PURPOSE

Although cesarean delivery is the most common surgical procedure in the United States, postoperative opioid prescribing varies greatly. We hypothesized that patient characteristics, procedural characteristics, or both would be associated with high vs low opioid use after discharge. This information could help individualize prescriptions.

Clostridioides difficileDiagnosticsMetabolomicsMicrobiome

BACKGROUND:

Prescribing of levothyroxine and rates of thyroid function testing may be sensitive to minor changes in the upper limit of the reference range for thyroid-stimulating hormone (TSH) that increase the proportion of abnormal results. We evaluated the population-level change in levothyroxine prescribing and TSH testing after a minor planned decrease in the upper limit of the reference range for TSH in a large urban centre with a single medical laboratory.

Purpose:

Unleashing the immune system by PD-1 and/or CTLA-4 blockade can cause severe immune-related toxicity necessitating immunosuppressive treatment. Whether immunosuppression for toxicity impacts survival is largely unknown.

We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology platform. The configuration of this gene fusion predicts the production of a kinase-activating JAK2 fusion protein, which would normally lead to a diagnosis of Philadelphia chromosome–like B-ALL (Ph-like B-ALL). However, the unusual presentation of eosinophilia led us to demonstrate the presence of this gene fusion in nonlymphoid hematopoietic cells by fluorescence in situ hybridization (FISH) studies with morphologic correlation. Therefore, we believe this disease, in fact, represents blast crisis arising from an underlying myeloid neoplasm with JAK2 rearrangements. This case illustrates the difficulty in differentiating Ph-like B-ALL and myeloid/lymphoid neoplasm with eosinophilia and gene rearrangements (MLN-EGR) in blast crisis. As currently defined, the diagnosis of MLN-EGR relies on the hematologic presentations and the identification of marker gene fusions (including PCM1-JAK2, ETV6-JAK2, and BCR-JAK2). However, these same gene fusions, when limited to B-lymphoblasts, also define Ph-like B-ALL. Yet, our case does not conform to either condition. Therefore, the assessment for lineage restriction of gene rearrangements to reflect the pathophysiologic difference between B-ALL and MLN-EGR in blast crisis is likely a more robust diagnostic approach and allows the inclusion of MLN-EGR with novel gene fusions.

Background:

Sex steroid hormones and sex hormone–binding globulin (SHBG) have been implicated in the etiology of invasive breast cancer, but their associations with risk of the precursor lesion, ductal carcinoma in situ (DCIS) of the breast, remain unclear.

Metastatic disease is the leading cause of death in patients with solid cancers. The progression to metastasis is a multistep process that involves detachment of tumor cells from their constraining basement membrane at the primary site, migration and intravasation into the circulation, survival in the circulation, extravasation into the secondary organ, and survival and growth at the secondary site. During these steps, tumor and immune cells interact and influence each other both within the tumor microenvironment and systemically. In particular, myeloid cells such as monocytes, macrophages, neutrophils, and myeloid-derived suppressor cells (myeloid regulatory cells) have been shown to play important roles in the metastatic process. These interactions open new avenues for targeting cancer metastasis, especially given the increasing interest in development of cancer immunotherapies. In this review, we describe the currently reported pathways and mechanisms involved in myeloid cell enhancement of the metastatic cascade.

BACKGROUND AND PURPOSE:

It is not known how radiomics using ultrasound images contribute to the detection of BRAF mutation. This study aimed to evaluate whether a radiomics study of gray-scale ultrasound can predict the presence or absence of B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation in papillary thyroid cancer.

[Having appointment with real estate experts #5] While buying a home is quite easy for high-income households, it is another story for the middle-class. With a wise and specific financial plan, the chances of owning a home can still lie within reach even if an average income.

For almost first-time home buyers, owning a home can be a very rewarding experience. With a little caution and some attention to detail, you can avoid costly mistakes.

As home sellers commonly propose to state a lower price in the sale contract than the actual transaction value, home buyers have to bear additional risks from such real estate transactions.

For a smooth and profitable deal, you should avoid these four common and costly home selling mistakes before your home hits the market.

If you make a mistake during the listing process, you might end up getting less than your home is worth or find that it takes significantly longer to sell your home than it should.

Home selling can be an emotional process, so don’t make it even tougher by letting your emotions run the process. Make sure that you don’t fall into any of these four of the most common home selling mistakes.

As with other types of investment, real estate investors need a good vision and smart strategies to make it profitable. Here are 6 important guides for investors to avoid loss and gain profit from their real estate investment.

Microsoft and Turn 10 Studios announced Forza Street is now available worldwide for free on iOS and Android.

