rc The big (research) book of British teeth By feeds.bmj.com Published On :: Tue, 15 Dec 2015 20:59:35 +0000 Despite what hollywood says, science has proven that British teeth are actually better than American. Richard Watt, head of the Research Department of Epidemiology and Public Health at UCL explains how they came to that conclusion. Read the full research: http://www.bmj.com/cgi/doi/10.1136/bmj.h6543 Full Article
rc Exercise induced bronchoconstriction By feeds.bmj.com Published On :: Sat, 09 Jan 2016 16:17:18 +0000 James Smoliga, from High Point University, North Carolina, and Ken Rundell, from The Commonwealth Medical College, Pennsylvania, join us to discuss how to test for, and manage, exercise induced bronchoconstriction, and particularly how to distinguish it from other respiratory conditions. Read the full review at... Full Article
rc "It's the workforce, stupid" - is the NHS workforce in crisis? By feeds.bmj.com Published On :: Wed, 09 Mar 2016 10:36:21 +0000 As the junior doctors in England strike, concerns for the workforce are foremost in the minds of those running the NHS. A summary is available here: http://www.bmj.com/content/352/bmj.i1510 In The BMJ roundtable, recorded at the Nuffield Trust Health Policy Summit on Friday 4 March 2016, we asked our participants if they think the NHS is in... Full Article
rc “I had two herniated discs in my back, and I was still running” - addicted to exercise By feeds.bmj.com Published On :: Thu, 27 Apr 2017 10:05:01 +0000 It’s been called “the universal panacea” - exercise has a positive effect on almost all health measures, and governments are actively campaigning for us to do more. But at the opposite end of the scale, the realisation that some people may be addicted to exercise is gaining traction. In this podcast we're joined by Heather Hausenblas - professor... Full Article
rc Future Earth - linking health and environmental research By feeds.bmj.com Published On :: Fri, 02 Jun 2017 15:02:50 +0000 The rapid changes in the global environment have led many scientists to conclude that we are living in a new geological epoch—the Anthropocene—in which human activities have become the dominant driving force transforming the Earth’s natural systems. A recent joint publication by the World Health Organization and Convention on Biological Diversity... Full Article
rc Exercise in old age - "we need kendo classes in Huddersfield" By feeds.bmj.com Published On :: Wed, 18 Oct 2017 16:24:10 +0000 There's a crisis in old age care - not just in the UK, around the world, as population demographics shift, and the proportion of older people increase - there's a worry about who's going to look after them, and how much is it going to cost? However, a new analysis on bmj.com says this picture need not be so gloomy - they say that encouraging... Full Article
rc What forced migration can tell us about diabetes By feeds.bmj.com Published On :: Tue, 08 May 2018 17:04:46 +0000 Worldwide, the rate of type II diabetes is estimated to be around 1 in 11 people - about 9%. For the Pima people of Arizona, 38% of the adult population have the condition - but across the border in Mexico, the rate drops down to 7%. The difference between the groups is their life experience - one side displaced, the other on their traditional... Full Article
rc Patient's rights in research - moving beyond participation By feeds.bmj.com Published On :: Thu, 25 Jul 2019 14:54:57 +0000 At EBM live recently, we ran a workshop with researchers, patients and clinicians to talk about patient rights in research - should patients be setting the full research agenda? Should they be full participants and authors? Helen Macdonald, BMJ’s UK research editor and co-host of our talk evidence podcast sat down to Paul Wicks, researcher and... Full Article
rc Talking up your research - Sex makes a difference By feeds.bmj.com Published On :: Fri, 20 Dec 2019 15:50:09 +0000 As editors, we feel like we’re spending a lot of time taking the superlatives out from articles - amazing, novel, important… But new research on BMJ.com suggests that we might not be doing that great a job, and that for some reason, papers authored by men tend to have more of them - because men put more in, or maybe a bias against woman writing in... Full Article
rc Big Tan - Is the sunbed industry targeting research? By feeds.bmj.com Published On :: Mon, 10 Feb 2020 17:42:30 +0000 In 2012, Eleni Linos, professor of dermatology at Stanford university, published a systematic review and meta-analysis of the link between non-melanoma cancer and sun-beds. That bit of pretty standard research, and a particular rapid response to it, has kicked of years of work - and in this podcast I talk to Eleni and her colleagues Stanton... Full Article
rc Talk Evidence - covid ethics, waste and a minimum RCT size By feeds.bmj.com Published On :: Fri, 24 Apr 2020 16:19:18 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
rc Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:26-08:00 This study aims to model genetic, immunologic, metabolomics, and proteomic biomarkers for development of islet autoimmunity (IA) and progression to type 1 diabetes in a prospective high-risk cohort. We studied 67 children: 42 who developed IA (20 of 42 progressed to diabetes) and 25 control subjects matched for sex and age. Biomarkers were assessed at four time points: earliest available sample, just prior to IA, just after IA, and just prior to diabetes onset. Predictors of IA and progression to diabetes were identified across disparate sources using an integrative machine learning algorithm and optimization-based feature selection. Our integrative approach was predictive of IA (area under the receiver operating characteristic curve [AUC] 0.91) and progression to diabetes (AUC 0.92) based on standard cross-validation (CV). Among the strongest predictors of IA were change in serum ascorbate, 3-methyl-oxobutyrate, and the PTPN22 (rs2476601) polymorphism. Serum glucose, ADP fibrinogen, and mannose were among the strongest predictors of progression to diabetes. This proof-of-principle analysis is the first study to integrate large, diverse biomarker data sets into a limited number of features, highlighting differences in pathways leading to IA from those predicting progression to diabetes. Integrated models, if validated in independent populations, could provide novel clues concerning the pathways leading to IA and type 1 diabetes. Full Article
rc Diabetes: precision approach will improve outcomes, says research director By feeds.bmj.com Published On :: Friday, January 11, 2019 - 13:51 Full Article
rc Pandemic demands proper nutrition, exercise By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:10:57 -0500 THE EDITOR, Madam: On Wednesday at 8:30 a.m., while watching TVJ, I saw Get Moving home workout series. Very good, TVJ and the Ministry of Health, for bringing this workout programme into our homes. Minister Tufton was a participant; he truly... Full Article
rc A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:28-07:00 A single bout of exercise enhances insulin action in the exercised muscle. However, not all human studies find that this translates into increased whole-body insulin action, suggesting that insulin action in rested muscle or other organs may be decreased by exercise. To investigate this, eight healthy men underwent a euglycemic-hyperinsulinemic clamp on 2 separate days: one day with prior one-legged knee-extensor exercise to local exhaustion (~2.5 h) and another day without exercise. Whole-body glucose disposal was ~18% lower on the exercise day as compared with the resting day due to decreased (~37%) insulin-stimulated glucose uptake in the nonexercised muscle. Insulin signaling at the level of Akt2 was impaired in the nonexercised muscle on the exercise day, suggesting that decreased insulin action in nonexercised muscle may reduce GLUT4 translocation in response to insulin. Thus, the effect of a single bout of exercise on whole-body insulin action depends on the balance between local effects increasing and systemic effects decreasing insulin action. Physiologically, this mechanism may serve to direct glucose into the muscles in need of glycogen replenishment. For insulin-treated patients, this complex relationship may explain the difficulties in predicting the adequate insulin dose for maintaining glucose homeostasis following physical activity. Full Article
