Dimitris Bertsimas, Bart Van Parys.

Source: The Annals of Statistics, Volume 48, Number 1, 300--323.

Abstract:
We present a novel binary convex reformulation of the sparse regression problem that constitutes a new duality perspective. We devise a new cutting plane method and provide evidence that it can solve to provable optimality the sparse regression problem for sample sizes $n$ and number of regressors $p$ in the 100,000s, that is, two orders of magnitude better than the current state of the art, in seconds. The ability to solve the problem for very high dimensions allows us to observe new phase transition phenomena. Contrary to traditional complexity theory which suggests that the difficulty of a problem increases with problem size, the sparse regression problem has the property that as the number of samples $n$ increases the problem becomes easier in that the solution recovers 100% of the true signal, and our approach solves the problem extremely fast (in fact faster than Lasso), while for small number of samples $n$, our approach takes a larger amount of time to solve the problem, but importantly the optimal solution provides a statistically more relevant regressor. We argue that our exact sparse regression approach presents a superior alternative over heuristic methods available at present.

Florentina Bunea, Christophe Giraud, Xi Luo, Martin Royer, Nicolas Verzelen.

Source: The Annals of Statistics, Volume 48, Number 1, 111--137.

Abstract:
The problem of variable clustering is that of estimating groups of similar components of a $p$-dimensional vector $X=(X_{1},ldots ,X_{p})$ from $n$ independent copies of $X$. There exists a large number of algorithms that return data-dependent groups of variables, but their interpretation is limited to the algorithm that produced them. An alternative is model-based clustering, in which one begins by defining population level clusters relative to a model that embeds notions of similarity. Algorithms tailored to such models yield estimated clusters with a clear statistical interpretation. We take this view here and introduce the class of $G$-block covariance models as a background model for variable clustering. In such models, two variables in a cluster are deemed similar if they have similar associations will all other variables. This can arise, for instance, when groups of variables are noise corrupted versions of the same latent factor. We quantify the difficulty of clustering data generated from a $G$-block covariance model in terms of cluster proximity, measured with respect to two related, but different, cluster separation metrics. We derive minimax cluster separation thresholds, which are the metric values below which no algorithm can recover the model-defined clusters exactly, and show that they are different for the two metrics. We therefore develop two algorithms, COD and PECOK, tailored to $G$-block covariance models, and study their minimax-optimality with respect to each metric. Of independent interest is the fact that the analysis of the PECOK algorithm, which is based on a corrected convex relaxation of the popular $K$-means algorithm, provides the first statistical analysis of such algorithms for variable clustering. Additionally, we compare our methods with another popular clustering method, spectral clustering. Extensive simulation studies, as well as our data analyses, confirm the applicability of our approach.

Qian Qin, James P. Hobert.

Source: The Annals of Statistics, Volume 47, Number 4, 2320--2347.

Abstract:
The use of MCMC algorithms in high dimensional Bayesian problems has become routine. This has spurred so-called convergence complexity analysis, the goal of which is to ascertain how the convergence rate of a Monte Carlo Markov chain scales with sample size, $n$, and/or number of covariates, $p$. This article provides a thorough convergence complexity analysis of Albert and Chib’s [ J. Amer. Statist. Assoc. 88 (1993) 669–679] data augmentation algorithm for the Bayesian probit regression model. The main tools used in this analysis are drift and minorization conditions. The usual pitfalls associated with this type of analysis are avoided by utilizing centered drift functions, which are minimized in high posterior probability regions, and by using a new technique to suppress high-dimensionality in the construction of minorization conditions. The main result is that the geometric convergence rate of the underlying Markov chain is bounded below 1 both as $n ightarrowinfty$ (with $p$ fixed), and as $p ightarrowinfty$ (with $n$ fixed). Furthermore, the first computable bounds on the total variation distance to stationarity are byproducts of the asymptotic analysis.

Xin Bing, Florentina Bunea, Marten Wegkamp.

Source: Bernoulli, Volume 26, Number 3, 1765--1796.