View the launch trailer below:

Here is an overview of the game:

This all-new Forza experience lets you jump into the game for quick, under-a-minute races where you compete to unlock new cars and upgrade parts to grow your car collection. We are excited for iOS and Android players to jump into this free to play mobile experience designed to be played anytime, anywhere, and excite anyone who loves cars.

Forza Street was also designed to be an evolving experience. The game is based in a street racing world with interesting characters, mystery, and  intrigue,  explored through a narrative driven campaign, weekly Spotlight Events, and limited time Themed Events, all of which provide players an opportunity to expand their car collections. For players looking for an additional challenge, weekly Rivals events let them take their collections against other players in the community in leaderboard based asynchronous challenges.

As a special gift to everyone who plays Forza Street between today and June 5 2020, players will receive a 2017 Ford GT and added in-game credits and gold to help you unlock new cars and grow your car collection! Don’t miss out on this chance to get this rare supercar added to your garage.

For gamers joining the fun via the Samsung Galaxy Store, we have two more gifts for you: anyone who downloads through the Galaxy Store on their Samsung devices will receive the 2015 Ford Mustang GT with a custom Galaxy themed paint. If players have the latest Galaxy S20 devices, they will also receive the 2015 Chevrolet Corvette Z06 with a Custom Galaxy, and in-game credits and gold.

Want to play Forza Street across multiple device? We got you covered – Forza Street supports Xbox Live. When you sign in with Xbox Live, players will be able to unlock Xbox Achievements and transfer game progress across your Windows, iOS, and Android devices.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443397/forza-street-now-available-for-ios-and-android/

This solar contact could provide a potential explanation for the asteroid's weird, two-tone surface.

When asteroid Armageddon is upon us, we can't just call Bruce Willis. Meet the people who really do watch the skies – and make detailed plans for our survival

The Hayabusa-2 spacecraft bombed the asteroid Ryugu in April. Analysing the crater it left behind suggests Ryugu is a relative youngster at 9 million years old

A tiny meteorite found in Antarctica doesn’t match any asteroid or comet we know of. Instead, it must have come from a mystery parent body that’s full of water

An unusually round and symmetrical deposit on Mars may be the result of an impact that popped the surface of the planet, causing a volcanic eruption less than 200,000 years ago

Arrokoth, a strange two-lobed space rock, was hit by another rock at some point – the collision may have snapped Arrokoth’s narrow neck before it reformed again

A bunch of asteroids near Jupiter and Neptune with orbits perpendicular to the plane of the solar system may have come here from a different star system

Skybot F-850 will spend a week on the ISS charming astronauts with its sense of humor

Job postings from a NASA contractor suggest that a new humanoid robot is under development

Your weekly selection of awesome robot videos

"I just couldn't be more proud of you and the prospect of your presidency," Newsom told Biden Friday during a campaign event.

There's been a spike in scam calls, emails and texts

Comfort, however, can be an issue

Facebook’s dedicated Gaming app is now live on Android, months before its planned June release. The social media giant pushed the app out two months prior to its scheduled unveiling amid a global pandemic that’s left people all over the world isolated at home, rapidly burning through entertainment options. The New York Times announced the […]

Noida Police Commissioner has written to national carrier Air India, requesting the airline to ensure that pilots and crew involved in repatriation flights should stay back in Delhi.

We are already seeing the pandemic's effects on mental health, and we need to act urgently to avoid a full-blown crisis, says Sam Howells  

People with rheumatoid arthritis often take medicines that can have damaging side-effects, but a system that uses red light to deliver drugs exactly where they are needed could help

False information about the pandemic is rampant; here’s how experts say you can identify what news to trust and what might be faulty

Google I/O isn’t happening this year, but we’ll get all the normal info next month.

Follow our live coronavirus updates here Coronavirus: the symptoms

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

Coronavirus: The symptoms

A mile-wide asteroid is on course to pass the Earth on Wednesday at a distance 16 times further than the moon.

Nasa plans to test potentially lifesaving technology by crashing a spacecraft into a smaller asteroid in 2021

Pub visits should be avoided when social distancing measures are eased, one of the UK's top medics has said.

Pub visits should be avoided even after coronavirus restrictions are lifted, England's deputy chief medical officer has indicated.

A man has been jailed after he viciously bit down on an officer's finger in a "sustained attack" to avoid being arrested.

Drug dealers are adopting new disguises so they can move around freeley during the coronavirus lockdown, a gang expert has said.

Millions of commuters will be told by Boris Johnson to change their "go to work" times to lengthen the rush hour as the country fires up its economic engines after lockdown.

A new paper analyzes what we know about the sample the probe grabbed last year.

Advanced hacker group seeded market with at least 8 apps likely since 2016.