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Maintenance Incharge Pharmaceutical Plant-Baddi (7 yr exp Liquid Line/Tablets/Capsules M/C Set up)

Company: P & I Management Consultants
Experience: 5 to 7
location: India
Ref: 24341067
Summary: Job Description: Qualification: B Tech/DME with 5-7 yr experience in Pharmaceutical unit Maintenance. Work Profile: • HVAC system planned/unplanned maintenance, breakdown & troubleshooting. • Having experience of process....




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Saint-Saëns and the stage: operas, plays, pageants, a ballet and a film / Hugh Macdonald

Lewis Library - ML410.S15 M3 2019




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Candyology 101 - Episode 35 - Whatchamacallit

In the latest Candyology 101 podcast, Maria and I tackled a little-celebrated candy bar, the Whatchamacallit. We’re also trying out a new format, which is a little shorter, like a handful of fun size candy bars!





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Boris Palmer: FDP macht umstrittenem Grünen-Politiker Aufnahmeangebot

Nach seinen provokanten Aussagen zur Corona-Pandemie diskutieren die Grünen über einen Parteiausschluss von Tübingens Oberbürgermeister Boris Palmer. Nun macht ihm die FDP Avancen.




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Corona in der Fußball-Bundesliga: Der Fall Dynamo Dresden könnte alle Saisonpläne zunichte machen

Fußball-Zweitligist Dynamo Dresden muss nach positiven Corona-Fällen für zwei Wochen in Quarantäne. Das könnte den Plan zur Fortsetzung der Saison gefährden. Denn die Chancengleichheit ist jetzt kaum noch gegeben.




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THE HIDDEN JEWEL OF HIMACHAL PRADESH

Renuka ji the hidden jewel of Himachal Pradesh Hidden amidst the thickly forested serene hills is set one of the prettiest mountain lakes in india and the biggest in Himachal Pradesh




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Video: Riding Kilimanjaro with Hans Rey & Danny MacAskill - Visual Podcast Ep.5



In the latest episode of Hans Rey's visual podcast, he looks back at his 2016 adventure with Danny MacAskill and Gerhard Czerner.




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Richard Stallman Joins Discussion About Changing Emacs' Appearance To Make It More Popular

Emacs "predates Linux, and was once far more popular," writes LWN.net, while adding that the text editor "has fallen into relative obscurity over the years." Then it reports on a "mega-thread" on the emacs-devel mailing list about how to make Emacs more appealing and attractive to users: The discussion started with a post from "ndame" asking why Emacs is "so square"; the appearance of things like buttons could be improved with rounded corners, they said. Richard Stallman, one of the original authors of Emacs, seemed somewhat dismissive in his reply: "Perhaps we should implement a mode that puts cosmetics on Emacs so it will appeal to those who judge by the surface of things." But Stefan Kangas thought there was more to it than that: I think it's unfortunate if we assume that this is all bells and whistles. Graphical design elements can also improve usability. I also don't know that it's helpful to assume that the rest of the world will take the enlightened stance.... He wondered if there was "any reason not to improve the default look". Stallman said that there are some technical barriers in finding someone interested in and capable of doing the work needed, but there is an overarching problem that needs to be addressed first: The code to interface Emacs to X-based GUIs needs rewriting by an expert, and has needed it for decades. Until it gets that rewrite, changes in it are likely to break something. Stallman did agree that the graphical design could improve usability, "but I have a feeling that the changes that would help are deeper issues than the shape of corners". It was a long and interesting discussion, touching on the popularity of both Vim and Visual Studio Code, while another post questioned whether Emacs should even be prioritizing its menu bar and tool bar. One post suggested "starter kits" to make the text editor more friendly to newcomers, another suggested making Cntrl-C cut-and-paste the default key binding, and one asked whether it was Emacs' terminology and keyboard shortcuts that might be confusing to users coming from Microsoft Word. "You are basically making a commitment to being or becoming a power user..." argued another post. "If you just want to do 'casual' text editing emacs is a very weird choice in 2020."

