Europe marked the 75th anniversary of the surrender of Nazi Germany to Allied forces in low-key fashion Friday because of coronavirus lockdown restrictions across the continent.The big celebrations planned were either cancelled or dramatically scaled back. There were no mass gatherings, no hugging or kissing, but the day of liberation was emotionally charged from Belfast to Berlin. For the few surviving World War II veterans, many living in nursing homes under virus lockdowns, it has been a…

Agricultural insurance has the potential to add immense value to agriculture value chains by facilitating access to means of production and changing behaviour by reducing uncertainty.

Doctors believe this will revolutionalise medicine, but there are ethical and safety concerns

Disqualified lawmaker Lau Siu-lai was denied the opportunity to respond to allegations of not genuinely upholding Hong Kong’s mini-constitution before she was barred from trying to win back her seat in the Legislative Council, a judge has observed.Mr Justice Anderson Chow Ka-ming made the remark on Thursday while hearing an election petition from Lau, who has asked the High Court to determine whether pro-establishment lawmaker Chan Hoi-yan had been duly elected to the office of Kowloon West…

After almost three months of hectic preparation, Denis Huen Yin-fan’s Hong Kong factory started delivering masks to customers last week to help protect them against the Covid-19 pandemic.Just as the supplies began reaching his clients, the Hong Kong government announced it will be distributing reusable and disposable masks to all households, free of charge, within weeks.Every household will receive reusable masks that can be washed up to 60 times, as well as a pack of 10 disposable masks.1.5…

While the coronavirus pandemic has forced the city’s tourism sector to a near standstill, agency head Christina Yuen Ho-yee is busier than ever, routinely working 12 hours a day.As the Covid-19 pandemic caused global lockdowns, sales at her firm, EGL Tours, dropped to zero between March and June, down from HK$500 million (US$64.5 million) in the same stretch last year.All of her roughly 600 staff members have been asked to take days of unpaid leave between April and June.But Yuen, the agency’s…

A former Pakistani child bride, who was wrongly accused of killing her husband at 13 and subsequently spent almost two decades in prison, is making history by being the first victim of a miscarriage of justice to seek compensation from the state, say legal human rights experts.   This March, Rani Tanveer, who was released in […]

The post Former Child Bride Holds Pakistan to Account for Wrongful Imprisonment in Historic Legal Challenge appeared first on Inter Press Service.

Army General Raúl Castro Ruz, President of the Councils of State and Ministers, held official talks, on Sunday December 7, with the Honorable Freundel Stuart, Prime Minister of Barbados, who is visiting the country as the head of the Barbados delegation to the 5th CARICOM-Cuba Summit.

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Online protests were held simultaneously in support of ABS-CBN.

The post Support pours for ABS-CBN as advocates hold online ‘Black Friday’ protest appeared first on Bulatlat.

TEHRAN: Virus-hit Iran allowed worshippers to attend Friday prayers for the first time in more than two months, but the capital remains under restrictions amid the Middle East’s deadliest coronavirus outbreak. Since reporting its first cases in mid-February, the Islamic republic has...

Human Rights Watch (HRW) said on Saturday that Saudi Arabian authorities recently detained and are holding incommunicado Prince Faisal bin Abdullah, who had previously been netted in an anti-corruption drive and released in late 2017.

The US-based rights group, citing a source with ties to the royal family, said Prince Faisal bin Abdullah, a son of late monarch King Abdullah, was detained by security forces on March 27 while self-isolating due to the coronavirus pandemic at a family compound northeast of the capital Riyadh.

Reuters could not immediately independently verify the detention. The Saudi government media office did not immediately respond to a detailed Reuters request for comment.

Earlier in March, authorities had detained King Salman’s brother, Prince Ahmed bin Abdulaziz, and former crown prince Mohammed bin Nayef, who was replaced in a 2017 palace coup and placed under house arrest, sources had told Reuters.

Sources with royal connections said at the time that the move was a preemptive effort to ensure compliance within the ruling Al Saud family ahead of an eventual succession to the throne by Crown Prince Mohammed bin Salman upon the king’s death or abdication.

It was not clear if the reported detention of Prince Faisal was related to those in early March, which also saw Ahmed’s son Nayef and Mohammed bin Nayef’s brother Nawaf detained.

