Israel Martínez-Hernández, Marc G. Genton.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 204--229.

Abstract:
As high-dimensional and high-frequency data are being collected on a large scale, the development of new statistical models is being pushed forward. Functional data analysis provides the required statistical methods to deal with large-scale and complex data by assuming that data are continuous functions, for example, realizations of a continuous process (curves) or continuous random field (surfaces), and that each curve or surface is considered as a single observation. Here, we provide an overview of functional data analysis when data are complex and spatially correlated. We provide definitions and estimators of the first and second moments of the corresponding functional random variable. We present two main approaches: The first assumes that data are realizations of a functional random field, that is, each observation is a curve with a spatial component. We call them spatial functional data . The second approach assumes that data are continuous deterministic fields observed over time. In this case, one observation is a surface or manifold, and we call them surface time series . For these two approaches, we describe software available for the statistical analysis. We also present a data illustration, using a high-resolution wind speed simulated dataset, as an example of the two approaches. The functional data approach offers a new paradigm of data analysis, where the continuous processes or random fields are considered as a single entity. We consider this approach to be very valuable in the context of big data.

In a public-private partnership to develop housing, resident services and hope for 102 working families in Haster Orangewood community, Jamboree Housing Corporation and the City of Anaheim announce...

(PRWeb April 27, 2020)

Read the full story at https://www.prweb.com/releases/jamboree_begins_construction_on_capstone_development_to_change_trajectory_of_neighborhood_in_anaheim_ca/prweb17073166.htm

John D. Cahoy
Jan 2, 2008; 28:264-278
Cellular

EL Bienenstock
Jan 1, 1982; 2:32-48
Articles

John D. Cahoy
Jan 2, 2008; 28:264-278
Cellular

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that play critical roles in neuronal development and nervous system function. Here, we developed a model to study NMDARs in early development in zebrafish, by generating CRISPR-mediated lesions in the NMDAR genes, grin1a and grin1b, which encode the obligatory GluN1 subunits. While receptors containing grin1a or grin1b show high Ca²⁺ permeability, like their mammalian counterpart, grin1a is expressed earlier and more broadly in development than grin1b. Both grin1a^–/– and grin1b^–/– zebrafish are viable. Unlike in rodents, where the grin1 knockout is embryonic lethal, grin1 double-mutant fish (grin1a^–/–; grin1b^–/–), which lack all NMDAR-mediated synaptic transmission, survive until ~10 d dpf (days post fertilization), providing a unique opportunity to explore NMDAR function during development and in generating behaviors. Many behavioral defects in the grin1 double-mutant larvae, including abnormal evoked responses to light and acoustic stimuli, prey-capture deficits, and a failure to habituate to acoustic stimuli, are replicated by short-term treatment with the NMDAR antagonist MK-801, suggesting that they arise from acute effects of compromised NMDAR-mediated transmission. Other defects, however, such as periods of hyperactivity and alterations in place preference, are not phenocopied by MK-801, suggesting a developmental origin. Together, we have developed a unique model to study NMDARs in the developing vertebrate nervous system.

SIGNIFICANCE STATEMENT Rapid communication between cells in the nervous system depends on ion channels that are directly activated by chemical neurotransmitters. One such ligand-gated ion channel, the NMDAR, impacts nearly all forms of nervous system function. It has been challenging, however, to study the prolonged absence of NMDARs in vertebrates, and hence their role in nervous system development, due to experimental limitations. Here, we demonstrate that zebrafish lacking all NMDAR transmission are viable through early development and are capable of a wide range of stereotypic behaviors. As such, this zebrafish model provides a unique opportunity to study the role of NMDAR in the development of the early vertebrate nervous system.

As FAO launches dedicated webpages on post-2015, here are seven things to know about the process and how FAO is playing its part. 7 - Post-2015 development agenda - The name refers to the process through which Member States agree on a new global development framework to succeed the Millennium Development Goals (MDGs), eight goals that followed the UN Millennium Declaration [...]

Migration has always existed. It has been a means to reunite with family, to find better jobs, to have a new experience or to start a better life. In 2015, the number of people migrating was up to 1 out of every 7 people in the world.   When it is a choice, migration can be a good way to spread [...]

Four years into the 2030 Agenda, there is still a large gap in data to understand where the world stands in achieving its shared goals, the SDGs. To support [...]

FAO will attend the fourth Annual Strategic Consultation with the Government of Japan on Tuesday 21 January 2020, in Tokyo, Japan. The objective is to review the progress of [...]

Business owners throughout northern Ontario will have the chance Friday morning to speak directly with federal Economic Development Minister Mélanie Joly.

