Air pollution is one of the leading causes of early deaths worldwide, with particulate matter (PM) as an emerging factor contributing to this trend. PM is classified based on its physical size, which ranges from PM₁₀ (diameter ≤10 μm) to PM_2.5 (≤2.5 μm) and PM_0.5 (≤0.5 μm). Smaller-sized PM can move freely through the air and readily infiltrate deep into the lungs, intensifying existing health issues and exacerbating complications. Lung complications are the most common issues arising from PM exposure due to the primary site of deposition in the respiratory system. Conditions such as asthma, COPD, idiopathic pulmonary fibrosis, lung cancer and various lung infections are all susceptible to worsening due to PM exposure. PM can epigenetically modify specific target sites, further complicating its impact on these conditions. Understanding these epigenetic mechanisms holds promise for addressing these complications in cases of PM exposure. This involves studying the effect of PM on different gene expressions and regulation through epigenetic modifications, including DNA methylation, histone modifications and microRNAs. Targeting and manipulating these epigenetic modifications and their mechanisms could be promising strategies for future treatments of lung complications. This review mainly focuses on different epigenetic modifications due to PM_2.5 exposure in the various lung complications mentioned above.

The main monogenic causes of pulmonary fibrosis in adults are mutations in telomere-related genes. These mutations may be associated with extrapulmonary signs (hepatic, haematological and dermatological) and typically present radiologically as usual interstitial pneumonia or unclassifiable fibrosis. In children, the monogenic causes of pulmonary fibrosis are dominated by mutations in surfactant-related genes. These mutations are not associated with extrapulmonary signs and often manifest radiologically as unclassifiable fibrosis with cysts that can lead to chest wall deformities in adults. This review discusses these mutations, along with most of the monogenic causes of interstitial lung disease, including interferon-related genes, mutations in genes causing cystic lung disease, Hermansky–Pudlak syndrome, pulmonary alveolar proteinosis, lysinuric protein intolerance and lysosomal storage disorders, and their pulmonary and extrapulmonary manifestations.

Publisher 11 bit studios and developer Fool’s Theory announced the character-driven RPG, The Thaumaturge, will launch for the PlayStation 5 and Xbox Series X|S on December 4.

The game first released for PC via Steam, Epic Games Store, and GOG in March.

View the console date reveal trailer below:

Read details on the game below:

The Thaumaturge is a historically rich, character-driven RPG set in 1905 Warsaw.

The game follows Wiktor, a world-weary thaumaturge returning to his roots in Warsaw—a bustling city teeming with cultural diversity, serving as a vivid backdrop for his journey. Wiktor’s story unravels the secrets of his troubled past alongside those of Warsaw’s eclectic residents, representing every facet of the city’s society. Ultimately, he may even uncover the intrigues of Rasputin, a shadowy figure weaving influence at the highest levels of the Imperial Court and within the Tsarist forces occupying Poland.

With his thaumaturgic powers, Wiktor sees beyond the ordinary, manipulating others’ wills to achieve his ends and forming connections with mystical beings known as Salutors. While these entities offer distinct advantages in turn-based combat and detective-style investigations, each also brings a unique burden—whether Pride, Recklessness, or another flaw—which Wiktor must absorb, making their powers a double-edged sword.

Features:

• Play an isometric RPG where your choices will shape the final outcome of the story.
• Use your unique skills to influence and manipulate other characters to bend their will to your liking.
• Tame the power of folklore-inspired demons called Salutors to gain an advantage when exploring the world and bringing adversaries to their knees.
• Experience unique turn-based combat and defeat your foes using both physical attacks and the skills of your tamed Salutors.
• Meet a rich gallery of characters from different parts of society on your journey and use your mystic abilities to discover their hidden secrets.
• Explore the rarely portrayed historical period of early 20th-century Warsaw, where crime and luxury are often two sides of the same coin.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463052/the-thaumaturge-launches-december-4-for-ps5-and-xbox-series-xs/

You can unsend or edit your iMessages with the latest iOS updates. Kurt the CyberGuy explains how you can save yourself some potential embarrassment.

