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Eco Equity is one of only a few Europe-based investors in medicinal cannabis from Africa and the Caribbean, an area in which the UK is missing an opportunity, according to CEO Jon-Paul Doran.

This salad is deliciously different from others. The warm bacon-shallot dressing gives its unique taste along with the poached egg & crispy bacon VIDEO https://www.youtube.com/watch?v=--7j7tQhXds -- posted by CLUBFOODY

Apple pie has never looked so good. -- posted by Food.com

The Crown Commercial Service (“CCS”) has now published a revised standard Selection Questionnaire and guidance in the form of Procurement Policy Note (PPN) 8/16. This can be found here. PPN 8/16 supersedes and replaces PPN 3/15 which con...

Auteur d'une excellente saison avec le RB Leipzig, Dayot Upamecano est tr�s convoit� sur le march�. ......

Alger -Le nombre de fonctionnaires...

Dubai: A 47-year-old pharmacist in the Indian state of Tamil Nadu, died on Thursday after consuming a “new cure” he had made for COVID-19. Indian tweeps shared reports of how the man, K. Sivanesan, made and drank the chemical concoction along with the owner of a popular Chennai-based herbal pharmaceutical company where he worked. According to a report by Indian newspaper, The Indian Express, the owner of Sujatha Bio Tech, along with his employee, tried to create a coronavirus cure, but consumed a...

The stigma around the plant needs to be addressed and citizens involved in new policies and processes in order for the market to change

The post Southern Africa’s cannabis industry offers opportunity for open-minded investors appeared first on The Mail & Guardian.

Tamannaah Bhatia has quashed the chitchat about her love life

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ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

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ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The Petroleum Division has admitted that it has violated the marginal gas policy guidelines 2013, and the terms of reference set by directorate general petroleum concessions , while...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The National Accountability Bureau Multan has sent a questionnaire to Opposition Leader in the National Assembly and President PML-N Shahbaz Sharif, ex-minister of state Balighur Rehman,...

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ISLAMABAD: The National Accountability Bureau Multan has sent a questionnaire to Opposition Leader in the National Assembly and President PML-N Shahbaz Sharif, ex-minister of state Balighur Rehman, former MNA Chaudhry Umair Mehmood and former law minister Punjab Rana Sanaullah Khan in the matter...

ISLAMABAD: The National Accountability Bureau Multan has sent a questionnaire to Opposition Leader in the National Assembly and President PML-N Shahbaz Sharif, ex-minister of state Balighur Rehman, former MNA Chaudhry Umair Mehmood and former law minister Punjab Rana Sanaullah Khan in the matter...

Important changes are underway for Southeast Asia’s relationship with its biggest trading partner, the People’s Republic of China.

Tata Value Homes Limited (TVHL), a 100% subsidiary of Tata Housing Development Company Limited, today strengthened its presence in South India by developing Spanish themed residential township at Sriperumbudur, near Chennai. The company plans to Invest around Rs 300 crore in setting up this township. Inspired by Spanish living, Santorini is designed by architects F+A. The township is spread across lush greenery at Sriperumbudur, one of the fastest growing corridors in Chennai. Speaking on the project Brotin Banerjee, MD & CEO, Tata Housing Development Co. Ltd., said, with rapid urbanisation and influx of global lifestyle trends more and more affluent home buyers are looking for homes to reflect the financial […]

CHENNAI: Strong English speaking skills and a wide mix of industries that promotes cross pollination of work culture has made Chennai one of the top 12 cities in the world for real estate investments. This is the first global recognition the city has received; it is also the lone Indian city on the list. The Candy GPS Report, published on Friday, identifies 12 cities around the globe with the potential to show strong residential property price growth in the next few years. The report — produced by Candy & Candy, Savills World Research and Deutsche Asset & Wealth Management — said, “Prices in these rising cities are generally much lower […]

Embedded connectivity is one of the latest technological trends that has been enthusiastically embraced by the automotive industry. As the modern car becomes increasingly connected, the number of vehicle radio services for aviation, infotainment, ADAS...