Abstract:
Topic models have become popular for the analysis of data that consists in a collection of n independent multinomial observations, with parameters $N_{i}inmathbb{N}$ and $Pi_{i}in[0,1]^{p}$ for $i=1,ldots,n$. The model links all cell probabilities, collected in a $p imes n$ matrix $Pi$, via the assumption that $Pi$ can be factorized as the product of two nonnegative matrices $Ain[0,1]^{p imes K}$ and $Win[0,1]^{K imes n}$. Topic models have been originally developed in text mining, when one browses through $n$ documents, based on a dictionary of $p$ words, and covering $K$ topics. In this terminology, the matrix $A$ is called the word-topic matrix, and is the main target of estimation. It can be viewed as a matrix of conditional probabilities, and it is uniquely defined, under appropriate separability assumptions, discussed in detail in this work. Notably, the unique $A$ is required to satisfy what is commonly known as the anchor word assumption, under which $A$ has an unknown number of rows respectively proportional to the canonical basis vectors in $mathbb{R}^{K}$. The indices of such rows are referred to as anchor words. Recent computationally feasible algorithms, with theoretical guarantees, utilize constructively this assumption by linking the estimation of the set of anchor words with that of estimating the $K$ vertices of a simplex. This crucial step in the estimation of $A$ requires $K$ to be known, and cannot be easily extended to the more realistic set-up when $K$ is unknown. This work takes a different view on anchor word estimation, and on the estimation of $A$. We propose a new method of estimation in topic models, that is not a variation on the existing simplex finding algorithms, and that estimates $K$ from the observed data. We derive new finite sample minimax lower bounds for the estimation of $A$, as well as new upper bounds for our proposed estimator. We describe the scenarios where our estimator is minimax adaptive. Our finite sample analysis is valid for any $n,N_{i},p$ and $K$, and both $p$ and $K$ are allowed to increase with $n$, a situation not handled well by previous analyses. We complement our theoretical results with a detailed simulation study. We illustrate that the new algorithm is faster and more accurate than the current ones, although we start out with a computational and theoretical disadvantage of not knowing the correct number of topics $K$, while we provide the competing methods with the correct value in our simulations.

Aliaksandr Hubin, Geir Storvik, Florian Frommlet.

Source: Bayesian Analysis, Volume 15, Number 1, 263--333.

Abstract:
Logic regression was developed more than a decade ago as a tool to construct predictors from Boolean combinations of binary covariates. It has been mainly used to model epistatic effects in genetic association studies, which is very appealing due to the intuitive interpretation of logic expressions to describe the interaction between genetic variations. Nevertheless logic regression has (partly due to computational challenges) remained less well known than other approaches to epistatic association mapping. Here we will adapt an advanced evolutionary algorithm called GMJMCMC (Genetically modified Mode Jumping Markov Chain Monte Carlo) to perform Bayesian model selection in the space of logic regression models. After describing the algorithmic details of GMJMCMC we perform a comprehensive simulation study that illustrates its performance given logic regression terms of various complexity. Specifically GMJMCMC is shown to be able to identify three-way and even four-way interactions with relatively large power, a level of complexity which has not been achieved by previous implementations of logic regression. We apply GMJMCMC to reanalyze QTL (quantitative trait locus) mapping data for Recombinant Inbred Lines in Arabidopsis thaliana and from a backcross population in Drosophila where we identify several interesting epistatic effects. The method is implemented in an R package which is available on github.

Quan Zhou, Yongtao Guan.

Source: Bayesian Analysis, Volume 14, Number 2, 573--594.

Abstract:
Bayesian variable selection regression (BVSR) is able to jointly analyze genome-wide genetic datasets, but the slow computation via Markov chain Monte Carlo (MCMC) hampered its wide-spread usage. Here we present a novel iterative method to solve a special class of linear systems, which can increase the speed of the BVSR model-fitting tenfold. The iterative method hinges on the complex factorization of the sum of two matrices and the solution path resides in the complex domain (instead of the real domain). Compared to the Gauss-Seidel method, the complex factorization converges almost instantaneously and its error is several magnitude smaller than that of the Gauss-Seidel method. More importantly, the error is always within the pre-specified precision while the Gauss-Seidel method is not. For large problems with thousands of covariates, the complex factorization is 10–100 times faster than either the Gauss-Seidel method or the direct method via the Cholesky decomposition. In BVSR, one needs to repetitively solve large penalized regression systems whose design matrices only change slightly between adjacent MCMC steps. This slight change in design matrix enables the adaptation of the iterative complex factorization method. The computational innovation will facilitate the wide-spread use of BVSR in reanalyzing genome-wide association datasets.