Read more of this story at Slashdot.




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Hike Machu Picchu: Routes to Get There and Hikes to Enjoy on Site

So you've decided to hike Machu Picchu? Well great! There's no doubt that you're in for the experience of a lifetime. However, the truth of the matter is that now you've got some additional decisions to make. You see, there's more than one route to arrive to the world-famous Inca site, and even once you've arrived there are a few choices to make as well.

But don't fret! If you're looking to hike Machu Picchu, we've got the information you need to start planning your trip.

Hike Machu Picchu: Arriving to the Site

1. Classic Inca Trail

The Classic Inca Trail is a four-day trek stretching some 42 kilometers along an ancient road built by the Incas themselves. This is undoubtedly the most famous route to Machu Picchu, and it's the one way that offers the opportunity to enter the city through its storied Sun Gate. Frankly, we've got tons of information on the Inca Trail on other pages of our site, so we won't waste too much space being redundant here. Check out these pages for more information on the trail's itinerary as well as for access to an Inca Trail map.

2. One-Day Inca Trail

Whether you're crunched for time or simply don't feel physically up to four full days of trekking, don't fret--a small taste of the world-famous Inca Trail is still available to you! A number of tour companies offer an abridged version of the trek, either one full day of hiking or a shortened day followed by a night of camping and a dawn arrival at Machu Picchu. Besides the Inca Trail's famed destination, the one-day version of the trek also takes you past Wiñay Wayna, another favorite ruins along the trail. The bad news here is that you'll still need to reserve one of only a few hundred daily Inca Trail passes, meaning that, just like the full Inca Trail, you'll need to book this trek months in advance.

3. Lares Trail

Just north of the world-famous Sacred Valley sits the comparatively lesser-known Lares Valley, and whereas the former can be swarmed with tourists especially during the high season, life in the Lares Valley continues humming along relatively unchanged. So whether you're looking for a simpler, more culturally-immersive experience or if you just didn't book an Inca Trail pass in time, the Lares Trail is an excellent option! Lucky for you, we've already gathered plenty of information on the Lares Trail including the trek's daily itinerary and a side-by-side comparison of the Lares and Inca Trails if you're struggling to decide how to hike Machu Picchu.

4. Vilcabamba Traverse Route

Warning--this option is neither for the faint of heart nor the out of shape! The Vilcabamba Traverse Route is one of the newest on the Peru trekking circuit, clocking in at nearly 100 kilometers over the course of a week of trekking. Though very difficult, the route is especially rewarding--think a variety of diverse biomes and the ruins of Choquequirao, often compared to Machu Picchu although less than 40% of the site has been excavated (pictured above). Though visited by only 5,000 or so brave trekkers last year, be warned--the local government is pushing a plan to build a cable car to the site! If you want to see the ruins in their current, undisturbed state, it would be best to go sooner than later.

Hike Machu Picchu: Once You're There

5. Huayna Picchu

Just because you've finally arrived at Machu Picchu doesn't mean your hiking experience has to end! The famous mountain soaring in the background of most iconic Machu Picchu photos is possible to hike, and the experience is certainly recommended. The views from the top are great, and on the way down you can even take a back route to the storied Temple of the Moon. For more information on Huayna Picchu, you can check out this past post on our site.

So that's it for today! If you're planning to hike Machu Picchu and have any questions you'd like to ask us, feel free to reach out in the comments section below. And, if you've already done one of these hikes, feel free to share your experience as well. We appreciate all of your comments!




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Machu Picchu

Machu Picchu, Peru

Although it's one of the most well-known archaeological wonders of the world, Machu Picchu still holds plenty of secrets and is on our shortlist of must-see destinations on a Peru trip.

Add picture with a caption showing actual clients with names linking to review.

