api

Play the Smithsonian Magazine Weekly Word Search: State Capitals

Find the capital cities, working from a list of state names




api

Thunder Bay physiotherapist has licence suspended for incident over a decade ago

A physiotherapist in Thunder Bay, Ont., has had his licence suspended until September, as part of a disciplinary hearing.



  • News/Canada/Thunder Bay

api

Volatility spillovers and capital buffers among the G-SIBs

We assess the dynamics of volatility spillovers among global systemically important banks (G-SIBs). We measure spillovers using vector-autoregressive models of range volatility of the equity prices of G-SIBs, together with machine learning methods. We then compare the size of these spillovers with the degree of systemic importance measured by the Basel Committee on Banking Supervision's G-SIB bucket designations.




api

Shaping the future of payments: BIS Quarterly Review

BIS Press Release - Shaping the future of payments: BIS Quarterly Review, 1 March 2020




api

Shaping the future of payments*

Commentary on Red Book statistics: Shaping the future of payments, November 2019





api

Workers, capitalists, and the government: fiscal policy and income (re)distribution

Bank of England Working Papers by Cristiano Cantore and Lukas Freund




api

Health administration students learn to manage rapid changes in health care

Students in Penn State’s Master of Health Administration program are learning first-hand how the skills and competencies they are acquiring in the classroom will be applied in their professional careers. A recent virtual roundtable event provided opportunities for students to learn real-world strategies from health care industry leaders that are being applied in response to the COVID-19 pandemic.




api

NHS contact tracing team reportedly mulls switch to Apple-Google API



In what could herald a course reversal for the UK's National Health Service, health officials in that country have reportedly asked a team of developers to "investigate" switching its contact tracing app to a cross-platform API provided by Apple and Google.




api

20181113api

Topics in this issue include:

New - Support for Additional Calendar Spread Options

Effective Sunday, December 2 (trade date Monday, December 3), pending all relevant CFTC regulatory review periods, CME ClearPort will support trade entry for the following Calendar Spread Options (CSOs):

For more information, please refer to SER-8279 in the Special Executive Report (SER) Notice Archive.

This enhancement will be available for customer testing in New Release on Wednesday, November 14.

Back to Top

 

Price Precision Extension

CME Group is implementing end-to-end technology changes to support increased price granularity. Currently, CME Group systems support a maximum of 7 decimals. With this initiative, products with up to 9 decimals may be listed and traded. Effective Sunday, January 13, 2019 (trade date Monday, January 14), pending regulatory approval, the 2 Year Treasury Note futures and spreads will move from 7 decimals to 8 to support trading at 1/8 of 1/32.

Customers are encouraged to move to support 9 decimals now; but there are no plans to list a product that uses the 9th decimal at this time.

The attributes listed below will be impacted.

For more on impacted products and CME Globex, iLink messaging, Drop Copy and Market Data impacts, view the CME Globex Client Impact Assessment.

Trade Capture Reports and Acknowledgements

Price will be impacted at the Trade Capture Report and Trade Instrument Leg Group levels.

Level Field Name FIXML Attribute Name
/TrdCaptRpt - inbound Trade Price LastPx
/TrdCaptRpt/TrdLeg - inbound Leg Last Price LastPx
/TrdCaptRptAck - outbound Trade Price LastPx
/TrdCaptRptAck/TrdLeg - outbound Leg Last Price LastPx
/TrdCaptRpt - outbound Trade Price LastPx
/TrdCaptRpt/TrdLeg - outbound Leg Last Price LastPx

Reference Data

Level Field Name FIXML Attribute Name
/SecDef/Instrmt MinPriceIncrement MinPxIncr
/DerivSecList/DerivSecDef/DerivInstrmt MinPriceIncrement MinPxIncr

These enhancements are currently available for customer testing in New Release.

Back to Top




api

20181219api

Topics in this issue include:

 

CME Reference Data API Launch

CME Group has launched CME Reference Data API, a real-time solution for accessing information on every instrument and product at CME Group.

Embed the CME Reference Data API in your system’s product matrices and databases to automate product reference data for all CME Group and hosted partner exchange markets.