A well-preserved section of the 2,000-year-old road, known as Watling Street, was unearthed under Old Kent Road in Southwark

The discovery could lead to a new treatment for millions of people with obesity and type 2 diabetes who do not respond well to current treatments.

1. Canada’s first human bird flu case: Teen in critical condition; dangers of H5N1 in kids and young  The Times of India
2. Teenager in critical condition with Canada’s first human case of bird flu  The Guardian
3. B.C. teen in critical condition in hospital with Canada’s 1st presumptive human case of bird flu  Global News Toronto
4. Bird flu alert in Canada as teen tests positive; officials launch investigation  Business Insider India
5. All you need to know about H5N1 avian influenza  CTV News

5 rare supernova images captured by NASA's Hubble Space Telescope  India.com

Top 10 Animals with the Strongest Senses  Moneycontrol

1. Sunita Williams breaks silence on weight loss rumours, says THIS has 'definitely changed' her body | Mint  Mint
2. "My Body Has Changed, But....": Sunita Williams On Health Aboard Space Station  NDTV
3. After Sunita Williams, NASA now worried about her stranded mission partner's losing body mass  Hindustan Times
4. Stranded Sunita Williams dismisses severe weight loss rumours, says she feels ‘healthier than ever’  The Times of India
5. Exclusive | NASA races to stabilize astronaut Sunita Williams' weight  New York Post

1. Kanguva Box Office Day 1 Advance Booking: Suriya Starrer Jumps By 353%, Already Enters Biggest Tamil Openers Of 2024!  Koimoi
2. 5 Reasons To Watch Suriya and Bobby Deol Starrer 'Kanguva' In Theatres  Zee News
3. Waiting for Suriya's 'Kanguva', watch these blockbuster films by National Award-winning actor for free  India TV News
4. Kanguva budget and actor salaries: Suriya took Rs 39 crore, Bobby Deol earned Rs 5 crore for his role – How much money others charged for the film  The Financial Express
5. Kanguva Movie Release, Review Live Updates: Suriya-starrer has already earned over Rs 7.3 crore before opening day  The Indian Express

1. Arvinder Singh Sahney takes charge as Chairman of IndianOil  ANI News
2. Arvinder Sahney takes the reins of IOC chairman  The Times of India
3. Arvinder Singh Sahney appointed Indian Oil CMD  Mint
4. WILL A K SAHNEY BE THE NEXT CHAIRMAN OF IOCL  Indian Mandarins
5. Arvinder Singh Sahney is new chairman of Indian Oil  The Hindu

1. Nitish Kumar tries to touch PM Modi's feet on stage | Watch  Hindustan Times
2. Video: Nitish Kumar Bends To Touch PM's Feet At Event, He Does This  NDTV
3. PM Modi states ‘1 lakh medical seats in India’, vows to add ‘75,000 more’, lays foundation stone of AIIMS in Bihar  Mint
4. Watch: PM Modi's unexpected gesture as Nitish Kumar bows down to touch his feet  The Times of India
5. PM Modi lays foundation stone for AIIMS Darbhanga in Bihar, says NDA Govt committed to welfare of people  The Hindu

1. Donald Trump meets Joe Biden in White House; both pledge smooth transition  The Hindu
2. Power Transition Will Be "As Smooth As You Can Get", Says Trump  NDTV
3. US President Biden meets President-elect Donald Trump at White House, leaders vow smooth transition of power  The Financial Express
4. Joe and Donald warm up by the White House fireplace  The Times of India
5. Biden greets Trump with handshake, both pledge smooth transition  Moneycontrol

Spread over three days, Hyderabad Comic Con 2024 will deep dive into fun with retro games and Indian creators

The tangled trio of Tahir Raj Bhasin, Anchal Singh and Shweta Tripathi is joined by fresh entrant Gurmeet Choudhary in the new season of ‘Yeh Kaali Kaali Ankhein’

The feverish Cannes-winning spectacle dazzles with audacity but stumbles under the weight of its own ambition

West was a star of the stage and the screen and died in his sleep, his children have announced

