by Brad McGregor | Prague Daily Monitor

Not only are US citizens living overseas able to vote in all the various US elections, when it comes to Democrats, they are also able to participate in the exciting primary process. Next week, those Americans will get their chance to go to the polls as part the Global Democrats Abroad Primary, which is held alongside 15 other state primaries on Super Tuesday—a day that usually decides the Democrats' nominee.

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A Hong Kong police officer arrested in connection with the seizure of 25kg of drugs worth HK$12 million is believed to have orchestrated its theft from the scene of a bust he was personally in charge of last week, according to police sources.If true, it would mean the announced record seizure of 296kg of Ice, a form of methamphetamine, actually involved 321kg.Sources said the station sergeant, who was arrested along with a constable in connection with the missing drugs, was in charge of the…

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Artificial intelligence could be enormously beneficial to society, and it could also lead to catastrophe. Governments can play a role determining the outcome of AI’s development.

SST and UMC Announce Qualification of Embedded SuperFlash® Technology on 40 nm CMOS Process

SST and SK hynix system ic Partner to Expand Availability of Embedded SuperFlash Technology

SST Announces Automotive Grade 1 Qualification of Embedded SuperFlash® Memory on UMC’s 55 nm Platform

Enhancing System Architecture Implementation for AI Applications, Microchip Delivers its Analog Embedded SuperFlash® Technology

Their unique blend of electric and magnetic properties was long thought impossible. Now multiferroics are shaking up fields from dark matter hunting to finding cancer

In a universe that unthinkingly follows the rules, human agency is an anomaly. Can physics ever make sense of our power to change the physical world at will?

A young boy chooses a nurse as the superhero he wants to play with over Batman and Spiderman in a new artwork by Banksy that encapsulates the gratitude Britons have felt toward the country's National...

The last "supermoon" of 2020 rose in the night sky on Thursday over a world beginning to re-emerge after weeks of coronavirus-related lockdowns.

The next generation of geothermal plants will unlock more of Earth's bountiful, underground energy and could allow the technology to finally fulfil its promise

An analysis of pollen suggests cannabis evolved on the Tibetan Plateau, not far from a cave that was frequented by our ancient Denisovan cousins

Diamonds that formed twice as deep as normal contain evidence of a pristine hunk of original Earth rock hiding deep underground

Reuters blogger Felix Salmon takes to kids’ toys to explain one of the most vexing problems facing Washington: the fiscal cliff. (December 12, 2012)

A young boy chooses a nurse as the superhero he wants to play with over Batman and Spiderman in a new artwork by Banksy that encapsulates the gratitude Britons have felt toward the country's National Health Service during the coronavirus crisis.

Their unique blend of electric and magnetic properties was long thought impossible. Now multiferroics are shaking up fields from dark matter hunting to finding cancer

So what if Rudolph can’t really fly? He and the herd have some truly amazing evolutionary adaptations that could inspire new treatments for human diseases

In a universe that unthinkingly follows the rules, human agency is an anomaly. Can physics ever make sense of our power to change the physical world at will?

A young boy chooses a nurse as the superhero he wants to play with over Batman and Spiderman in a new artwork by Banksy that encapsulates the gratitude Britons have felt toward the country's National Health Service during the coronavirus crisis.

Bamboo is a renewable material that when microwaved becomes stronger by weight than steel or concrete – which could make it ideal for constructing buildings, cars and planes

Title: With 'Super Gonorrhea' a Threat, Many Still Getting Wrong Antibiotics
Category: Health News
Created: 4/27/2018 12:00:00 AM
Last Editorial Review: 4/30/2018 12:00:00 AM

Title: AHA News: Being an African American 'Superwoman' Might Come With a Price
Category: Health News
Created: 2/11/2020 12:00:00 AM
Last Editorial Review: 2/12/2020 12:00:00 AM

Title: Too Much Super Bowl Can Mean Too Little Sleep
Category: Health News
Created: 1/31/2020 12:00:00 AM
Last Editorial Review: 1/31/2020 12:00:00 AM

ABSTRACT

Humans encode proteins, called restriction factors, that inhibit replication of viruses such as HIV-1. The members of one family of antiviral proteins, apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; shortened here to A3), act by deaminating cytidines to uridines during the reverse transcription reaction of HIV-1. The A3 locus encodes seven genes, named A3A to A3H. These genes have either one or two cytidine deaminase domains, and several of these A3s potently restrict HIV-1. A3C, which has only a single cytidine deaminase domain, however, inhibits HIV-1 only very weakly. We tested novel double domain protein combinations by genetically linking two A3C genes to make a synthetic tandem domain protein. This protein created a "super restriction factor" that had more potent antiviral activity than the native A3C protein, which correlated with increased packaging into virions. Furthermore, disabling one of the active sites of the synthetic tandem domain protein resulted in an even greater increase in the antiviral activity—recapitulating a similar evolution seen in A3F and A3G (double domain A3s that use only a single catalytically active deaminase domain). These A3C tandem domain proteins do not have an increase in mutational activity but instead inhibit formation of reverse transcription products, which correlates with their ability to form large higher-order complexes in cells. Finally, the A3C-A3C super restriction factor largely escaped antagonism by the HIV-1 viral protein Vif.

