Wien : W. Braumuller, 1878.

London : Black, Young & Young, 1835.

Munchen : J.F. Lehmann, 1892.

Berlin : A. Hirschwald, 1865.

Berlin : A. Hirschwald, 1854.

Wien : Urban & Schwarzenberg, 1879.

Berlin : A. Hirschwald, 1872.

Berlin : A. Hirschwald, 1870.

Berlin : A. Hirschwald, 1886.

Berlin : A. Hirschwald, 1879.

Halle : M. Niemeyer, 1895.

Wien : Doll, 1817-

Leipzig : F. Deuticke, 1891.

Jena : Fischer, 1905.

Cassel : T. Fischer, 1884.

Leipzig : W. Engelmann, 1866.

Leipzig : Vogel, 1904.

Stuttgart : Enke, 1904.

Stuttgart : Enke, 1905.

Leipzig : F.C.W. Vogel, 1891.

Berlin : A. Hirschwald, 1870.

Paris : Georges Carre, 1896.

Berlin : Heuser, 1894.

Berlin : A. Hirschwald, 1896-1900.

Tubingen : H. Laupp, 1889.

How to tune in to Tom Wilson's best games on Sunday.

Alex Ovechkin can lay claim as the best Capitals player to wear No. 8, but what about the rest of the jersey numbers? Who are the best Caps for every number?

Alex Ovechkin can lay claim as the best Capitals player to wear No. 8, but what about the rest of the jersey numbers? Who are the best Caps for every number?

The Washington Capitals on Friday placed Brendan Leipsic on unconditional waivers to terminate his contract after he made disparaging comments about women and teammates in a private social media chat. In a conversation involving his brother and Florida Panthers minor leaguer Jack Rodewald, Leipsic commented on the physical appearances of Vancouver forward Tanner Pearson's wife and Edmonton captain Connor McDavid's girlfriend. The NHL called it ''inexcusable conduct'' and said it would address the matter with the Capitals and Panthers.

The Washington Capitals have placed former Winterhawks wing Brendan Leipsic on unconditional waivers with the intention of his contract being terminated after private messages revealed misogynistic comments. > The Washington Capitals have placed Brendan Leipsic on unconditional waivers for purposes of terminating his contract.https://t.co/UnADibu2yQ

The Washington Capitals decided to part ways with forward Brendan Leipsic on Friday after he made vulgar and disparaging comments on an social media chat group. The 25-year old Canadian was placed on waivers by the NHL club after his Instagram group chat messages were leaked earlier this week. The chat included inappropriate remarks about Edmonton Oilers forward Connor McDavid's girlfriend and the wife of Vancouver Canucks player Tanner Pearson.

Troy Brouwer scored the game-winning goal as the Capitals beat the Blackhawks at Nationals Park on Jan. 1, 2015. Relive the excitement with Monday night's replay.

Washington announced it is terminating the contract of forward Brendan Leipsic after his mysogynistic comments on Instagram were leaked.

2019

Middletown, DE : Amazon, 2018.

Rockville, Maryland : National Institute on Drug Abuse, 1995.

We focus on the challenge of finding a diverse collection of quality solutions on complex continuous domains. While quality diver-sity (QD) algorithms like Novelty Search with Local Competition (NSLC) and MAP-Elites are designed to generate a diverse range of solutions, these algorithms require a large number of evaluations for exploration of continuous spaces. Meanwhile, variants of the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) are among the best-performing derivative-free optimizers in single-objective continuous domains. This paper proposes a new QD algorithm called Covariance Matrix Adaptation MAP-Elites (CMA-ME). Our new algorithm combines the self-adaptation techniques of CMA-ES with archiving and mapping techniques for maintaining diversity in QD. Results from experiments based on standard continuous optimization benchmarks show that CMA-ME finds better-quality solutions than MAP-Elites; similarly, results on the strategic game Hearthstone show that CMA-ME finds both a higher overall quality and broader diversity of strategies than both CMA-ES and MAP-Elites. Overall, CMA-ME more than doubles the performance of MAP-Elites using standard QD performance metrics. These results suggest that QD algorithms augmented by operators from state-of-the-art optimization algorithms can yield high-performing methods for simultaneously exploring and optimizing continuous search spaces, with significant applications to design, testing, and reinforcement learning among other domains.

Spanish translation of "Frequently asked questions on market risk capital requirements" by the Basel Committee, March 2018.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

Phototransduction in Drosophila is mediated by phospholipase C (PLC) and Ca²⁺-permeable TRP channels, but the function of endoplasmic reticulum (ER) Ca²⁺ stores in this important model for Ca²⁺ signaling remains obscure. We therefore expressed a low affinity Ca²⁺ indicator (ER-GCaMP6-150) in the ER, and measured its fluorescence both in dissociated ommatidia and in vivo from intact flies of both sexes. Blue excitation light induced a rapid (tau ~0.8 s), PLC-dependent decrease in fluorescence, representing depletion of ER Ca²⁺ stores, followed by a slower decay, typically reaching ~50% of initial dark-adapted levels, with significant depletion occurring under natural levels of illumination. The ER stores refilled in the dark within 100–200 s. Both rapid and slow store depletion were largely unaffected in InsP₃ receptor mutants, but were much reduced in trp mutants. Strikingly, rapid (but not slow) depletion of ER stores was blocked by removing external Na⁺ and in mutants of the Na⁺/Ca²⁺ exchanger, CalX, which we immuno-localized to ER membranes in addition to its established localization in the plasma membrane. Conversely, overexpression of calx greatly enhanced rapid depletion. These results indicate that rapid store depletion is mediated by Na⁺/Ca²⁺ exchange across the ER membrane induced by Na⁺ influx via the light-sensitive channels. Although too slow to be involved in channel activation, this Na⁺/Ca²⁺ exchange-dependent release explains the decades-old observation of a light-induced rise in cytosolic Ca²⁺ in photoreceptors exposed to Ca²⁺-free solutions.

SIGNIFICANCE STATEMENT Phototransduction in Drosophila is mediated by phospholipase C, which activates TRP cation channels by an unknown mechanism. Despite much speculation, it is unknown whether endoplasmic reticulum (ER) Ca²⁺ stores play any role. We therefore engineered flies expressing a genetically encoded Ca²⁺ indicator in the photoreceptor ER. Although NCX Na⁺/Ca²⁺ exchangers are classically believed to operate only at the plasma membrane, we demonstrate a rapid light-induced depletion of ER Ca²⁺ stores mediated by Na⁺/Ca²⁺ exchange across the ER membrane. This NCX-dependent release was too slow to be involved in channel activation, but explains the decades-old observation of a light-induced rise in cytosolic Ca²⁺ in photoreceptors bathed in Ca²⁺-free solutions.

When one ponders the vast stretches of wheat being culled from the swaths of farmland in the Ukraine the mind doesn’t quickly leap to the thought of a pastry shop in Cairo. Or a bakery in Indonesia.  

A recent excavation located the first physical evidence of the capital of the Maya kingdom of Sak Tz'i', founded in 750 B.C.