court, for legal probe and arrest of those accused in the #BoisLockerRoom controversy that started earlier this week in the country. On May 3, leaked images from a private Instagram chat group went viral in India, drawing criticism for sharing nude images of underage girls. The petition says that members of the private Instagram group chat, 'Bois Locker Room', who belong to affluent families, have threatened to leak explicit photos and hack the accounts of the women who exposed the group chat, stirring up a social media storm across the country. The leaked screenshots had revealed that a group of teenage boys from...




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Second Group of Russian Servicemen Helping Italy to Fight Coronavirus Heading Back Home

Moscow sent over a dozen military transport planes with equipment and specialists to Italy back in March to help the country in its efforts to stop the spread of the COVID-19 infection. ......




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Eversheds Sutherland has advised Doncasters Group on the sale of its UK Fabrications and Blaenavon Forgings businesses

Eversheds Sutherland has advised Doncasters Group on the sale of its UK Fabrications and Blaenavon Forgings businesses to Arlington Capital Partners as two separate transactions. The deals were led by Corporate partner Richard Kyle with support from...




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Taiko group Kodo makes a plea for donations amid the COVID-19 crisis

With Japanese drumming group Kodo forced to cancel this year's tour, the group has made an appeal for donations and equipment.




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11 fined for group gatherings larger than four

No one caught breaking mandatory quarantine




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Indian police question teen boy after ‘bois locker room’ Instagram chat group makes light of rape

Indian police are investigating an online chat group that made light of gang-rape and caused a backlash on social media over trivialising sexual assault, with one teenage boy questioned on Tuesday.An Instagram chat group called “bois locker room” was the top trending hashtag on Twitter in India, with many tweets using screenshots from the group to highlight derogatory comments made about women, sexism or victim blaming.Sexual violence against women has become a major issue in India since the…




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Million Moments group resumes protests: Prague March 1st

Prague Daily Monitor

Along with spring comes Million Moments next protests, scheduled for March 1st in Prague. The planned gathering place is Hradčanská, from which the movement will take a scenic walk to Staroměstské náměstí and begin the official protest. The planned protests are the result of Wednesday's election of Stanislav Křeček as Ombudsman. The movement will inform the public on February 16th about dates for protests in other main cities across the country.

read more




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Hong Kong lunchtime protesters return after coronavirus social-distancing rules are eased but police quickly disperse group in mall with pepper spray

Police dispersed lunchtime protesters with pepper spray in an upscale Hong Kong shopping centre just 12 hours after the government relaxed some coronavirus social-distancing measures and allowed people to gather in groups of eight on Friday.Shortly after dozens of anti-government demonstrators began yelling slogans and belting out their anthem, officers entered the IFC Mall in Central to cordon off their protest site, forcing the Apple store to lower its shutters.Later, police used pepper spray…




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Refugee women killed in Turkish strikes on Kurdish group in Iraq

Iraq's Foreign Ministry said the attack "constituted a serious violation of international humanitarian law."




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Children in Ontario group homes and foster care test positive for coronavirus

Two of four children found to have COVID-19 have recovered, while five of eight staff at group homes and youth detention centres who tested positive have recovered.




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'At least 90,000 healthcare workers infected by COVID-19', says nursing group

1




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Rights group says Saudi Arabia is holding a senior prince incommunicado since March

Human Rights Watch (HRW) said on Saturday that Saudi Arabian authorities recently detained and are holding incommunicado Prince Faisal bin Abdullah, who had previously been netted in an anti-corruption drive and released in late 2017.

The US-based rights group, citing a source with ties to the royal family, said Prince Faisal bin Abdullah, a son of late monarch King Abdullah, was detained by security forces on March 27 while self-isolating due to the coronavirus pandemic at a family compound northeast of the capital Riyadh.

Reuters could not immediately independently verify the detention. The Saudi government media office did not immediately respond to a detailed Reuters request for comment.

Earlier in March, authorities had detained King Salman’s brother, Prince Ahmed bin Abdulaziz, and former crown prince Mohammed bin Nayef, who was replaced in a 2017 palace coup and placed under house arrest, sources had told Reuters.

Sources with royal connections said at the time that the move was a preemptive effort to ensure compliance within the ruling Al Saud family ahead of an eventual succession to the throne by Crown Prince Mohammed bin Salman upon the king’s death or abdication.