The rise of generative AI (gen AI) and ChatGPT has brought large language models (LLMs) to the forefront of technological innovation. Unlike traditional AI, these LLMs can process and generate language in a way that mimics human reasoning. Businesses are leveraging this technology in various ways, including content generation, customer service interactions, and document summarization. Gen AI offers businesses a chance to streamline operations and improve efficiency. However, LLMs are not universally…

Good morning, Bay Area. Prepare for more rain Wednesday as a cold front pushes across California's north coast. And if you are flying, expect more confusion over the name of the airport that resides in Oakland. A federal judge granted an injunction to stop Oakland's airport from calling itself the San Francisco Bay Oakland International Airport, a move that rankled San Francisco International airport, who sued claiming the name change would cause confusion. Mark Calvey has more. In stock news, Instacart…

<p>On 21 October 2024, Brazilian pharmaceutical&nbsp;giant&nbsp;EMS proposed a partnership with competitor Hypera Pharma,&nbsp;setting&nbsp;a course&nbsp;to become&nbsp;Brazil’s&nbsp;largest drug manufacturer.</p>

<p>On 25 September&nbsp;2024, the Brazilian Society of Rheumatology (SBR,&nbsp;<i>Sociedade Brasileira de Reumatologia</i>) shared its position&nbsp;and consensus&nbsp;on the interchangeability between reference products and biosimilars, a topic of great importance for clinical practice, especially in light of recent regulatory developments by&nbsp;Brazilian Health Regulatory Agency, ANVISA (<i>Agência Nacional de Vigilância Sanitária</i>)&nbsp;and other international authorities.&nbsp;</p>

12 men and three women, aged between 19 and 63, were arrested for various offences during a multi-agency enforcement operation against errant public entertainment outlets on Friday (Nov 8) night. The offences include working without a valid work permit, suspected drink driving, driving without a valid license and insurance, suspected consumption and possession of controlled drugs, and the possession of scheduled weapons.  Members of the media, including AsiaOne, were invited to observe the enforcement operations, led by Bedok Police Division, in Joo Chiat on Friday night.  The enforcement operation is part of their ongoing efforts to clamp down on illicit activities and regulatory offences in the area, said the police in a statement on Wednesday. Upon arriving at the scene just after midnight on Saturday, members of the media were led to the second floor of the first KTV outlet. 

NEW DELHI — A toxic haze enveloped India's national capital on the morning of Nov 13 as temperatures dropped and pollution surged, reducing visibility in some parts and prompting a warning from airport authorities that flights may be affected. Delhi overtook Pakistan's Lahore as the world's most polluted city in Swiss group IQAir's live rankings, with an air quality index (AQI) score of more than 1,000, considered "hazardous", but India's pollution authority said the AQI was around 350. Officials were not immediately available to explain the variation. Vehicles drive on a highway on a polluted smoggy morning in New Delhi, India, Nov 7, 2024. PHOTO: Reuters file The India Meteorological Department (IMD) said the pollution had reduced visibility to 100 metres in some places by around 8am local time.

COLOMBO — Chanu Nimesha is contesting Sri Lanka's parliamentary election on Thursday (Nov 14) as the first openly transgender candidate, hoping to forge a more inclusive and tolerant political culture on the South Asian island. Transgender people are estimated to make up about one per cent of Sri Lanka's 22 million people, according to Equal Ground, a local civil society group. They frequently face social rejection, lack legal protection and have almost no representation in political parties. Nimesha, who is contesting from Kegalle — about 80km east of Colombo — said she was the first transgender person to run for a seat in the 225-strong parliament and that her message of social justice had been well received. "I'm not concerned about winning or losing," she said, sitting in her one-bedroom flat. "But it is important for me to be present in this space, to be seen, to inspire others like me. I want to help everyone, not just my community."

Immigrant rights lawyers are preparing to fight back against Donald Trump’s plans to carry out the largest mass deportation in U.S. history once he takes office again in January. The president-elect has already named some leading anti-immigration figures for his incoming administration who will lead the plan, including former ICE head Tom Homan and his longtime aide Stephen Miller. Trump’s picks were central in family separations, the Muslim ban, attacks on Deferred Action for Childhood Arrivals, or DACA, and other anti-immigrant policies during the first Trump administration. Trump is also reportedly planning to greatly expand immigrant detention in private for-profit prisons, and during the campaign he spoke of invoking the Alien Enemies Act of 1798 to speed up deportations. “We have been preparing nearly a year for this,” says attorney Lee Gelernt, deputy director of the ACLU Immigrants’ Rights Project, who argued some of the most high-profile immigration cases during the first Trump administration. He stresses that while groups like the ACLU will challenge the Trump administration in the courts, “it needs to be a national effort” to prevent abuses. “We are not opposed to basic immigration reform, but this cannot be a situation where we’re just going after immigrants left and right.”