rc Addressing Resource Conflicts: Working Towards More Effective Resolution of Natural Resource Disputes By feedproxy.google.com Published On :: Tue, 16 Sep 2014 17:15:01 +0000 Invitation Only Research Event 26 June 2014 - 9:00am to 5:00pm Chatham House, London Disputes over resources are a persistent challenge to international peace and security. Natural resources (such as oil, natural gas, minerals, timber and water) are a major source of national income for many countries and, alongside land, are essential to the livelihoods of many millions of people. There is a growing recognition among researchers and decision-makers that in many fragile states disputes over these resources have fed into, and underpinned, violent conflict and instability. Although international engagement in national resource disputes is not always desirable or feasible, where it is necessary and possible to support, supplement (or even substitute) national dispute resolution processes it is important to think through the parameters of such action: Who gets involved? With what financial resources? When does an intervention begin? How do they act? This one-day roundtable will bring together around 30 experts from policy, academia and business to discuss these questions and more.The event will be held under the Chatham House Rule. Attendance is by invitation only. Event attributes Chatham House Rule Department/project Energy, Environment and Resources Programme, Resources Climate Conflict and Peacebuilding Owen Grafham Manager, Energy, Environment and Resources Programme +44 (0)20 7957 5708 Email Full Article
rc Resource Development in Fragile and Conflict-Affected States: Can it Promote Peace? By feedproxy.google.com Published On :: Wed, 10 Dec 2014 14:15:02 +0000 Research Event 30 September 2014 - 1:30pm to 4:45pm Chatham House, London The discovery of valuable natural resources such as hydrocarbons or minerals in conflict-affected states or disputed regions can be a double-edged sword. While economic growth may help overcome conflict and consolidate peace, much of the academic literature links the economic, social and environmental impacts of resource development with an increased risk of violent conflict between or within fragile states. Recently however, the role of business in advancing peace has emerged as a topic of increasing discussion in academia and in forums such as the UN Global Compact. Resource development has also become a key objective for donor development strategies in fragile states such as Afghanistan, Somalia and Myanmar, on the assumption that extractive sector development can contribute to stability and security. This event will gather key stakeholders from business and policy to investigate if and where natural resource development has contributed to peace-building, built cooperation among stakeholders or helped to resolve, rather than exacerbate, tensions. If so, it will endeavour to draw out common, replicable lessons of what made these developments successful from a peace-building perspective.The event will be held under the Chatham House Rule. Event attributes Chatham House Rule Department/project Energy, Environment and Resources Programme, Resources Climate Conflict and Peacebuilding Full Article
rc Valuing Vital Resources in India: Potential for Integrated Approaches to Water, Energy and Agricultural Sustainability By feedproxy.google.com Published On :: Tue, 06 Jan 2015 11:15:01 +0000 Invitation Only Research Event 16 January 2015 - 9:00am to 2:00pm The India Habitat Centre, New Delhi, India Event participants Dr Ashwini Swain, Fellow, CUTS Institute for Regulation and CompetitionGlada Lahn, Senior Research Fellow, Energy, Environment and Resources, Chatham HouseDr Gareth Price, Senior Research Fellow, Asia Programme, Chatham House As part of the international dialogue on Valuing Vital Resources, this seminar will convene policy-makers, scholars, technical practitioners, NGOs, multilateral agencies and the media to discuss recommendations for new policy approaches in India to reorient energy and water use in agriculture. The aim is to gain input to practical policy proposals and identify the work now needed to make them robust. Attendance is by invitation only. Please note this event is held in New Delhi, all times are local. This event is organized together with the CUTS Institute for Regulation & Competition (CIRC). Event attributes External event Department/project Energy, Environment and Resources Programme, Valuing Vital Resources Glada Lahn Senior Research Fellow, Energy, Environment and Resources Programme, Chatham House Email Full Article
rc The Role of Resource Politics in China-US Relations By feedproxy.google.com Published On :: Wed, 07 Jan 2015 16:30:02 +0000 Research Event 16 January 2015 - 12:00pm to 1:00pm Chatham House, London Event participants Dr David Zweig, Chair Professor, Division of Social Science, Hong Kong University of Science and TechnologyChair: Dr Michal Meidan, Associate Fellow, Asia Programme, Chatham House China’s resource diplomacy transpires in a world still dominated by the United States. Drawing on extensive research on global energy politics, the speaker will argue that despite Chinese claims that the US is instrumentalizing energy to contain its rise, there is little evidence to suggest that the latter intends to use the ‘oil weapon’. Department/project Asia-Pacific Programme Joshua Webb +44 (0)20 7314 3678 Email Full Article
rc Governance in the DRC: Securing Resources for Development By feedproxy.google.com Published On :: Fri, 16 Jan 2015 14:30:02 +0000 Invitation Only Research Event 21 January 2015 - 10:30am to 11:30am Chatham House, London Event participants Moïse Katumbi Chapwe, Governor, Katanga Province, Democratic Republic of the Congo Katanga Province in the Democratic Republic of Congo (DRC) is immensely wealthy in minerals such as copper, uranium and gold, and is home to around fifty per cent of the world’s cobalt reserves. Rising outputs from the province’s copper and cobalt mines have contributed to the DRC’s average GDP growth of 8.5 per cent over the past two years. However, despite visible infrastructure developments in the province to service the industry, few Congolese are benefiting from the revenues and the economy is yet to diversify.Moïse Katumbi Chapwe, the governor of Katanga Province, will discuss his approach to resource governance and will examine how regional governments can capitalise on resource revenues to improve livelihoods. Attendance at this event is by invitation only. Department/project Africa Programme, Central and East Africa Full Article