It was not clear if the reported detention of Prince Faisal was related to those in early March, which also saw Ahmed’s son Nayef and Mohammed bin Nayef’s brother Nawaf detained.

Saudi authorities have not commented on those detentions, which follow crackdowns on dissent in which clerics, intellectuals and rights activists have been arrested, and an anti-corruption drive launched in 2017 that netted scores of royals, ministers and businessmen.

Critics have said the campaigns were part of moves by Crown Prince Mohammed, the king’s son and the kingdom’s de facto ruler, to consolidate his grip on power.

“Now we have to add Prince Faisal to the hundreds detained in Saudi Arabia without a clear legal basis,” said Michael Page, deputy Middle East director at HRW.

The kingdom has regularly denied allegations of unfair detention.

Authorities said last year the government was winding down the anti-corruption campaign after 15 months, but would continue to go after graft.

HRW said Prince Faisal’s whereabouts or status are not known.

“The source said that Prince Faisal has not publicly criticised authorities since his December 2017 arrest and that family members are concerned about his health as he has a heart condition,” it added.

In late December 2017, a senior Saudi official said Prince Faisal and another royal, Prince Meshaal bin Abdullah, were released from Riyadh’s Ritz-Carlton hotel, where people nabbed in the anti-corruption drive were being held, after reaching an undisclosed financial settlement with the government.




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Realty group investors allege fraud

CHANDIGARH: TDI Investors Association, which includes 70 member investors from Chandigarh, on Wednesday created a row, alleging that the owners had cheated them of Rs 150 crore. The association, in a press conference, alleged that a legal agreement was signed between the company and the members in 2005 after which they paid 80% of the cost for showrooms in the mall and were promised possession by 2008. The members blamed the company of not giving them possession till date and neither paying them the returns. The project includes 70 shops varying from 400 sq ft to 1,000 sq ft. TDI chairman Ravinder Taneja, however, trashed the allegations, blaming the authorities […]




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Dentons advises CPI Property Group on acquisition of a majority stake in Chałubińskiego 8 office building

Dentons’ Real Estate team advised CPI Property Group (CPI), the largest commercial property owner in the Czech Republic, Berlin and the CEE region, on the acquisition of a 50.3% share in the ownership of Chałubińskiego 8 office building in Warsaw. The divestment was made by First Property Group, an investment company and the manager of real estate funds operating in Great Britain and Central Europe.




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Logix group looking to raise Rs 250cr FDI for Noida project

NEW DELHI: Realty firm Logix group plans to raise Rs 250 crore from foreign investors for the development of its ongoing mixed-use commercial project in Noida. The company is developing this commercial project at an investment of Rs 1,000 crore and is looking to raise FDI to complete this project. The 6-acre project ‘Noida City Center’ includes a 7 lakh sq ft shopping mall, 2.5 lakh sq ft office towers, two hotels with combined 400 rooms and 100 service apartments. “Total project cost of this commercial project is Rs 1,000 crore,” Logix group CMD Shakti Nath said. The investments are largely met through internal accruals, he said, adding that the […]



  • Noida
  • Real Estate India

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Unitech group’s UCP gets bids up to Rs 2,700cr for Gurgaon SEZ

NEW DELHI: Unitech Corporate Parks, a Unitech group firm listed in London, has received bids of up to Rs 2,700 crore from six companies, including Blackstone, for sale of its IT Special economic Zone (SEZ) in Gurgaon. Listed on London’s Alternative Investment Market and set up to invest in commercial real estate of India, UCP has 60 per cent stake in the Gurgaon SEZ comprising 3.6 million sq ft commercial space. Unitech has remaining stake in the SEZ. UCP has given the mandate to property consultant Jones Lang LaSalle India to find out potential buyers. According to sources, UCP, which has put the Gurgaon SEZ on the block, has received […]




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Securities group asks SEC to intervene for brokers in audit-trail database fight

U.S. brokers should not be forced to sign an agreement that could make them liable for breaches of a massive new industry trading database that they have no control over, a leading financial industry...




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Rights group says Saudi Arabia is holding a senior prince incommunicado since March

Human Rights Watch (HRW) said on Saturday that Saudi Arabian authorities recently detained and are holding incommunicado Prince Faisal bin Abdullah, who had previously been netted in an anti-corruption drive and released in late 2017.




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Day Care, Play Groups Cut Leukemia Risk?