Statement by Mr Ignazio Visco, Governor of the Bank of Italy and Governor of the Constituency of Albania, Greece, Italy, Malta, Portugal, San Marino and Timor-Leste, at the 101st Meeting (virtual) of the Development Committee (Joint Ministerial Committee of the Boards of Governors of the Bank and the Fund on the Transfer of Real Resources to Developing Countries), Washington DC, 17 April 2020.

Alexandra Stone and Blake Gillikin will serve as college marshals for spring 2020 commencement.

Student marshals will represent each department for spring 2020 commencement

By Maureen Ferguson

One can be forgiven for thinking all of Washington, D.C., has been consumed by impeachment frenzy these past weeks. Look closer, though, and you’ll see that while Trump administration lawyers have been tied down by the Senate trial, other administration officials have been engaged in a flurry of policy making. These new policies have gone largely unnoticed, but they are of crucial – and positive – importance to all people of faith.   

 

The last weeks alone have witnessed sweeping developments on prayer in public schools, discrimination against religious organizations, mandatory abortion coverage in health insurance plans, and government funding of programs encouraging childbirth over abortion. Additionally, the president himself attended the March for Life, and Vice President Pence held a significant meeting with Pope Francis.

 

On school prayer, Education Secretary Betsy DeVos issued guidance clarifying that students do not compromise their right to pray because they attend a public school or university. The DeVos directive also ensures that religious student groups remain on equal footing with secular student groups. This is a critical response to the recent trend of universities’ disallowing any and all religious expression or association at public institutions of higher education. As DeVos stated, "Too many misinterpret a separation of church and state as an invitation for government to separate people from their faith."

 

Public colleges and universities won’t be able to get away with this any longer, thanks to the Trump Administration. The DeVos directive reaffirms the First Amendment right of students to express religious beliefs in their schoolwork as well as to gather to pray at appropriate times. This sends a strong message to school bureaucrats inclined to ban students from praying before high school football games or to defund Christian student groups at public universities.

 

The administration also issued far-reaching rules stating that religious and non-religious charities must be treated equally in the federal grant process. Team Trump has leveled the playing field. Religious charities will now be free to compete for federal grants to serve their fellow Americans. Not only is this a huge win for religious freedom, but it’s also a huge win for the poor and vulnerable. Because, as we know, Catholic and other religious charities are highly regarded as among best in the field of adoption and foster care, caring for victims of human trafficking, providing for the elderly and the poor, and working with refugees and other vulnerable immigrant populations. Nine federal agencies participated in this rule making. The new rule applies across the entire federal government, removing discriminatory regulatory burdens that push religious entities out of the public square – and out of public service. In short, our nation’s social safety net just got stronger.

 

Another significant announcement is that the administration will vigorously enforce the Weldon Amendment, a longstanding law protecting conscience rights. California has been flagrantly violating this law by forcing all health insurance plans in the state, including Catholic health plans, to cover and pay for elective abortions. The U.S. Conference of Catholic Bishops called the policy “abhorrent, unjust and illegal… [a] supreme injustice.” The bishops welcomed the Trump administration’s action as “extraordinarily good news for the right to life, conscientious objection, religious freedom, and the rule of law.”

 

Moreover, the Department of Health and Human Services just came down squarely in support of state healthcare programs that recognize the sanctity of life. Texas had decided years ago that its Medicaid program would support pregnant women and their unborn children, but not abortion-promoting groups like Planned Parenthood. The Obama administration went after Texas but the Trump Administration just granted the necessary waiver supporting Texas’ pro-life policy.

 

That’s all policy, but it’s worth noting again what President Trump and Vice President Pence have been doing themselves. Trump addressed the March for Life rally in person, something no other president has done. Ever. The vice president also spoke to the pro-life March via video from St. Peter’s square at the Vatican, where Pence also had an hour-long private meeting with Pope Francis. The pope and vice president reportedly had a very warm meeting in which they agreed that the cause of life is the “most pressing moral issue of our time.” They also shared their commitment to persecuted Christians and other religious minorities in the Middle East. Pence talked of how proud he is that the United States has partnered with the Knight of Columbus to help rebuild Christian communities once decimated by ISIS in the Nineveh plain.

 

So while the media obsesses over Bolton bombshells and the McConnell vs. Schumer showdown, hardworking policy makers across the administration, empowered by the president to act, have made a significant difference in the lives of people of faith – and the children of God they serve.

Women's Under-17 teams gathered in Nyon for a friendly tournament this week, with associations welcoming UEFA's drive to give young players chances for further development.

Research shows demands put on school principals are increasing when it comes to instructional leadership. Greater demands bring out increasing gaps, and a need for better leadership development.