Saudi authorities have not commented on those detentions, which follow crackdowns on dissent in which clerics, intellectuals and rights activists have been arrested, and an anti-corruption drive launched in 2017 that netted scores of royals, ministers and businessmen.

Critics have said the campaigns were part of moves by Crown Prince Mohammed, the king’s son and the kingdom’s de facto ruler, to consolidate his grip on power.

“Now we have to add Prince Faisal to the hundreds detained in Saudi Arabia without a clear legal basis,” said Michael Page, deputy Middle East director at HRW.

The kingdom has regularly denied allegations of unfair detention.

Authorities said last year the government was winding down the anti-corruption campaign after 15 months, but would continue to go after graft.

HRW said Prince Faisal’s whereabouts or status are not known.

“The source said that Prince Faisal has not publicly criticised authorities since his December 2017 arrest and that family members are concerned about his health as he has a heart condition,” it added.

In late December 2017, a senior Saudi official said Prince Faisal and another royal, Prince Meshaal bin Abdullah, were released from Riyadh’s Ritz-Carlton hotel, where people nabbed in the anti-corruption drive were being held, after reaching an undisclosed financial settlement with the government.

Some groups in the economy may need the government-assistance policy on security to lower the economic uncertainty they face.

Humans, chimpanzees, gorillas and bats have evolved to be good at metabolising alcohol, according to a study that suggests many mammals can get drunk

Armed with drones, helicopters and military-grade software, a British photographer has developed a new way to remember glaciers

Australia's most populous states held back from relaxing coronavirus restrictions on Saturday although other states began allowing small gatherings and were preparing to open restaurants and shops.

Human Rights Watch (HRW) said on Saturday that Saudi Arabian authorities recently detained and are holding incommunicado Prince Faisal bin Abdullah, who had previously been netted in an anti-corruption drive and released in late 2017.

Former British Prime Minister Tony Blair said on Monday that a UK-U.S. trade deal would be very difficult to agree, saying protectionist sentiment worldwide was making trade agreements harder to negotiate.

Reuters’ blogger Felix Salmon shares a surprising list of which companies over the last 90 years have generated the most wealth for shareholders, and which ones have destroyed it.

Our best shot at understanding and even reversing human ageing will come not from studying ourselves, but from 10,000 of our canine companions

Notorious for making us sick, viruses are weird, undead organisms – but new insights are revealing they may have created life's glorious complexity in the first place

Humans, chimpanzees, gorillas and bats have evolved to be good at metabolising alcohol, according to a study that suggests many mammals can get drunk

Title: Gene Variants Hold New Clues to Autism
Category: Health News
Created: 4/29/2009 12:00:00 AM
Last Editorial Review: 4/29/2009 12:00:00 AM

Title: Health Tip: Holding Your Infant Skin to Skin
Category: Health News
Created: 5/2/2013 8:35:00 AM
Last Editorial Review: 5/2/2013 12:00:00 AM

Title: Pangolins Hold Clues to How COVID-19 Began -- and Might End
Category: Health News
Created: 5/8/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Learning more about this evolutionary advantage in pangolins may suggest possible treatments for coronavirus in humans, the team said.

ABSTRACT

Burkholderia pseudomallei, the founding member of the B. pseudomallei complex (Bpc), is a biothreat agent and causes melioidosis, a disease whose treatment mainly relies on ceftazidime and meropenem. The concern is that B. pseudomallei could enhance its drug resistance repertoire by the acquisition of DNA from resistant near-neighbor species. Burkholderia ubonensis, a member of the B. cepacia complex (Bcc), is commonly coisolated from environments where B. pseudomallei is present. Unlike B. pseudomallei, in which significant primary carbapenem resistance is rare, it is not uncommon in B. ubonensis, but the underlying mechanisms are unknown. We established that carbapenem resistance in B. ubonensis is due to an inducible class A PenB β-lactamase, as has been shown for other Bcc bacteria. Inducibility is not sufficient for high-level resistance but also requires other determinants, such as a PenB that is more robust than that present in susceptible isolates, as well as other resistance factors. Curiously and diagnostic for the two complexes, both Bpc and Bcc bacteria contain distinct annotated PenA class A β-lactamases. However, the protein from Bcc bacteria is missing its essential active-site serine and, therefore, is not a β-lactamase. Regulated expression of a transcriptional penB'-lacZ (β-galactosidase) fusion in the B. pseudomallei surrogate B. thailandensis confirms that although Bpc bacteria lack an inducible β-lactamase, they contain the components required for responding to aberrant peptidoglycan synthesis resulting from β-lactam challenge. Understanding the diversity of antimicrobial resistance in Burkholderia species is informative about how the challenges arising from potential resistance transfer between them can be met.