CME Reference Data API includes:

  • Contract specifications
  • Product codes and symbols
  • Trade and order type eligibility
  • Instrument life cycle dates: first and last trade date, notices, delivery and settlement

Key Benefits:

  • Reduce the risk of errors with automated definitions
  • Machine-readable API delivers product and instrument information without human intervention
  • Access CME Group markets and products faster
  • A cost-effective solution to accessing product data

Request Access:

Contact Global Account Management to obtain access to the Reference Data API:

U.S.: +1 312 634 8700
Europe: +44 20 3379 3754
Asia: +65 6593 5505

Additional Resources:

Back to Top

 

Price Precision Extension

CME Group is implementing end-to-end technology changes to support increased price granularity. Currently, CME Group systems support a maximum of 7 decimals. With this initiative, products with up to 9 decimals may be listed and traded. Effective Sunday, January 13, 2019 (trade date Monday, January 14), pending regulatory approval, the 2 Year Treasury Note futures and spreads will move from 7 decimals to 8 to support trading at 1/8 of 1/32.

Customers are encouraged to move to support 9 decimals now; but there are no plans to list a product that uses the 9th decimal at this time.

The attributes listed below will be impacted.

For more on impacted products and CME Globex, iLink messaging, Drop Copy and Market Data impacts, view the CME Globex Client Impact Assessment.

Trade Capture Reports and Acknowledgements

Price will be impacted at the Trade Capture Report and Trade Instrument Leg Group levels.

Level Field Name FIXML Attribute Name
/TrdCaptRpt - inbound Trade Price LastPx
/TrdCaptRpt/TrdLeg - inbound Leg Last Price LastPx
/TrdCaptRptAck - outbound Trade Price LastPx
/TrdCaptRptAck/TrdLeg - outbound Leg Last Price LastPx
/TrdCaptRpt - outbound Trade Price LastPx
/TrdCaptRpt/TrdLeg - outbound Leg Last Price LastPx

Reference Data

Level Field Name FIXML Attribute Name
/SecDef/Instrmt MinPriceIncrement MinPxIncr
/DerivSecList/DerivSecDef/DerivInstrmt MinPriceIncrement MinPxIncr

These enhancements are currently available for customer testing in New Release.

Back to Top




api

CME ClearPort API Entity Reference Data Changes for Brokers

Please be advised that effective Sunday, August 25, 2013 (for the August 26th business date) there will be changes to CME ClearPort API Entity Reference Data that will impact Party Detail List Reports and Party Entitlement Reports for CME ClearPort API Brokers and CME ClearPort API Platforms who request Entity Reference Data on behalf of Brokers.

These changes will be available for testing in the New Release environment on August 14th.

Changes to Existing Reponses

When a Broker (or Platform on behalf of Broker) submits a request for all related accounts using the Party Details List Request message or a request for all related accounts which trade a particular product using the Party Entitlement Request message, the following information is provided for each account in Related Party Detail blocks:  The Clearing ID of the Account’s Clearing Firm (Party Role 1), the Trading Firm / Account Owner’s firm identifier (Party Role 7),  and the Broker Firm’s firm identifier (Party Role 30).

Going forward, when the same requests are submitted, an additional Related Party Detail block will appear on the response if there is an Asset Manager Firm assigned to the account:  the Asset Manager Firm’s identifier (Party Role 49).

In the following examples, ACCT1 has been assigned an Asset Manager by the Clearing Firm, while ACCT2 has not.

<FIXML v="5.0 SP2" xv="109" s="20090815" cv="CME.0001">

<PtyDetlListRpt ReqID="123437" RptID="1376864472358" ReqRslt="0" Txt="Valid request">

<Hdr SID="CME" SSub="CPAPI" TID="PLTFM" TSub="username"/>

<PtyDetl ID="ACCT1" Src="C" R="24">

<AltPty ID="A-12345" Src="H"/>

<ReltdPtyDetl ID="123" Src="C" R="1">

<Rltnshp Rltnshp="2"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="trading_firm1" Src="C" R="7">

<Rltnshp Rltnshp="36"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="broker_firm1" Src="C" R="30">

<Rltnshp Rltnshp="22"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="asset_mgr_firm1" Src="C" R="49">

<Rltnshp Rltnshp="32"/>

</ReltdPtyDetl>

</PtyDetl>

<PtyDetl ID="ACCT2" Src="C" R="24">

<AltPty ID="A-67890" Src="H"/>

<ReltdPtyDetl ID="456" Src="C" R="1">

<Rltnshp Rltnshp="2"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="trading_firm2" Src="C" R="7">

