South Dakota Gov. Kristi Noem (R) “has given an ultimatum to...

On April 17, the Alberto Ángel Fernández administration in Argentina officially unveiled its offer for debt restructuring on USD 66 billion foreign currency-denominated bonds. Starting on that date, the offer is valid for 20 days, a period during which difficult negotiations with bondholders are expected to take place. Based on the first reactions from some […]

The post Argentina’s Debt Restructuring “Groundhog Day”… or Maybe Not? Three Key Points appeared first on Inter Press Service.

  This week’s industrial action by University lecturers and other members of staff brings back into focus the risk of disruption on campus from students and others who are affected by the strike action. Disruption on campus can arise...

The latest round of industrial action by University lecturers and other members of staff brings back into focus the risk of disruption on campus from students and others who are affected by the strike action. Disruption on campus can arise and ...

It’s always worth listening to smart people with ideas that go against the grain.

Nina Thomas allegedly pointed a loaded gun at her husband's head upon finding him in bed with another woman last month, according to police in ...

Commercial Court rules that St Philip's Hospital owner Frank Portelli cannot decide the hospital's fate on his own as HSBC Bank seeks repayment of €11.5 million in loans, appoints two provisional administrators

Age, milk output and breed are some of factors to keep in mind as you choose to reduce your herd

ISLAMABAD/LAHORE: Pakistan’s position in the global ranking in respect of COVID-19 dropped from 24th to 22nd on Friday after the number of positive cases increased to 26,806 with addition of 1,791 new cases.The country ranked 20th and 29th in the global ranking on May 6 after reporting 1,000...

Ag APPISLAMABAD: Pakistan’s position in the global ranking in respect of COVID-19 dropped from 24th to 22nd on Friday after the number of positive cases increased to 26,806 with addition of 1,791 new cases.The country ranked 20th and 29th in the global ranking on May 6 after reporting 1,000...

The NCC, under Imran Khan, had decided to substantially ease the lockdown from Saturday (today) after detailed deliberations and consultations with the provinces

The Federal Urdu University of Arts, Science, and Technology on Thursday held its 42nd senate meeting at the Governor House Sindh.The online meeting was chaired by President of Pakistan Dr Arif Alvi, who is also the varsity’s chancellor. The meeting approved the nomination of two faculty...

radeep Sharma Tribune News Service Chandigarh, January 23 The group-housing societies, residential colonies of employers and commercial-cum-residential complexes of developers will be supplied power on single-point (bulk supply) system by the electricity department from April 1. While the electricity bills for February/March would be issued as per the existing practice, the bills from April onwards would be issued as per the single-point metering system, according to an order issued by the Chief General Manager (Commercial), Uttar Haryana Bijli Vitran Nigam (UHBVN). The new system would be implemented in housing colonies having 20 or more houses. The order said on the basis of the reading of April 1, the bills of […]

13 lawyers from our Singapore office have volunteered and been appointed to serve as assessors under temporary COVID-19 legislation. 

In his first full-fledged review of the monetary policy, Reserve Bank of India (RBI) Governor Raghuram Rajan stuck to the continuing hawkish stance of inflation control first, which has seen the repo rate go up by another 25 basis points. The repo rate is the rate at which the central bank lends money (liquidity) to the financial system, and is the key policy rate. After the RBI action on October 29, it stands at 7.75 per cent. The most rate sensitive sector that always watches the central bank’s action closely is real estate. Equated monthly instalments (EMIs) are the biggest expense for a typical household, and with the floating interest […]

STAMFORD, CT – HARMAN (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, today announced that Pradeep Chaudhry has been appointed Country Manager for its India operations, effective January 1, 2016....

Armed with drones, helicopters and military-grade software, a British photographer has developed a new way to remember glaciers

Many ancient monuments are claimed to be aligned to celestial phenomena, but we now have the first statistical evidence this is the case for the Egyptian pyramids

Many ancient monuments are claimed to be aligned to celestial phenomena, but we now have the first statistical evidence this is the case for the Egyptian pyramids

Title: Twins Study Points to Environmental Cause for MS
Category: Health News
Created: 4/28/2010 2:10:00 PM
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Title: Studies Point to Reasons for Mammograms in 40s
Category: Health News
Created: 5/1/2012 11:00:00 AM
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Title: Scientists Pinpoint Brain's 'Hunger Circuit' in Mice
Category: Health News
Created: 4/28/2015 12:00:00 AM
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Title: Cheap Test Might Pinpoint Where Zika Mosquitoes Lurk
Category: Health News
Created: 5/3/2017 12:00:00 AM
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Category: Health News
Created: 4/27/2018 12:00:00 AM
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Created: 5/8/2020 12:00:00 AM
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Four new members have been appointed to serve on the PMC National Advisory Committee: Philip Bourne, of the University of California, San Diego; Sophia Colamarino, an independent consultant in San Francisco; Paul Courant, of the University of Michigan; and Patricia Thibodeau, of Duke University. Each member will serve a 4-year term. The next meeting of the committee is scheduled for Friday, June 17, 2011. For more information on the committee, see PMC National Advisory Committee.