IMPORTANCE Burkholderia pseudomallei causes melioidosis, a tropical disease that is highly fatal if not properly treated. Our data show that, in contrast to B. pseudomallei, B. ubonensis β-lactam resistance is fundamentally different because intrinsic resistance is mediated by an inducible class A β-lactamase. This includes resistance to carbapenems. Our work demonstrates that studies with near-neighbor species are informative about the diversity of antimicrobial resistance in Burkholderia and can also provide clues about the potential of resistance transfer between bacteria inhabiting the same environment. Knowledge about potential adverse challenges resulting from the horizontal transfer of resistance genes between members of the two complexes enables the design of effective countermeasures.

Plants require a high concentration of ascorbate as a redox buffer for survival under stress conditions, such as high light. Dehydroascorbate reductases (DHARs) are enzymes that catalyze the reduction of DHA to ascorbate using reduced glutathione (GSH) as an electron donor, allowing rapid ascorbate recycling. However, a recent study using an Arabidopsis (Arabidopsis thaliana) triple mutant lacking all three DHAR genes (herein called dhar) did not find evidence for their role in ascorbate recycling under oxidative stress. To further study the function of DHARs, we generated dhar Arabidopsis plants as well as a quadruple mutant line combining dhar with an additional vtc2 mutation that causes ascorbate deficiency. Measurements of ascorbate in these mutants under low- or high-light conditions indicated that DHARs have a nonnegligible impact on full ascorbate accumulation under high light, but that they are dispensable when ascorbate concentrations are low to moderate. Because GSH itself can reduce DHA nonenzymatically, we used the pad2 mutant that contains ~30% of the wild-type GSH level. The pad2 mutant accumulated ascorbate at a wild-type level under high light; however, when the pad2 mutation was combined with dhar, there was near-complete inhibition of high-light–dependent ascorbate accumulation. The lack of ascorbate accumulation was consistent with a marked increase in the ascorbate degradation product threonate. These findings indicate that ascorbate recycling capacity is limited in dhar pad2 plants, and that both DHAR activity and GSH content set a threshold for high-light–induced ascorbate accumulation.

Clostridioides difficile infection (CDI) is one of the most common health care-associated infections that can cause significant morbidity and mortality. CDI diagnosis involves laboratory testing in conjunction with clinical assessment. The objective of this study was to assess the performance of various C. difficile tests and to compare clinical characteristics, Xpert C. difficile/Epi (PCR) cycle threshold (C_T), and Singulex Clarity C. diff toxins A/B (Clarity) concentrations between groups with discordant test results. Unformed stool specimens from 200 hospitalized adults (100 PCR positive and 100 negative) were tested by cell cytotoxicity neutralization assay (CCNA), C. diff Quik Chek Complete (Quik Chek), Premier Toxins A and B, and Clarity. Clinical data, including CDI severity and CDI risk factors, were compared between discordant test results. Compared to CCNA, PCR had the highest sensitivity at 100% and Quik Chek had the highest specificity at 100%. Among clinical and laboratory data studied, prevalences of leukocytosis, prior antibiotic use, and hospitalizations were consistently higher across all subgroups in comparisons of toxin-positive to toxin-negative patients. Among PCR-positive samples, the median C_T was lower in toxin-positive samples than in toxin-negative samples; however, C_T ranges overlapped. Among Clarity-positive samples, the quantitative toxin concentration was significantly higher in toxin-positive samples than in toxin-negative samples as determined by CCNA and Quik Chek Toxin A and B. Laboratory tests for CDI vary in sensitivity and specificity. The quantitative toxin concentration may offer value in guiding CDI diagnosis and treatment. The presence of leukocytosis, prior antibiotic use, and previous hospitalizations may assist with CDI diagnosis, while other clinical parameters may not be consistently reliable.