Title: Day Care, Play Groups Cut Leukemia Risk?
Category: Health News
Created: 4/30/2008 12:00:00 AM
Last Editorial Review: 4/30/2008 12:00:00 AM




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Group Doctor Visits May Help Parkinson's Patients

Title: Group Doctor Visits May Help Parkinson's Patients
Category: Health News
Created: 4/28/2011 11:01:00 AM
Last Editorial Review: 4/28/2011 12:00:00 AM




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Pediatrician Group Issues Home Birth Policy Statement

Title: Pediatrician Group Issues Home Birth Policy Statement
Category: Health News
Created: 4/29/2013 10:35:00 AM
Last Editorial Review: 4/29/2013 12:00:00 AM




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Urologists' Group Issues Updated Guidelines on PSA Test

Title: Urologists' Group Issues Updated Guidelines on PSA Test
Category: Health News
Created: 5/3/2013 12:35:00 PM
Last Editorial Review: 5/3/2013 12:00:00 AM




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Pediatrics Group Advises Doctors on How to Spot Child Abuse

Title: Pediatrics Group Advises Doctors on How to Spot Child Abuse
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM




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Condition Affecting Kids With COVID-19 Remains Very Rare, Heart Group Says

Title: Condition Affecting Kids With COVID-19 Remains Very Rare, Heart Group Says
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM




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Testosterone Supplements Won't Help Most Men, Doctors' Group Says

Title: Testosterone Supplements Won't Help Most Men, Doctors' Group Says
Category: Health News
Created: 1/6/2020 12:00:00 AM
Last Editorial Review: 1/7/2020 12:00:00 AM




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Erratum for 'The Chalk Group (Upper Cretaceous) of the Northern Province, eastern England - a review, Proceedings of the Yorkshire Geological Society, 62, 153-177




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Vaccine-Induced Th1-Type Response Protects against Invasive Group A Streptococcus Infection in the Absence of Opsonizing Antibodies

ABSTRACT

Recent global advocacy efforts have highlighted the importance of development of a vaccine against group A Streptococcus (GAS). Combo5 is a non-M protein-based vaccine that provides protection against GAS skin infection in mice and reduces the severity of pharyngitis in nonhuman primates. However, Combo5 with the addition of aluminum hydroxide (alum) as an adjuvant failed to protect against invasive GAS infection of mice. Here, we show that formulation of Combo5 with adjuvants containing saponin QS21 significantly improves protective efficacy, even though all 7 adjuvants tested generated high antigen-specific IgG antibody titers, including alum. Detailed characterization of Combo5 formulated with SMQ adjuvant, a squalene-in-water emulsion containing a TLR4 agonist and QS21, showed significant differences from the results obtained with alum in IgG subclasses generated following immunization, with an absence of GAS opsonizing antibodies. SMQ, but not alum, generated strong interleukin-6 (IL-6), gamma interferon (IFN-), and tumor necrosis alpha (TNF-α) responses. This work highlights the importance of adjuvant selection for non-M protein-based GAS vaccines to optimize immune responses and protective efficacy.

IMPORTANCE Availability of a group A Streptococcus vaccine remains an unmet public health need. Here, we tested different adjuvant formulations to improve the protective efficacy of non-M protein vaccine Combo5 in an invasive disease model. We show that novel adjuvants can dramatically shape the type of immune response developed following immunization with Combo5 and significantly improve protection. In addition, protection afforded by Combo5 is not mediated by opsonizing antibodies, believed to be the main correlate of protection against GAS infections. Overall, this report highlights the importance of adjuvant selection in raising protective immune responses against GAS invasive infection. Adjuvants that can provide a more balanced Th1/Th2-type response may be required to optimize protection of GAS vaccines, particularly those based on non-M protein antigens.




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A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim

ABSTRACT

Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibiotic to which GBS is intrinsically resistant. Reductions in the MIC of TMP reached as high as 512-fold across a diverse panel of isolates. To better understand HMOs’ mechanism of action, we characterized the metabolic response of GBS to HMO treatment using ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UPLC-HRMS/MS) analysis. These data showed that when challenged by HMOs, GBS undergoes significant perturbations in metabolic pathways related to the biosynthesis and incorporation of macromolecules involved in membrane construction. This study represents reports the metabolic characterization of a cell that is perturbed by HMOs.