<Rltnshp Rltnshp="36"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="broker_firm1" Src="C" R="30">

 

 

<Rltnshp Rltnshp="22"/>

</ReltdPtyDetl>

</PtyDetl>

</PtyDetlListRpt>

</FIXML>

 

<FIXML v="5.0 SP2" xv="109" s="20090815" cv="CME.0001">

<PtyEntlmntRpt ReqID="123412" RptID="1376865078371" ReqRslt="0" Txt="Valid request">

<Hdr SID="CME" SSub="CPAPI" TID="PLTFM" TSub="username"/>

<PtyEntlmnt>

<PtyDetl ID="ACCT1" Src="C" R="24">

<AltPty ID="A-12345" Src="H"/>

<ReltdPtyDetl ID="broker_firm1" Src="C" R="30">

<Rltnshp Rltnshp="22"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="trading_firm1" Src="C" R="7">

<Rltnshp Rltnshp="36"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="asset_mgr_firm1" Src="C" R="49">

<Rltnshp Rltnshp="32"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="123" Src="C" R="1">

<Rltnshp Rltnshp="2"/>

</ReltdPtyDetl>

</PtyDetl>

<PtyDetl ID="ACCT2" Src="C" R="24">

<AltPty ID="A-67890" Src="H"/>

<ReltdPtyDetl ID="broker_firm1" Src="C" R="30">

<Rltnshp Rltnshp="22"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="trading_firm2" Src="C" R="7">

<Rltnshp Rltnshp="36"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="456" Src="C" R="1">

<Rltnshp Rltnshp="2"/>

</ReltdPtyDetl>

</PtyDetl>

<Entlmnt Typ="0" Ind="Y">

<InstrmtScope Oper="1" ID="NN" Src="H" SecTyp="FUT"

 

Exch="NYMEX"/>

 

 

</Entlmnt>

 

</PtyEntlmnt>

</PtyEntlmntRpt>

 

</FIXML>

 

NEW- Broker Requests Asset Manager Users at an Asset Manager Firm

In a previous CME ClearPort API release a change was made to allow Brokers (or Platforms on behalf of Brokers) to specify asset manager users in party role 36 (instead of a trader at the account owner firm) to satisfy the trader individual requirements for applicable market types like energy and metals.  Now Brokers can use ClearPort API reference data to obtain a list of asset manager users for their related accounts.  Once the above responses are received, the Broker or Platform can use each related Asset

Manager Firm (Party Role 49) to request a list of users at the firm:

 

Request

<FIXML v="5.0 SP2" xv="109" s="20090815" cv="CME.0001">

<PtyDetlListReq ReqID="123437">

<Hdr SID="PLTFM" SSub="username" TID="CME" TSub="CPAPI"/>

<ReqPty ID="broker_firm1" R="30"/>

<Pty ID="asset_mgr_firm1" R="49"/>

<ReqR R="36"/>

</PtyDetlListReq>

</FIXML>

 

 

 

 

Response

 

<FIXML v="5.0 SP2" xv="109" s="20090815" cv="CME.0001">

<PtyDetlListRpt ReqID="123437" RptID="1376866782295" ReqRslt="0" Txt="Valid request">

<Hdr SID="CME" SSub="CPAPI" TID="PLTFM" TSub="username"/>

<PtyDetl ID="asset_mgr_user1" Src="C" R="36">

<Sub ID="First Last" Typ="9"/>

<ReltdPtyDetl ID="asset_mgr_firm1" Src="C" R="49">

<Sub ID="Company Name" Typ="5"/>

<Rltnshp Rltnshp="6"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="CMD" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="CME" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="DME" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="NYMEX" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="COMEX" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

<ReltdPtyDetl ID="CBT" Src="C" R="22">

<Rltnshp Rltnshp="12"/>

</ReltdPtyDetl>

</PtyDetl>

</PtyDetlListRpt>

</FIXML>

 

For more detailed information regarding entity reference data retrieval through CME ClearPort API, please see the CME ClearPort API Reference Data Guide:

http://www.cmegroup.com/clearing/files/Clearport_Reference_Data_API_FIXML_Message_Specification_

and_Samples.pdf

 

If you have questions or need help facilitating your tests in the New Release environment, please contact:

 