Spanish translation of "Pillar 3 disclosure requirements - updated framework", December 2018

Sourdough librarian Karl De Smedt has traveled the world to gather more than 120 jars of starters

Armchair travelers can also enjoy 360-degree views of the city's famed Northern Lights

The village of La Loche is calling on the provincial government to force the closure of liquor stores in the community, which is in the throes of a COVID-19 outbreak. 

Publication by Mr Dimitar Radev, Governor of the Bulgarian National Bank, in the Quarterly Bulletin of the Association of Banks in Bulgaria, issue 61, March 2020.

Officials with the Saskatchewan Health Authority have said people are still gathering and drinking together which has contributed to the spread of the virus.

Five members of Calgary city council use a name in their political life that doesn't always line up with their birth certificate.

Villagers placed the bodies of three victims of a deadly gas leak from an LG Polymers plant in southern India at the gates of the site on Saturday and demanded the factory be shut down immediately and its top management arrested.

A 23-year-old man has been granted bail, after being charged in the death of a Saskatchewan farmer with a wife and two kids whose body was found dumped north of Calgary.

An inmate at the Calgary Remand Centre has tested positive for COVID-19, marking the first time a case has been reported at an Alberta correctional facility.

Current and comprehensive news stories from around Calgary and Southern Alberta

Denver Newsroom, May 7, 2020 / 03:48 pm (CNA).- For the first time in over a century, the annual May 13 celebrations at the Fatima shrine will take place without the physical presence of pilgrims, the bishop of Fatima confirmed this week.

Cardinal Antonio Marto said in a May 3 statement that the celebrations for the Feast of Our Lady of Fatima “will take place as was announced April 6, without the physical presence of pilgrims, in the name of prudence to avoid the risk of spreading the novel coronavirus.”

“As planned in conjunction with the civil authorities, the May 12 and 13 celebrations for this year cannot have the physical presence of the pilgrims and will be transmitted by broadcast and digital media,” he continued.

The cardinal explained that hosting “an unpredictable multitude of people” gathering at a time when the coronavirus pandemic is still a serious threat would go against the efforts of health authorities to gradually lift restrictions imposed to slow the spread of the virus.

“We therefore respect, in an attitude of collaboration with the competent civil authorities, the guidelines for these celebrations to be held with a symbolic presence of participants,” Marto said.

The clarification over the Fatima feast day came as the Portuguese government gradually begins to ease restrictions that had been put in place in response to the pandemic, prompting speculation over whether the May 13 celebrations would be able to take place as normal. The annual event typically draws hundreds of thousands from around the world to the shrine.

The Portuguese Bishops’ Conference had announced earlier this month that public Masses could tentatively resume the weekend of Pentecost, May 30-31, in accordance with guidelines to be established by the country’s health department and the Catholic Church.

Cardinal Marto stressed that the decision to suspend public religious celebrations was based in a sense of responsibility toward the public health, as a way of loving one’s neighbor.

“[A]s much as our hearts would like to be in Fatima celebrating together in the same place, as has been the case since 1917, prudence counsels us not to do so this time,” he said, adding that Catholics can look forward to an end to the pandemic and an opportunity to gather together joyfully in the future.

Fr. Carlos Cabecinhas, rector of the Shrine of Our Lady of Fatima, encouraged pilgrims who are unable to physically attend the events to make an interior pilgrimage, participating in the events of the Solemnity of Our Lady of Fatima through the internet or social media.

“This is a painful time: the shrine exists to welcome the pilgrims and we cannot do so, this is a cause for great sadness; but this decision is also an act of responsibility toward the pilgrims, protecting their health and welfare,” the priest said.

The shrine’s website offers four steps to guide people on this interior pilgrimage.

According to the website, “the celebrations of May 12 and 13 will maintain the usual schedule with recitation of the Rosary at 9:30 p.m. followed by the Candlelight Procession. On the 13th the Rosary will be prayed at 9:00 a.m. followed by the International Mass and the Farewell Procession.”

In March, 24 countries were consecrated to the Sacred Heart of Jesus and the Immaculate Heart of Mary at the Shrine of Our Lady of Fatima.

At that ceremony, Cardinal Marto recalled that Saints Francisco and Jacinto Marto, shepherd children to whom an angel, and then the Blessed Virgin Mary appeared in 1916 and 1917 at Fatima, both died amid the victims of the Spanish flu pandemic.

To date, Johns Hopkins University has reported 26,182 cases of novel coronavirus in Portugal, with 1089 deaths.