rc The Resource Curse Revisited By feedproxy.google.com Published On :: Mon, 03 Aug 2015 14:18:29 +0000 4 August 2015 A new paper finds that while natural resources may provide low-income countries with a significant development opportunity, the prevailing extractives-led growth agenda is in urgent need of re-evaluation. Full Report Appendix Professor Paul Stevens Distinguished Fellow, Energy, Environment and Resources Programme Glada Lahn Senior Research Fellow, Energy, Environment and Resources Programme @Glada_Lahn Jaakko Kooroshy, Former Research Fellow, Energy, Environment and Resources Department, Chatham House (2011–14) 20150804ResourceCurse2.jpg Hoping to make a little money from Sudan's ocean of black gold, a woman sells tea to roughnecks at an oil rig near Bentiu, Sudan. Photo by Getty Images. SummaryThis paper challenges the view that the ‘resource curse’ – for which so many academics found evidence in previous decades – has now been laid to rest.During the commodities boom of the past decade, a number of influential policy and corporate institutions have encouraged poor countries to capitalize on below-ground resources for economic growth and development. The key assumption is that improved management of the extractives sector will enable it to spearhead positive national development and avoid resource curse effects such as declining global competitiveness in the rest of the economy and a widening wealth gap. This assumption continues to influence governance advice and country investment choices.The extractives-led growth agenda promoted by donors and international advisers in multilateral banks, consultancies and some development agencies has tended to reinforce domestic, government and investor pressures to pursue a ‘fast-track’ approach to extractives projects. This appears logical, given the obvious benefits of foreign-investment inflows and export revenues for countries suffering from poverty, lack of infrastructure and high levels of indebtedness.However, there is an urgent need to re-evaluate whether the policy advice stemming from this agenda can serve as an antidote to the negative effects identified in the resource-curse literature. First, there is often a mismatch between governance advice given and the capacity of countries to follow it. Second, the global context has changed: exporters are suffering as a result of the current downturn in commodity prices, while reliance on the sale of high-carbon fuels is challenged by the global shift to lower-carbon technologies and energy efficiency.Extractive revenues should not be viewed as income to be consumed, but as representing a reshuffling of the national portfolio of assets. Converting extractive resources below ground into cash above ground raises key questions about how this cash can be deployed to create productive assets for the future which do not rely on depletable resources.Diversification of the economy away from the resource sector over an appropriate timeframe remains a key priority. In many cases, this will require slower development of projects to allow time for institutional capacity in government and the private sector to develop.More economic and governance capacity needs to be in place before investment begins in a project, to enable investment and eventual revenues to generate real benefits to the rest of the economy, as well as appropriate, sustainable diversification. Department/project Energy, Environment and Resources Programme, Conflict or co-existence in extractive industries Full Article
rc Navigating the New Normal: China and Global Resource Governance By feedproxy.google.com Published On :: Mon, 25 Jan 2016 16:29:44 +0000 28 January 2016 How China responds to the challenges of resource security and sustainability, working with others, will help define its reputation as a responsible actor on the world stage in the next decade, according to a new paper. Felix Preston Former Senior Research Fellow and Deputy Research Director, Energy, Environment and Resources Rob Bailey Former Research Director, Energy, Environment and Resources @ClimateRob Siân Bradley Research Fellow, Energy, Environment and Resources Programme @ChathamSian Dr Wei Jigang, Senior Research Fellow, Department of Industrial Economy, Development Research Center of the State Council (DRC)Dr Zhao Changwen, Director, Department of Industrial Economy, Development Research Center of the State Council (DRC) 2016-01-27-china-resource-governance-2.jpg Qingdao, China. Photo: Getty Images. It is time to upgrade global resource governanceMeaningful progress cannot be achieved without ChinaChina will need to be both innovative and pragmatic in its approachNew modes of cooperation are neededChanges in China’s economy present opportunities and risks Executive summaryChina’s new role in the global governance of natural resources is coming to the fore against a backdrop of profound uncertainty, driven by the convergence of three interlinked trends. At home, China’s leaders are navigating the structural shift to slower but higher-quality growth, a phase of development referred to as the ‘new normal’, while facing considerable environmental and resource security challenges. Globally, the slowdown in China’s economy has sent reverberations through commodity markets, pulling the plug on the decade-long commodities ‘super cycle’. Meanwhile, China is taking on a growing role in global governance, from the G20 and multilateral development banks, to its regional partnerships in Latin America and Africa.During the resources boom of the last decade, policy-makers and businesses in consumer countries were focused on high and volatile resource prices. The risks posed by resource nationalism in producer countries were seen in the proliferation of export restrictions and the increase in investment disputes. Today, the tables have turned, leaving producer countries facing economic pressure from falling revenues and investments. Many organizations have called on governments to phase out subsidies for fossil fuels and other natural resources while prices are low. The international policy debate is shifting to the immediate challenges presented by a massive oversupply of many energy and mineral commodities, and the longer-term risk of ‘stranded assets’.These new resource realities will provide the context for China’s growing global role, as well as setting the tenor of its relations with producer countries. Over the past decade, narratives around China often focused on its real or perceived impacts from resource production overseas and consumption at home. In the next, China’s approach to resource security and sustainability will help define its reputation, and whether it is perceived as a responsible actor on the world stage and as a development partner. The collection of international narratives, norms, rules and organizations that currently guides resource production, trade and consumption – what we call ‘global resource governance' in this report – will provide the framework.Much political leadership will be required to overcome the barriers to China assuming a more active role in global resource governance. On the one hand, there has been slow progress in expanding China’s role in organizations from the World Bank to the International Energy Agency (IEA). On the other, new instruments or processes initiated by China can be seen as a challenge to the existing rules-based order, as the US reaction to the establishment of the Asian Infrastructure Investment Bank (AIIB) demonstrated. Yet developments such as the US–China Joint Presidential Statement on Climate Change in September 2015, ahead of the Paris Climate Conference, show that it is possible to forge cooperation and boost the prospects for progress on public goods at the multilateral level, even in politically fraught areas.China’s international role on natural resources is also closely tied to ongoing reforms at home. The introduction of ‘ecological civilization’ as a guiding principle for China’s development at the Communist Party’s 17th Congress in 2007 marked a recognition of the need not only to address China’s domestic challenges such as air quality and water scarcity but also shift to an environmentally sustainable model of economic development. In 2015 China’s leaders set out the key incentives, accountability and mechanisms to deliver the ecological civilization in China’s 13th Five-Year Plan. Central elements of this vision, such as building sustainable cities, pursuing environmentally-friendly economic growth and developing the circular economy will have major impacts on China’s future resource consumption and import needs.Globally, the speed and scale of the economic realignments have taken most experts and policy-makers by surprise – in many respects, China’s new normal is the world’s new normal. The greatest challenge that China’s government faces is managing a shift to slower but higher-quality growth. It is clear that the ramifications of this reach far beyond the confines of the Chinese economy or global