Amber from the Cretaceous period trapped a leaf-footed bug with extremely long and wide antennae, which may have helped disguise the insect or confuse predators

An analysis of pollen suggests cannabis evolved on the Tibetan Plateau, not far from a cave that was frequented by our ancient Denisovan cousins

ABSTRACT

Streptococcus pneumoniae (or pneumococcus) is a highly prevalent human pathogen. Toll-like receptors (TLRs) function as immune sensors that can trigger host defenses against this bacterium. Defects in TLR-activated signaling pathways, including deficiency in the adaptor protein myeloid differentiation factor 88 (MyD88), are associated with markedly increased susceptibility to infection. However, the individual MyD88-dependent TLRs predominantly involved in antipneumococcal defenses have not been identified yet. Here we find that triple knockout mice simultaneously lacking TLR7, TLR9, and TLR13, which sense the presence of bacterial DNA (TLR9) and RNA (TLR7 and TLR13) in the phagolysosomes of phagocytic cells, display a phenotype that largely resembles that of MyD88-deficient mice and rapidly succumb to pneumococcal pneumonitis due to defective neutrophil influx into the lung. Accordingly, TLR7/9/13 triple knockout resident alveolar macrophages were largely unable to respond to pneumococci with the production of neutrophil-attracting chemokines and cytokines. Mice with single deficiencies of TLR7, TLR9, or TLR13 showed unaltered ability to control lung infection but were moderately more susceptible to encephalitis, in association with a decreased ability of microglia to mount cytokine responses in vitro. Our data point to a dominant, tissue-specific role of nucleic acid-sensing pathways in innate immune recognition of S. pneumoniae and also show that endosomal TLRs are largely capable of compensating for the absence of each other, which seems crucial to prevent pneumococci from escaping immune recognition. These results may be useful to develop novel strategies to treat infections by antibiotic-resistant pneumococci based on stimulation of the innate immune system.

IMPORTANCE The pneumococcus is a bacterium that frequently causes infections in the lungs, ears, sinus cavities, and meninges. During these infections, body defenses are triggered by tissue-resident cells that use specialized receptors, such as Toll-like receptors (TLRs), to sense the presence of bacteria. We show here that pneumococci are predominantly detected by TLRs that are located inside intracellular vacuoles, including endosomes, where these receptors can sense the presence of nucleic acids released from ingested bacteria. Mice that simultaneously lacked three of these receptors (specifically, TLR7, TLR9, and TLR13) were extremely susceptible to lung infection and rapidly died after inhalation of pneumococci. Moreover, tissue-resident macrophages from these mice were impaired in their ability to respond to the presence of pneumococci by producing inflammatory mediators capable of recruiting polymorphonuclear leucocytes to infection sites. This information may be useful to develop drugs to treat pneumococcal infections, particularly those caused by antibiotic-resistant strains.

Key Points

Key Points

Key Points

Key Points

The initial response to an addictive substance can facilitate repeated use: That is, individuals experiencing more positive effects are more likely to use that drug again. Increasing evidence suggests that psychoactive cannabinoid use in adolescence enhances the behavioral effects of cocaine. However, despite the behavioral data, there is no neurobiological...

Fredrik Andreasson, Arne Hegemann, Andreas Nord, and Jan-Ake Nilsson

The capacity to get rid of excess heat produced during hard work is a possible constraint on parental effort during reproduction [heat dissipation limit (HDL) theory]. We released hard-working blue tits (Cyanistes caeruleus) from this constraint by experimentally removing ventral plumage. We then assessed whether this changed their reproductive effort (feeding rate and nestling size) and levels of self-maintenance (change in body mass and innate immune function). Feather-clipped females reduced the number of feeding visits and increased levels of constitutive innate immunity compared with unclipped females but did not fledge smaller nestlings. Thus, they increased self-maintenance without compromising current reproductive output. In contrast, feather clipping did not affect the number of feeding visits or innate immune function in males, despite increased heat loss rate. Our results show that analyses of physiological parameters, such as constitutive innate immune function, can be important when trying to understand sources of variation in investment in self-maintenance versus reproductive effort and that risk of overheating can influence innate immune function during reproduction.