 

German translation of the BIS press release about the BIS Quarterly Review, March 2019

Rome Newsroom, May 8, 2020 / 02:00 pm (CNA).- After the Congregation for the Doctrine of the Faith ruled that the hospitals of the Brothers of Charity in Belgium can no longer be considered as Catholic, the religious order is seeking to prevent the hospital network from using its name, their general superior told CNA. 

Br. René Stockman, general superior of the Congregation of the Brothers of Charity, said he fought to keep the Catholic identity and mission of the hospitals intact. But when the Brothers of Charity Organization, the non-profit group which manages the hospitals, approved pro-euthanasia guidelines 2017, he immediately referred the matter to the Congregation for the Doctrine of the Faith, which issued its decision at the end of March.

The CDF decision was communicated in a letter dated March 30, stating that "with deep sadness" the "psychiatric hospitals managed by the Provincialate of the Brothers of Charity association in Belgium will no longer be able to consider themselves Catholic institutions."

Stockman said he was now working to stop the 15-hospital network run by the Brothers of Charity Organization, the non-profit which brought in the pro-euthanasia policy, from continuing to use the order’s name.

“As a congregation,” Br. Stockman said, “we will clearly ask them not to use the name Brothers of Charity anymore for the psychiatric hospitals,” adding that ”we will do everything to come to clear arrangements without going to legal fight.” 

“We hope that we can make it [work] in that way,” he said, but the non-profit’s board have signalled resistance. 

Raf De Rycke, president of the Brothers of Charity Organization, said on May 5 that he intends to continue using the order’s name, and claimed the hospitals fulfil the same mission, and the same vision as ever, despite bringing in euthanasia.

The Stockman said the order was always adamant that they would never accept the possibility of euthanasia in their hospitals, but only a few brothers remain working in the hospitals, mostly in management roles. The order has asked them to leave their positions, now that they can no longer be considered Catholic. 

But, he said, “there are many doctors who don’t agree with the situation and they made their objection of conscience, but it becomes more difficult for them in an environment where the management is developing clear guidelines on how to perform the process and moving towards euthanasia when a psychiatric patient is asking for it.”

Belgium has ushered in ever-expanding access to euthanasia in recent years, including for mental health patients, even minors, suffering from conditions like depression. Belgian law prohibits contractual clauses or other provisions prohibiting doctors working in institutions to euthanize patients. A doctor or nurse still has the individual freedom of conscience to refuse to euthanize or participate to euthanasia, but the same freedom is no longer afforded to insitutions. 

Stockman said there was no question of not complying with Rome’s decision, and he hoped it would inspire others to reconsider the gravity of the spread of euthanasia.

“We hope that also others will reflect on it, especially in the field of mental health care. It is the first time that the Holy See through the CDF has given a clear answer on the growing practice of euthanasia in the field of mental health care,” he told CNA.  

Belgium has ushered in ever-expanding access to euthanasia in recent years, including for mental health patients, even minors, suffering from conditions like depression.

In an official statement published on their website, the Brothers of Charity Organization has accused Stockman of using the issue of euthanasia "within a broader and longer-lasting conflict” between the order and the non-profit on the use of assets. 

The non-profit suggested that Stockman has long wanted to devote more resources to the Brothers’ missions in Africa and Asian, as vocations have dried up in Belgium, where most of the order’s members are over eighty. Meanwhile, in the developing world, the congregation is growing; last year Br. Stockman welcomed 27 new novices in Nairobi.

The Brothers of Charity Organization frames the dispute as one of control over assets, and its statement said they "do not see the need to adapt our operations after this [CDF] letter because we are convinced that we are acting correctly."

The situation is being monitored closely by other Catholic organizations in the country who see it as a possible test case. So far, the bishops have remained circumspect.

In a May 6 statement, the Belgian Episcopal Conference said that "the bishops experience this as an excruciating and complex affair, in which different types of topics and different lines of responsibility meet." 

The conference called for "a prolonged dialogue between all those involved,” while stressing their "utmost appreciation for the commitment of the Brothers of Charity in Belgium and all their employees to the benefit of mentally disabled, sick or injured people."

Calls for dialogue, however, may prove wishful thinking. As part of its review of the situation, the CDF sent Bishop Jan Hendriks, auxiliary of Amsterdam, as an apostolic visitor to try to resolve the situation, but, the Congregation said, he was unable to find "a viable solution that avoids any form of responsibility of the institution for euthanasia."