Machu Picchu is an enigma, some would say a paradox because it is known as both the best known yet least known about of the Inca sites. Since its discovery on July 24, 1911, by North American Hiram Bingham, Machu Picchu has been considered one of the world's greatest architectural and archaeological monuments, due to its extraordinary magnificence and harmonious structure. Machu Picchu is definitely one of the most fascinating sites in Peru.

At 2,400 meters above sea level, in the province of Urubamba, department of Cusco, Machu Picchu surprises us because of the way its stone constructions are spread over a narrow and uneven mountain top, bordering a sheer 400 meter cliff side of the Urubamba River canyon.

Why and how was Machu Picchu built?

Machu Picchu is a citadel shrouded in mystery, and to this day archaeologists have not definitively uncovered the purpose of this city of stone. The site covers an area of about one square mile, and stands in a region that the Incas considered to be magical, due to the meeting of the Andes mountains with the mighty Amazon river. When 135 bodies were discovered while exploring the site, 109 of which were female, some believed that Machu Picchu could have been a monastery where acllas (young girls) were trained to serve the Inca and the Willac Uno (High Priest). Others said it may simply have been an advance settlement for further expansions planned by the Incas. Perhaps the mystery may never be fully explained.

The surprising perfection and beauty of Machu Picchu's walls, built by joining stone to stone without using any cement or adhesive whatsoever, has led to many theories developing around how the city was constructed as well. It is said that a bird by the name of Kak'aqllu knew the formula for softening rock but by command, perhaps by the ancient Inca gods, had its tongue torn out. Others say there was a magic plant that could dissolve and compress stone. Nonetheless, mysteries and myths aside, the obvious wisdom and skill of the city's ancient builders -- evidenced by Machu Picchu's many squares, aqueducts, watchtowers, observatories and its sun clock -- is quite clear.

Many people may be drawn to Peru by Machu Picchu, yet it is considered by many of our guests, to be just one of many of the ruins featuring on the "highlights reel"of their trip. See reviews to read more

How to get to Machu Picchu - One day or multi day trails

You can take a one day trip to Peru from Cuzco or Lima, and walk up to this citadel in the clouds high in the Andes, or you can take some time to get acclimatised and trek via several trails that lead to Machu Picchu, most taking around 4 to 5 days to complete. Alot of people begin their Peru trip with the intent of visiting Machu Picchu, but don't know how much more there is to see and do in and around Machu Picchu.

After all, if you are going to Peru to experience a South American trip of a lifetime, why not learn about all the activities and other ruins there are to discover.

Popular activities on our Peru trips (including Machu Picchu):

  1. Hiking the Lares or Classic Inca Trail
  2. Exploring Machu Picchu - facts about Machu Picchu
  3. Hiking in the Amazon jungle
  4. Sea kayaking on Lake Titicaca
  5. Staying with a local family on Amantani Island
  6. Hiking Sacsayhuamán fortress
  7. Hiking and cycle in the Sacred Valley of the Incas
  8. Exploring Cuzco
  9. Cycling through Andean villages and La Raya Pass
  10. Hiking Amantani and Taquile Islands

[link to above pages Will]

You may be surprised at the number of activities you can do in Peru, in fact it's a surprise to alot of people that it is possible to enjoy these "non Machu Picchu focused" activities at all. Our philosophy is a little different to many tour companies, we believe that if you are going to travel all the way to a new country to experience a whole new culture, why not experience as many perspectives, local cultures and ruins as you can while you are there.

Obviously the most popular trail chosen by visitors wanting to visit Machu Picchu is the Inca Trail. Some people prefer the Lares trail because it offers a much more immersive experience in Peruvian village culture. If you wants to experience some of the traditions and village life the early Inca's enjoyed, you can stay with their descendants in one of the many villages along the Lares Trail.

If you want to hike the traditional route,  take a sneak peak below at some of what the Inca Trail has to offer.