With a busy season ahead, involving all 54 member associations, the latest round of UEFA development tournaments for Under-16 national sides are under way, starting in the Algarve.

Vitamin D levels in the general population have decreased considerably over the past decade. The implications of maternal vitamin D insufficiency during pregnancy for offspring neurocognitive development remain unclear.

Studying a large sample and using a prospective longitudinal design, this study demonstrates a link between maternal vitamin D insufficiency during pregnancy and offspring language impairment. There was no association with childhood behavioral or emotional problems. (Read the full article)

The availability of rapid response systems to assist deteriorating patients is the standard of care in children’s hospitals. Metrics for evaluating their effectiveness include cardiac and respiratory arrest rates, rare events that require years of data to show significant improvements.

A proximate outcome for in-hospital mortality among patients receiving rapid response system assistance was developed. This "critical deterioration" metric was eightfold more common than arrests and demonstrated criterion and construct validity, facilitating meaningful evaluation over shorter periods of time. (Read the full article)

Cross-sectional studies have shown an increased risk of mental health difficulties in children with developmental coordination disorder. However, there has been limited longitudinal research in this area controlling for confounding factors and assessing the role of potential mediators.

Children with "probable" developmental coordination disorder at 7 years had a significantly increased risk mental health difficulties at 10 years. Protective factors for self-reported depression included high IQ, high self-esteem, good social communication skills, and the absence of bullying. (Read the full article)

Autism is widely considered a heterogeneous disorder in terms of etiology and phenotype. Although autism is usually a lifelong disorder, little is known about the rate or timing of how children develop regarding their communication and social functioning.

Utilizing annual evaluations for a large population of children with autism, we describe the 6 most common trajectories from diagnosis through age 14 years. Trajectories revealed considerable variation, and high socioeconomic status children were more likely to experience rapid improvement. (Read the full article)

Although developmental care in NICUs reduces the stress experienced by preterm infants, the actual level of developmental care may vary and little is known about how the level of developmental care relates to preterm infants’ neurobehavioral performance.

The study demonstrates the relationship between variations in developmental care in NICUs and the neurobehavior of preterm infants. Infants from NICUs with high-quality developmental care compared with infants from units with low quality of care evidenced a better neurobehavioral profile. (Read the full article)

Diabetes during pregnancy has been associated with general development impairments in offspring; however, associations between autism and maternal diabetes have been inconsistent. Few studies have examined related conditions accompanied by underlying increased insulin resistance and their association with developmental outcomes.

This population-based study in young children provides evidence that maternal metabolic conditions are a risk factor for autism, developmental delay without autistic symptoms, and impairments in several domains of development, particularly expressive language, after adjusting for sociodemographic and other characteristics. (Read the full article)

Assessing for adequacy of supervision in the clinical setting is challenging and may result in significant variability in care. Clinicians must quickly decide if a child and family necessitate direct counseling, further intervention, or require reporting to state agencies.

This study identified the most important characteristics for the evaluation of the adequacy of supervision of a young child. A standardized scale using these characteristics may result in an efficient means to reduce variability in care. (Read the full article)

Conflicting results exist concerning long-term outcome in healthy infants with metabolic acidosis at birth.

Neonates who appear well after perinatal metabolic acidosis do not have an increased risk of neurologic or behavioral problems in need of referral actions or pedagogic arrangements at the age of 6.5 years. (Read the full article)

Although soy protein–based infant formula is known to support physical growth equal to that of infants fed cow's milk–based formula, data are lacking on developmental status of infants fed soy formula compared with breast milk or milk formula.

Infants fed soy protein–based formula scored within normal limits on standardized developmental testing and did not differ from infants fed cow’s milk–based formula. Breastfed infants have a slight advantage on cognitive development compared with formula-fed infants. (Read the full article)

Fetal factors that predispose infants to necrotizing enterocolitis (NEC) have been extensively studied. Maternal factors that may affect future risk for NEC are less clear.

We hypothesized that maternal factors were the primary cause of NEC. Through a case-control design we determined that maternal smoking predisposes infants to the development of NEC. Our results highlight the importance of smoking cessation in pregnancy. (Read the full article)

Moderately preterm-born children (32–35^6/7 weeks’ gestation) are at risk for both neonatal morbidities after birth and developmental delays in early childhood. It is unknown whether neonatal morbidities contribute to the developmental delays of this particular group.