The conference also said that "based on their pastoral responsibility, the bishops will continue to work for unity and solidarity in the ecclesial community. They maintain their trust and will continue to cooperate with all the health institutions of Christian civil society."

Stockman did not comment on the bishops’ conference statement.

“Of course,” he said, “we feel, as a congregation, alone [in this fight], but [we are proceeding] in line with the doctrine of the Church, with the clear statement made by our general chapter in 2018 and with our charism of charity.” 

Rome Newsroom, May 8, 2020 / 02:00 pm (CNA).- After the Congregation for the Doctrine of the Faith ruled that the hospitals of the Brothers of Charity in Belgium can no longer be considered as Catholic, the religious order is seeking to prevent the hospital network from using its name, their general superior told CNA. 

Br. René Stockman, general superior of the Congregation of the Brothers of Charity, said he fought to keep the Catholic identity and mission of the hospitals intact. But when the Brothers of Charity Organization, the non-profit group which manages the hospitals, approved pro-euthanasia guidelines 2017, he immediately referred the matter to the Congregation for the Doctrine of the Faith, which issued its decision at the end of March.

The CDF decision was communicated in a letter dated March 30, stating that "with deep sadness" the "psychiatric hospitals managed by the Provincialate of the Brothers of Charity association in Belgium will no longer be able to consider themselves Catholic institutions."

Stockman said he was now working to stop the 15-hospital network run by the Brothers of Charity Organization, the non-profit which brought in the pro-euthanasia policy, from continuing to use the order’s name.

“As a congregation,” Br. Stockman said, “we will clearly ask them not to use the name Brothers of Charity anymore for the psychiatric hospitals,” adding that ”we will do everything to come to clear arrangements without going to legal fight.” 

“We hope that we can make it [work] in that way,” he said, but the non-profit’s board have signalled resistance. 

Raf De Rycke, president of the Brothers of Charity Organization, said on May 5 that he intends to continue using the order’s name, and claimed the hospitals fulfil the same mission, and the same vision as ever, despite bringing in euthanasia.

The Stockman said the order was always adamant that they would never accept the possibility of euthanasia in their hospitals, but only a few brothers remain working in the hospitals, mostly in management roles. The order has asked them to leave their positions, now that they can no longer be considered Catholic. 

But, he said, “there are many doctors who don’t agree with the situation and they made their objection of conscience, but it becomes more difficult for them in an environment where the management is developing clear guidelines on how to perform the process and moving towards euthanasia when a psychiatric patient is asking for it.”

Belgium has ushered in ever-expanding access to euthanasia in recent years, including for mental health patients, even minors, suffering from conditions like depression. Belgian law prohibits contractual clauses or other provisions prohibiting doctors working in institutions to euthanize patients. A doctor or nurse still has the individual freedom of conscience to refuse to euthanize or participate to euthanasia, but the same freedom is no longer afforded to insitutions. 

Stockman said there was no question of not complying with Rome’s decision, and he hoped it would inspire others to reconsider the gravity of the spread of euthanasia.

“We hope that also others will reflect on it, especially in the field of mental health care. It is the first time that the Holy See through the CDF has given a clear answer on the growing practice of euthanasia in the field of mental health care,” he told CNA.  

Belgium has ushered in ever-expanding access to euthanasia in recent years, including for mental health patients, even minors, suffering from conditions like depression.

In an official statement published on their website, the Brothers of Charity Organization has accused Stockman of using the issue of euthanasia "within a broader and longer-lasting conflict” between the order and the non-profit on the use of assets. 

The non-profit suggested that Stockman has long wanted to devote more resources to the Brothers’ missions in Africa and Asian, as vocations have dried up in Belgium, where most of the order’s members are over eighty. Meanwhile, in the developing world, the congregation is growing; last year Br. Stockman welcomed 27 new novices in Nairobi.

The Brothers of Charity Organization frames the dispute as one of control over assets, and its statement said they "do not see the need to adapt our operations after this [CDF] letter because we are convinced that we are acting correctly."

The situation is being monitored closely by other Catholic organizations in the country who see it as a possible test case. So far, the bishops have remained circumspect.

In a May 6 statement, the Belgian Episcopal Conference said that "the bishops experience this as an excruciating and complex affair, in which different types of topics and different lines of responsibility meet." 