The following new members have been appointed to serve on the PMC National Advisory Committee: Martha Bedard, Dean of Libraries at the University of New Mexico; and Lorraine Haricombe, Dean of Libraries at the University of Kansas and a member of SPARC's board. The next meeting of the committee is scheduled for June 19, 2012. For more information, see PMC National Advisory Committee.

As of February 1, 2013, the following new members have been appointed to serve on the PMC National Advisory Committee: Ms. Sharon Terry of the Genetic Alliance; Dr. C. Victor Jongneel of the University of Illinois at Urbana-Champaign; Dr. Bevin Engelward of the Massachusetts Institute of Technology; Dr. Randall Morse of the Wadsworth Center; and Dr. Adelita Cantu of the University of Texas. For more information, see PMC National Advisory Committee.

There is increasing interest in developing diagnostics that discriminate individual mutagenic mechanisms in a range of applications that include identifying population-specific mutagenesis and resolving distinct mutation signatures in cancer samples. Analyses for these applications assume that mutagenic mechanisms have a distinct relationship with neighboring bases that allows them to be distinguished. Direct support for this assumption is limited to a small number of simple cases, e.g., CpG hypermutability. We have evaluated whether the mechanistic origin of a point mutation can be resolved using only sequence context for a more complicated case. We contrasted single nucleotide variants originating from the multitude of mutagenic processes that normally operate in the mouse germline with those induced by the potent mutagen N-ethyl-N-nitrosourea (ENU). The considerable overlap in the mutation spectra of these two samples make this a challenging problem. Employing a new, robust log-linear modeling method, we demonstrate that neighboring bases contain information regarding point mutation direction that differs between the ENU-induced and spontaneous mutation variant classes. A logistic regression classifier exhibited strong performance at discriminating between the different mutation classes. Concordance between the feature set of the best classifier and information content analyses suggest our results can be generalized to other mutation classification problems. We conclude that machine learning can be used to build a practical classification tool to identify the mutation mechanism for individual genetic variants. Software implementing our approach is freely available under an open-source license.

Antimicrobial peptides play an important role in host defense against Vibrio cholerae. Generally, the V. cholerae O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strains has been reported in recent years, including in the devastating Yemen cholera outbreak during 2016-2018. To investigate the factor(s) responsible for the shift in the trend of sensitivity to PB, we studied the two-component system encoded by carRS, regulating the lipid A modification of El Tor vibrios, and found that only carR contains a single nucleotide polymorphism (SNP) in recently emerged PB-sensitive strains. We designated the two alleles present in PB-resistant and -sensitive strains carR^r and carR^s alleles, respectively, and replaced the carR^s allele of a sensitive strain with the carR^r allele, using an allelic-exchange approach. The sensitive strain then became resistant. The PB-resistant strain N16961 was made susceptible to PB in a similar fashion. Our in silico CarR protein models suggested that the D89N substitution in the more stable CarR^s protein brings the two structural domains of CarR closer, constricting the DNA binding cleft. This probably reduces the expression of the carR-regulated almEFG operon, inducing PB susceptibility. Expression of almEFG in PB-sensitive strains was found to be downregulated under natural culturing conditions. In addition, the expression of carR and almEG decreased in all strains with increased concentrations of extracellular Ca²⁺ but increased with a rise in pH. The downregulation of almEFG in CarR^s strains confirmed that the G265A mutation is responsible for the emergence of PB-sensitive El Tor strains.

Introduction:

Understanding patients’ perspectives about their diabetes and what causes those perspectives to shift is critical to building a treatment strategy with the patient and facilitating patient self-management behavior. Key "turning points" can provide crucial opportunities to enact a change in perspective. The goal of this study is to identify "turning points" that have significance to diabetes-related health.

There are roughly 48,000 deaths caused by influenza annually and an estimated 200,000 people who have undiagnosed human immunodeficiency virus (HIV). These are examples of acute and chronic illnesses that can be identified by employing a CLIA-waived test. Pharmacies across the country have been incorporating CLIA-waived point-of-care tests (POCT) into disease screening and management programs offered in the pharmacy. The rationale behind these programs is discussed. Additionally, a summary of clinical data for some of these programs in the infectious disease arena is provided. Finally, we discuss the future potential for CLIA-waived POCT-based programs in community pharmacies.

