CG Dotti
Apr 1, 1988; 8:1454-1468
Articles

You can reduce the story of CRM to a lot of things, especially its many component parts. Social networking, cloud computing and analytics are mentioned often. We don't need an exhaustive list, but if we stop there I think we miss a lot. To me CRM isn't about the parts, although like most people following the industry, I get a modicum of joy when a vendor adds something new to the toolbox.

Prohibitin (PHB) is a critical protein involved in many cellular activities. In brain, PHB resides in mitochondria, where it forms a large protein complex with PHB2 in the inner TFmembrane, which serves as a scaffolding platform for proteins involved in mitochondrial structural and functional integrity. PHB overexpression at moderate levels provides neuroprotection in experimental brain injury models. In addition, PHB expression is involved in ischemic preconditioning, as its expression is enhanced in preconditioning paradigms. However, the mechanisms of PHB functional regulation are still unknown. Observations that nitric oxide (NO) plays a key role in ischemia preconditioning compelled us to postulate that the neuroprotective effect of PHB could be regulated by NO. Here, we test this hypothesis in a neuronal model of ischemia–reperfusion injury and show that NO and PHB are mutually required for neuronal resilience against oxygen and glucose deprivation stress. Further, we demonstrate that NO post-translationally modifies PHB through protein S-nitrosylation and regulates PHB neuroprotective function, in a nitric oxide synthase-dependent manner. These results uncover the mechanisms of a previously unrecognized form of molecular regulation of PHB that underlies its neuroprotective function.

SIGNIFICANCE STATEMENT Prohibitin (PHB) is a critical mitochondrial protein that exerts a potent neuroprotective effect when mildly upregulated in mice. However, how the neuroprotective function of PHB is regulated is still unknown. Here, we demonstrate a novel regulatory mechanism for PHB that involves nitric oxide (NO) and shows that PHB and NO interact directly, resulting in protein S-nitrosylation on residue Cys⁶⁹ of PHB. We further show that nitrosylation of PHB may be essential for its ability to preserve neuronal viability under hypoxic stress. Thus, our study reveals a previously unknown mechanism of functional regulation of PHB that has potential therapeutic implications for neurologic disorders.

In the face of changing weather driven by climate change and the increasing demand for food, Conservation Agriculture (CA) aims to achieve sustainable and profitable agriculture and improve farmers’ livelihoods. Here are five things you need to know. 1. CA observes three main principles that you should remember Direct seeding involves growing crops without mechanical seedbed preparation and with minimal soil disturbance [...]

“Children subjected to child labour need our support and action so they can enjoy their right to education and health and become productive farmers and workers as adults to escape poverty and hunger.” - José Graziano da Silva, FAO Director- General  Child labour is not unique to a particular country, ethnicity, culture, or ideology. Today, there are about 100 million boys [...]

On the frontline of climate change, effects are real and measurable. As climate change evolves, food and agriculture need to follow suit. Rising temperatures, changes in rainfall, erratic weather patterns and the prevalence of pests and diseases resulting from climate change threaten agricultural productivity and therefore undermine global food security. Simultaneously, the world’s population is growing steadily and expected to reach [...]

Some of the most innovative ways being used to improve agricultural practices involve nuclear technology. Nuclear applications in agriculture rely on the use of isotopes and radiation techniques to combat pests and diseases, increase crop production, protect land and water resources, ensure food safety and authenticity, and increase livestock production. FAO and the International Atomic Energy Agency (IAEA) have been expanding [...]

Kalu, in the Amhara region of northern Ethiopia, is home to 28-year-old Yimam Ali. However, many young people from this region of Ethiopia move to the Middle East looking for work and a better life. The amount of job opportunities in the country has not matched its growth. 71 percent of Ethiopia’s population is under the age of 30 and many [...]