commodity markets; yet the situation remains fluid and the nature of a new equilibrium is difficult to predict. This only makes it more urgent to consider the strategic and practical options available to policy-makers, both in China and around the world.This report is the result of two years of joint research between Chatham House and the Development Research Center of the State Council (DRC), including six expert workshops in China and conversations with international organizations. It discusses key policy areas in global resource governance as they relate to China – in light of recent falls in commodity prices, China’s shifting economic situation, and its growing global role in the ‘new normal’. The scope of the research is limited to non-renewable energy, metals and mineral resources; throughout this report, the term ‘resources’ refers to these commodities. Other traded commodities such as agricultural goods are not included, and land, water and air are discussed only in the context of their important linkages with energy and metals. The report considers the costs and benefits of a more active role for China in global resources governance. It recognizes that different commodities face different challenges and require different governance frameworks, and that different regions require context-specific responses. The report also considers the risks of more limited engagement of China and other new actors, which could mean declining relevance for existing processes and institutions that govern resource production, trade and consumption, and a diminished capacity to tackle longer-term challenges like climate change. Related documents Joint Report: Navigating the New Normal: China and Global Resource Governancepdf | 4.24 MB 引领新常态 中国与全球资源治理pdf | 4.69 MB Chart: China's imports of natural resourcespdf | 118.83 KB Map: China’s resource interdependenciespdf | 906.25 KB Map: The Belt and Roadpdf | 525.6 KB Department/project Energy, Environment and Resources Programme, Resource Trade Full Article
rc Resources, Sovereignty and Geopolitics By feedproxy.google.com Published On :: Mon, 23 May 2016 07:30:01 +0000 Invitation Only Research Event 26 May 2016 - 2:00pm to 27 May 2016 - 4:30pm Harbour Grand Kowloon Hotel, Hong Kong This workshop will bring together experts from across Asia to discuss the challenges around natural resources that cause them to become drivers of conflict in the region, particularly in the context of territorial disputes, geopolitical competition and concerns over national sovereignty.Attendance at this event is by invitation only. Event attributes External event Department/project Asia-Pacific Programme, Energy, Environment and Resources Programme Full Article
rc A Wider Circle? The Circular Economy in Developing Countries By feedproxy.google.com Published On :: Fri, 01 Dec 2017 15:13:36 +0000 5 December 2017 Lower-income countries are in many ways more ‘circular’ than their developed-economy counterparts – the question is how to turn this into a development opportunity. Read online Download PDF Felix Preston Former Senior Research Fellow and Deputy Research Director, Energy, Environment and Resources Johanna Lehne Former Research Associate, Energy, Environment and Resources 2017-12-05-circular-economy.jpg A stack of recycled paper ready to be bound into books at a workshop in Kolkata, India. Photo: Felix Preston. SummaryThere is growing optimism about the potential of the ‘circular economy’ (CE) as a new model for sustainable growth in developing countries. A CE is one in which products are recycled, repaired or reused rather than thrown away, and in which waste from one process becomes an input into other processes. In recent months there has been CE-related activity in countries as diverse as Laos, Rwanda and Colombia.A CE strategy could help lower-income countries ‘leapfrog’ to a more sustainable development pathway that avoids locking in resource-intensive practices and infrastructure. But a stronger evidence base is needed to show how the agenda can deliver opportunities for industrialization, as well as addressing environmental insecurity.Lower-income countries are in many ways more ‘circular’ than their developed-economy counterparts – the question is how to turn this into a development opportunity. Much economic activity in lower-income countries revolves around sorting and reusing waste. However, higher-value, employment-generating opportunities for reuse and remanufacturing are yet to be captured.The existence of circular activities in developing countries provides excellent political ‘entry points’, which could enable governments, the private sector, civil society and other actors to promote innovative economic models. The CE could provide a powerful narrative, helping to build momentum around a set of ideas that can be applied in and tailored to multiple sectors or cities.There is a window of opportunity in which to align the efforts of development organizations and partner countries. Donors are exploring how the agenda should be aligned with the Sustainable Development Goals (SDGs) and the Paris Climate Agreement. Wider international cooperation on the CE could involve trade partnerships, regional hubs or pilot zones. Department/project Energy, Environment and Resources Programme Full Article
rc Cholecystokinin 2 Receptor Agonist 177Lu-PP-F11N for Radionuclide Therapy of Medullary Thyroid Carcinoma: Results of the Lumed Phase 0a Study By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Treatment of patients with advanced medullary thyroid carcinoma (MTC) is still a challenge. For more than 2 decades, it has been known that the cholecystokinin 2 receptor is a promising target for the treatment of MTC with radiolabeled minigastrin analogs. Unfortunately, kidney toxicity has precluded their therapeutic application so far. In 6 consecutive patients, we evaluated with advanced 3-dimensional dosimetry whether improved minigastrin analog 177Lu-DOTA-(d-Glu)6-Ala-Tyr-Gly-Trp-Nle-Asp-PheNH2 (177Lu-PP-F11N) is a suitable agent for the treatment of MTC. Methods: Patients received 2 injections of about 1 GBq (~80 μg) of 177Lu-PP-F11N with and without a solution of succinylated gelatin (SG, a plasma expander used for nephroprotection) in a random crossover sequence to evaluate biodistribution, pharmacokinetics, and tumor and organ dosimetry. An electrocardiogram was obtained and blood count and blood chemistry were measured up to 12 wk after the administration of 177Lu-PP-F11N to assess safety. Results: In all patients, 177Lu-PP-F11N accumulation was visible in tumor tissue, stomach, and kidneys. Altogether, 13 tumors were eligible for dosimetry. The median absorbed doses for tumors, stomach, kidneys, and bone marrow were 0.88 (interquartile range [IQR]: 0.85–1.04), 0.42 (IQR: 0.25–1.01), 0.11 (IQR: 0.07–0.13), and 0.028 (IQR: 0.026–0.034) Gy/GBq, respectively. These doses resulted in median tumor-to-kidney dose ratios of 11.6 (IQR: 8.11–14.4) without SG and 13.0 (IQR: 10.2–18.6) with SG; these values were not significantly different (P = 1.0). The median tumor-to-stomach dose ratio was 3.34 (IQR: 1.14–4.70). Adverse reactions (mainly hypotension, flushing, and hypokalemia) were self-limiting and not higher than grade 1. Conclusion: 177Lu-PP-F11N accumulates specifically in MTC at a dose that is sufficient for a therapeutic approach. With a low kidney and bone marrow radiation dose, 177Lu-PP-F11N shows a promising biodistribution. The dose-limiting organ is most likely the stomach. Further clinical studies are necessary to evaluate the maximum tolerated dose and the efficacy of 177Lu-PP-F11N. Full Article
rc SNMMI at NRC Commissioners Meeting By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Full Article