Although studies of mixed chimerism following hematopoietic stem cell transplantation in patients with sickle cell disease (SCD) may provide insights into the engraftment needed to correct the disease and into immunological reconstitution, an extensive multilineage analysis is lacking. We analyzed chimerism simultaneously in peripheral erythroid and granulomonocytic precursors/progenitors, highly purified B and T lymphocytes, monocytes, granulocytes and red blood cells (RBC). Thirty-four patients with mixed chimerism and ≥12 months of follow-up were included. A selective advantage of donor RBC and their progenitors/precursors led to full chimerism in mature RBC (despite partial engraftment of other lineages), and resulted in the clinical control of the disease. Six patients with donor chimerism <50% had hemolysis (reticulocytosis) and higher HbS than their donor. Four of them had donor chimerism <30%, including a patient with AA donor (hemoglobin >10 g/dL) and three with AS donors (hemoglobin <10 g/dL). However, only one vaso-occlusive crisis occurred with 68.7% HbS. Except in the patients with the lowest chimerism, the donor engraftment was lower for T cells than for the other lineages. In a context of mixed chimerism after hematopoietic stem cell transplantation for SCD, myeloid (rather than T cell) engraftment was the key efficacy criterion. Results show that myeloid chimerism as low as 30% was sufficient to prevent a vaso-occlusive crisis in transplants from an AA donor but not constantly from an AS donor. However, the correction of hemolysis requires higher donor chimerism levels (i.e. ≥50%) in both AA and AS recipients. In the future, this group of patients may need a different therapeutic approach.

Burkholderia cepacia (formerly Pseudomonas cepacia) was once thought to be a single bacterial species but has expanded to the Burkholderia cepacia complex (Bcc), comprising 24 closely related opportunistic pathogenic species. These bacteria have a widespread environmental distribution, an extraordinary metabolic versatility, a complex genome with three chromosomes, and a high capacity for rapid mutation and adaptation. Additionally, they present an inherent resistance to antibiotics and antiseptics, as well as the abilities to survive under nutrient-limited conditions and to metabolize the organic matter present in oligotrophic aquatic environments, even using certain antimicrobials as carbon sources. These traits constitute the reason that Bcc bacteria are considered feared contaminants of aqueous pharmaceutical and personal care products and the frequent reason behind nonsterile product recalls. Contamination with Bcc has caused numerous nosocomial outbreaks in health care facilities, presenting a health threat, particularly for patients with cystic fibrosis and chronic granulomatous disease and for immunocompromised individuals. This review addresses the role of Bcc bacteria as a potential public health problem, the mechanisms behind their success as contaminants of pharmaceutical products, particularly in the presence of biocides, the difficulties encountered in their detection, and the preventive measures applied during manufacturing processes to control contamination with these objectionable microorganisms. A summary of Bcc-related outbreaks in different clinical settings, due to contamination of diverse types of pharmaceutical products, is provided.

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This image of an enormous ship under construction features in a new book and show that challenge common ideas about beauty - while the real ship may help cut carbon emissions

Safety fears derail plan to import reactors.

U.S. Chief Justice John Roberts on Friday put a temporary hold on the disclosure to a Democratic-led House of Representatives committee of grand jury material redacted from former Special Counsel Robert Mueller's report on Russian interference in the 2016 election.

The notoriously independent-minded federal judge who once said he was disgusted by the conduct of Michael Flynn could block the administration's bid to drop criminal charges against the former adviser to President Donald Trump, legal experts said.

The U.S. Senate on Wednesday approved William Evanina, President Donald Trump's nominee for a top counterintelligence position, after he was blocked for almost two years over a Republican request for documents related to the investigation of Russia and Trump's 2016 election campaign.

The U.S. Senate failed on Thursday to override President Donald Trump's veto of a resolution that would have reined in his ability to wage war against Iran by requiring him to obtain congressional authorization for military action.

One in four Portuguese with a monthly household income of 650 euros ($705) or less have lost all their income because of the economic impact of the coronavirus outbreak, a study by the National School of Public Health showed on Saturday.

Paris will hold a men's fashion week in virtual format from July 9 to July 13 for the Men Spring/Summer collections 2021, organisers said on Wednesday.

Follow our live coronavirus updates HERE Coronavirus: the symptoms

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