IMPORTANCE Group B Streptococcus is an important human pathogen that causes serious infections during pregnancy which can lead to chorioamnionitis, funisitis, premature rupture of gestational membranes, preterm birth, neonatal sepsis, and death. GBS is evolving antimicrobial resistance mechanisms, and the work presented in this paper provides evidence that prebiotics such as human milk oligosaccharides can act as adjuvants to restore the utility of antibiotics.




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Transitions between the steps of forward and reverse splicing of group IIC introns [ARTICLE]

Group II introns are mobile genetic elements that perform both self-splicing and intron mobility reactions. These ribozymes are comprised of a catalytic RNA core that binds to an intron-encoded protein (IEP) to form a ribonucleoprotein (RNP) complex. Splicing proceeds through two competing reactions: hydrolysis or branching. Group IIC intron ribozymes have a minimal RNA architecture, and splice almost exclusively through hydrolysis in ribozyme reactions. Addition of the IEP allows the splicing reaction to form branched lariat RNPs capable of intron mobility. Here we examine ribozyme splicing, IEP-dependent splicing, and mobility reactions of a group IIC intron from the thermophilic bacterium Thermoanerobacter italicus (Ta.it.I1). We show that Ta.it.I1 is highly active for ribozyme activity, forming linear hydrolytic intron products. Addition of purified IEP switches activity to the canonical lariat forming splicing reaction. We demonstrate that the Ta.it.I1 group IIC intron coordinates the progression of the forward splicing reaction through a –' interaction between intron domains II and VI. We further show that branched splicing is supported in the absence of the IEP when the –' interaction is mutated. We also investigated the regulation of the two steps of reverse splicing during intron mobility into DNA substrates. Using a fluorescent mobility assay that simultaneously visualizes all steps of intron integration into DNA, we show that completion of reverse splicing is tightly coupled to cDNA synthesis regardless of mutation of the –' interaction.




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Associations Between Racial and Ethnic Groups and Foot Self-Inspection in People With Diabetes

OBJECTIVE

Daily foot self-inspection may permit earlier detection and treatment of a foot lesion, reducing the risk of infection and lower-limb amputation (LLA). Though race and ethnicity are strongly associated with LLA risk, with higher risk seen in African Americans (AA), American Indians/Alaska Natives (AI/AN), and Native Hawaiians/Pacific Islanders (NH/PI), associations between foot self-inspection and racial and ethnic groups are inconsistent. We aimed to assess differences in foot self-inspection among people with diabetes by race/ethnicity.

RESEARCH DESIGN AND METHODS

Using national, cross-sectional data from the 2015–2017 Behavioral Risk Factor Surveillance System surveys and including 88,424 individuals with diabetes, we estimated prevalence ratios (PRs) and associated 95% CIs of daily foot checking for sores or irritation by racial and ethnic groups using log-binomial linear regression models, after accounting for survey weights.

RESULTS

Compared with whites (who had a weighted prevalence [P] of daily foot self-inspection of 57%), AA (P 67%, PR 1.18 [95% CI 1.14, 1.23]), AI/AN (P 66%, PR 1.15 [95% CI 1.07, 1.25]), and NH/PI (P 71%, PR 1.25 [95% CI 1.03, 1.52]) had higher prevalences of daily foot self-inspection. The prevalence of daily foot inspection was significantly lower among Asians (P 35%, PR 0.62 [95% CI 0.48, 0.81]) and Hispanics (P 53%, PR 0.93 [95% CI 0.88, 0.99]) compared with whites. Associations did not vary importantly by insulin use, years since diabetes diagnosis, or having received diabetes self-management education.

CONCLUSIONS

The higher frequency of foot self-inspection in racial and ethnic groups at elevated risk of diabetes-related LLA is not sufficient to eliminate LLA disparities; additional interventions are needed to achieve this aim.