IMPORTANCE As a part of the innate immune system, humans encode proteins that inhibit viruses such as HIV-1. These broadly acting antiviral proteins do not protect humans from viral infections because viruses encode proteins that antagonize the host antiviral proteins to evade the innate immune system. One such example of a host antiviral protein is APOBEC3C (A3C), which weakly inhibits HIV-1. Here, we show that we can improve the antiviral activity of A3C by duplicating the DNA sequence to create a synthetic tandem domain and, furthermore, that the proteins thus generated are relatively resistant to the viral antagonist Vif. Together, these data give insights about how nature has evolved a defense against viral pathogens such as HIV.

Despite the ecological relevance of diatoms, many aspects of their photosynthetic machinery remain poorly understood. Diatoms differ from the green lineage of oxygenic organisms by their photosynthetic pigments and light-harvesting complex (Lhc) proteins, the latter of which are also called fucoxanthin-chlorophyll proteins (FCP). These are composed of three groups of proteins: Lhcf as the main group, Lhcr that are PSI associated, and Lhcx that are involved in photoprotection. The FCP complexes are assembled in trimers and higher oligomers. Several studies have investigated the biochemical properties of purified FCP complexes, but limited knowledge is available about their interaction with the photosystem cores. In this study, isolation of stable supercomplexes from the centric diatom Thalassiosira pseudonana was achieved. To preserve in vivo structure, the separation of thylakoid complexes was performed by native PAGE and sucrose density centrifugation. Different subpopulations of PSI and PSII supercomplexes were isolated and their subunits identified. Analysis of Lhc antenna composition identified Lhc(s) specific for either PSI (Lhcr 1, 3, 4, 7, 10–14, and Lhcf10) or PSII (Lhcf 1–7, 11, and Lhcr2). Lhcx6_1 was reproducibly found in PSII supercomplexes, whereas its association with PSI was unclear. No evidence was found for the interaction between photosystems and higher oligomeric FCPs, comprising Lhcf8 as the main component. Although the subunit composition of the PSII supercomplexes in comparison with that of the trimeric FCP complexes indicated a close mutual association, the higher oligomeric pool is only weakly associated with the photosystems, albeit its abundance in the thylakoid membrane.

Key Points

High magnetic fields have revealed a surprisingly small Fermi surface in underdoped cuprates, possibly resulting from Fermi-surface reconstruction due to an order parameter that breaks translational symmetry of the crystal lattice. A crucial issue concerns the doping extent of such a state and its relationship to the principal pseudogap and...

Laterites preserved on both sides of the Western Ghats Escarpment of Peninsular India have formed by long-term lateritic weathering essentially after India–Seychelles continental break-up following Deccan Traps emplacement (c. 63 myr ago). Supergene manganese ores of the Western Ghats were formed on Late Archean manganese protores. Among Mn oxides composing the ores, cryptomelane (K-rich Mn oxide) was characterized and dated by ⁴⁰Ar/³⁹Ar geochronology. Measured ages complement those previously obtained in other South Indian manganese ores from the hinterland plateau and further document three major weathering periods, c. 53–44, c. 39–22 and c. 14–10 Ma, the last being documented for the first time in India. These periods coincide with global palaeoclimatic proxies and date the lateritic weathering of three successive palaeolandscapes of the Western Ghats that evolved under slow denudation (c. 8 m Ma^–1) over the last 44 myr and were mostly incised during the Neogene (<22 Ma). This indicates that the Western Ghats are a relict of a South Indian plateau preserved at the headwaters of very long east-flowing river systems and above the Western Ghats Escarpment. Topography and denudation history of this landscape do not require Neogene tilt of the Peninsula as recently proposed.

