BORIS Johnson has said Britain needs the "same spirit of national endeavour" to defeat the coronavirus as Second World War veterans demonstrated to topple Adolf Hitler.

A district reading intervention specialist explains how she makes sense of a sea of data to foster more proficient readers.

It's resulted in a creepy Orwellian environment where Google, Facebook, Amazon, and others have replaced Big Brother.

Expert says labels, books, and writing centers all help with skill development

Illinois Gov. Bruce Rauner said that half of Chicago teachers were "illiterate" in a 2011 email, recently released to a city newspaper.

Dozens of states offer the seal of biliteracy, but more than 80 percent of students who earn the honor are concentrated in just five states, a new report reveals.

The pathophysiology of pediatric sports-related concussion (SRC) is largely unknown. Studies of concussed adults have identified neuronal and axonal injury and time-limited metabolic disruptions. An experimental animal model has also demonstrated physiologic perturbations, including reduced cerebral blood flow (CBF).

Using MRI techniques, we found no evidence of neuronal, axonal, or metabolic disruptions in 12 children with SRC. However, when compared with controls, statistically significant alterations in CBF were defined and frequently persisted beyond 30 days after injury. (Read the full article)

High-grade vesicoureteral reflux is a risk factor for impaired renal function. Diagnosis by voiding cystourethrography is invasive and highly uncomfortable. As only a minority of children show high-grade vesicoureteral reflux, this exposes the majority to unnecessary distress.

This case-control study proved that high-grade vesicoureteral reflux is identifiable with high sensitivity using urinary proteome analysis, based on capillary electrophoresis coupled to mass spectrometry in a cohort suspected of having vesicoureteral reflux, thus sparing the majority of children from invasive diagnostics. (Read the full article)

Preterm, growth-restricted infants are at high risk of necrotizing enterocolitis (NEC). NEC occurs most frequently in infants who have received enteral feeds. It is common practice to delay introduction of enteral feeds in these infants.

Early introduction of enteral feeds results in earlier achievement of full enteral feeding. Early feeding is not associated with a higher risk of NEC. Delayed feeding is associated with a higher risk of cholestasis. (Read the full article)

In utero exposure to glucocorticoids in animal models influences vascular development. Studies in young adults have shown that exposure to antenatal glucocorticoids alters glucose metabolism, but it is not known whether there are any cardiovascular effects.

Glucocorticoid exposure is associated with a localized increase in aortic arch stiffness, similar in magnitude to term-born individuals a decade older. The change in stiffness does not relate to changes in glucose metabolism that were also evident in this cohort. (Read the full article)

Bilateral acute otitis media (AOM) is considered more severe than unilateral AOM, and several guidelines recommend more active management of bilateral AOM. However, severity of symptoms and otoscopic signs of bilateral and unilateral AOM have previously not been comprehensively studied.

Bilateral AOM seems to be clinically only a slightly more severe illness than unilateral AOM. When assessing AOM severity, bilaterality should not be used as a determining criterion; instead, the child’s symptoms together with otoscopic signs should also be acknowledged. (Read the full article)

The ideal management of children with vesicoureteral reflux (VUR) remains a source of debate. There is little evidence to support many of the current management practices for children with VUR who have had 1 or 2 urinary tract infections.

Baseline associations, including bladder and bowel dysfunction and imaging studies, from the largest randomized, controlled trial conducted to date aimed at assessing the value of antimicrobial prophylaxis in children with urinary tract infection and VUR are presented. (Read the full article)

Prenatal and postnatal organophosphate (cholinesterase inhibitor) pesticide exposure has been associated with delays in attention, memory, intelligence, and inhibitory control. Two recent studies reported decreased attention and working memory with greater exposure to organophosphates in boys but not in girls.

This is the first study to report associations between decreased acetylcholinesterase activity, a stable marker of cholinesterase inhibitor pesticide exposure, and lower overall neurodevelopment, attention, inhibitory control, and memory. These associations were present in boys but not in girls. (Read the full article)

Preterm infants dependent on parenteral nutrition are vulnerable to deficits in early postnatal nutritional intake. This coincides with a period of suboptimal head growth. Observational studies indicate that poor nutritional intake is associated with suboptimal head growth and neurodevelopmental outcome.

This study provides randomized controlled trial evidence that head growth failure in the first 4 weeks of life can be ameliorated with early nutritional intervention. Early macronutrient intake can be enhanced by optimizing a standardized, concentrated neonatal parenteral nutrition regimen. (Read the full article)

The familial nature of vesicoureteral reflux (VUR) is well recognized. Several studies have shown that siblings of children with VUR are at much higher risk for reflux than the general pediatric population with a reported prevalence between 26% and 50%.