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Reinventing the Medical Assistant Staffing Model at No Cost in a Large Medical Group [Innovations in Primary Care]




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Comparative Whole-Genome Phylogeny of Animal, Environmental, and Human Strains Confirms the Genogroup Organization and Diversity of the Stenotrophomonas maltophilia Complex [Public and Environmental Health Microbiology]

The Stenotrophomonas maltophilia complex (Smc) comprises opportunistic environmental Gram-negative bacilli responsible for a variety of infections in both humans and animals. Beyond its large genetic diversity, its genetic organization in genogroups was recently confirmed through the whole-genome sequencing of human and environmental strains. As they are poorly represented in these analyses, we sequenced the whole genomes of 93 animal strains to determine their genetic background and characteristics. Combining these data with 81 newly sequenced human strains and the genomes available from RefSeq, we performed a genomic analysis that included 375 nonduplicated genomes with various origins (animal, 104; human, 226; environment, 30; unknown, 15). Phylogenetic analysis and clustering based on genome-wide average nucleotide identity confirmed and specified the genetic organization of Smc in at least 20 genogroups. Two new genogroups were identified, and two previously described groups were further divided into two subgroups each. Comparing the strains isolated from different host types and their genogroup affiliation, we observed a clear disequilibrium in certain groups. Surprisingly, some antimicrobial resistance genes, integrons, and/or clusters of attC sites lacking integron-integrase (CALIN) sequences targeting antimicrobial compounds extensively used in animals were mainly identified in animal strains. We also identified genes commonly found in animal strains coding for efflux systems. The result of a large whole-genome analysis performed by us supports the hypothesis of the putative contribution of animals as a reservoir of Stenotrophomonas maltophilia complex strains and/or resistance genes for strains in humans.

IMPORTANCE Given its naturally large antimicrobial resistance profile, the Stenotrophomonas maltophilia complex (Smc) is a set of emerging pathogens of immunosuppressed and cystic fibrosis patients. As it is group of environmental microorganisms, this adaptation to humans is an opportunity to understand the genetic and metabolic selective mechanisms involved in this process. The previously reported genomic organization was incomplete, as data from animal strains were underrepresented. We added the missing piece of the puzzle with whole-genome sequencing of 93 strains of animal origin. Beyond describing the phylogenetic organization, we confirmed the genetic diversity of the Smc, which could not be estimated through routine phenotype- or matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF)-based laboratory tests. Animals strains seem to play a key role in the diversity of Smc and could act as a reservoir for mobile resistance genes. Some genogroups seem to be associated with particular hosts; the genetic support of this association and the role of the determinants/corresponding genes need to be explored.




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Meningococcal Group B Vaccination




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One Size Does Not Fit All: Marked Heterogeneity in Incidence of and Survival from Gastric Cancer among Asian American Subgroups

Background:

Asian Americans are at higher risk for noncardia gastric cancers (NCGC) relative to non-Hispanic Whites (NHW). Asian Americans are genetically, linguistically, and culturally heterogeneous, yet have mostly been treated as a single population in prior studies. This aggregation may obscure important subgroup-specific cancer patterns.

Methods:

We utilized data from 13 regional United States cancer registries from 1990 to 2014 to determine secular trends in incidence and survivorship from NCGC. Data were analyzed for NHWs and the six largest Asian American subgroups: Chinese, Japanese, Filipino, Korean, Vietnamese, and South Asian (Indian/Pakistani).

Results:

There exists substantial heterogeneity in NCGC incidence between Asian subgroups, with Koreans (48.6 per 100,000 person-years) having seven-fold higher age-adjusted incidence than South Asians (7.4 per 100,000 person-years). Asians had generally earlier stages of diagnosis and higher rates of surgical resection compared with NHWs. All Asian subgroups also demonstrated higher 5-year observed survival compared with NHWs, with Koreans (41.3%) and South Asians (42.8%) having survival double that of NHWs (20.1%, P < 0.001). In multivariable regression, differences in stage of diagnosis and rates of resection partially explained the difference in survivorship between Asian subgroups.

Conclusions:

We find substantial differences in incidence, staging, histology, treatment, and survivorship from NCGC between Asian subgroups, data which challenge our traditional perceptions about gastric cancer in Asians. Both biological heterogeneity and cultural/environmental differences may underlie these findings.

Impact:

These data are relevant to the national discourse regarding the appropriate role of gastric cancer screening, and identifies high-risk racial/ethnic subgroups who many benefit from customized risk attenuation programs.




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Treatment Outcomes of Endovascular Embolization Only in Patients with Unruptured Brain Arteriovenous Malformations: A Subgroup Analysis of ARUBA (A Randomized Trial of Unruptured Brain Arteriovenous Malformations) [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Endovascular embolization only has been advocated for treatment of brain arteriovenous malformations in recent trials. Our aim was to evaluate the results of embolization only in a cohort of patients who were enrolled in the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) study at 39 clinical sites in 9 countries.