rc Fibrotic Encapsulation Is the Dominant Source of Continuous Glucose Monitor Delays By diabetes.diabetesjournals.org Published On :: 2019-09-20T12:00:23-07:00 Continuous glucose monitor (CGM) readings are delayed relative to blood glucose, and this delay is usually attributed to the latency of interstitial glucose levels. However, CGM-independent data suggest rapid equilibration of interstitial glucose. This study sought to determine the loci of CGM delays. Electrical current was measured directly from CGM electrodes to define sensor kinetics in the absence of smoothing algorithms. CGMs were implanted in mice, and sensor versus blood glucose responses were measured after an intravenous glucose challenge. Dispersion of a fluorescent glucose analog (2-NBDG) into the CGM microenvironment was observed in vivo using intravital microscopy. Tissue deposited on the sensor and nonimplanted subcutaneous adipose tissue was then collected for histological analysis. The time to half-maximum CGM response in vitro was 35 ± 2 s. In vivo, CGMs took 24 ± 7 min to reach maximum current versus 2 ± 1 min to maximum blood glucose (P = 0.0017). 2-NBDG took 21 ± 7 min to reach maximum fluorescence at the sensor versus 6 ± 6 min in adipose tissue (P = 0.0011). Collagen content was closely correlated with 2-NBDG latency (R = 0.96, P = 0.0004). Diffusion of glucose into the tissue deposited on a CGM is substantially delayed relative to interstitial fluid. A CGM that resists fibrous encapsulation would better approximate real-time deviations in blood glucose. Full Article
rc Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study By feeds.bmj.com Published On :: Tuesday, April 21, 2020 - 14:45 Full Article
rc Prognosis of unrecognised myocardial infarction determined by electrocardiography or cardiac magnetic resonance imaging: systematic review and meta-analysis By feeds.bmj.com Published On :: Thursday, May 7, 2020 - 11:41 Full Article
rc Just Circular Economy Transitions in Latin America By feedproxy.google.com Published On :: Tue, 10 Dec 2019 14:40:01 +0000 Invitation Only Research Event 11 December 2019 - 9:00am to 12 December 2019 - 5:00pm Montevideo, Uruguay To identify and promote collaborative opportunities for an inclusive and sustainable circular economy transition at the international level, a clearer understanding and discussions of the potential winners and losers of such a transition is needed. In short, a ‘win-win-win’ vision for the environment, people and the economy, needs to be built and credible pathways to achieving this vision.This research workshop, organized by Chatham House and UNIDO, will build on previous and ongoing research by Chatham House, and others, to drive forward an inclusive circular economy agenda and promote a just transition from linear to circular economic models. Chatham House, in collaboration with partners, aims to provide a strong evidence base of the opportunities and trade-offs in this transition from linear to circular models by robustly analysing the political economies in key regions in the developing world and engaging with leading stakeholders from governments, international organizations, civil society and the business community.Latin America is an important geographical region for the circular economy especially in view of the circular bioeconomy and the agenda around inclusiveness. Several countries are beginning to embrace the circular economy concept and related policies. This workshop will bring together circular economy leaders from policy, business and civil society across Latin American countries to identify and discuss challenges, large-scale positive sum opportunities, investment needs, existing alliances and the potential to scale up circular economy practices. The second day of the workshop includes site visits to various circular economy projects in Uruguay.Attendance at this event is by invitation only. Department/project Energy, Environment and Resources Programme, Building Transformative Alliances for an Inclusive Global Circular Economy Melissa MacEwen Project Manager, Energy, Environment and Resources Programme Email Full Article
rc Virtual Event: Chatham House Circular Economy Conference By feedproxy.google.com Published On :: Fri, 13 Dec 2019 08:25:01 +0000 Research Event 1 April 2020 - 10:00am to 2 April 2020 - 2:30pm Agendapdf | 137.89 KB The circular economy, that minimizes waste and keeps materials and products in circulation for as long as possible, is increasingly regarded as a promising model for driving sustainable and resilient economic growth in both developed and emerging economies. To successfully scale circular practices and ensure the transition from a linear to a circular model leaves no one behind, an inclusive and collaborative approach is required.The current global health crisis has significantly disrupted the global economy and our societies. We are experiencing a radical transformation in the way society, government and businesses operate. The ways we work, socialize, produce and consume have changed dramatically. Does the current situation offer a window of opportunity to accelerate the transition to a circular economy? Or will it pose further challenges to change the current linear system of ‘take-make-throw away’ to a circular system? The current situation also highlights the need to ensure the vulnerable are protected and no-one is left behind – in line with the principles of the Sustainable Development Goals (SDGs). The SDGs also remind us that, despite the urgency of the current pandemic, the world needs to keep in mind the long-term nature of the circular economy transition and global sustainability objectives including the global climate targets and meeting the needs of future generations. Until recently, the discussions around the circular economy have predominantly focused on industrialized economies of Europe and China. However, a great deal of circular economy activity is already taking place in emerging economies, as the recent Chatham House report An Inclusive Circular Economy: Priorities for Developing Countries, discusses. Many countries across sub-Saharan Africa, South Asia, Southeast Asia and Latin America are adopting national policies and launching initiatives to promote the circular economy. To promote collaborative opportunities for an inclusive and sustainable circular economy transition at the international level, a clearer understanding of the opportunities, trade-offs and winners and losers of such a transition is needed. Supporting transformative alliances and finding solutions to overcome challenges especially in poorer countries, disadvantaged industry sectors and consumers is equally critical. In short, a ‘win-win-win’ vision for the environment, people and the economy, needs to be built together with credible pathways to achieving this vision. This virtual conference brings together circular economy leaders from policy, business, academia and civil society across the emerging economies and the developed world to identify best practices, initiatives and existing alliances that can help to build the pathways for achieving this vision. It builds on previous and ongoing research by Chatham House, and others, to drive forward an inclusive circular economy agenda and promote a just transition from linear to circular economic models. The first day of the virtual conference consists of keynote speeches and panel discussions focusing on the cross-cutting themes of just transition and inclusive circular economy as well as interconnections with other global key agendas and themes: Inclusive policy approaches for solving the global waste crisis.Financing the circular economy and closing the investment gap.Trade in the circular economy: closed local economies or global collaborating systems?During the second day of the conference, more specific circular economy themes are discussed in virtual panels including the following topics:Beyond plastic recycling: innovations for sustainable packaging.Advancing multilateral action on marine plastic pollution.Industry 4.0 and circular economy: identifying opportunities for developing countries.The Chatham House Circular Economy conference forms part of the programme of events to celebrate the Chatham House Centenary highlighting the main goals for the institute’s second century. Department/project Energy, Environment and Resources Programme, Building Transformative Alliances for an Inclusive Global Circular Economy Melissa MacEwen Project Manager, Energy, Environment and Resources Programme Email Full Article