27-year-old Amiat Ahmed and her two-year-old son live with Amiat’s parents in the South Wollo Zone of Amhara Region, Ethiopia. Like many other young people in her region, Amiat used to feel that there were limited opportunities to earn income in her village, which led to her decision to migrate to Saudi Arabia.  

Youth around the world are increasingly turning away from agriculture. Traditionally requiring tough manual labour and offering low wages, agriculture does not often appeal to new generations who generally prefer to try their luck finding jobs in cities.  

Museum closures and event cancellations abound as officials rush to contain the new coronavirus' spread

Tour world-class museums, read historic cookbooks, browse interactive maps and more

Universities, libraries and museums are among the organizations seeking personal stories about the pandemic's effects on daily life

In the late 1300s, tea was introduced to Japan from mainland China, transported in delicate jars. Over the years, as drinking tea became a prized activity in Japan, so too did the jars in which it was stored

Overcoming scorching heat and little rain, experimental vineyards teach winemakers to cope with climate change

You can reduce the story of CRM to a lot of things, especially its many component parts. Social networking, cloud computing and analytics are mentioned often. We don't need an exhaustive list, but if we stop there I think we miss a lot. To me CRM isn't about the parts, although like most people following the industry, I get a modicum of joy when a vendor adds something new to the toolbox.

Ralph Goodale says building water diversion conduits in Lake Diefenbaker could help grow Saskatchewan's economy and environment but it comes with a $3 billion price tag.

It turns out a small black box with a dangling red wire and little blue light investigated by Windsor's bomb squad Tuesday isn't actually dangerous — at least to the living.

Last March, analysts and tech bloggers dumped out arrogant contempt over Apple's latest product introduction. This year, those new offerings helped save Apple's Q2 earnings and are projected to bolster its June quarter performance despite the pandemic.

God transforms the hearts of teens from two people groups, who normally do not interact, to bring them together for worship, Bible study and friendship.

CNA Staff, Apr 14, 2020 / 02:00 pm (CNA).- Cardinal George Pell has said culture wars and anti-Catholic sentiment could have played a part in the decision of Victoria police to pursue charges against him, even while they lacked supportive evidence of the allegations in his case.

Cardinal Pell described Victoria police as having “advertised for business” against him in an April 14 interview with Sky News Australia. Pell was asked about the decision by Victoria police to launch an open-ended investigation into him, despite having received no complaints of a crime.

The interview was Pell’s first televised appearance since his release last week after more than 400 days in prison. On the evidence of a single accuser, Pell was convicted in December 2018 of sexually assaulting two choirboys at the Melbourne Cathedral in 1996.

On April 7, the Australian High Court unanimously ruled that the evidence presented during the trial would not have allowed the jury to avoid reasonable doubt and ordered Pell’s acquittal and release.

On the day of his release, Pell told CNA that “The only basis for long term healing is truth and the only basis for justice is truth, because justice means truth for all.”

Pell spoke with Sky News’ Andrew Bolt about the decision by local police to bring 28 allegations of sexual abuse against him, only to see 27 of them dropped before reaching court. The remaining allegation resulted in Pell’s conviction by a Victoria jury and eventual acquittal by the High Court.

Asked directly if he thought police were “out to get” him, Pell said he did not know.

“I don’t know how you explain it, but it is certainly extraordinary,” Pell said.

Asked if he thought there was an anti-Catholic bias at work in the decision of police to charge him and by judges at the Victoria Court of Appeal to sustain his conviction, despite the evidence which eventually led to his exoneration, Pell said it was a possibility.

“I’ve seen too many people [make the leap] from possible to probable to fact. Certainly, people do not like Christians who teach Christianity, especially on life and family and issues like that.”

“The culture wars are real,” Pell said. “There is a systematic attempt to remove the Judeo-Christian legal foundations [on for example] marriage, life, gender, sex.”

“Unfortunately, there’s less rational discussion and more playing the man, more abuse and intimidation, and that’s not good for a democracy.”