Market Operations Technical Support

24 Hour 6 Days a Week Support available from Sundays at 5PM ET to Fridays at 5PM ET

Phone: 800-275-6215 / 212-301-4720

Email:  thirdpartyservices@cmegroup.com




api

Hindering SADC From Shaping Poll Landscape

Zanu PF's limited commitment to the Global Political Agreement (GPA) and the resultant institutionalisation of the Government of National Unity (GNU) is why the party began to push for elections as from 2010, a strategy seen as steering the total collapse of the agreement.




api

Doctors and therapists point to Jesus

On a recent outreach to several towns in the Amazon jungle, OM Peru worked with the Presbyterian Church of Moyabamba and its annexes.




api

Anaerobic Necrotizing Pneumonia: Another Potential Life-threatening Complication of Vaping?

An adolescent girl with a history of frequent electronic cigarette use of nicotine was hospitalized with severe necrotizing pneumonia. Blood cultures obtained before the administration of empirical broad-spectrum intravenous antibiotics had positive results for the growth of Fusobacterium necrophorum. The pathogen is an uncommon but well-known cause of anaerobic pneumonia with unique features that are collectively referred to as Lemierre syndrome or postanginal sepsis. The syndrome begins as a pharyngeal infection. Untreated, the infection progresses to involve the ipsilateral internal jugular vein, resulting in septic thrombophlebitis with direct spread from the neck to the lungs causing multifocal necrotizing pneumonia. The teenager we present in this report had neither a preceding pharyngeal infection nor Doppler ultrasonographic evidence for the presence of deep neck vein thrombi, leading us to explore alternative mechanisms for her pneumonia. We propose the possibility that her behavior of frequent vaping led to sufficient pharyngeal irritation such that F necrophorum colonizing her oropharynx was inhaled directly into her lungs during electronic cigarette use. Preexisting, but not yet recognized, vaping-related lung injury may have also contributed to her risk of developing the infection. The patient was hospitalized for 10 days. At follow-up one month later, she still became short of breath with minimal exertion.




api

Eosinophilic Pneumonia and Lymphadenopathy Associated With Vaping and Tetrahydrocannabinol Use

Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia. Although the exact etiology of idiopathic acute eosinophilic pneumonia remains unknown, an acute hypersensitivity reaction to an inhaled antigen is suggested, which is further supported by recent public health risks of vaping (electronic cigarette) use and the development of lung disease. In this case, a patient with a year-long history of vaping in conjunction with tetrahydrocannabinol cartridge use who was diagnosed with idiopathic acute eosinophilic pneumonia with associated bilateral hilar lymphadenopathy is described.




api

Fin24.com | MONEY CLINIC: How can I invest my R1.2m savings without eroding my capital?

A Fin24 set to retire this year is looking to invest his R1.2m savings in order to receive a monthly payout.




api

Decline in air traffic in Tegel and Schönefeld in April / Covid 19 pandemic puts a limit to air traffic in the capital

27,593 passengers departed from and landed at Berlin's airports Schönefeld and Tegel in April. That is just 1 per cent of air traffic in comparison to April 2019. 22,079 passengers flew from Tegel, and 5,541 from Schönefeld.




api

Rapid Deployment of Remote Learning: Lessons From 4 Districts

Chief technology officers are facing an unprecedented test of digital preparedness due to the coronavirus pandemic, struggling with shortfalls of available learning devices and huge Wi-Fi access challenges.




api

SNP MP accused of capitalising on virus crisis following 'brazenly disloyal' remarks at virtual meeting

AN SNP MP has been accused of capitalising on the virus crisis to undermine Nicola Sturgeon and boost their own profile following a series of remarks made in an online party meeting.




api

K-12 Marketplace Sees Major Flow of Venture Capital

Industry observers attribute the rise to heightened interest in ed-tech initiatives, decreasing technology costs, and the move to Common Core standards.




api

Citing Class Sizes, Services, Teachers In California's Capital City Walk Out

Hundreds of teachers across the Sacramento Unified school district walked out of their classrooms and onto picket lines last week for the first time in 30 years, staging a one-day strike alleging unfair labor practices by the California district.




api

Parents of disabled students act as teachers, therapists




api

Development of a Pragmatic Measure for Evaluating and Optimizing Rapid Response Systems

The availability of rapid response systems to assist deteriorating patients is the standard of care in children’s hospitals. Metrics for evaluating their effectiveness include cardiac and respiratory arrest rates, rare events that require years of data to show significant improvements.