There is increased risk of renal cortical abnormalities in siblings with a previous urinary tract infection, siblings with high-grade VUR, and siblings >1 year of age. This information may be useful when counseling parents about the risk of familial VUR. (Read the full article)

Hospitalized pediatric patients are often exposed to many medications during an inpatient admission. Drug–drug interactions may increase the risk of developing medication-related adverse drug events, leading to serious clinical morbidity and mortality.

Exposure to "major" potential drug–drug interactions occurs in 41% of pediatric hospitalizations in children’s hospitals. One-half of all these exposures were due to less common specific drug pairs (≤3% of patients exposed per hospital day) and thus may be less clinically familiar. (Read the full article)

Pennsylvania College of Technology dental hygiene students and volunteer dental professionals will provide free dental hygiene services to veterans, members of the armed services, and their dependents on Saturday, April 4.

Catch your opponents cold by improving your team's counterattack with this training exercise.

Like other Americans, liberal and conservative teachers perceive news sources' credibility differently. How does that affect their teaching of media literacy?

Durlobactam (DUR, also known as ETX2514) is a novel β-lactamase inhibitor with broad activity against Ambler class A, C, and D β-lactamases. Addition of DUR to sulbactam (SUL) in vitro restores SUL activity against clinical isolates of Acinetobacter baumannii. The safety and pharmacokinetics (PK) of DUR alone and with SUL and/or imipenem/cilastatin (IMI/CIL) were evaluated in healthy subjects. This was a randomized, placebo-controlled study. In Part A, subjects including an elderly cohort (DUR 1 g) received single ascending doses of DUR 0.25-8 g. In Part B, multiple ascending dose of DUR 0.25-2 g were administered every 6 hours (q6h) for 29 doses. In Parts C and D, the drug-drug interaction (DDI) potential, including safety, of DUR (1 g) with SUL (1 g) and/or IMI/CIL (0.5/0.5 g) was investigated after single and multiple doses. Plasma and urine concentrations of DUR, SUL, and IMI/CIL were determined. Among 124 subjects, DUR was generally safe and well tolerated either alone or in combination with SUL and/or IMI/CIL. After single and multiple doses, DUR demonstrated linear dose proportional exposure across the studied dose ranges. Renal excretion was a predominant clearance mechanism. No drug:drug interaction potential was identified between DUR and SUL and/or IMI/CIL. SUL-DUR, 1 g (of each component) administered q6h with a 3 hour IV infusion, is under development for the treatment of serious infections due to A. baumannii.

Ebola Virus (EBOV) is among the most devastating pathogens causing fatal hemorrhagic fever in humans. The 2013–2016 epidemics resulted in over 11000 deaths, while another outbreak is currently ongoing. Since there is no FDA-approved drug so far to fight EBOV infection, there is an urgent need to focus on drug discovery. Considering the tight correlation between the high EBOV virulence and its ability to suppress the type-I Interferon (IFN-I) system, identifying molecules targeting viral protein VP24, one of the main virulence determinants blocking IFN response, is a promising novel anti-EBOV therapy approach. Hence, in the effort of finding novel EBOV inhibitors, a screening of a small set of flavonoids was performed, showing that Quercetin and Wogonin can suppress the VP24 effect on IFN-I signaling inhibition. The mechanism of action of the most active compound, Quercetin, showing an IC₅₀ value of 7.4 μM, was characterized to significantly restore the IFN-I signaling cascade, blocked by VP24, by directly interfering with the VP24 binding to karyopherin-α and thus restoring P-STAT1 nuclear transport and IFN genes transcription. Quercetin significantly blocked viral infection, specifically targeting EBOV VP24 anti-IFN-I function. Overall, Quercetin is the first identified inhibitor of the EBOV VP24 anti-IFN function, representing a molecule interacting with a viral binding site that is very promising for further drug development aiming to block EBOV infection at the early steps.

Money Smart Week SA, a financial literacy campaign aimed at motivating and empowering South Africans to become more educated about their finances, is taking place from March 23 to 28, 2020.

Metropolitan is sponsoring a financial literacy short course hosted on FunDza, an online literacy portal dedicated to helping South Africans better their skills.

The popular Netgear Nighthawk R6700 wireless router is just $68 right now. Plus, you can save on a 32-inch Dell monitor and Apple AirPods with the wireless charging case.

Graham A. Colditz
Jul 1, 1995; 96:29-35
ARTICLES

Like other Americans, liberal and conservative teachers perceive news sources' credibility differently. How does that affect their teaching of media literacy?

Penn State Fayette, The Eberly Campus has introduced a new phone-based resource for area veterans.