Hike to Machu Picchu on the ancient Inca Trail

The Inca Trail between the Sacred Valley of the Urubamba River and the mysterious abandoned citadel of Machu Picchu is one of the world's classic treks. Climbing out of the river valley, crossing rugged mountain passes over 13,000 ft high, the trail winds through the Andes, passing numerous significant Inca ruins en route before descending through the Sun Gate to the silent stone city of Machu Picchu. To hike the Inca Trail is a thrilling experience and a great privilege. You need a permit from the Peruvian government to set foot on it, and there are strict limits on the number of permits issued each year.

But the Inca Trail is much more than a great hike. It is one small portion of an incredible network of such trails crossing high mountain ranges, bleak deserts, and raging Andean rivers, tying the Inca Empire together. At its peak expansion, Tahuantinsuyo (or The Four Corners as the empire was known) extended from what is now southern Colombia in the north, to central Chile in the south, covering a distance of about 5500 km (3400 mi). To rule such a vast domain, the emperor, or Inca, forged a remarkable communications system of approximately 18,600 miles of trails, paved through much of its length, stepped where need be, through tunnels where necessary, and using gossamer suspension bridges built of straw ropes to cross rivers unfordable in the wet season.

The roads served to move the conquering Inca armies, and were generally wide enough for a minimum of two warriors to travel abreast. A system of runners stationed at rest houses known as tambos sped messages along the roadways, much like the Pony Express mail of the old American West. The Inca, at his empire's capital in Cuzco, could receive news from far away Quito as rapidly as a letter crosses between the two cities in today's mail.

As remarkable as this highway system was in the days when it was built, used and maintained, it is an astounding testimony to its construction that so many segments remain serviceable today, after half a millennium of neglect. Clearly the Inca highway system ranks as one of the greatest engineering achievements of pre-industrial man.

The full Inca Trail is approximately 40km long. Spread over 4 days, this amounts to about five hours walking per day, although you can walk at your own pace - you are not forced to walk with your group the whole time. It is not a difficult walk, although there are a couple of high passes, and a steep climb on the second day, so a basic level of fitness is required.

Alternative Routes To Get To Machu Picchu other than the Inca Trail (link to another page how to get to machu picchu)

Lares Trail (link)

Inca Trail (link)

Aventura Fantastica!

“This was our second Active Adventures trip and while we went to Peru mainly to see Machu Picchu, I feel it was only a fraction of the fun we had during our trip. For me, hiking at 14,000+ feet, climbing rocks via ferrata to go zip lining was an awesome experience despite being very prone to altitude illness (we got there a day early and I was fine by the second day) and having a hubby who is very afraid of heights. Machu Picchu was magnificent but I really enjoyed the less crowded Incan and pre-Incan sites we visited more because we had them nearly all to ourselves. Our tour leader Jhayro and another local guide Daniel (who we had for 3 days in Peru) also made our trip extra special being so friendly and fun to be with both while leading us on adventures as well as during meals and on the bus.

The food we had in Peru was excellent and that is coming from someone who is usually viewed as a picky eater with a fussy stomach. My hubby, who is a much more adventurous eater than I, tried alpaca and guinea pig and both were surprisingly good (yes, I tried them too!). After a couple days, we were used to not drinking the tap water or flushing paper down toilets so neither were a big deal. In fact, when we were in Quito, it seemed strange to be able to do so!

For the Galapagos portion of our trip, we were led by Jose since our scheduled guide Pablo couldn't be there due to a family emergency. Jose was very knowledgable about the local geology, flora, fauna and variety of other things and with several in our group being (former) teachers or scientists, we sure did ask a lot of questions. The unique wildlife of the islands was the primary reason I wanted to visit and I loved seeing Galapagos turtles again as I'd not seen them since I was a child back in the 60's (I remember riding on some in a zoo which I know now was so wrong!). It was my first time seeing marine iguanas and blue footed boobies in the wild and I also enjoyed seeing a variety of other creatures that are in other places but we don't see very often, even living in Hawaii which has very similar geology.

Like Hawaii, each of the Galapagos Islands was different and it was interesting to see how they varied. The different forms of transportation we used to get from island to island were also adventures in themselves: 2 hour ride on a speed boat and an hourish ride on a teeny prop plane!