During the interview, the cardinal was also asked if he believed that there was any connection between his work to reform the Vatican finances during his time as Prefect for the Economy and the emergence of charges against him in Victoria.

“Most of the senior people in Rome who are in any way sympathetic to financial reform believe that they are [connected]. But I have seen too much from people, as I said, going to possibility to probability to fact – I don’t have any evidence of that.”

“But one of my fears was that what we had done [to reform the Vatican finances] would remain hidden for ten years or so, and they’d would be revealed and the baddies would say ‘Well, Pell and Casey [Pell’s chief advisor] were in charge then, they turned a blind eye and did nothing to it.’”

“Thanks be to God all that’s gone, because there was a flurry of articles just before Christmas exposing all sorts of things like a disastrous purchase – actually a couple of them – in London, and it was very clearly demonstrated that we tenaciously opposed those things.”

“What we were pushing and saying has been massively vindicated,” Pell said. “Now you can see why they sacked the auditor [Libero Milone], why they got rid of the external auditors.”

Asked how high up in the curial hierarchy financial corruption goes, Pell said “Who knows? It’s a little bit like [anti-Catholicism] in Victoria, you’re not quite sure where the vein runs, how thick and broad it is, and how high it goes.”

But the cardinal also made clear that, in financial reforming efforts, Pope Francis had “absolutely” supported him and that “at the feet of the pope we’ve got Cardinal [Pietro] Parolin, he’s certainly not corrupt. Just how high up [the corruption goes] is an interesting hypothesis.”

Pell said that despite the difficulties he faced in prison, where he was held in solitary confinement for much of the time for his own safety, he bore no anger towards his accuser.

“I’ve got no anger, no hostility towards my complainant, I never have,” said Pell.

“I am called to forgive what happened to me that might have been a little unjust, and there is this heroic Christian call to forgiveness in the most appalling circumstances.”

But, Pell said, he had no hesitation in condemning the terrible scandal of sexual abuse in the Church.

“I totally condemn those sorts of activities [of abuse] and the damage that it has done to people – and I have seen the damage that it has done to people.”

“One of the things that grieves me is the suggestion that I’m anti-victim or not sufficiently sympathetic. I devoted a lot of time and energy to trying to get [victims] justice, and to get them help and compensation.”

Pell noted that as archbishop in the 1990s he set up the Melbourne Response to deal with sexual abuse in the Church and bringing about justice and compensation for victims.

“I worked hard,” Pell said, “when it wasn’t easy or fashionable, to get something in place – not run by clerics – that would give some protection and redress to these people, and I have worked consistently at that since at least the middle 90s.”

The cardinal said he had kept the same routine while in prison that, as a bishop, he had often urged on priests who found themselves “in a bit of trouble;” getting up early and at a set time, praying, exercising, and eating well.

“If you can’t pray when you are in trouble, your faith is very weak indeed.”

Asked if he had ever asked God, in the words of Christ on the cross, “why have you forsaken me?” Pell responded “No.”

“But I have said ‘My God, my God, what are you up to?’”

“One of the strangest teachings about Christianity – and the most useful – is that you can offer up your suffering,” Pell said. “Suffering is not just a brute fact. A Christian can offer that up to the Good God.”

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory at the link below.

The rates will be effective after the close of business on April 22, 2020.

For the full text of this advisory, please click here.

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory at the link below.

The rates will be effective after the close of business on 4/23/2020.

For the full text of this advisory, please click here.

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory at the link below.

The rates will be effective after the close of business on 4/24/2020.

Click here for the full text of the advisory

20-175

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory in the link below. Please email any questions to Clearing.RiskManagement@cmegroup.com

The rates will be effective after the close of business on Friday, April 24, 2020.

For the full text of this advisory, please click here.

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory at the link below.

The rates will be effective after the close of business on 4/28/2020.