A proximate outcome for in-hospital mortality among patients receiving rapid response system assistance was developed. This "critical deterioration" metric was eightfold more common than arrests and demonstrated criterion and construct validity, facilitating meaningful evaluation over shorter periods of time. (Read the full article)




api

Preliminary Development of a Rapid Assessment of Supervision Scale for Young Children

Assessing for adequacy of supervision in the clinical setting is challenging and may result in significant variability in care. Clinicians must quickly decide if a child and family necessitate direct counseling, further intervention, or require reporting to state agencies.

This study identified the most important characteristics for the evaluation of the adequacy of supervision of a young child. A standardized scale using these characteristics may result in an efficient means to reduce variability in care. (Read the full article)




api

Vaccine-Type Human Papillomavirus and Evidence of Herd Protection After Vaccine Introduction

Clinical trials have demonstrated that prophylactic human papillomavirus (HPV) vaccines are highly effective in preventing HPV infection, but the impact of vaccination on HPV prevalence rates in real-world, community settings is uncertain.

This study provides evidence of a substantial decrease in the prevalence of vaccine-type HPV among young women and evidence of herd protection in a community only 4 years after the quadrivalent HPV vaccine was licensed. (Read the full article)




api

The HEADS-ED: A Rapid Mental Health Screening Tool for Pediatric Patients in the Emergency Department

The American Academy of Pediatrics prioritized detection of mental illness in children presenting to emergency departments (ED) by using standardized clinical tools. Only a minority of ED physicians indicate that they use evidence-based screening methods to assess mental health concerns.

This study presents the psychometrics of the HEADS ED (home, education, activities/peers, drugs/alcohol, suicidality, emotions/behavior, discharge resources), a brief, standardized screening tool for pediatric EDs. This tool ensures key information is obtained for decision-making, determining acuity level, and areas of need. (Read the full article)




api

Sexual Activity-Related Outcomes After Human Papillomavirus Vaccination of 11- to 12-Year-Olds

Concerns persist about sexual disinhibition after human papillomavirus (HPV) vaccination of preteenage girls. Self-reported surveys have indicated few anticipated behavior changes after HPV vaccination. Little is known about sexual activity–related clinical outcomes after HPV vaccination.

Utilizing managed care organization electronic data, we evaluated the incidence of adverse outcomes of sexual activity among vaccinated preteenage girls and found little difference between those who received HPV vaccine and those who did not. (Read the full article)




api

Validation of Rapid Neurodevelopmental Assessment for 2- to 5-Year-Old Children in Bangladesh

In inverse proportion to the steadily declining under-5 mortality rate, prevalence of childhood disability has doubled in the past decade in Bangladesh. The Rapid Neurodevelopmental Assessment (RNDA) tool has been shown to be reliable and valid for assessment of a range of neurodevelopmental impairments (NDIs) and disabilities in children younger than 2 years. There is currently a lack of professional expertise for assessing NDIs in 2- to 5-year-old children in low- and middle-income countries.

We developed a set of instruments as part of the RNDA for administration by a single professional with experience in child development to assess >2- to 5-year-old children for a wide range of NDIs. The tool was acceptable to mothers, interrater reliability was high, and proportions of children with NDIs were elevated among the lowest income groups and in stunted children, demonstrating discriminant validity. The RNDA was valid for identifying >2- to 5-year-old children with a range of NDIs, especially in cognitive, behavior, and motor functions. Validity of the RNDA for vision, hearing, and seizure disorders needs further research. (Read the full article)




api

Use of Antihypotensive Therapies in Extremely Preterm Infants

Extremely preterm infants who receive antihypotensive therapy have worse outcomes than untreated infants. The reasons for this are not clear. High-quality randomized trials have not been performed to date because of logistical challenges, thereby necessitating alternative methods of investigation.

Antihypotensive therapy administration was not associated with improved in-hospital outcomes for any of the 15 definitions of low blood pressure investigated. Alternative methods of deciding who to treat are needed to maximize patient benefit and minimize harm. (Read the full article)




api

Comparison of Rapid Cranial MRI to CT for Ventricular Shunt Malfunction

Rapid cranial MRI is a radiation-free method to assess children with possible ventricular shunt malfunction. However, the test performance of rapid cranial MRI has never been compared with that of cranial CT, the current reference standard.