Of all neonatal morbidities commonly seen in moderately preterm-born children, only hypoglycemia increased the risk of developmental delay after moderately preterm birth. A concerted effort to prevent hypoglycemia after birth might enhance developmental outcome in this group. (Read the full article)

Loud snoring, which spikes at ~2 to 3 years of age, has been associated with behavior problems in school-aged children in cross-sectional studies, but no longitudinal studies have quantified predictors and the behavioral impact of persistent snoring in preschool-aged children.

Persistent loud snoring, which occurs in 9% of children 2 to 3 years of age, is linked with behavior problems. Higher socioeconomic status and a history of breastfeeding were associated with lower rates of transient and persistent snoring in young children. (Read the full article)

Previous studies suggest that abnormal findings on conventional EEG during the neonatal period are associated with death or severe brain injury in preterm infants. However, large cohort studies on preterm EEG for predicting later neurodevelopmental outcome remain scarce.

This study demonstrates precise prognostic values of conventional EEG for predicting neurodevelopmental outcome in the current perinatal care setting. Additionally, its prognostic values are independent of severe injury on neuroimaging and clinical risk factors. (Read the full article)

There are no studies to support the clinical awareness of persistent Tanner stage (TS) 4 breast development in adulthood, and forensic experts continue to use TS 4 as evidence of age <18 years in cases of alleged child pornography.

One-fourth of nonclinical images of women over 18 years of age could be considered by a single forensic expert to represent TS 4. This observation, and substantial discordance in interpretation by pediatric endocrinologists, renders testimony based on this distinction invalid. (Read the full article)

Inflammatory bowel disease pathogenesis is incompletely understood. Previous pediatric studies suggested associations between antibiotic use and inflammatory bowel disease development but were limited by recall bias, lack of controls, incomplete antibiotic capture, or included exposures between symptom onset and diagnosis.

Our population-based cohort study suggests that certain childhood antibiotic exposures are associated with an increased risk of developing inflammatory bowel disease. Our findings have implications for understanding the condition’s pathogenesis and provide additional stimulus for reducing unnecessary childhood antibiotic use. (Read the full article)

Children born late preterm (34–36 weeks’ gestation) are at increased risk of adverse early childhood outcomes compared with term-born children. The impact of the neonatal experience on longer-term outcomes of these infants has not yet been well considered.

This study provides information regarding the development of late preterm infants at 3 years. Late preterm infants who received neonatal intensive or high-dependency care had similar developmental outcomes to children born late preterm who did not receive this care. (Read the full article)

Brain maturation processes of very premature children are adversely affected by serious neonatal infections. Differences in brain development persist into childhood and adolescence, and underpin widespread neurocognitive and behavioral deficits in very preterm children.

We present evidence for long-term beneficial effects of early nutritional intervention with glutamine in very preterm infants on brain development at 8 years of age, mediated by a decrease in the number of serious neonatal infections. (Read the full article)

Today’s adolescents increasingly use the Internet to explore their sexual identity. There is public concern that the Internet, because of its accessibility, affordability, and anonymity, stimulates adolescents to engage in online sexual risk behavior (eg, sending sexual images to strangers).

This 4-wave panel study is the first to delineate the typical development of online sexual risk behavior, its relationship with offline sexual risk behavior, and the factors (eg, sensation seeking, family cohesion, life satisfaction, education, online communication) that predict both behaviors. (Read the full article)

With increasing survival rates, there is growing interest in long-term quality of life among patients with univentricular heart defects, and neurodevelopmental deficits play a major role in adverse outcome.

Although median cognitive performance was within normal limits, major neurodevelopmental impairment was found in one-fourth, and minor neurologic dysfunction in almost half of patients. Brain MRI showed mostly ischemic findings of different degrees in the majority of patients. (Read the full article)

Developmental screening using standardized tools has been endorsed by professional groups to improve rates of identification and referral for young children who have developmental delays. Little is known about the effectiveness of these tools among a high-risk urban population.

Using a randomized design, we found that a program of developmental screening improved the percentage and time to identification of developmental delay, referral, and eligibility for early intervention among a poor, racially diverse urban population of young children. (Read the full article)

Infants and toddlers with deformational plagiocephaly (DP) score lower on developmental measures than children without DP and lower than expected relative to test norms.

This study is the first to examine developmental outcomes in preschool-aged children with DP relative to demographically similar children without DP using a standardized, clinician administered assessment. (Read the full article)

Paternal mental disorders during the postnatal period are associated with an increased risk for behavioral and emotional problems in their children; however, less is known about the effect of fathers’ mental health during pregnancy on children’s development.

The study demonstrated a positive association between fathers’ prenatal mental health and their children’s subsequent socioemotional and behavioral development. Psychological distress in fathers was associated with a risk for emotional difficulties in their children at 36 months of age. (Read the full article)