The only thing that was not quite what we expected with this trip was that some of the activities listed on the Galapagos Island itinerary we did not get to do. Nevertheless, the trip was fantastic and being probably my one and only trip to South America, it will always be remembered.”

Shirley Pratt – Hawaii, United States
Iguana, May 2016

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  • Machu Picchu Inca Trail

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History of Machu Picchu

History of Machu Picchu

Archaeological evidence uncovered around the site suggests that the area was first used for agricultural purposes back in 760 B.C.

The war of Vilcambamba Pachacutec in 1440 established the first settlement at the site. It was called the Tahuantinsuyo Empire which was later followed by the formation of the government of Manco Capac.

It is thought that Machu Picchu was first inhabited by 300-1000 inhabitants, who were of the highest Class or "llactas".

The valleys around these areas were important for their agricultural contribution, however after death of the Emperor Pachacutec, it lost it's importance, with the establishment of new sites like Ollaytantambo and Vilcambamba. The building of these new sites by his successors, in more accessible terrain made Machu Picchu less appealing.

From 1527 to 1532, two brothers Huáscar and Atahualpa fought against each other in a civil war over the Inca Empire. Their father, Inca Huayna Capac had given each brother a section of the empire to manage, one in Huáscar in Cuzco and Atahualpa in Quito. When Huayna Capac and his heir, Ninan Cuyuchi, died somewhere between 1525 and 1527, the two brothers Atahualpa and Huáscar went to war over who should rule.  The population who had come to live in the Machu Picchu area from rural or remote locations left after the war ended to return to where they came from. Later another brother, Manco Inca was sent into exile in Vilcambamba, and Machu Picchu was deserted.

Antonio Raimondi was an Italian geographer and scientist from Milan who visited Machu Picchu in 1851. In 1867 Augusto Berns arrived to mine the site.

Hiram Bingham re-discovered the ruins in 1911. He documented and publicised his "discovery".

Hiram Bingham



  • Machu Picchu Inca Trail

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UK-Africa Relations: Reflections on the Role of African Diplomacy in London

Invitation Only Research Event

13 January 2014 - 11:00am to 12:00pm

Chatham House, London

Event participants

HE Professor Kwaku Danso-Boafo, High Commissioner for Ghana to the United Kingdom
Chair: Alex Vines OBE, Research Director, Area Studies and International Law; Head, Africa Programme, Chatham House

Rapid economic growth and more widespread political stability have catalyzed increased international engagement with Africa in the past decade, as African states develop more significant roles in the global economy and political cooperation in geopolitics. Accompanying this is a shift in British engagement with African states from one with a development aid emphasis to one focused on trade and political cooperation.

HE Professor Kwaku Danso-Boafo will reflect on his time in London, developments in UK-Africa relations, the role of diplomatic engagements in informing and strengthening bilateral relations and the prospects for intergovernmental cooperation on African and global issues.

Attendance at this event is by invitation only.

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NF-{kappa}B mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages [Signal Transduction]

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.




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RNA interference machinery influences epithelial cell biology

Epithelial cells are held together and connected by several different types of structures that form cell-cell contacts.




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Opinion: Iain Macwhirter: It's easy to scare people into staying home; harder to persuade them to come out again

What if the lockdown was lifted and nobody came? A lot of people seem quite happy with life under Covid, especially educated middle-class people on social media who are happily swapping Spotify playlists and recipes for sourdough bread.




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Texmaco Rail: Maintain ‘Buy’ with TP of Rs 69

While we like the company’s diversified segmental presence, we moderate our order inflow and execution assumptions due to the ongoing economic slowdown and slower traction in railway EPC projects.




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Medical Diplomacy: India extends a helping hand to African nations

In April, Prime Minister Narendra Modi in a telephonic conversation with South African President Cyril Ramaphosa had conveyed India’s "full support" to the African continent to deal with fighting the spread of COVID-19.