The accuracy of rapid cranial MRI was not inferior to that of CT for diagnosing ventricular shunt malfunction. Rapid cranial MRI is an important radiation-sparing diagnostic alternative for children presenting emergently with possible ventricular shunt malfunction. (Read the full article)




api

Long-term Study of a Quadrivalent Human Papillomavirus Vaccine

The short-term immunogenicity and safety of a HPV4 vaccine have been previously evaluated in preadolescents and adolescents. To date, no long-term studies of the safety, effectiveness, and immunogenicity of the HPV4 vaccine have been reported in this age group.

The HPV4 vaccine administered to adolescents demonstrated durability in clinically effective protection and sustained antibody titers over 8 years. These data, along with extensive postapproval safety surveillance data, should help reinforce national recommendations for HPV vaccination of preadolescents and adolescents. (Read the full article)




api

The Early Benefits of Human Papillomavirus Vaccination on Cervical Dysplasia and Anogenital Warts

Clinical trials of the quadrivalent human papillomavirus vaccine show it to be highly efficacious in preventing vaccine-type–specific cervical dysplasia and anogenital warts, but few studies have assessed its effects in the real world and none have done so at the program/population level.

This study provides strong evidence of the early benefits of quadrivalent human papillomavirus vaccination on reductions in cervical dysplasia and possible reductions in anogenital warts among girls aged 14 to 17 years, offering additional justification for not delaying vaccination until girls are older. (Read the full article)




api

Coadministration of a 9-Valent Human Papillomavirus Vaccine With Meningococcal and Tdap Vaccines

Previous studies have shown that concomitant administration of the quadrivalent human papillomavirus vaccine with MCV4 and Tdap was generally well tolerated and did not interfere with the immune responses to the respective vaccines.

Concomitant administration of the novel 9-valent human papillomavirus vaccine with MCV4 and Tdap, 2 vaccines that are currently recommended for routine vaccination of adolescents, did not compromise the safety, tolerability, and immunogenicity of the individual vaccines. (Read the full article)




api

Escaping the Conflict Trap: Promoting Good Governance in the Congo




api

Chad: Escaping from the Oil Trap




api

Imaginación para salvar República Centroafricana. Cómo actuar con rapidez y eficacia para evitar la somalización del país.

Los conflictos en los países pequeños suelen agravarse debido a la indiferencia internacional. Sin embargo, en el caso de la República Centroafricana (RCA), el problema es ligeramente distinto. Hay una importante presencia internacional en este Estado, pero los actores principales han decidido mantenerse al margen y esperar en vez de intervenir activamente en la crisis.




api

Rapid-Release Griffithsin Fibers for the Dual Prevention of HSV-2 and HIV-1 Infections [Antiviral Agents]

The biologic Griffithsin (GRFT) has recently emerged as a candidate to safely prevent sexually transmitted infections (STIs) including human immunodeficiency virus (HIV-1) and herpes simplex virus 2 (HSV-2). However, to date, there are few delivery platforms that are available to effectively deliver biologics to the female reproductive tract (FRT). The goal of this work was to evaluate rapid-release polyethylene oxide (PEO), polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) fibers, that incorporate GRFT, in in vitro (HIV-1 and HSV-2) and in vivo (HSV-2) infection models. GRFT loading was determined via ELISA, and the bioactivity of GRFT fibers was assessed using in vitro HIV-1 pseudovirus and HSV-2 plaque assays. Afterwards, the efficacy of GRFT fibers was assessed in a murine model of lethal HSV-2 infection. Finally, murine reproductive tracts and vaginal lavages were evaluated for histology and cytokine expression, 24 and 72 hr after fiber administration, to determine safety. All rapid-release formulations achieved high levels of GRFT incorporation and were completely efficacious against in vitro HIV-1 and HSV-2 infections. Importantly, all rapid-release GRFT fibers provided potent protection in a murine model of HSV-2 infection. Moreover, histology and cytokine levels, evaluated from collected murine reproductive tissues and vaginal lavages treated with blank fibers, showed no increased cytokine production or histological aberrations, demonstrating the preliminary safety of rapid-release GRFT fibers in vaginal tissue.




api

Novel ionophores active against La Crosse virus identified through rapid antiviral screening [Antiviral Agents]