rc Circular Economy Finance Roundtable By feedproxy.google.com Published On :: Thu, 19 Dec 2019 11:00:01 +0000 Invitation Only Research Event 4 March 2020 - 1:00pm to 5:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Agendapdf | 124.9 KB The circular economy minimises waste and keeps materials and products in circulation for as long as possible. It is increasingly regarded as a promising model for achieving the Sustainable Development Goals (SDGs) and the global climate goals of the Paris Agreement, as well as driving sustainable and resilient economic growth in both developed and emerging economies.The financial industry has a key role to play in scaling up circular practices and ensure the transition from a linear to a circular model. Interest and action from policymakers, the financial industry, and other stakeholders towards financing the circular economy is already emerging in the form of thematic circular economy funds and innovative financial vehicles, as well as new investment criteria, guidance and standards.However, as more activities around circular economy financing are emerging, questions that arise concern issues of common definitions and standards, consistency with green climate finance and development finance as well as distributive justice and good governance.Specific questions to be discussed during this event include:What is the current circular economy finance landscape in terms of initiatives, definitions, criteria and guidance?What are the roles of public and private funding and blended finance in financing the circular economy?What lessons can be learned from green climate finance initiatives and ESG related factors and risks? What types of financial products for small and medium sized enterprises (SMEs) in developing countries are required?How can the finance industry support inclusive and just transitions to the circular economy?This roundtable will bring together experts representing public and private finance and investment to discuss these questions and share best practise to forge pathways for joined up approach on circular economy finance.The roundtable will build on previous and ongoing research by Chatham House and others, to drive forward a global and inclusive circular economy agenda. Attendance at this event is by invitation only. Department/project Energy, Environment and Resources Programme, Building Transformative Alliances for an Inclusive Global Circular Economy Johanna Tilkanen Project Manager, Energy, Environment and Resources Department Email Full Article
rc Promoting a Just Transition to an Inclusive Circular Economy By feedproxy.google.com Published On :: Wed, 01 Apr 2020 11:19:03 +0000 1 April 2020 Considerations of justice and social equity are as important for the circular economy transition as they are in the contexts of low-carbon transitions and digitalization of the economy. This paper sets out the just transition approach, and its relevance in climate change and energy transition debates. Read online Download PDF Patrick Schröder Senior Research Fellow, Energy, Environment and Resources Programme @patricks_CH Google Scholar 2020-04-01-circular-economy.jpg Residents of Mount Ijen take sulphur at Ijen Crater, Banyuwangi, East Java, on 2 July 2018. Photo: Getty Images. Summary Many social and political issues have so far been neglected in planning for the circular economy transition. This paper aims to redress this by considering how ‘just transition’ and social equity may be achieved through policy and practice.The prevailing economic model is linear, in that resources are extracted, transformed into products, used, and finally discarded. In contrast, the circular economy recognizes that natural resources are finite, and aims to keep the materials in products in circulation for as long as possible: reusing, repairing, remanufacturing, sharing and recycling. While the concept of the circular economy is largely focused on developing new technologies and businesses to enable keeping materials in circulation, it also includes the notions of ‘designing out’ waste, substituting renewable materials for non-renewable ones, and restoring natural systems.The UN 2030 Agenda demonstrates that environmental, social and economic sustainability objectives cannot be separated. As the links between the environmental issues of climate change, overconsumption of resources and waste generation, and social issues of inequality and the future of work become increasingly obvious, the urgency to connect environmental with social justice is gaining in significance. The language of ‘just transition’ – a transition that ensures environmental sustainability, decent work, social inclusion and poverty eradication – has started to penetrate debates and research on sustainability policy, particularly in the contexts of climate change and low-carbon energy transition.A just transition framework for the circular economy can identify opportunities that reduce waste and stimulate product innovation, while at the same time contributing positively to sustainable human development. And a just transition is needed to reduce inequalities within and between countries, and to ensure that the commitment of the UN Sustainable Development Goals to leave no one behind is fulfilled.It is important to identify the likely impacts on employment as a result of digitalization and industrial restructuring. Combining circular economy policies with social protection measures will be important in order to ensure that the burden of efforts to promote circularity will not fall on the poor through worsening working conditions and health impacts, reduced livelihoods, or job losses. Identifying potential winners and losers through participatory ‘roadmapping’ can help shape effective cooperation mechanisms and partnerships nationally and internationally.Many low- and middle-income countries that rely heavily on ‘linear’ sectors such as mining, manufacturing of non-repairable fast-moving consumer goods, textiles and agriculture, and the export of these commodities to higher-income countries, are likely to be negatively affected by the shift to circularity. These countries will need support from the international community through targeted assistance programmes if international trade in established commodities and manufactures declines in the medium to long term. International cooperation to create effective and fair governance mechanisms, and policy coordination at regional, national and local levels will play an important role in shaping a just transition. Multilateral technical assistance programmes will need to be designed and implemented, in particular to support low- and middle-income countries.Governments, international development finance institutions and banks are among the bodies beginning to establish circular economy investment funds and programmes. Just transition principles are yet to be applied to many of these new finance mechanisms, and will need to be integrated into development finance to support the circular economy transition.New international cooperation programmes, and a global mechanism to mobilize dedicated support funds for countries in need, will be critical to successful implementation across global value chains. Transparent and accountable institutions will also be important in ensuring that just transition funds reach those affected as intended. Department/project Energy, Environment and Resources Programme Full Article