Supplementary material: Full details of field and sample description, methods and analytical data including electron probe microanalyses of cryptomelane, and isotopic analyses and degassing spectra of irradiated cryptomelane grains are available at https://doi.org/10.6084/m9.figshare.c.4726661

In children requiring lopinavir coformulated with ritonavir in a 4:1 ratio (lopinavir-ritonavir-4:1) and rifampin, adding ritonavir to achieve a 4:4 ratio with lopinavir (LPV/r-4:4) overcomes the drug-drug interaction. Possible drug-drug interactions within this regimen may affect abacavir concentrations, but this has never been studied. Children weighing <15 kg needing rifampin and LPV/r-4:4 were enrolled in a pharmacokinetic study and underwent intensive pharmacokinetic sampling on 3 visits: (i) during the intensive and (ii) continuation phases of antituberculosis treatment with LPV/r-4:4 and (iii) 1 month after antituberculosis treatment completion on LPV/r-4:1. Pharmacometric modeling and simulation were used to compare exposures across weight bands with adult target exposures. Eighty-seven children with a median (interquartile range) age and weight of 19 (4 to 64) months and 8.7 (3.9 to 14.9) kg, respectively, were included in the abacavir analysis. Abacavir pharmacokinetics were best described by a two-compartment model with first-order elimination and transit compartment absorption. After allometric scaling adjusted for the effect of body size, maturation could be identified: clearance was predicted to be fully mature at about 2 years of age and to reach half of this mature value at about 2 months of age. Abacavir bioavailability decreased 36% during treatment with rifampin and LPV/r-4:4 but remained within the median adult recommended exposure, except for children in the 3- to 4.9-kg weight band, in which the exposures were higher. The observed predose morning trough concentrations were higher than the evening values. Though abacavir exposure significantly decreased during concomitant administration of rifampin and LPV/r-4:4, it remained within acceptable ranges. (This study is registered in ClinicalTrials.gov under identifier NCT02348177.)

Super Flower Moon 2020 time आज इस साल का आखिरी सुपरमून (Supermoon 2020) देखा जाएगा। मई माह में इस सुपर मून को सुपर फ्लॉवर मून (Super Flower Moon) भी कहा जाता है।

7 मई को साल का आखिरी सुपरमून है। सुपरमून उसे कहते हैं जब चंद्रमा अपनी कक्षा में चक्कर काटते हुए पृथ्वी के सबसे करीब आ जाता है। चांद के पृथ्वी के नजदीक आने पर चंद्रमा का आकार और चमक काफी बढ़ जाती है।

Durian fruits, famous for their bad smell, could be used to make electrodes in ultra-fast chargers for electric cars and gadgets

Bamboo is a renewable material that when microwaved becomes stronger by weight than steel or concrete – which could make it ideal for constructing buildings, cars and planes

A strange supernova that’s 100 times brighter than it should be has long been a mystery, but it may be explained by the explosion slamming into a cloud of gas

Astronomers have spotted a star that is exploding with a brightness 100 times less than expected – and it’s a mystery exactly why the explosion is so dim

When the Soviet Union lands on the moon first people in the US are shocked. But For All Mankind provides an even bigger surprise when one cosmonaut's identity is revealed, says Emily Wilson

Exoplanet WASP-76b, which is about 390 light years from the solar system, has a strange iron signature in its atmosphere, suggesting the metal is raining down on the planet's night side

Some black holes are way bigger than we can explain, and they may have come from supermassive stars that formed by devouring the other stars around them

An explosion 4.6 billion light years away has released 10 times more energy than the sun will put out in its lifetime, making it the most extreme supernova ever found

Argonne will use the CS-1 to help discover cancer therapies and understand colliding blackholes

Record low bond yields are pushing superannuation funds and insurers into alternative investments.

Kate Middleton is pregnant! I mean sure, there’s news about a successor to Planescape: Torment. And yeah there’s potentially a new Star Ocean game. But...

It’s a special edition of the RPGCast this week. Jon, Alex, Anna Marie, and Chris appreciate loot, bank Pokémon, link between and transfer worlds in...

Researchers have uncovered how bats can carry the Middle East respiratory syndrome (MERS) coronavirus without getting sick -- research that could shed light on how coronaviruses make the jump to humans and other animals.

A princess seeking revenge after her royal privileges are revoked? A drifter trying to get away from her awful father? Or maybe a guardian of Captain Britain?

Now that Meghan Markle has had her royal purse strings cut, the time has come for her to prove that she is capable of making a living on her own merits. And, ever the everywoman, it has been reported that Markle’s first step is exactly the same one that we’d all make upon finding ourselves suddenly short of money – she has instructed her agent to find her a role in a superhero film.

At this point it’s best to assume that she’s looking for something more substantial than her pre-royal movie career offered; she won’t want a made-for-TV superhero movie, or to appear in a single scene of a larger film as a nameless woman whose only purpose in the universe is to give the middle-aged leading man something to absent-mindedly flirt at. So, who should she play? Luckily, as crowded as the superhero genre currently is, there is still plenty of untapped potential for her. Here are my suggestions.