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Ugandan Shilling(UGX)/Macedonian Denar(MKD)

1 Ugandan Shilling = 0.015 Macedonian Denar




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Salvadoran Colon(SVC)/Macedonian Denar(MKD)

1 Salvadoran Colon = 6.4933 Macedonian Denar




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Romanian Leu(RON)/Macedonian Denar(MKD)

1 Romanian Leu = 12.7603 Macedonian Denar




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1 Ukrainian Hryvnia = 2.1174 Macedonian Denar




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1 Tanzanian Shilling = 0.0246 Macedonian Denar




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1 Venezuelan Bolivar Fuerte = 5.6898 Macedonian Denar



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1 Yemeni Rial = 0.227 Macedonian Denar




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1 Paraguayan Guarani = 0.0087 Macedonian Denar




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1 Hong Kong Dollar = 7.3165 Macedonian Denar



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1 Kuwaiti Dinar = 183.6968 Macedonian Denar




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1 Saudi Riyal = 15.1286 Macedonian Denar




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1 Tunisian Dinar = 19.5113 Macedonian Denar




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1 South African Rand = 3.0967 Macedonian Denar



  • South African Rand

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Norwegian Krone(NOK)/Macedonian Denar(MKD)

1 Norwegian Krone = 5.562 Macedonian Denar




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Argentine Peso(ARS)/Macedonian Denar(MKD)

1 Argentine Peso = 0.8549 Macedonian Denar




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Moroccan Dirham(MAD)/Macedonian Denar(MKD)

1 Moroccan Dirham = 5.7839 Macedonian Denar




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US Dollar(USD)/Macedonian Denar(MKD)

1 US Dollar = 56.8268 Macedonian Denar




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Icelandic Krona(ISK)/Macedonian Denar(MKD)

1 Icelandic Krona = 0.3886 Macedonian Denar




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Kazakhstan Tenge(KZT)/Macedonian Denar(MKD)

1 Kazakhstan Tenge = 0.1347 Macedonian Denar




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Namibian Dollar(NAD)/Macedonian Denar(MKD)

1 Namibian Dollar = 3.0667 Macedonian Denar




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Israeli New Sheqel(ILS)/Macedonian Denar(MKD)

1 Israeli New Sheqel = 16.2052 Macedonian Denar



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Costa Rican Colon(CRC)/Macedonian Denar(MKD)

1 Costa Rican Colon = 0.0999 Macedonian Denar



  • Costa Rican Colon

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British Pound Sterling(GBP)/Macedonian Denar(MKD)

1 British Pound Sterling = 70.4993 Macedonian Denar



  • British Pound Sterling

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Omani Rial(OMR)/Macedonian Denar(MKD)

1 Omani Rial = 148.1999 Macedonian Denar




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Honduran Lempira(HNL)/Macedonian Denar(MKD)

1 Honduran Lempira = 2.2703 Macedonian Denar




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Australian Dollar(AUD)/Macedonian Denar(MKD)

1 Australian Dollar = 37.132 Macedonian Denar




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Chinese Yuan Renminbi(CNY)/Macedonian Denar(MKD)

1 Chinese Yuan Renminbi = 8.033 Macedonian Denar



  • Chinese Yuan Renminbi

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Hungarian Forint(HUF)/Macedonian Denar(MKD)

1 Hungarian Forint = 0.1759 Macedonian Denar




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Philippine Peso(PHP)/Macedonian Denar(MKD)

1 Philippine Peso = 1.1254 Macedonian Denar




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Kenyan Shilling(KES)/Macedonian Denar(MKD)

1 Kenyan Shilling = 0.5358 Macedonian Denar




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Latvian Lat(LVL)/Macedonian Denar(MKD)

1 Latvian Lat = 93.9457 Macedonian Denar




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Egyptian Pound(EGP)/Macedonian Denar(MKD)

1 Egyptian Pound = 3.6513 Macedonian Denar