The conference called for "a prolonged dialogue between all those involved,” while stressing their "utmost appreciation for the commitment of the Brothers of Charity in Belgium and all their employees to the benefit of mentally disabled, sick or injured people."

Calls for dialogue, however, may prove wishful thinking. As part of its review of the situation, the CDF sent Bishop Jan Hendriks, auxiliary of Amsterdam, as an apostolic visitor to try to resolve the situation, but, the Congregation said, he was unable to find "a viable solution that avoids any form of responsibility of the institution for euthanasia."

The conference also said that "based on their pastoral responsibility, the bishops will continue to work for unity and solidarity in the ecclesial community. They maintain their trust and will continue to cooperate with all the health institutions of Christian civil society."

Stockman did not comment on the bishops’ conference statement.

“Of course,” he said, “we feel, as a congregation, alone [in this fight], but [we are proceeding] in line with the doctrine of the Church, with the clear statement made by our general chapter in 2018 and with our charism of charity.” 

CNA Staff, May 4, 2020 / 12:01 pm (CNA).- The Congregation for the Doctrine of the Faith has ordered 15 psychiatric hospitals in Belgium which belong to the Brothers of Charity to cease identifying as Catholic institutions after they allowed the euthanization of patients in 2017.

The hospitals are managed by a civil non-profit corporation with the same name as the Brothers of Charity religious congregation which owns them.

The CDF decision was communicated in a letter dated March 30, stating that "with deep sadness" the "psychiatric hospitals managed by the Provincialate of the Brothers of Charity association in Belgium will no longer be able to consider themselves Catholic institutions."

In a statement responding to the CDF's decision, the superior general of the Brothers of Charity, Br. René Stockman, said that "with a heavy heart" the religious congregation "must let go of its psychiatric centers in Belgium."

Br. Stockman pointed out that it is "painful" that the psychiatric centers of the Brothers of Charity in Belgium have lost their Catholic status, considering also that the brothers "were among the pioneers in the field of mental health care in Belgium."

At the same time, Stockman said he recognizes that "the congregation [the Brothers of Charity] has no choice but to remain faithful to the charism of charity, which cannot be reconciled with the practice of euthanasia on psychiatric patients."

The decision by the Vatican's doctrinal office ends three years of disputes between the Brothers of Charity and the corporation which manages their hospitals in Belgium.

In 2017, the board decided to allow euthanasia to be carried out in its hospitals in Belgium, where the euthanasia law is among the most broad.

At the time of the decision, the board of the corporation was composed of 15 members, with only three of them religious brothers of the congregation. 

Two of the three religious brothers among the board members, Luc Lemmens, 61, and Veron Raes, 57, supported the euthanasia decision. Their terms on the board ended at the end of September 2018 and were not renewed.

The religious congregation, especially Stockman, protested the decision, reiterating the Brothers of Charity's rejection of euthanasia in their hospitals.

The brothers appealed to the Vatican, which asked the psychiatric hospitals to change their protocol allowing euthanasia as “a medical act” under certain conditions.

The hospital management responded with a long statement in September 2017, in which it contested a lack of dialogue and maintained the hospital was "perfectly consistent" with Christian doctrine.

The CDF's direction that the hospitals must no longer identify as Catholic was communicated in a letter signed by CDF prefect Cardinal Luis Francisco Ladaria Ferrer and secretary Archbishop Giacomo Morandi.

The letter retraced the developments of the story, recalling that the document allowing euthanasia in the brothers' hospitals "refers neither to God, nor to Holy Scripture, nor to the Christian vision of Man."

According to the letter, the CDF had spoken with the Brothers of Charity and had also informed Pope Francis of the gravity of the situation.

Other audiences had also taken place beginning June 2017, including with the Congregation for Institutes of Consecrated Life and Societies of Apostolic Life, the Secretariat of State, the representatives of the Brothers of Charity and the managing corporation, as well as representatives of the Belgian bishops' conference.

The Holy See also sent Bishop Jan Hendriks, auxiliary of Amsterdam, as an apostolic visitor, but he did not register any steps forward nor a desire to find "a viable solution that avoids any form of responsibility of the institution for euthanasia."

The request of the CDF to the Brothers of Charity and to the managing corporation was clear: “affirm in writing and in an unequivocal way their adherence to the principles of the sacredness of human life and the unacceptability of euthanasia, and, as a consequence, the absolute refusal to carry it out in the institutions they depend on."