Bunyaviruses are significant human pathogens, causing diseases ranging from hemorrhagic fevers to encephalitis. Among these viruses, La Crosse virus (LACV), a member of the California serogroup, circulates in the eastern and midwestern United States. While LACV infection is often asymptomatic, dozens of cases of encephalitis are reported yearly. Unfortunately, no antivirals have been approved to treat LACV infection. Here, we developed a method to rapidly test potential antivirals against LACV infection. From this screen, we identified several potential antiviral molecules, including known antivirals. Additionally, we identified many novel antivirals that exhibited antiviral activity without affecting cellular viability. Valinomycin, a potassium ionophore, was among our top targets. We found that valinomycin exhibited potent anti-LACV activity in multiple cell types in a dose-dependent manner. Valinomycin did not affect particle stability or infectivity, suggesting that it may preclude virus replication by altering cellular potassium ions, a known determinant of LACV entry. We extended these results to other ionophores and found that the antiviral activity of valinomycin extended to other viral families including bunyaviruses (Rift Valley fever virus, Keystone virus), enteroviruses (Coxsackievirus, rhinovirus), flavirivuses (Zika), and coronaviruses (HCoV-229E and MERS-CoV). In all viral infections, we observed significant reductions in virus titer in valinomycin-treated cells. In sum, we demonstrate the importance of potassium ions to virus infection, suggesting a potential therapeutic target to disrupt virus replication.

Importance No antivirals are approved for the treatment of bunyavirus infection. The ability to rapidly screen compounds and identify novel antivirals is one means to accelerate drug discovery for viruses with no approved treatments. We used this approach to screen hundreds of compounds against La Crosse virus, an emerging bunyavirus that causes significant disease, including encephalitis. We identified several known and previously unidentified antivirals. We focused on a potassium ionophore, valinomycin, due to its promising in vitro antiviral activity. We demonstrate that valinomycin, as well as a selection of other ionophores, exhibits activity against La Crosse virus as well as several other distantly related bunyaviruses. We finally observe that valinomycin has activity against a wide array of human viral pathogens, suggesting that disrupting potassium ion homeostasis with valinomycin may be a potent host pathway to target to quell virus infection.




api

Fin24.com | Investors struggling to find returns and protect their capital in unusual prevailing climate

Extremely low or negative yields in global markets make it challenging for investors to generate meaningful returns, says Brian McMillan of Investec Structured Products.




api

PHP Wikipedia API

Package:
Summary:
Edit and retrieve content from Wikipedia
Groups:
Author:
Description:
This class can be used to edit and retrieve content from Wikipedia...

Read more at https://www.phpclasses.org/package/11609-PHP-Edit-and-retrieve-content-from-Wikipedia.html#2020-04-17-12:29:39




api

Minimal Twilio PHP API Send SMS

Package:
Summary:
Send SMS messages using the Twilio API
Groups:
Author:
Description:
This package can be used to send SMS messages using the Twilio API...

Read more at https://www.phpclasses.org/package/11620-PHP-Send-SMS-messages-using-the-Twilio-API.html#2020-04-19-01:34:29




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PHP Zoom API

Package:
Summary:
Access Zoom video conference application REST API
Groups:
Author:
Description:
This class can be used to access Zoom video conference application REST API...

Read more at https://www.phpclasses.org/package/11621-PHP-Access-Zoom-video-conference-application-REST-API.html#2020-04-20-07:39:22




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Wintrust Financial Corporation to Present at RBC Capital Markets Global Financial Institutions Conference on March 10, 2020

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.




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10 Ways to Use Zapier to Automate Your Work

No more copying and pasting tasks from email to your to-do list or chasing after customers via email. Zapier can automate these tasks and many others, too. Here's how.




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Fin24.com | Capital growth still disappoints

Although cash should still be seen as a "trashy" asset class, investors do not have many other places to park their money, says an analyst.




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Fin24.com | Dividends: Reaping what you know

The table shows 100 companies finished 2009 on dividend yields in excess of 5%.




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Lebanese banks draft national rescue plan that keeps some of their capital

Lebanese banks are working on a national financial rescue plan that would preserve some of their capital rather than writing it all off as outlined in a government program, the banking association head said.




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Announcement of Capital and Business Alliance with XTIA Ltd.




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Xiaomi Mi 10 5G With 108-Megapixel Camera Launched in India

Mi 10 5G has been officially launched in India. The new Mi smartphone by Xiaomi is powered by a Qualcomm Snapdragon 865 SoC and is available with up to 256GB of onboard storage.