Click here for the full text of the advisory

20-178

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory at the link below. Please email any questions to Clearing.RiskManagement@cmegroup.com

The rates will be effective after the close of business on Friday, May 1, 2020.

For the full text of this advisory, please click here.

As per the normal review of market volatility to ensure adequate collateral coverage, the Chicago Mercantile Exchange Inc., Clearing House Risk Management staff approved the performance bond requirements for the following products listed in the advisory at the link below. Please email any questions to Clearing.RiskManagement@cmegroup.com

The rates will be effective after the close of business on Friday, May 8, 2020.

For the full text of this advisory, please click here.

A local Chinese mother teaches Cantonese to three Pakistani mothers before they all watch the film 'Magdalena: Released from Shame' together.

OM Hong Kong extends friendship to the city's vibrant Pakistani community.

Behind the glow of city lights, a group of people easily go unnoticed—lost sheep in desperate need of the hope of the gospel.

OM team in Hong Kong breaks cross-cultural ground, learning how to reach out to the ethnic minority, largely ignored by the Chinese population.

Vatican City, May 6, 2020 / 05:30 am (CNA).- The coronavirus crisis can be an opportunity to recenter work on the dignity of each person, Pope Francis said in an appeal at the end of his general audience broadcast on Wednesday. 

“On May 1, I received several messages about the world of work and its problems. I was particularly struck by that of the agricultural workers, among them many migrants, who work in the Italian countryside. Unfortunately, many are very harshly exploited,” Pope Francis said May 6.

“It is true that the current crisis affects everyone, but people's dignity must always be respected. That is why I add my voice to the appeal of these workers and of all exploited workers. May the crisis give us the opportunity to make the dignity of the person and of work the center of our concern,” he said. 

Amid fears of a food shortage, the Italian government is currently discussing whether to legalize some undocumented migrant workers. These workers are particularly vulnerable to exploitation with illegal contracts that can pay less than half of Italy’s minimum wage for the agricultural sector.

May 1 is recognized as Labor Day in Italy and many countries throughout Europe, however it is not an official holiday in the Vatican, which instead celebrates the feast of St. Joseph the Worker, established by Pope Pius XII in 1955.

On the feast day, the pope asked St. Joseph to help Catholics fight for dignified work. He prayed that “no one might be without work and all might be paid a just wage.”

Pope Francis said in his Wednesday audience that prayer is “a cry that comes for the heart of those who believe and entrust themselves to God.” The pope began a new cycle of weekly catechesis on May 6 focused on prayer. 

“Not only do Christians pray, they share the cry of prayer with all men and women. But the horizon can still be widened. Paul says that the whole creation ‘groans and suffers the pains of childbirth,’” he said, quoting St. Paul’s letter to the Romans.

“The Catechism states that ‘humility is the foundation of prayer,’” the pope said. “Prayer … comes from our precarious state, from our continuous thirst for God.”

Pope Francis focused his catechesis on the Gospel account of Bartimaeus, the blind beggar from Jericho.

Bartimaeus “uses the only weapon in his possession: his voice. He starts shouting: ‘Son of David, Jesus, have mercy on me,’” the pope explained.

“And Jesus listens to his cry. Bartimaeus' prayer touches his heart, the heart of God, and the doors of salvation are opened for him,” he said. “He recognizes in that poor, helpless, despised man, all the power of his faith, which attracts the mercy and power of God.”

“Stronger than any argument, there is a voice in the human heart that calls out. We all have this voice inside. A voice that comes out spontaneously, without anyone commanding it, a voice that questions the meaning of our journey down here, especially when we are in the dark: ‘Jesus, have mercy on me! Jesus, have mercy on me!’ This is a beautiful prayer,” Pope Francis said.

Balboa, Panama :: Logos Hope's volunteers make an uplifting visit to a shelter for migrant men, testing their eyesight and handing out reading glasses.

IF there's one thing that online news proves without any shadow of uncertainty, it's that there's no knowing what will capture the popular imagination.