Environmental defenders are raising alarm over Donald Trump’s pick to lead the Environmental Protection Agency, former New York Congressmember Lee Zeldin, who has a history of opposing critical environmental protections and clean energy job investments. Zeldin’s nomination comes as Trump is reportedly discussing moving the EPA headquarters outside of Washington, D.C., which could lead to an exodus of staff and expertise from the agency. “I really don’t think this is about government efficiency. I think this is about terrorizing the career staff,” says Judith Enck, who served as a regional administrator of the EPA in the Obama administration.

Cities such as Gurugram, Ghaziabad, Mumbai and Bengaluru are being targeted by Income Tax Department.Notices to taxpayers for the 2021-22 and 2022-23 ass

This is regarding the document required for a change of address on the GST portal. The partnership firm conducts business from a location owned by one of the partners. Would an electricity bill suffice as a document for proof of address? Additionally, should it be mentioned as 'owned property' un

How to change additional place of business as main place of business in gst portal

I passed my Group2 Ca inter exams in May 2024, but noticed that that my gender was displayed incorrectly as female in exam form after a few months of passing the exams when I filled up the exam form for G1 January 2025. Gender is not displayed in Admit card and Marksheet, so did not notice it at

I passed my Group2 Ca inter exams in May 2024, but noticed that that my gender was displayed incorrectly as female in exam form after a few months of passing the exams when I filled up the exam form for G1 January 2025. Gender is not displayed in Admit card and Marksheet, so did not notice it at that time, I am worried whether my result will be cancelled or any discplinary action would be taken against me by institute?
I have already updated Gender in my profile by raising a request on SSP portal, and it is showing male now in the profile but in the future Jan 2025 exam form and the previous exam forms showing me as a female. wrote to ICAI but no reply from them.

Indian-American women politicians are making a mark in this year's general elections in the US with Democrat Kamala Harris all set to be elected as the first Senator from the community.

Indian-American Amul Thapar is among the shortlisted potential nominees for Supreme Court judge picked by President-elect Donald Trump.

My mouth was open when i saw this shoe. It is nice to know about the 150 year old fashion. 

Christmas Gifts Knowledge

From December 24 to January 6 is the next year for the Christmas festival. During the festival, national Christians held a grand ceremony. Christmas was...

A recent survey conducted by TimesJobs suggests that recruiters are never interested in a CV longer than two pages. The survey also reveals that about 43 pct pinpoints the importance of a CV’s length.

A former college lecturer who helped create over 15,000 jobs across the north-east by training youths to become entrepreneurs has won an award from the Schwab Foundation for Social Entrepreneurship.

Indian automobile industry can contribute over 12 pct to the country's gross domestic product (GDP) and generate around 6.5 crore additional jobs over the next decade, a top Maruti Suzuki India official said on Wednesday.

The average size of funding received by start-ups from angel investors grew 27 pct to Rs.4.67 crore in 2015, from Rs.1.06 crore in 2009, a report said.

Zomato, online restaurant discovery and delivery firm is now planning to invest in new businesses such as cloud kitchens. In the past 12 months, the company has managed to boost its revenue and cut down the burn rate.

Ancelotti for a long time in the future can not use the team's heart and soul Harvey - Alonso. According to Spanish media reports said Alonso being sidelined at least until the end of October or early November in order to come back, ...

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Shopping is a great fun if budget is not a constraint. Shopping coupons were initially introduced as promotional coupons for entertaining online shoppers by offering some extra discounts against each online purchase deals. Later on the...

In today's market name badges are available in varying types from which the organizations can choose the one that perfectly meets their requirement. Generally these badges are made using three basic...