rc Why an Inclusive Circular Economy is Needed to Prepare for Future Global Crises By feedproxy.google.com Published On :: Wed, 15 Apr 2020 13:23:01 +0000 15 April 2020 Patrick Schröder Senior Research Fellow, Energy, Environment and Resources Programme @patricks_CH Google Scholar The risks associated with existing production and consumption systems have been harshly exposed amid the current global health crisis but an inclusive circular economy could ensure both short-term and long-term resilience for future challenges. 2020-04-15-Waste-Collection-Peru.jpg Lima city employees picking up garbage during lockdown measures in Peru amid the COVID-19 crisis. Photo: Getty Images. The world is currently witnessing how vulnerable existing production and consumption systems are, with the current global health crisis harshly exposing the magnitude of the risks associated with the global economy in its current form, grounded, as it is, in a linear system that uses a ‘take–make–throw away’ approach.These ‘linear risks’ associated with the existing global supply chain system are extremely high for national economies overly dependent on natural resource extraction and exports of commodities like minerals and metals. Equally vulnerable are countries with large manufacturing sectors of ready-made garments and non-repairable consumer goods for western markets. Furthermore, workers and communities working in these sectors are vulnerable to these changes as a result of disruptive technologies and reduced demand.In a recently published Chatham House research paper, ‘Promoting a Just Transition to an Inclusive Circular Economy’, we highlight why a circular economy approach presents the world with a solution to old and new global risks – from marine plastic pollution to climate change and resource scarcity.Taking the long viewSo far, action to transition to a circular economy has been slow compared to the current crisis which has mobilized rapid global action. For proponents of transitioning to a circular economy, this requires taking the long view. The pandemic has shown us that global emergencies can fast-forward processes that otherwise might take years, even decades, to play out or reverse achievements which have taken years to accomplish.In this vein, there are three striking points of convergence between the COVID-19 pandemic and the need to transition to an inclusive circular economy.Firstly, the current crisis is a stark reminder that the circular economy is not only necessary to ensure long-term resource security but also short-term supplies of important materials. In many cities across the US, the UK and Europe, councils have suspended recycling to focus on essential waste collection services. The UK Recycling Association, for example, has warned about carboard shortages due to disrupted recycling operations with possible shortages for food and medicine packaging on the horizon.Similarly, in China, most recycling sites were shut during the country’s lockdown presenting implications for global recycling markets with additional concerns that there will be a fibre shortage across Europe and possibly around the world.Furthermore, worldwide COVID-19 lockdowns are resulting in a resurgence in the use of single-use packaging creating a new wave of plastic waste especially from food deliveries – already seen in China – with illegal waste fly-tipping dramatically increasing in the UK since the lockdown.In this vein, concerns over the current global health crisis is reversing previous positive trends where many cities had established recycling schemes and companies and consumers had switched to reusable alternatives.Secondly, the need to improve the working conditions of the people working in the informal circular economy, such as waste pickers and recyclers, is imperative. Many waste materials and recyclables that are being handled and collected may be contaminated as a result of being mixed with medical waste.Now, more than ever, key workers in waste management, collection and recycling require personal protective equipment and social protection to ensure their safety as well as the continuation of essential waste collection so as not to increase the potential for new risks associated with additional infectious diseases.In India, almost 450 million workers including construction workers, street vendors and landless agricultural labourers, work in the informal sector. In the current climate, the poorest who are unable to work pose a great risk to the Indian economy which could find itself having to shut down.Moreover, many informal workers live in make-shift settlements areas such as Asia’s largest slum, Dharavi in Mumbai, where health authorities are now facing serious challenges to contain the spread of the disease. Lack of access to handwashing and sanitation facilities, however, further increase these risks but circular, decentralized solutions could make important contributions to sustainable sanitation, health and improved community resilience.Thirdly, it is anticipated that in the long term several global supply chains will be radically changed as a result of transformed demand patterns and the increase in circular practices such as urban mining for the recovery and recycling of metals or the reuse and recycling of textile fibres and localized additive manufacturing (e.g. 3D printing).Many of these supply chains and trade flows have now been already severely disrupted due to the COVID-19 pandemic. For example, the global garment industry has been particularly hard-hit due to the closure of outlets amid falling demand for apparel.It is important to note, workers at the bottom of these garment supply chains are among the most vulnerable and most affected by the crisis as global fashion brands, for example, have been cancelling orders – in the order of $6 billion in the case of Bangladesh alone. Only after intense negotiations are some brands assuming financial responsibility in the form of compensation wage funds to help suppliers in Myanmar, Cambodia and Bangladesh to pay workers during the ongoing crisis.In addition, the current pandemic is damaging demand for raw materials thereby affecting mining countries. Demand for Africa’s commodities in China, for example, has declined significantly, with the impact on African economies expected to be serious, with 15 per cent of the world’s copper and 20 per cent of the world’s zinc mines currently going offline. A further threat is expected to come from falling commodity prices as a result of the curtailment of manufacturing activity in China particularly for crude oil, copper, iron ore and other industrial commodities which, in these cases, will have direct impacts on the Australian and Canadian mining sectors.This is all being compounded by an associated decline in consumer demand worldwide. For example, many South African mining companies – leading producers of metals and minerals – have started closing their mining operations following the government’s announcement of a lockdown in order to prevent the transmission of the virus among miners who often work in confined spaces and in close proximity with one another. As workers are laid off due to COVID-19, there are indications that the mining industry will see fast-tracking towards automated mining operations. All of these linear risks that have been exposed through the COVID-19 pandemic reinforce the need for a just transition to a circular economy. But while the reduction in the consumption of resources is necessary to achieve sustainability, the social impacts on low- and middle- income countries and their workers requires international support mechanisms.In addition, the current situation also highlights the need to find a new approach to globalized retail chains and a balance between local and global trade based on international cooperation across global value chains rather than implementation of trade protectionist measures.In this vein, all of the recovery plans from the global COVID-19 pandemic need to be aligned with the principles of an inclusive circular economy in order to ensure both short-term and long-term resilience and preparedness for future challenges and disruptions. Full Article
rc RCP warns over shortage of stroke physicians By feeds.bmj.com Published On :: Tuesday, November 29, 2016 - 06:30 Full Article