Cinnamaldehyde (Cin), a bioactive cinnamon essential oil from traditional Chinese medicine herb Cinnamomum cassia, has been reported to have multipharmacological activities including anti-inflammation. However, its role and molecular mechanism of anti-inflammatory activity in musculoskeletal tissues remains unclear. Here, we first investigated the effects and molecular mechanisms of Cin in human synoviocyte cells. Then in vivo therapeutic effect of Cin on collagen-induced arthritis (CIA) also studied. Cell Counting Kit ‎CCK-8 assay was performed to evaluate the cell cytotoxicity. Proinflammatory cytokine expression was evaluated using quantitative polymerase chain reaction and ELISA. Protein expression was measured by western blotting. The in vivo effect of Cin (75 mg/kg per day) was evaluated in rats with CIA by gavage administration. Disease progression was assessed by clinical scoring, radiographic, and histologic examinations. Cin significantly inhibited interleukin (IL)-1β–induced IL-6, IL-8, and tumor necrosis factor-α release from human synoviocyte cells. The molecular analysis revealed that Cin impaired IL-6–induced activation of Janus kinase 2 (JAK2), signal transducer and activator of transcription 1 (STAT1), and STAT3 signaling pathway by inhibiting the phosphorylation of JAK2, STAT1, and STAT3, without affecting NF-B pathway. Cin reduced collagen-induced swollen paw volume of arthritic rats. The anti-inflammation effects of Cin were associated with decreased severity of arthritis, joint swelling, and reduced bone erosion and destruction. Furthermore, serum IL-6 level was decreased when Cin administered therapeutically to CIA rats. Cin suppresses IL-1β–induced inflammation in synoviocytes through the JAK/STAT pathway and alleviated collagen-induced arthritis in rats. These data indicated that Cin might be a potential traditional Chinese medicine–derived, disease-modifying, antirheumatic herbal drug.

Metastatic breast cancer is prevalent worldwide, and one of the most common sites of metastasis is long bones. Of patients with disease, the major symptom is pain, yet current medications fail to adequately result in analgesic efficacy and present major undesirable adverse effects. In our study, we investigate the potential of a novel monoacylglycerol lipase (MAGL) inhibitor, MJN110, in a murine model of cancer-induced bone pain. Literature has previously demonstrated that MAGL inhibitors function to increase the endogenous concentrations of 2-arachydonylglycerol, which then activates CB1 and CB2 receptors to inhibit inflammation and pain. We demonstrate that administration of MJN110 significantly and dose dependently alleviates spontaneous pain behavior during acute administration compared with vehicle control. In addition, MJN110 maintains its efficacy in a chronic-dosing paradigm over the course of 7 days without signs of receptor sensitization. In vitro analysis of MJN110 demonstrated a dose-dependent and significant decrease in cell viability and proliferation of 66.1 breast adenocarcinoma cells to a greater extent than KML29, an alternate MAGL inhibitor, or the CB2 agonist JWH015. Chronic administration of the compound did not appear to affect tumor burden, as evidenced by radiograph or histologic analysis. Together, these data support the application for MJN110 as a novel therapeutic for cancer-induced bone pain.

Paint your home blue before selling it, as the color brings a sense of peace, softness. Many people love blue and it may help you sell home more quickly.

This is a video of the result of Youtuber Lil'Alien [Agentalex9 Alt.] feeding Rick Astley's rickrolling classic 'Never Gonna Give You Up' into the Jukebox neural network developed by OpenAI to create more song lyrics for the song. The music video consists of AI upscaled gifs from the original video. If you're really interested in the technology utilized and just what the hell is going on, there are a bunch of links on the video's Youtube page HERE. I just managed to watch the whole video and I can attest that, uh, that was really something. "Something good?" Haha, now let's not get ahead of ourselves. Keep going for whatever this is.

It’s E3 prep week and we missed a show so that means you get a super nice beefy show going into E3. We hope you...