MATERIALS AND METHODS:

We analyzed the rates and severity of stroke and death in patients who underwent embolization only. Events were identified through in-person neurologic follow-up visits performed at 6-month intervals during the first 2 years and annually, with telephone contact every 6 months thereafter. All event-related data were reviewed by independent adjudicators.

RESULTS:

Among 30 patients who had embolization planned, 26 underwent embolization only. A total of 13 stroke events were reported in the follow-up period among 26 subjects (ischemic, hemorrhagic, or both in 4, 7, and 2 subjects, respectively). The adverse event occurred after the first embolization in 11 of 13 patients. One patient had a major motor deficit, and 2 patients developed major visual field deficits. One event was fatal. The modified Rankin Scale score was 0–2 at last follow-up in 11 of the 12 stroke survivors. Estimated stroke-free survival was 46% at 12 months.

CONCLUSIONS:

Although the rates of stroke and/or death were high in patients treated with embolization only in ARUBA, the rates of favorable outcomes following stroke were high during follow-up.




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The FRED for Cerebral Aneurysms of the Posterior Circulation: A Subgroup Analysis of the EuFRED Registry [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Flow diversion for the posterior circulation remains a promising treatment option for selected posterior circulation aneurysms. The Flow-Redirection Intraluminal Device (FRED) system has not been previously assessed in a large cohort of patients with posterior circulation aneurysms. The purpose of the present study was to assess safety and efficacy of FRED in this location.

MATERIALS AND METHODS:

Consecutive patients with posterior circulation aneurysms treated at 8 centers participating in the European FRED study (EuFRED) between April 2012 and January 2019 were retrospectively reviewed. Complication and radiographic and functional outcomes were evaluated.

RESULTS:

Eighty-four patients (median age, 54 years) with 84 posterior circulation aneurysms were treated with the FRED. A total of 25 aneurysms (29.8%) had previously ruptured, even though most aneurysms were diagnosed incidentally (45.2%). The intradural vertebral artery was the most common location (50%), and saccular, the most common morphology (40.5%). The median size was 7 mm. There were 8 (9.5%) symptomatic thromboembolic and no hemorrhagic complications. Thromboembolic complications occurred mostly (90.9%) in nonsaccular aneurysms. On last follow-up at a median of 24 months, 78.2% of aneurysms were completely occluded. Functional outcome at a median of 27 months was favorable in 94% of patients. All mortalities occurred in patients with acute subarachnoid hemorrhage and its sequelae.

CONCLUSIONS:

The largest cohort of posterior circulation aneurysms treated with the FRED to date demonstrated favorable safety and efficacy profiles of the device for this indication. Treatment in the setting of acute subarachnoid hemorrhage was strongly related to mortality, regardless of whether procedural complications occurred.




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Kim Long Nam Group




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Cần bán khu nghỉ dưỡng cuối tuần cao cấp của TT Lương Sơn gần sát tập đoàn An Thịnh Group

- Khu nghỉ dưỡng cuối tuần cực hot củ thị trấn Lương Sơn có DT: 8000m2 có 600m2 đất ở thuộc xã Cư Yên, Lương Sơn, Hòa Bình. - Khu nghỉ dưỡng nằm sát với tập đoàn An Thịnh Group là một trong những khu phân lô biệt thự nhà vườn cao cấp nhất thị trấn Lương Sơn đang hoạt động rất mạn...




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Công Ty Cổ Phần Tập Đoàn SenGroup




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Công ty Đầu tư & Phát triển Bất động sản Nam Group




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Phú Vinh Group




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Astronomy group finds Starlink satellites will have 'negative impact'

The International Astronomical Union has concluded a review of satellite mega constellations such as SpaceX's Starlink satellites and found they will have a major impact on large telescopes, but not naked eye astronomy




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Rights group says Saudi Arabia is holding a senior prince incommunicado since March




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Anti-racism group stage Stretford protest over police stun gun shooting

Desmond Mombeyarara, 34, was with his son when officers shot him with a stun gun

Anti-racism protesters have gathered outside a petrol station in Greater Manchester to demonstrate against the stun gun shooting by police of a black man in the company of his distressed son.

Desmond Mombeyarara, 34, was shot with a stun gun by police on Wednesday evening after officers stopped him for allegedly speeding.

Continue reading...




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Narco-terrorist with links to Kashmiri terror groups nabbed by NIA in Haryana