Try to make sense of this if you can. The other day, a fund-raising event for the Democratic presidential candidate Pete Buttigieg, who is gay, was disrupted by protesters. But they weren’t the kind of protesters you’d expect to get angry about a gay candidate. The protesters were gay themselves. It was a protest against a gay man staged by gays. It was gays against gays. It was pink on pink. It was confusing.

A FEW weeks ago, Wendy James was trending on Twitter. It’s been happening quite often over the last few months, a result of BBC Four’s repeats of Top of the Pops reaching 1988 and 1989, the years in which a pink-lipsticked, bra-flaunting James launched herself on the public consciousness as the brash, blonde frontwoman of Transvision Vamp.

The evidence that culturally responsive teaching can fix the nation's schools for children of color is promising, but woefully incomplete, writes Heather C. Hill.

IT’S all too easy to lose track of many of the quirky, moving, interesting films that have been shot in Scotland over the years. Some of the sparkling gems on these pages attracted decent reviews upon release before fading from view; others slipped under most people’s radar. The 10 films here are funny, or dark, or insightful. All have something to say; all are worth tracking down, and watching, whether it’s for the first time, or the first time since they were released.

The California district rolled out a culturally-specific program to support black male students, and the program has led to positive outcomes for students who had an opportunity to participate.

The California district rolled out a culturally-specific program to support black male students, and the program has led to positive outcomes for students who had an opportunity to participate.

Marlo Warburton, a 7th and 8th grade math teacher at Longfellow Arts and Technology Middle School in Berkeley, Calif., shares how greeting her students in the morning and expressing appreciation during dismissal are valuable opportunities for character building and for fostering teacher-student rela

Children with special health care needs present clinically with varied functional difficulties across an array of health conditions. Little attention has been given to the interaction of these descriptors at a population level, thereby not addressing the complexity of functional difficulties and their impact on the health of CSHCN.

The data demonstrate the relationships among functional difficulties and health conditions, which then improve our understanding of CSHCN and their needs. Functional difficulties contribute significantly to outcomes, such as emergency room visits, parental work patterns, and limitations in daily activities, and have implications for practice, training, policy, and research. (Read the full article)

Several studies have analyzed fatal or nonfatal youth injury incidence in US agricultural settings, but none have combined those estimates to form an overall picture. The only detailed study of costs related to such injuries is restricted to nonfatal injury.

This study provides a comprehensive analysis of the annual incidence and cost of agricultural youth injuries in the United States. It analyzes them from different perspectives: fatal versus nonfatal, at work versus not at work, and requiring hospitalization versus not requiring hospitalization. (Read the full article)

Cross-sectional studies have shown an increased risk of mental health difficulties in children with developmental coordination disorder. However, there has been limited longitudinal research in this area controlling for confounding factors and assessing the role of potential mediators.

Children with "probable" developmental coordination disorder at 7 years had a significantly increased risk mental health difficulties at 10 years. Protective factors for self-reported depression included high IQ, high self-esteem, good social communication skills, and the absence of bullying. (Read the full article)

Disparities in outcomes of ethnic minority children have been reported, and have been ascribed to having barriers to access to health care. Minority parents have indicated that difficulties in access are because of problems with transportation and being non-English speaking.

This population-based study of Texas infants with severe congenital heart disease reports that neither home distance from a cardiac center nor Hispanic children having a Latin American–born parent were risk factors for first-year mortality. (Read the full article)

Childhood obesity is already prevalent by preschool age, particularly among Latinos. Parents have tremendous influence on factors that contribute to childhood obesity (eg, diet, physical activity); thus, family plays a crucial role in pediatric obesity prevention.

This randomized controlled trial examined the effect of a behavioral intervention involving Latino-American parent–preschool-aged child dyads. The intervention resulted in reductions in absolute BMI across the 3-month study period, with patterns suggesting the largest effect for obese children. (Read the full article)