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rc Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma [DNA and Chromosomes] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 The actin cytoskeleton is extremely dynamic and supports diverse cellular functions in many physiological and pathological processes, including tumorigenesis. However, the mechanisms that regulate the actin-related protein 2/3 (ARP2/3) complex and thereby promote actin polymerization and organization in cancer cells are not well-understood. We previously implicated the proline-rich 11 (PRR11) protein in lung cancer development. In this study, using immunofluorescence staining, actin polymerization assays, and siRNA-mediated gene silencing, we uncovered that cytoplasmic PRR11 is involved in F-actin polymerization and organization. We found that dysregulation of PRR11 expression results in F-actin rearrangement and nuclear instability in non-small cell lung cancer cells. Results from molecular mechanistic experiments indicated that PRR11 associates with and recruits the ARP2/3 complex, facilitates F-actin polymerization, and thereby disrupts the F-actin cytoskeleton, leading to abnormal nuclear lamina assembly and chromatin reorganization. Inhibition of the ARP2/3 complex activity abolished irregular F-actin polymerization, lamina assembly, and chromatin reorganization due to PRR11 overexpression. Notably, experiments with truncated PRR11 variants revealed that PRR11 regulates F-actin through different regions. We found that deletion of either the N or C terminus of PRR11 abrogates its effects on F-actin polymerization and nuclear instability and that deletion of amino acid residues 100–184 or 100–200 strongly induces an F-actin structure called the actin comet tail, not observed with WT PRR11. Our findings indicate that cytoplasmic PRR11 plays an essential role in regulating F-actin assembly and nuclear stability by recruiting the ARP2/3 complex in human non-small cell lung carcinoma cells. Full Article
rc Atomic force microscopy-based characterization of the interaction of PriA helicase with stalled DNA replication forks [DNA and Chromosomes] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 In bacteria, the restart of stalled DNA replication forks requires the DNA helicase PriA. PriA can recognize and remodel abandoned DNA replication forks, unwind DNA in the 3'-to-5' direction, and facilitate the loading of the helicase DnaB onto the DNA to restart replication. Single-stranded DNA–binding protein (SSB) is typically present at the abandoned forks, but it is unclear how SSB and PriA interact, although it has been shown that the two proteins interact both physically and functionally. Here, we used atomic force microscopy to visualize the interaction of PriA with DNA substrates with or without SSB. These experiments were done in the absence of ATP to delineate the substrate recognition pattern of PriA before its ATP-catalyzed DNA-unwinding reaction. These analyses revealed that in the absence of SSB, PriA binds preferentially to a fork substrate with a gap in the leading strand. Such a preference has not been observed for 5'- and 3'-tailed duplexes, suggesting that it is the fork structure that plays an essential role in PriA's selection of DNA substrates. Furthermore, we found that in the absence of SSB, PriA binds exclusively to the fork regions of the DNA substrates. In contrast, fork-bound SSB loads PriA onto the duplex DNA arms of forks, suggesting a remodeling of PriA by SSB. We also demonstrate that the remodeling of PriA requires a functional C-terminal domain of SSB. In summary, our atomic force microscopy analyses reveal key details in the interactions between PriA and stalled DNA replication forks with or without SSB. Full Article
rc Immigration Data Matters: How to Find the Most Accurate Resources By www.migrationpolicy.org Published On :: Mon, 19 Mar 2018 18:21:59 -0400 With immigration increasingly visible in the news and the political space in the United States and internationally, getting access to accurate, high-quality data is essential to understand immigration’s demographic effects and impacts on the economy, education and labor systems, and communities. This event marks the release of the Immigration Data Matters guide. Full Article
rc Vanishing Frontiers: The Forces Driving Mexico and the United States Together By www.migrationpolicy.org Published On :: Tue, 05 Jun 2018 17:31:26 -0400 Marking the release of MPI President Andrew Selee's latest book, speakers explore emerging trends in migration, economic interdependence, technology innovation, and cultural exchange that are transforming the relationship between the United States and Mexico, and the policy implications of these changes for the future. Full Article
rc Immigration Data Matters: How to Find the Most Accurate Resources By www.migrationpolicy.org Published On :: Tue, 06 Mar 2018 16:02:40 -0500 At this release of an updated version of the popular Immigration Data Matters guide, presenters discuss how to navigate and access the increasing number of data sources on immigration and immigrants in the United States and internationally. Full Article
rc Revving Up the Deportation Machinery: Enforcement under Trump and the Pushback By www.migrationpolicy.org Published On :: Tue, 24 Apr 2018 14:19:32 -0400 The Trump administration has significantly cranked up the immigration enforcement machinery in the U.S. interior. Yet even as arrests and deportations are up in the early Trump months, they remain less than half their peaks. This report demonstrates how pushback from California and other "sanctuary" locations makes it quite unlikely that ICE will be able to match record enforcement levels. Full Article
rc The Changing Landscape of Interior Immigration Enforcement Under Trump By www.migrationpolicy.org Published On :: Tue, 08 May 2018 16:09:32 -0400 Discussion at this event focused on findings from MPI's report examining the interior immigration enforcement system in the United States, including ICE data on deportations and arrests, and the responses of state and local governments, civil society, and consulates. Full Article
rc Examining the Adequacy and Enforcement of Our Nation’s Immigration Laws By www.migrationpolicy.org Published On :: Tue, 03 Feb 2015 09:37:48 -0500 Testimony of Marc R. Rosenblum, Deputy Director, U.S. Immigration Program, before the House Judiciary Committee on the efficacy of immigration enforcement at the U.S. border and in the interior. Full Article
rc Targeted Enforcement: Projecting the Effects of Executive Action on Deportations By www.migrationpolicy.org Published On :: Thu, 23 Jul 2015 16:15:50 -0400 Marking the release of an MPI report, this briefing explores the effects of recent revisions in DHS immigration enforcement priorities on deportations within the U.S. interior. Full Article
rc State and Local Labor Standards Enforcement in Immigrant-Dense Industries By www.migrationpolicy.org Published On :: Tue, 06 Mar 2018 21:26:21 -0500 Marking the release of an MPI report, this discussion focuses on the dynamics in low-wage workplaces and immigration law that have contributed to systematic violations of labor standards and explores new and effective enforcement strategies that state and local governments across the United States are utilizing. Full Article
rc State and Local Labor Standards Enforcement in Immigrant-Dense Industries By www.migrationpolicy.org Published On :: Thu, 15 Mar 2018 19:59:17 -0400 This discussion, featuring California's Labor Commissioner and the head of the Tennessee Bureau of Workers' Compensation, launched a report that examines state innovations in labor standards enforcement in low-wage, immigrant-dense industries. With wage underpayment, payroll fraud, and other violations widespread in industries such as construction and car-washing, the discussion focused on how targeted enforcement can deter practices that hurt native-born and immigrant workers alike, cost state tax revenue, and disadvantage law-abiding employers. Full Article