A multidisciplinary endocrinologist-led shared medical appointment (SMA) model showed statistically significant reductions in A1C from baseline over 3 years that were not significantly different from appointments with endocrinologists or primary care providers alone within a resource-poor population. Similarly, the SMA model achieved clinical outcomes on par with endocrinologist-only visits with the added benefit of improving endocrine provider productivity and specialty access for patients. Greater patient engagement with the SMA model was associated with significantly lower A1C.

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. This fusion occurs in stem cell leukemia/lymphoma, which can progress to atypical chronic myeloid leukemia, acute myeloid leukemia, or B-cell lymphoma. This work focuses on the biochemical characterization of BCR-FGFR1 and identification of novel therapeutic targets. The tyrosine kinase activity of FGFR1 is required for biological activity as shown using transformation assays, interleukin-3 independent cell proliferation, and liquid chromatography/mass spectroscopy analyses. Furthermore, BCR contributes a coiled-coil oligomerization domain, also essential for oncogenic transformation by BCR-FGFR1. The importance of salt bridge formation within the coiled-coil domain is demonstrated, as disruption of three salt bridges abrogates cellular transforming ability. Lastly, BCR-FGFR1 acts as a client of the chaperonin heat shock protein 90 (Hsp90), suggesting that BCR-FGFR1 relies on Hsp90 complex to evade proteasomal degradation. Transformed cells expressing BCR-FGFR1 are sensitive to the Hsp90 inhibitor Ganetespib, and also respond to combined treatment with Ganetespib plus the FGFR inhibitor BGJ398. Collectively, these data suggest novel therapeutic approaches for future stem cell leukemia/lymphoma treatment: inhibition of BCR oligomerization by disruption of required salt bridges; and inhibition of the chaperonin Hsp90 complex.

The impact on survival of steroids and TNFα blockade to treat immune-related toxicity from checkpoint blockade with ipilimumab, nivolumab/pembrolizumab, or combined ipilimumab and nivolumab was assessed using data from a large national database. Using steroids was associated with better survival than the use of TNFα-blocking antibodies such as infliximab.

See related article by Verheijden et al., p. 2268

Plazomicin was active against 97.0% of 8,783 Enterobacterales isolates collected in the United States (2016 and 2017), and only 6 isolates carried 16S rRNA methyltransferases conferring resistance to virtually all aminoglycosides. Plazomicin (89.2% to 95.9% susceptible) displayed greater activity than amikacin (72.5% to 78.6%), gentamicin (30.4% to 45.9%), and tobramycin (7.8% to 22.4%) against carbapenem-resistant and extensively drug-resistant isolates. The discrepancies among the susceptibility rates for these agents was greater when applying breakpoints generated using the same stringent contemporary methods applied to determine plazomicin breakpoints.

Structured diabetes education (SDE) is an evidence-based intervention that supports self-management in people with type 2 diabetes. In the United Kingdom, health care providers working in primary care settings are responsible for referring people with type 2 diabetes to SDE programs. However, national audits record a high percentage of nonattenders. We explored the personal experience of living with type 2 diabetes that led to individuals declining invitations to attend SDE programs. The themes suggested that emotional, cognitive, and social issues related to diagnosis and living with diabetes may be responsible for declining to attend SDE and that these factors may be masked by explanations of practical barriers. A person-centered approach to understanding the personal meaning of being diagnosed and living with type 2 diabetes may help to identify individuals’ psychosocial barriers to attending SDE.

Adeno-associated virus (AAV) recombinants are currently the vector of choice for many gene therapy applications. As experimental therapies progress to clinical trials, the need to characterize recombinant adeno-associated viruses (rAAVs) accurately and reproducibly increases. Accurate determination of rAAV infectious titer is important for determining the activity of each vector lot and for ensuring lot-to-lot consistency. The following protocol developed in our laboratory uses a 96-well TCID₅₀ format and quantitative polymerase chain reaction (qPCR) detection for the determination of rAAV infectious titer.

An analysis of the daily steps taken by about 5000 people in the US has found that a higher step count is linked to a lower yearly risk of death, although the effect tails off above 12,000 steps

Laser pointer attacks on aircraft have become increasingly rare over the years in Saskatchewan, as figures from Transport Canada show.

In the middle of the ongoing coronavirus pandemic, Missoni went...

The post Missoni Appoints New CEO appeared first on Man's World India.

Baltimore Ravens safety Earl Thomas appears to have reconciled with his wife after reports emerged earlier this week that she held him at gunpoint last month after discovering an alleged affair. 

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