The corporation "did not give assurance on these points."

The CDF therefore reiterated that "euthanasia remains an inadmissible act, even in extreme cases," and strengthened the statement by citing St. John Paul II's 1995 encyclical Evangelium vitae, and a Jan. 30 speech by Pope Francis to the CDF.

The CDF stressed that "Catholic teaching affirms the sacred value of human life," the "importance of caring for and accompanying the sick and disabled," as well as "the Christian value of suffering, the moral unacceptability of euthanasia" and "the impossibility of introducing this practice in Catholic hospitals, not even in extreme cases, as well as of collaborating in this regard with civil institutions."

The Brothers of Charity is a religious congregation of lay brothers founded in 1807 in Belgium, whose specialization is care for the sick and those with psychiatric diseases.

At the congregation's July 2018 general chapter the group stressed that the Brothers of Charity "believes in sacredness and absolute respect for every human life, from conception to natural death. The general chapter requires that each brother, associate member and others associated with the mission of the congregation adhere to the doctrine of the Catholic Church on ethical issues."

Acne vulgaris is an extraordinarily common skin condition in adolescents. The mainstays of acne treatment have remained largely unchanged over recent years. In the context of increasing antibiotic resistance worldwide, there is a global movement away from antibiotic monotherapy toward their more restrictive use. Classically reserved for nodulocystic acne, isotretinoin has become the drug of choice by dermatologists for moderate to severe acne. Given the virtually ubiquitous nature of acne in teenagers, there remains an appreciable need for novel therapies. In this article, we will cover the currently used acne treatments, evaluate the issues and data supporting their use, explore the issues of compliance and the mental health implications of acne care, and recommend directions for the field of acne management in adolescents in the years ahead.

RIESLING is perhaps the most famous, unappreciated, abused and generally misunderstood wine of all time and it’s probably also the one most of us cut our teeth on many years ago.

Alan Scott, creative director at Johnstons of Elgin

IF ever we needed to indulge in a bout of collective escapism, if only for 60 minutes on a Sunday night, then that time is now. Thankfully ITV has just the thing – Belgravia, the latest big budget costume drama from Downton Abbey creator Julian Fellowes and a series that positively ripples with dimples, quiffs, honey-coloured chiffon frocks, eye-popping millinery and glamorous uniforms.

Bulgaria coach Luboslav Penev and his staff encouraged over 120 children taking part in a grassroots event in Sofia designed to increase participation in football and other sports.

As lawmakers weigh expansion of the state’s voucher and tax-credit scholarship programs, some renew a push for anti-discrimination protection for lesbian, gay, bisexual, transgender, and queer students.

Breastfeeding and oral sucrose have shown an analgesic effect in premature newborn infants for minor painful procedures. Studies suggest that the analgesic properties of breast milk are superior to oral sucrose in term neonates.

For premature infants from 32 to 37 weeks, there is no significant difference in analgesic effect between breast milk and oral sucrose. Breast milk is a safe and natural method for pain relief in late preterm infants. (Read the full article)

Pain during routine infant immunization causes parental anxiety. Oral sucrose solutions are effective pain-reduction strategies. Few studies have measured a combined strategy of a physical intervention along with sucrose to decrease the infant’s pain response.

We demonstrate that a physical, nonpharmacological intervention called the 5 S’s (swaddling, side/stomach position, shushing, swinging, and sucking) provides significant pain reduction with or without sucrose during routine 2- and 4-month vaccinations. (Read the full article)

Peer victimization predicts numerous health risks. Lesbian, gay, and bisexual (LGB)-identified youth report greater peer victimization than do heterosexual-identified youth. No longitudinal studies have been conducted on developmental trends of peer victimization and emotional distress among LGB and heterosexual youth.

We provide the first longitudinal evidence on developmental trends of peer victimization and emotional distress for LGB- and heterosexual-identified youth. The findings suggest peer victimization of LGB-identified youth decreases in absolute, but not necessarily relative, terms and contributes to later emotional distress disparities. (Read the full article)

Parents of children with chronic cough have poor quality of life and often seek multiple consultations. There are few randomized controlled trials on the management of cough or on the efficacy of management algorithms outside of inpatient settings.