The exercise yard lies just below my window. Every day I pace around it 12 times before returning to solitary confinement. The King George V park in Bearsden, of course, does not resemble the interior of any jail and the restrictions on my liberty are minor in comparison to those who have been imprisoned down the ages.

The Sokolov-Miller Family Financial and Life Skills Center at Penn State has a slate of programming for Financial Literacy Month this April and is offering help to anyone in the University community who is anxious about their financial future.

In this first extract from the new UEFA EURO 2016 technical report, the expert panel reflect on the decreasing proportion of goals scored from counterattacks.

Today, 98% of households with 2- to 8-year-old children include a mobile device, like smartphones, tablets, and iPods or other smart-mobile devices, an increase from 75% in 2013. We are really connected, but not connecting at all.

A new report from Student Achievement Partners claims that the popular reading program from literacy giant Lucy Calkins doesn't align to evidence-based practice. The review is the first in a new series that will evaluate reading programs against the scientific research base.

At a roundtable discussion in Washington, D.C., leaders advocated for states to play a stronger role in championing science-backed instruction and translating research into practice, focusing on levers like teacher training, certification, and system-wide professional learning.

In India and China, indigenous drug manufacturers market arbitrarily combined parenteral β-lactam and β-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy assessments being undertaken. Such unorthodox combinations compromise clinical outcomes and also potentially contribute to resistance development.

"At the end of the class, over tea and mini-cakes, we take time to get to know them, to help them with administrative tasks or to discuss Bible stories," shares Louise.

Students and faculty members at Penn State Behrend's Black School of Business are contributing to and assessing a financial literacy curriculum that is being taught at nearly 400 high schools in eight states.

As the wife of former President George H.W. Bush, she used the bully pulpit of her office as first lady to advance the issue on behalf of both for children and parents.

Two adults were significantly impacted by learning to read and write in recent adult literacy classes run by OM in Bangladesh.

Loans for Heroes, which provides veterans with reduced mortgage rates, has funded $3.3 million in mortgage loans since it launched in May of 2012.

On any given night, 100 Veterans in Delaware are homeless. For seven years, Henry Smith was one of them. An honorably discharged Veteran of the U.S. Army, Mr. Smith lived off and on in rooming houses and in 2015 was referred by the Wilmington VA Medical Center to Connections’ VA-funded Supportive Services for Veteran Families (SSVF) program. SSVF provides a range of supportive services and assistance to help Veterans secure housing stability. He entered the program on November 5, 2015 and was housed on December 3. “After being homeless for seven years, I thought housing was impossible,” said Mr. Smith. “My apartment is quiet, clean, and well-kept. Connections worked hard to establish a rapport with the landlord, and I hope more vets get the opportunity to be housed.”

The Trust Fund helps Delaware veterans cover emergency expenses DOVER, DE – Delaware State Housing Authority employees have raised $1,580 for the Delaware Veterans Trust Fund, an account created in 2013 to help Delaware veterans pay for emergency costs, including medical expenses, utility bills and home repairs. Delaware’s Commission of Veterans Affairs administers the Trust […]

Governor Markell announced on Friday that Delaware has effectively ended veteran homelessness, receiving certification last month from the United States Interagency Council on Homelessness, the U.S. Department of Housing and Urban Development and the U.S. Department of Veterans Affairs.

Delaware joined the national effort to house homeless veterans in 2015 WILMINGTON, Del. – Governor John Carney announced on Thursday that Delaware has now housed more than 500 formerly homeless veterans since joining the national Mayors Challenge to End Veteran Homelessness in 2015. “Our veterans served because of a heartfelt duty to country. We owe […]

Worldwide, teachers may struggle to help students learn computer skills, finds a study of computer literacy rates across a dozen countries.

Having access to a computer or tablet doesn't necessarily make students computer literate, according to a study of computer-literacy skills across countries.

The 2017 results of the Program for the International Assessment of Adult Competencies finds that America's adult workforce is no more skillful in reading, math, or digital problem-solving than it was five years ago.

Bank Audi proposed using government assets as collateral to offset the losses of the Central Bank and commercial banks that were the result of lending to the state.

When/Where: Friday, September 22, 2017 -Starting at 9am – 2pm. Schutte Park, 10 Electric Avenue, Dover, DE  19904 We would like to invite Delaware Veterans to attend our annual Stand Down event this year. Community and VA Services will be provided to all veterans. Federal, State and local service providers will be helping with housing, medical, dental, […]

Dover’s Veterans Day Parade – Saturday, Nov. 4th at 9:30 am – Downtown Dover (Loockerman St. to Federal St.) The City of Dover is hosting this year’s Veterans Day Parade along with the Delaware Commission of Veterans Affairs. Please join us Saturday morning on November 4th at 9:30am. For those who are interested in participating, please […]