In a multicenter, trial, we found that the management of children with chronic cough, in accordance with a standardized algorithm, improves clinical outcomes. Earlier application of the algorithm leads to earlier cough resolution and improved parental quality of life. (Read the full article)

Abusive head trauma (AHT) is a rare phenomenon that results in devastating injuries to children. It is necessary to analyze large samples to examine changes in rates over time.

This is the first study to examine rates of AHT at the national, regional, and state level. The results provide a more detailed description of AHT trends than has been previously available. (Read the full article)

Self-medication with over-the-counter (OTC) analgesics, particularly paracetamol (PCM), among children is widespread and increasing. Parents often administer the medicine. The health care system has little knowledge or possibility to regulate OTC medication, and use of PCM for children may be partly unjustified.

Maternal frequent self-medication with OTC analgesics is associated with frequent use of OTC analgesics, particularly PCM, among 6- to 11-year-old schoolchildren, even when the child’s frequency of pain is accounted for. (Read the full article)

Juvenile-onset fibromyalgia (JFM) is a poorly understood chronic pain condition, typically identified in adolescence and accompanied by physical and social impairment and mood difficulties. There are no long-term studies on the prognosis of adolescents with JFM into adulthood.

This prospective study demonstrated that pain and other symptoms persisted into adulthood for >80% of JFM patients, with associated impairments in physical functioning and mood. At follow-up, one-half of the sample met full criteria for adult fibromyalgia. (Read the full article)

Quality measures developed by the Pediatric Quality Measures Program are required to assess disparities in performance according to special health care need status. Methods are needed to identify children according to level of medical complexity in administrative data.

The Pediatric Medical Complexity Algorithm is a new, publicly available algorithm that identifies the small proportion of children with complex chronic disease in Medicaid claims and hospital discharge data with good sensitivity and good to excellent specificity. (Read the full article)

Sleep apnea is a common condition in childhood, mainly managed by tonsillectomy. Codeine was recently contraindicated for pain management after surgery. Controversy exists regarding the safety and effectiveness of alternative medications, morphine, and ibuprofen.

Our findings suggest that ibuprofen does not increase tonsillar bleeding and in combination with acetaminophen is effective for pain management after tonsillectomy. Furthermore, standard morphine doses increased postoperative respiratory events and were not safe in all children. (Read the full article)

Increasing data suggest that neonatal pain has long-term consequences. Pharmacologic interventions for minor pain are ineffective, and nonpharmacologic techniques (sucrose taste, pacifier suckling, breastfeeding) are effective and now widely used.

The taste of sucrose has been shown to be an effective and widely used analgesic for infants, and this study demonstrates that combining brief exposure to natural radiant warmth with the taste of sucrose improves the analgesic effect for the infant. (Read the full article)

There are no validated claims-based algorithms for identifying children with disabilities (CWD) to facilitate larger-scale studies of care quality for CWD.

This study develops the CWD algorithm, a claims-based algorithm for identifying diagnostic codes with a ≥75% chance of indicating CWD, and triangulates the algorithm against parent report and physician chart abstraction. (Read the full article)

An educator's experience teaching math is important, but performance on math-content-certification tests is the best predictor of how well a teacher's students will perform in early algebra, finds a new study by the Regional Educational Laboratory Central at Marzano Research.

A group of Bulgarian teenagers and leaders took part in this year’s TeenStreet Europe for the first time and experienced God in new ways.

This year at the sports and English camp in Bulgaria, the team noticed the fruit of building on relationships over time.

On the first week of its new term, the U.S. Supreme Court held two hours of intense arguments about whether the main federal job-discrimination law protects gay, lesbian, and transgender employees.

This Sweepstakes is open to individuals 18 and older who are legal US residents.

We travel to Kielce to find out more about one of the leading grassroots events for children in Poland.

The story of how Germany won their seventh title, beating debut finalists the Netherlands..

At CES, LG Display is showing off a 65-inch concept TV that can bend at the edges, allowing it to switch from a flat-screen display to a curved one in about five seconds. The company also put a bendable OLED on a foldable tablet/laptop.

Don't watch the Super Bowl on your old, grainy TV. Head over to the PCMag Shop to score a big discount on the 65-Inch LG OLED B9 Series 4K smart OLED TV.

An educator's experience teaching math is important, but performance on math-content-certification tests is the best predictor of how well a teacher's students will perform in early algebra, finds a new study by the Regional Educational Laboratory Central at Marzano Research.